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Connexin 43 Functions as a Positive Regulator of Stem Cell Differentiation into Definitive Endoderm and Pancreatic Progenitors.

Yang W, Lampe PD, Kensel-Hammes P, Hesson J, Ware CB, Crisa L, Cirulli V.

iScience. 2019 Sep 27;19:450-460. doi: 10.1016/j.isci.2019.07.033. Epub 2019 Jul 24.


Enhancer Chromatin and 3D Genome Architecture Changes from Naive to Primed Human Embryonic Stem Cell States.

Battle SL, Doni Jayavelu N, Azad RN, Hesson J, Ahmed FN, Overbey EG, Zoller JA, Mathieu J, Ruohola-Baker H, Ware CB, Hawkins RD.

Stem Cell Reports. 2019 May 14;12(5):1129-1144. doi: 10.1016/j.stemcr.2019.04.004. Epub 2019 May 2.


Global Brain Transcriptome Analysis of a Tpp1 Neuronal Ceroid Lipofuscinoses Mouse Model.

Domowicz MS, Chan WC, Claudio-Vázquez P, Henry JG, Ware CB, Andrade J, Dawson G, Schwartz NB.

ASN Neuro. 2019 Jan-Dec;11:1759091419843393. doi: 10.1177/1759091419843393.


Folliculin regulates mTORC1/2 and WNT pathways in early human pluripotency.

Mathieu J, Detraux D, Kuppers D, Wang Y, Cavanaugh C, Sidhu S, Levy S, Robitaille AM, Ferreccio A, Bottorff T, McAlister A, Somasundaram L, Artoni F, Battle S, Hawkins RD, Moon RT, Ware CB, Paddison PJ, Ruohola-Baker H.

Nat Commun. 2019 Feb 7;10(1):632. doi: 10.1038/s41467-018-08020-0.


Using DNase Hi-C techniques to map global and local three-dimensional genome architecture at high resolution.

Ma W, Ay F, Lee C, Gulsoy G, Deng X, Cook S, Hesson J, Cavanaugh C, Ware CB, Krumm A, Shendure J, Blau CA, Disteche CM, Noble WS, Duan Z.

Methods. 2018 Jun 1;142:59-73. doi: 10.1016/j.ymeth.2018.01.014. Epub 2018 Jan 31.


Epigenetic memory via concordant DNA methylation is inversely correlated to developmental potential of mammalian cells.

Choi M, Genereux DP, Goodson J, Al-Azzawi H, Allain SQ, Simon N, Palasek S, Ware CB, Cavanaugh C, Miller DG, Johnson WC, Sinclair KD, Stöger R, Laird CD.

PLoS Genet. 2017 Nov 6;13(11):e1007060. doi: 10.1371/journal.pgen.1007060. eCollection 2017 Nov.


Concise Review: Lessons from Naïve Human Pluripotent Cells.

Ware CB.

Stem Cells. 2017 Jan;35(1):35-41. doi: 10.1002/stem.2507. Epub 2016 Nov 10. Review.


Conversion of Prostate Adenocarcinoma to Small Cell Carcinoma-Like by Reprogramming.

Borges GT, Vêncio EF, Quek SI, Chen A, Salvanha DM, Vêncio RZ, Nguyen HM, Vessella RL, Cavanaugh C, Ware CB, Troisch P, Liu AY.

J Cell Physiol. 2016 Sep;231(9):2040-7. doi: 10.1002/jcp.25313. Epub 2016 Feb 4.


The metabolome regulates the epigenetic landscape during naive-to-primed human embryonic stem cell transition.

Sperber H, Mathieu J, Wang Y, Ferreccio A, Hesson J, Xu Z, Fischer KA, Devi A, Detraux D, Gu H, Battle SL, Showalter M, Valensisi C, Bielas JH, Ericson NG, Margaretha L, Robitaille AM, Margineantu D, Fiehn O, Hockenbery D, Blau CA, Raftery D, Margolin AA, Hawkins RD, Moon RT, Ware CB, Ruohola-Baker H.

Nat Cell Biol. 2015 Dec;17(12):1523-35. doi: 10.1038/ncb3264. Epub 2015 Nov 16.


The GIPC1-Akt1 Pathway Is Required for the Specification of the Eye Field in Mouse Embryonic Stem Cells.

La Torre A, Hoshino A, Cavanaugh C, Ware CB, Reh TA.

Stem Cells. 2015 Sep;33(9):2674-85. doi: 10.1002/stem.2062. Epub 2015 Jun 24.


Intrinsic retroviral reactivation in human preimplantation embryos and pluripotent cells.

Grow EJ, Flynn RA, Chavez SL, Bayless NL, Wossidlo M, Wesche DJ, Martin L, Ware CB, Blish CA, Chang HY, Pera RA, Wysocka J.

Nature. 2015 Jun 11;522(7555):221-5. doi: 10.1038/nature14308. Epub 2015 Apr 20.


Fine-scale chromatin interaction maps reveal the cis-regulatory landscape of human lincRNA genes.

Ma W, Ay F, Lee C, Gulsoy G, Deng X, Cook S, Hesson J, Cavanaugh C, Ware CB, Krumm A, Shendure J, Blau CA, Disteche CM, Noble WS, Duan Z.

Nat Methods. 2015 Jan;12(1):71-8. doi: 10.1038/nmeth.3205. Epub 2014 Dec 1.


Reprogramming of prostate cancer cells--technical challenges.

Borges GT, Vêncio EF, Vêncio RZ, Vessella RL, Ware CB, Liu AY.

Curr Urol Rep. 2015 Jan;16(1):468. doi: 10.1007/s11934-014-0468-4. Review.


Naive embryonic stem cells: the future of stem cell research?

Ware CB.

Regen Med. 2014;9(4):401-3. doi: 10.2217/rme.14.31. No abstract available.


Derivation of naive human embryonic stem cells.

Ware CB, Nelson AM, Mecham B, Hesson J, Zhou W, Jonlin EC, Jimenez-Caliani AJ, Deng X, Cavanaugh C, Cook S, Tesar PJ, Okada J, Margaretha L, Sperber H, Choi M, Blau CA, Treuting PM, Hawkins RD, Cirulli V, Ruohola-Baker H.

Proc Natl Acad Sci U S A. 2014 Mar 25;111(12):4484-9. doi: 10.1073/pnas.1319738111. Epub 2014 Mar 12.


Reprogramming of prostate cancer-associated stromal cells to embryonic stem-like.

Vêncio EF, Nelson AM, Cavanaugh C, Ware CB, Milller DG, Garcia JC, Vêncio RZ, Loprieno MA, Liu AY.

Prostate. 2012 Sep 15;72(13):1453-63. doi: 10.1002/pros.22497. Epub 2012 Feb 7.


Lineage relationship of prostate cancer cell types based on gene expression.

Pascal LE, Vêncio RZ, Vessella RL, Ware CB, Vêncio EF, Denyer G, Liu AY.

BMC Med Genomics. 2011 May 23;4:46. doi: 10.1186/1755-8794-4-46.


Facioscapulohumeral dystrophy: incomplete suppression of a retrotransposed gene.

Snider L, Geng LN, Lemmers RJ, Kyba M, Ware CB, Nelson AM, Tawil R, Filippova GN, van der Maarel SM, Tapscott SJ, Miller DG.

PLoS Genet. 2010 Oct 28;6(10):e1001181. doi: 10.1371/journal.pgen.1001181.


Histone deacetylase inhibition elicits an evolutionarily conserved self-renewal program in embryonic stem cells.

Ware CB, Wang L, Mecham BH, Shen L, Nelson AM, Bar M, Lamba DA, Dauphin DS, Buckingham B, Askari B, Lim R, Tewari M, Gartler SM, Issa JP, Pavlidis P, Duan Z, Blau CA.

Cell Stem Cell. 2009 Apr 3;4(4):359-69. doi: 10.1016/j.stem.2009.03.001.


Diverse hematopoietic potentials of five human embryonic stem cell lines.

Chang KH, Nelson AM, Fields PA, Hesson JL, Ulyanova T, Cao H, Nakamoto B, Ware CB, Papayannopoulou T.

Exp Cell Res. 2008 Oct 1;314(16):2930-40. doi: 10.1016/j.yexcr.2008.07.019. Epub 2008 Jul 29.


A controlled-cooling protocol for cryopreservation of human and non-human primate embryonic stem cells.

Ware CB, Baran SW.

Methods Mol Biol. 2007;407:43-9. doi: 10.1007/978-1-59745-536-7_4.


Self-renewal of human embryonic stem cells requires insulin-like growth factor-1 receptor and ERBB2 receptor signaling.

Wang L, Schulz TC, Sherrer ES, Dauphin DS, Shin S, Nelson AM, Ware CB, Zhan M, Song CZ, Chen X, Brimble SN, McLean A, Galeano MJ, Uhl EW, D'Amour KA, Chesnut JD, Rao MS, Blau CA, Robins AJ.

Blood. 2007 Dec 1;110(12):4111-9. Epub 2007 Aug 29.


Transduction of human embryonic stem cells by foamy virus vectors.

Gharwan H, Hirata RK, Wang P, Richard RE, Wang L, Olson E, Allen J, Ware CB, Russell DW.

Mol Ther. 2007 Oct;15(10):1827-33. Epub 2007 Jul 10.


Glutamate cysteine ligase modifier subunit deficiency and gender as determinants of acetaminophen-induced hepatotoxicity in mice.

McConnachie LA, Mohar I, Hudson FN, Ware CB, Ladiges WC, Fernandez C, Chatterton-Kirchmeier S, White CC, Pierce RH, Kavanagh TJ.

Toxicol Sci. 2007 Oct;99(2):628-36. Epub 2007 Jun 21.


Cryopreservation of rhesus macaque embryonic stem cells.

Baran SW, Ware CB.

Stem Cells Dev. 2007 Apr;16(2):339-44.


Transplantation of undifferentiated murine embryonic stem cells in the heart: teratoma formation and immune response.

Nussbaum J, Minami E, Laflamme MA, Virag JA, Ware CB, Masino A, Muskheli V, Pabon L, Reinecke H, Murry CE.

FASEB J. 2007 May;21(7):1345-57. Epub 2007 Feb 6.


A comparison of NIH-approved human ESC lines.

Ware CB, Nelson AM, Blau CA.

Stem Cells. 2006 Dec;24(12):2677-84. Epub 2006 Aug 17.


Efficient generation of retinal progenitor cells from human embryonic stem cells.

Lamba DA, Karl MO, Ware CB, Reh TA.

Proc Natl Acad Sci U S A. 2006 Aug 22;103(34):12769-74. Epub 2006 Aug 14.


Acetaminophen-induced liver injury is attenuated in male glutamate-cysteine ligase transgenic mice.

Botta D, Shi S, White CC, Dabrowski MJ, Keener CL, Srinouanprachanh SL, Farin FM, Ware CB, Ladiges WC, Pierce RH, Fausto N, Kavanagh TJ.

J Biol Chem. 2006 Sep 29;281(39):28865-75. Epub 2006 Jul 13.


Definitive-like erythroid cells derived from human embryonic stem cells coexpress high levels of embryonic and fetal globins with little or no adult globin.

Chang KH, Nelson AM, Cao H, Wang L, Nakamoto B, Ware CB, Papayannopoulou T.

Blood. 2006 Sep 1;108(5):1515-23. Epub 2006 Apr 27.


Leukemia inhibitory factor signaling is implicated in embrionic development of the HPA axis.

Ware CB, Kariagina A, Zonis S, Alon D, Chesnokova V.

FEBS Lett. 2005 Aug 15;579(20):4465-9.


A knock-in mouse model of gastrointestinal stromal tumor harboring kit K641E.

Rubin BP, Antonescu CR, Scott-Browne JP, Comstock ML, Gu Y, Tanas MR, Ware CB, Woodell J.

Cancer Res. 2005 Aug 1;65(15):6631-9.


Controlled-rate freezing of human ES cells.

Ware CB, Nelson AM, Blau CA.

Biotechniques. 2005 Jun;38(6):879-80, 882-3.


Androgen receptor YAC transgenic mice recapitulate SBMA motor neuronopathy and implicate VEGF164 in the motor neuron degeneration.

Sopher BL, Thomas PS Jr, LaFevre-Bernt MA, Holm IE, Wilke SA, Ware CB, Jin LW, Libby RT, Ellerby LM, La Spada AR.

Neuron. 2004 Mar 4;41(5):687-99.


Utility of a C57BL/6 ES line versus 129 ES lines for targeted mutations in mice.

Ware CB, Siverts LA, Nelson AM, Morton JF, Ladiges WC.

Transgenic Res. 2003 Dec;12(6):743-6.


Isoform-specific knockout of FE65 leads to impaired learning and memory.

Wang B, Hu Q, Hearn MG, Shimizu K, Ware CB, Liggitt DH, Jin LW, Cool BH, Storm DR, Martin GM.

J Neurosci Res. 2004 Jan 1;75(1):12-24.


Genomic context drives SCA7 CAG repeat instability, while expressed SCA7 cDNAs are intergenerationally and somatically stable in transgenic mice.

Libby RT, Monckton DG, Fu YH, Martinez RA, McAbney JP, Lau R, Einum DD, Nichol K, Ware CB, Ptacek LJ, Pearson CE, La Spada AR.

Hum Mol Genet. 2003 Jan 1;12(1):41-50.


Polyglutamine-expanded ataxin-7 promotes non-cell-autonomous purkinje cell degeneration and displays proteolytic cleavage in ataxic transgenic mice.

Garden GA, Libby RT, Fu YH, Kinoshita Y, Huang J, Possin DE, Smith AC, Martinez RA, Fine GC, Grote SK, Ware CB, Einum DD, Morrison RS, Ptacek LJ, Sopher BL, La Spada AR.

J Neurosci. 2002 Jun 15;22(12):4897-905.


Deficient neurogenesis in forebrain-specific presenilin-1 knockout mice is associated with reduced clearance of hippocampal memory traces.

Feng R, Rampon C, Tang YP, Shrom D, Jin J, Kyin M, Sopher B, Miller MW, Ware CB, Martin GM, Kim SH, Langdon RB, Sisodia SS, Tsien JZ.

Neuron. 2001 Dec 6;32(5):911-26. Erratum in: Neuron 2002 Jan 17;33(2):313.


Polyglutamine-expanded ataxin-7 antagonizes CRX function and induces cone-rod dystrophy in a mouse model of SCA7.

La Spada AR, Fu YH, Sopher BL, Libby RT, Wang X, Li LY, Einum DD, Huang J, Possin DE, Smith AC, Martinez RA, Koszdin KL, Treuting PM, Ware CB, Hurley JB, Ptácek LJ, Chen S.

Neuron. 2001 Sep 27;31(6):913-27. Erratum in: Neuron 2001 Dec 6;32(5):957-8.


Transgenic animals in toxicology.

Ladiges WC, Ware CB.

Curr Protoc Toxicol. 2001;Chapter 1:Unit1.3. doi: 10.1002/0471140856.tx0103s00. Review.


Cellular Werner phenotypes in mice expressing a putative dominant-negative human WRN gene.

Wang L, Ogburn CE, Ware CB, Ladiges WC, Youssoufian H, Martin GM, Oshima J.

Genetics. 2000 Jan;154(1):357-62.


Mesenchymal to epithelial conversion in rat metanephros is induced by LIF.

Barasch J, Yang J, Ware CB, Taga T, Yoshida K, Erdjument-Bromage H, Tempst P, Parravicini E, Malach S, Aranoff T, Oliver JA.

Cell. 1999 Nov 12;99(4):377-86.


Neurotrophic factors [activity-dependent neurotrophic factor (ADNF) and basic fibroblast growth factor (bFGF)] interrupt excitotoxic neurodegenerative cascades promoted by a PS1 mutation.

Guo Q, Sebastian L, Sopher BL, Miller MW, Glazner GW, Ware CB, Martin GM, Mattson MP.

Proc Natl Acad Sci U S A. 1999 Mar 30;96(7):4125-30.


Increased vulnerability of hippocampal neurons to excitotoxic necrosis in presenilin-1 mutant knock-in mice.

Guo Q, Fu W, Sopher BL, Miller MW, Ware CB, Martin GM, Mattson MP.

Nat Med. 1999 Jan;5(1):101-6.


TNF receptor-deficient mice reveal divergent roles for p55 and p75 in several models of inflammation.

Peschon JJ, Torrance DS, Stocking KL, Glaccum MB, Otten C, Willis CR, Charrier K, Morrissey PJ, Ware CB, Mohler KM.

J Immunol. 1998 Jan 15;160(2):943-52.


Neural precursor differentiation into astrocytes requires signaling through the leukemia inhibitory factor receptor.

Koblar SA, Turnley AM, Classon BJ, Reid KL, Ware CB, Cheema SS, Murphy M, Bartlett PF.

Proc Natl Acad Sci U S A. 1998 Mar 17;95(6):3178-81.


Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.

Ware CB, Horowitz MC, Renshaw BR, Hunt JS, Liggitt D, Koblar SA, Gliniak BC, McKenna HJ, Papayannopoulou T, Thoma B, et al.

Development. 1995 May;121(5):1283-99.

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