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Items: 1 to 50 of 79

1.

Stability in metabolic phenotypes and inferred metagenome profiles before the onset of colitis-induced inflammation.

Glymenaki M, Barnes A, O'Hagan S, Warhurst G, McBain AJ, Wilson ID, Kell DB, Else KJ, Cruickshank SM.

Sci Rep. 2017 Aug 18;7(1):8836. doi: 10.1038/s41598-017-08732-1.

2.

Compositional Changes in the Gut Mucus Microbiota Precede the Onset of Colitis-Induced Inflammation.

Glymenaki M, Singh G, Brass A, Warhurst G, McBain AJ, Else KJ, Cruickshank SM.

Inflamm Bowel Dis. 2017 Jun;23(6):912-922. doi: 10.1097/MIB.0000000000001118.

PMID:
28498157
3.

Breast Cancer Resistance Protein Abundance, but Not mRNA Expression, Correlates With Estrone-3-Sulfate Transport in Caco-2.

Harwood MD, Neuhoff S, Rostami-Hodjegan A, Warhurst G.

J Pharm Sci. 2016 Apr;105(4):1370-5. doi: 10.1016/j.xphs.2016.01.018. Epub 2016 Mar 4.

PMID:
26952881
4.

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-glycoprotein and Breast Cancer Resistance Protein: Part II. The Impact of Cross-Laboratory Variations of Intestinal Transporter Relative Expression Factors on Predicted Drug Disposition.

Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G, Rostami-Hodjegan A.

Drug Metab Dispos. 2016 Mar;44(3):476-80. doi: 10.1124/dmd.115.067777. Epub 2016 Feb 3.

PMID:
26842595
5.

In Vitro-In Vivo Extrapolation Scaling Factors for Intestinal P-Glycoprotein and Breast Cancer Resistance Protein: Part I: A Cross-Laboratory Comparison of Transporter-Protein Abundances and Relative Expression Factors in Human Intestine and Caco-2 Cells.

Harwood MD, Achour B, Neuhoff S, Russell MR, Carlson G, Warhurst G; Amin Rostami-Hodjegan.

Drug Metab Dispos. 2016 Mar;44(3):297-307. doi: 10.1124/dmd.115.067371. Epub 2015 Dec 2.

PMID:
26631742
6.

Removal of Contaminant DNA by Combined UV-EMA Treatment Allows Low Copy Number Detection of Clinically Relevant Bacteria Using Pan-Bacterial Real-Time PCR.

Humphrey B, McLeod N, Turner C, Sutton JM, Dark PM, Warhurst G.

PLoS One. 2015 Jul 14;10(7):e0132954. doi: 10.1371/journal.pone.0132954. eCollection 2015.

7.

Rapid detection of health-care-associated bloodstream infection in critical care using multipathogen real-time polymerase chain reaction technology: a diagnostic accuracy study and systematic review.

Warhurst G, Dunn G, Chadwick P, Blackwood B, McAuley D, Perkins GD, McMullan R, Gates S, Bentley A, Young D, Carlson GL, Dark P.

Health Technol Assess. 2015 May;19(35):1-142. doi: 10.3310/hta19350. Review.

8.

Application of an LC-MS/MS method for the simultaneous quantification of human intestinal transporter proteins absolute abundance using a QconCAT technique.

Harwood MD, Achour B, Russell MR, Carlson GL, Warhurst G, Rostami-Hodjegan A.

J Pharm Biomed Anal. 2015 Jun 10;110:27-33. doi: 10.1016/j.jpba.2015.02.043. Epub 2015 Feb 28.

9.

Accuracy of LightCycler(®) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review and meta-analysis.

Dark P, Blackwood B, Gates S, McAuley D, Perkins GD, McMullan R, Wilson C, Graham D, Timms K, Warhurst G.

Intensive Care Med. 2015 Jan;41(1):21-33. doi: 10.1007/s00134-014-3553-8. Epub 2014 Nov 22. Review.

PMID:
25416643
10.

Diagnostic accuracy of SeptiFast multi-pathogen real-time PCR in the setting of suspected healthcare-associated bloodstream infection.

Warhurst G, Maddi S, Dunn G, Ghrew M, Chadwick P, Alexander P, Bentley A, Moore J, Sharman M, Carlson GL, Young D, Dark P.

Intensive Care Med. 2015 Jan;41(1):86-93. doi: 10.1007/s00134-014-3551-x. Epub 2014 Nov 19.

PMID:
25406409
11.

Lost in centrifugation: accounting for transporter protein losses in quantitative targeted absolute proteomics.

Harwood MD, Russell MR, Neuhoff S, Warhurst G, Rostami-Hodjegan A.

Drug Metab Dispos. 2014 Oct;42(10):1766-72. doi: 10.1124/dmd.114.058446. Epub 2014 Jul 24.

PMID:
25061159
12.

Increased susceptibility to Trichuris muris infection and exacerbation of colitis in Mdr1a-/- mice.

Bhardwaj EK, Else KJ, Rogan MT, Warhurst G.

World J Gastroenterol. 2014 Feb 21;20(7):1797-806. doi: 10.3748/wjg.v20.i7.1797.

13.

Absolute abundance and function of intestinal drug transporters: a prerequisite for fully mechanistic in vitro-in vivo extrapolation of oral drug absorption.

Harwood MD, Neuhoff S, Carlson GL, Warhurst G, Rostami-Hodjegan A.

Biopharm Drug Dispos. 2013 Jan;34(1):2-28. doi: 10.1002/bdd.1810. Epub 2012 Oct 8. Review.

PMID:
22927116
14.

Combined molecular gram typing and high-resolution melting analysis for rapid identification of a syndromic panel of bacteria responsible for sepsis-associated bloodstream infection.

Ozbak H, Dark P, Maddi S, Chadwick P, Warhurst G.

J Mol Diagn. 2012 Mar-Apr;14(2):176-84. doi: 10.1016/j.jmoldx.2011.12.004. Epub 2012 Jan 21.

PMID:
22269179
15.

Accuracy of LightCycler(R) SeptiFast for the detection and identification of pathogens in the blood of patients with suspected sepsis: a systematic review protocol.

Dark P, Wilson C, Blackwood B, McAuley DF, Perkins GD, McMullan R, Gates S, Warhurst G.

BMJ Open. 2012 Jan 12;2(1):e000392. doi: 10.1136/bmjopen-2011-000392. Print 2012.

16.

The clinical diagnostic accuracy of rapid detection of healthcare-associated bloodstream infection in intensive care using multipathogen real-time PCR technology.

Dark P, Dunn G, Chadwick P, Young D, Bentley A, Carlson G, Warhurst G.

BMJ Open. 2011 Jun 30;1(1):e000181. doi: 10.1136/bmjopen-2011-000181.

17.
18.

Detecting sepsis-associated bloodstream infection acquired in intensive care using multi-pathogen real-time PCR.

Dark P, Chadwick P, Warhurst G.

J Infect. 2009 Oct;59(4):296-8. doi: 10.1016/j.jinf.2009.08.002. Epub 2009 Aug 18. No abstract available.

PMID:
19695286
19.

Bench-to-bedside review: the promise of rapid infection diagnosis during sepsis using polymerase chain reaction-based pathogen detection.

Dark PM, Dean P, Warhurst G.

Crit Care. 2009;13(4):217. doi: 10.1186/cc7886. Epub 2009 Jul 15. Review.

20.

Potentiation of flagellin responses in gut epithelial cells by interferon-gamma is associated with STAT-independent regulation of MyD88 expression.

Bannon C, Davies PJ, Collett A, Warhurst G.

Biochem J. 2009 Sep 14;423(1):119-28. doi: 10.1042/BJ20090392.

PMID:
19619129
21.

The K5 capsule of Escherichia coli strain Nissle 1917 is important in mediating interactions with intestinal epithelial cells and chemokine induction.

Hafez M, Hayes K, Goldrick M, Warhurst G, Grencis R, Roberts IS.

Infect Immun. 2009 Jul;77(7):2995-3003. doi: 10.1128/IAI.00040-09. Epub 2009 Apr 20.

22.

Characterisation of Escherichia coli strains involved in transcytosis across gut epithelial cells exposed to metabolic and inflammatory stress.

Macutkiewicz C, Carlson G, Clark E, Dobrindt U, Roberts I, Warhurst G.

Microbes Infect. 2008 Apr;10(4):424-31. doi: 10.1016/j.micinf.2008.01.001. Epub 2008 Jan 12.

PMID:
18403240
23.

Early molecular and functional changes in colonic epithelium that precede increased gut permeability during colitis development in mdr1a(-/-) mice.

Collett A, Higgs NB, Gironella M, Zeef LA, Hayes A, Salmo E, Haboubi N, Iovanna JL, Carlson GL, Warhurst G.

Inflamm Bowel Dis. 2008 May;14(5):620-31. doi: 10.1002/ibd.20375.

PMID:
18275070
25.

Colonic secretion studied in vitro in rats fed polyunsaturated fatty acids.

Mahmood B, Higgs N, Howl L, Warhurst G.

Bangladesh Med Res Counc Bull. 2006 Dec;32(3):72-7.

PMID:
17867271
26.

Genotypic and physiological characterization of Saccharomyces boulardii, the probiotic strain of Saccharomyces cerevisiae.

Edwards-Ingram L, Gitsham P, Burton N, Warhurst G, Clarke I, Hoyle D, Oliver SG, Stateva L.

Appl Environ Microbiol. 2007 Apr;73(8):2458-67. Epub 2007 Feb 9.

27.

Interferon-gamma selectively increases epithelial permeability to large molecules by activating different populations of paracellular pores.

Watson CJ, Hoare CJ, Garrod DR, Carlson GL, Warhurst G.

J Cell Sci. 2005 Nov 15;118(Pt 22):5221-30. Epub 2005 Oct 25.

28.

Comparison of P-glycoprotein-mediated drug-digoxin interactions in Caco-2 with human and rodent intestine: relevance to in vivo prediction.

Collett A, Tanianis-Hughes J, Carlson GL, Harwood MD, Warhurst G.

Eur J Pharm Sci. 2005 Dec;26(5):386-93. Epub 2005 Sep 8.

PMID:
16153812
29.

Variability of bacterial translocation in the absence of intestinal mucosal damage following injury and the influence of interleukin-6.

Gunji H, Scarth S, Carlson GL, Warhurst G, Little RA, Hopkins SJ.

Pathophysiology. 2006 Feb 21;13(1):39-49. Epub 2005 Aug 11.

PMID:
16099144
30.

Interferon gamma induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft-mediated process.

Clark E, Hoare C, Tanianis-Hughes J, Carlson GL, Warhurst G.

Gastroenterology. 2005 May;128(5):1258-67.

PMID:
15887109
31.
32.
33.
34.

Region-dependent modulation of intestinal permeability by drug efflux transporters: in vitro studies in mdr1a(-/-) mouse intestine.

Stephens RH, Tanianis-Hughes J, Higgs NB, Humphrey M, Warhurst G.

J Pharmacol Exp Ther. 2002 Dec;303(3):1095-101.

PMID:
12438532
35.

Resolution of P-glycoprotein and non-P-glycoprotein effects on drug permeability using intestinal tissues from mdr1a (-/-) mice.

Stephens RH, O'Neill CA, Bennett J, Humphrey M, Henry B, Rowland M, Warhurst G.

Br J Pharmacol. 2002 Apr;135(8):2038-46.

36.
37.

Somatostatin enhances cAMP-dependent short-circuit current in human colon via somatostatin receptor subtype-2.

Hope N, Butt G, Ross I, Warhurst G, Arn M, Grigor M, Lubcke R, Barbezat GO.

Dig Dis Sci. 2001 Nov;46(11):2499-503.

PMID:
11713960
38.

Functional modeling of tight junctions in intestinal cell monolayers using polyethylene glycol oligomers.

Watson CJ, Rowland M, Warhurst G.

Am J Physiol Cell Physiol. 2001 Aug;281(2):C388-97.

39.

Somatostatin and octreotide stimulate short-circuit current in human colonic epithelium.

Arn M, Butt G, Lubcke R, Ross I, Grigor M, Warhurst G, Barbezat G.

Dig Dis Sci. 2000 Nov;45(11):2100-7.

PMID:
11215722
40.

Kinetic profiling of P-glycoprotein-mediated drug efflux in rat and human intestinal epithelia.

Stephens RH, O'Neill CA, Warhurst A, Carlson GL, Rowland M, Warhurst G.

J Pharmacol Exp Ther. 2001 Feb;296(2):584-91.

PMID:
11160647
41.
42.

Carbachol potentiates cholera toxin-induced secretion in a colonic epithelial cell line (HT29-19A) and rat ileal mucosa in vitro.

Mahmood B, Warhurst G, Higgs N, Turnberg LA.

J Health Popul Nutr. 2000 Jun;18(1):49-53.

PMID:
11014771
43.

L-Type calcium channels in enterochromaffin cells from guinea pig and human duodenal crypts: an in situ study.

Lomax RB, Gallego S, Novalbos J, García AG, Warhurst G.

Gastroenterology. 1999 Dec;117(6):1363-9.

PMID:
10579977
44.

Somatostatin peptides inhibit basolateral potassium channels in human colonic crypts.

Sandle GI, Warhurst G, Butterfield I, Higgs NB, Lomax RB.

Am J Physiol. 1999 Nov;277(5):G967-75. doi: 10.1152/ajpgi.1999.277.5.G967.

PMID:
10564102
45.

Direct inhibitory effect of nicardipine on basolateral K+ channels in human colonic crypts.

Sandle GI, Butterfield I, Higgs NB, Warhurst G.

Pflugers Arch. 1999 Mar;437(4):596-602.

PMID:
10089573
46.
47.

Fatty acids stimulate cholecystokinin secretion via an acyl chain length-specific, Ca2+-dependent mechanism in the enteroendocrine cell line STC-1.

McLaughlin JT, Lomax RB, Hall L, Dockray GJ, Thompson DG, Warhurst G.

J Physiol. 1998 Nov 15;513 ( Pt 1):11-8.

48.

Species differences in size discrimination in the paracellular pathway reflected by oral bioavailability of poly(ethylene glycol) and D-peptides.

He YL, Murby S, Warhurst G, Gifford L, Walker D, Ayrton J, Eastmond R, Rowland M.

J Pharm Sci. 1998 May;87(5):626-33.

PMID:
9572915
50.

Somatostatin inhibits Ca(2+)-activated K+ channels in human colonic crypts.

Butterfield I, Warhurst G, Sandle GI.

Biochem Soc Trans. 1997 Aug;25(3):433S. No abstract available.

PMID:
9388657

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