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Longitudinal serum S100β and brain aging in the Lothian Birth Cohort 1936.

Cox SR, Allerhand M, Ritchie SJ, Muñoz Maniega S, Valdés Hernández M, Harris SE, Dickie DA, Anblagan D, Aribisala BS, Morris Z, Sherwood R, Abbott NJ, Starr JM, Bastin ME, Wardlaw JM, Deary IJ.

Neurobiol Aging. 2018 May 31;69:274-282. doi: 10.1016/j.neurobiolaging.2018.05.029. [Epub ahead of print]


Response by Loos et al to Letter Regarding Article, "Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging".

Loos CMJ, Staals J, Wardlaw JM.

Stroke. 2018 Jun 18. pii: STROKEAHA.118.021876. doi: 10.1161/STROKEAHA.118.021876. [Epub ahead of print] No abstract available.


William M. Feinberg Award for Excellence in Clinical Stroke: Small Vessel Disease; a Big Problem, But Fixable.

Wardlaw JM.

Stroke. 2018 Jun 12. pii: STROKEAHA.118.021184. doi: 10.1161/STROKEAHA.118.021184. [Epub ahead of print] Review. No abstract available.


Longitudinal MRI dynamics of recent small subcortical infarcts and possible predictors.

Pinter D, Gattringer T, Enzinger C, Seifert-Held T, Kneihsl M, Fandler S, Pichler A, Barro C, Eppinger S, Pirpamer L, Bachmaier G, Ropele S, Wardlaw JM, Kuhle J, Khalil M, Fazekas F.

J Cereb Blood Flow Metab. 2018 Jan 1:271678X18775215. doi: 10.1177/0271678X18775215. [Epub ahead of print]


Understanding the role of the perivascular space in cerebral small vessel disease.

Brown R, Benveniste H, Black SE, Charpak S, Dichgans M, Joutel A, Nedergaard M, Smith KJ, Zlokovic BV, Wardlaw JM.

Cardiovasc Res. 2018 May 2. doi: 10.1093/cvr/cvy113. [Epub ahead of print]


Cognitive function, disease burden and the structural connectome in systemic lupus erythematosus.

Wiseman SJ, Bastin ME, Amft EN, Belch JFF, Ralston SH, Wardlaw JM.

Lupus. 2018 Jul;27(8):1329-1337. doi: 10.1177/0961203318772666. Epub 2018 May 3.


Protocol for a prospective collaborative systematic review and meta-analysis of individual patient data from randomized controlled trials of vasoactive drugs in acute stroke: The Blood pressure in Acute Stroke Collaboration, stage-3.

Sandset EC, Sanossian N, Woodhouse LJ, Anderson C, Berge E, Lees KR, Potter JF, Robinson TG, Sprigg N, Wardlaw JM, Bath PM; Blood pressure in Acute Stroke Collaboration Investigators.

Int J Stroke. 2018 Jan 1:1747493018772733. doi: 10.1177/1747493018772733. [Epub ahead of print]


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30. Review.


The brain health index: Towards a combined measure of neurovascular and neurodegenerative structural brain injury.

Dickie DA, Valdés Hernández MDC, Makin SD, Staals J, Wiseman SJ, Bastin ME, Wardlaw JM.

Int J Stroke. 2018 Jan 1:1747493018770222. doi: 10.1177/1747493018770222. [Epub ahead of print]


Widespread associations between trait conscientiousness and thickness of brain cortical regions.

Lewis GJ, Dickie DA, Cox SR, Karama S, Evans AC, Starr JM, Bastin ME, Wardlaw JM, Deary IJ.

Neuroimage. 2018 Aug 1;176:22-28. doi: 10.1016/j.neuroimage.2018.04.033. Epub 2018 Apr 14.


Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease.

Bailey EL, McBride MW, McClure JD, Beattie W, Graham D, Dominiczak AF, Smith C, Wardlaw JM.

Clin Sci (Lond). 2018 Apr 9. pii: CS20171572. doi: 10.1042/CS20171572. [Epub ahead of print]


Towards Standardization of Quantitative Retinal Vascular Parameters: Comparison of SIVA and VAMPIRE Measurements in the Lothian Birth Cohort 1936.

McGrory S, Taylor AM, Pellegrini E, Ballerini L, Kirin M, Doubal FN, Wardlaw JM, Doney ASF, Dhillon B, Starr JM, Trucco E, Deary IJ, MacGillivray TJ.

Transl Vis Sci Technol. 2018 Mar 23;7(2):12. doi: 10.1167/tvst.7.2.12. eCollection 2018 Mar.


Considerations on accuracy, pattern and possible underlying factors of brain microbleed progression in older adults with absence or mild presence of vascular pathology.

Harper AM, Clayson L, Wardlaw JM, Valdés Hernández MDC; Alzheimer’s Disease Neuroimaging Initiative.

J Int Med Res. 2018 Jan 1:300060518755623. doi: 10.1177/0300060518755623. [Epub ahead of print]


Visual Rating Scales of White Matter Hyperintensities and Atrophy: Comparison of Computed Tomography and Magnetic Resonance Imaging.

Ferguson KJ, Cvoro V, MacLullich AMJ, Shenkin SD, Sandercock PAG, Sakka E, Wardlaw JM.

J Stroke Cerebrovasc Dis. 2018 Jul;27(7):1815-1821. doi: 10.1016/j.jstrokecerebrovasdis.2018.02.028. Epub 2018 Mar 23.


Long-Term Morphological Changes of Symptomatic Lacunar Infarcts and Surrounding White Matter on Structural Magnetic Resonance Imaging.

Loos CMJ, Makin SDJ, Staals J, Dennis MS, van Oostenbrugge RJ, Wardlaw JM.

Stroke. 2018 May;49(5):1183-1188. doi: 10.1161/STROKEAHA.117.020495. Epub 2018 Mar 22.


Coupled changes in hippocampal structure and cognitive ability in later life.

Anblagan D, Valdés Hernández MC, Ritchie SJ, Aribisala BS, Royle NA, Hamilton IF, Cox SR, Gow AJ, Pattie A, Corley J, Starr JM, Muñoz Maniega S, Bastin ME, Deary IJ, Wardlaw JM.

Brain Behav. 2018 Jan 4;8(2):e00838. doi: 10.1002/brb3.838. eCollection 2018 Feb.


Perivascular Spaces Segmentation in Brain MRI Using Optimal 3D Filtering.

Ballerini L, Lovreglio R, Valdés Hernández MDC, Ramirez J, MacIntosh BJ, Black SE, Wardlaw JM.

Sci Rep. 2018 Feb 1;8(1):2132. doi: 10.1038/s41598-018-19781-5.


The Edinburgh CT and genetic diagnostic criteria for lobar intracerebral haemorrhage associated with cerebral amyloid angiopathy: model development and diagnostic test accuracy study.

Rodrigues MA, Samarasekera N, Lerpiniere C, Humphreys C, McCarron MO, White PM, Nicoll JAR, Sudlow CLM, Cordonnier C, Wardlaw JM, Smith C, Al-Shahi Salman R.

Lancet Neurol. 2018 Mar;17(3):232-240. doi: 10.1016/S1474-4422(18)30006-1. Epub 2018 Jan 10.


Variance components associated with long-echo-time MR spectroscopic imaging in human brain at 1.5T and 3T.

Thrippleton MJ, Parikh JP, Semple SIK, Harris BA, Andrews PJD, Wardlaw JM, Marshall I.

PLoS One. 2017 Dec 29;12(12):e0189872. doi: 10.1371/journal.pone.0189872. eCollection 2017.


Correction: Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance.

González-Castro V, Valdés Hernández MDC, Chappell FM, Armitage PA, Makin S, Wardlaw JM.

Clin Sci (Lond). 2017 Dec 14;131(24):2959. doi: 10.1042/CS20170051_COR. Print 2017 Dec 15. No abstract available.


Intracranial pulsatility in patients with cerebral small vessel disease: a systematic review.

Shi Y, Thrippleton MJ, Marshall I, Wardlaw JM.

Clin Sci (Lond). 2018 Jan 16;132(1):157-171. doi: 10.1042/CS20171280. Print 2018 Jan 16.


Effects of alteplase for acute stroke according to criteria defining the European Union and United States marketing authorizations: Individual-patient-data meta-analysis of randomized trials.

Hacke W, Lyden P, Emberson J, Baigent C, Blackwell L, Albers G, Bluhmki E, Brott T, Cohen G, Davis SM, Donnan GA, Grotta JC, Howard G, Kaste M, Koga M, von Kummer R, Lansberg MG, Lindley RI, Olivot JM, Parsons M, Sandercock PA, Toni D, Toyoda K, Wahlgren N, Wardlaw JM, Whiteley WN, Del Zoppo G, Lees KR; Stroke Thrombolysis Trialists’ Collaborators Group.

Int J Stroke. 2018 Feb;13(2):175-189. doi: 10.1177/1747493017744464. Epub 2017 Nov 24.


Relationship between race and outcome in Asian, Black, and Caucasian patients with spontaneous intracerebral hemorrhage: Data from the Virtual International Stroke Trials Archive and Efficacy of Nitric Oxide in Stroke trial.

Krishnan K, Beishon L, Berge E, Christensen H, Dineen RA, Ozturk S, Sprigg N, Wardlaw JM, Bath PM; VISTA-ICH collaboration and ENOS Investigators.

Int J Stroke. 2018 Jun;13(4):362-373. doi: 10.1177/1747493017744463. Epub 2017 Nov 22.


Brain structural differences between 73- and 92-year olds matched for childhood intelligence, social background, and intracranial volume.

Ritchie SJ, Dickie DA, Cox SR, Valdés Hernández MDC, Sibbett R, Pattie A, Anblagan D, Redmond P, Royle NA, Corley J, Maniega SM, Taylor AM, Karama S, Booth T, Gow AJ, Starr JM, Bastin ME, Wardlaw JM, Deary IJ.

Neurobiol Aging. 2018 Feb;62:146-158. doi: 10.1016/j.neurobiolaging.2017.10.005. Epub 2017 Oct 16.


Cognitive abilities, brain white matter hyperintensity volume, and structural network connectivity in older age.

Wiseman SJ, Booth T, Ritchie SJ, Cox SR, Muñoz Maniega S, Valdés Hernández MDC, Dickie DA, Royle NA, Starr JM, Deary IJ, Wardlaw JM, Bastin ME.

Hum Brain Mapp. 2018 Feb;39(2):622-632. doi: 10.1002/hbm.23857. Epub 2017 Nov 14.


Optimizing the Definitions of Stroke, Transient Ischemic Attack, and Infarction for Research and Application in Clinical Practice.

Abbott AL, Silvestrini M, Topakian R, Golledge J, Brunser AM, de Borst GJ, Harbaugh RE, Doubal FN, Rundek T, Thapar A, Davies AH, Kam A, Wardlaw JM.

Front Neurol. 2017 Oct 18;8:537. doi: 10.3389/fneur.2017.00537. eCollection 2017.


Dietary Iodine Exposure and Brain Structures and Cognition in Older People. Exploratory Analysis in the Lothian Birth Cohort 1936.

Del C Valdés Hernández M, Kyle J, Allan J, Allerhand M, Clark H, Muñoz Manieg S, Royle NA, Gow AJ, Pattie A, Corley J, Bastin ME, Starr JM, Wardlaw JM, Deary IJ, Combet E.

J Nutr Health Aging. 2017;21(9):971-979. doi: 10.1007/s12603-017-0954-8.


Cohort Profile: Stratifying Resilience and Depression Longitudinally (STRADL): a questionnaire follow-up of Generation Scotland: Scottish Family Health Study (GS:SFHS).

Navrady LB, Wolters MK, MacIntyre DJ, Clarke TK, Campbell AI, Murray AD, Evans KL, Seckl J, Haley C, Milburn K, Wardlaw JM, Porteous DJ, Deary IJ, McIntosh AM.

Int J Epidemiol. 2018 Feb 1;47(1):13-14g. doi: 10.1093/ije/dyx115. No abstract available.


Update on cerebral small vessel disease: a dynamic whole-brain disease.

Shi Y, Wardlaw JM.

Stroke Vasc Neurol. 2016 Oct 25;1(3):83-92. doi: 10.1136/svn-2016-000035. eCollection 2016 Sep. Review.


Cerebrovascular reactivity measurement in cerebral small vessel disease: Rationale and reproducibility of a protocol for MRI acquisition and image processing.

Thrippleton MJ, Shi Y, Blair G, Hamilton I, Waiter G, Schwarzbauer C, Pernet C, Andrews PJ, Marshall I, Doubal F, Wardlaw JM.

Int J Stroke. 2018 Feb;13(2):195-206. doi: 10.1177/1747493017730740. Epub 2017 Sep 21.


Maximizing the Potential of Longitudinal Cohorts for Research in Neurodegenerative Diseases: A Community Perspective.

Moody CJ, Mitchell D, Kiser G, Aarsland D, Berg D, Brayne C, Costa A, Ikram MA, Mountain G, Rohrer JD, Teunissen CE, van den Berg LH, Wardlaw JM.

Front Neurosci. 2017 Aug 29;11:467. doi: 10.3389/fnins.2017.00467. eCollection 2017.


Preventing cognitive decline and dementia from cerebral small vessel disease: The LACI-1 Trial. Protocol and statistical analysis plan of a phase IIa dose escalation trial testing tolerability, safety and effect on intermediary endpoints of isosorbide mononitrate and cilostazol, separately and in combination.

Blair GW, Appleton JP, Law ZK, Doubal F, Flaherty K, Dooley R, Shuler K, Richardson C, Hamilton I, Shi Y, Stringer M, Boyd J, Thrippleton MJ, Sprigg N, Bath PM, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):530-538. doi: 10.1177/1747493017731947. Epub 2017 Sep 14.


The relation between total cerebral small vessel disease burden and gait impairment in patients with minor stroke.

Loos CM, McHutchison C, Cvoro V, Makin SD, Staals J, Chappell F, Dennis MS, van Oostenbrugge RJ, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):518-524. doi: 10.1177/1747493017730780. Epub 2017 Sep 14.


Small Vessel Disease and Dietary Salt Intake: Cross-Sectional Study and Systematic Review.

Makin SDJ, Mubki GF, Doubal FN, Shuler K, Staals J, Dennis MS, Wardlaw JM.

J Stroke Cerebrovasc Dis. 2017 Dec;26(12):3020-3028. doi: 10.1016/j.jstrokecerebrovasdis.2017.08.004. Epub 2017 Sep 8.


Brain cortical characteristics of lifetime cognitive ageing.

Cox SR, Bastin ME, Ritchie SJ, Dickie DA, Liewald DC, Muñoz Maniega S, Redmond P, Royle NA, Pattie A, Valdés Hernández M, Corley J, Aribisala BS, McIntosh AM, Wardlaw JM, Deary IJ.

Brain Struct Funct. 2018 Jan;223(1):509-518. doi: 10.1007/s00429-017-1505-0. Epub 2017 Sep 6.


Blood pressure variability and leukoaraiosis in acute ischemic stroke.

Dickie DA, Aribisala B, Mair G, Berge E, Lindley RI, Sandercock P, von Kummer R, von Heijne A, Peeters A, Cala L, Farrall A, Morris Z, Bradey N, Potter G, Adami A, Wardlaw JM.

Int J Stroke. 2018 Jul;13(5):473-480. doi: 10.1177/1747493017729267. Epub 2017 Sep 5.


Processing speed and the relationship between Trail Making Test-B performance, cortical thinning and white matter microstructure in older adults.

MacPherson SE, Cox SR, Dickie DA, Karama S, Starr JM, Evans AC, Bastin ME, Wardlaw JM, Deary IJ.

Cortex. 2017 Oct;95:92-103. doi: 10.1016/j.cortex.2017.07.021. Epub 2017 Aug 9.


Metric to quantify white matter damage on brain magnetic resonance images.

Valdés Hernández MDC, Chappell FM, Muñoz Maniega S, Dickie DA, Royle NA, Morris Z, Anblagan D, Sakka E, Armitage PA, Bastin ME, Deary IJ, Wardlaw JM.

Neuroradiology. 2017 Oct;59(10):951-962. doi: 10.1007/s00234-017-1892-1. Epub 2017 Aug 16.


White matter hyperintensity reduction and outcomes after minor stroke.

Wardlaw JM, Chappell FM, Valdés Hernández MDC, Makin SDJ, Staals J, Shuler K, Thrippleton MJ, Armitage PA, Muñoz-Maniega S, Heye AK, Sakka E, Dennis MS.

Neurology. 2017 Sep 5;89(10):1003-1010. doi: 10.1212/WNL.0000000000004328. Epub 2017 Aug 9.


Application of Texture Analysis to Study Small Vessel Disease and Blood-Brain Barrier Integrity.

Valdés Hernández MDC, González-Castro V, Chappell FM, Sakka E, Makin S, Armitage PA, Nailon WH, Wardlaw JM.

Front Neurol. 2017 Jul 19;8:327. doi: 10.3389/fneur.2017.00327. eCollection 2017.


Ambulance-delivered transdermal glyceryl trinitrate versus sham for ultra-acute stroke: Rationale, design and protocol for the Rapid Intervention with Glyceryl trinitrate in Hypertensive stroke Trial-2 (RIGHT-2) trial (ISRCTN26986053).

Appleton JP, Scutt P, Dixon M, Howard H, Haywood L, Havard D, Hepburn T, England T, Sprigg N, Woodhouse LJ, Wardlaw JM, Montgomery AA, Pocock S, Bath PM; RIGHT-2 Investigators.

Int J Stroke. 2017 Jan 1:1747493017724627. doi: 10.1177/1747493017724627. [Epub ahead of print]


Infections Up to 76 Days After Stroke Increase Disability and Death.

Learoyd AE, Woodhouse L, Shaw L, Sprigg N, Bereczki D, Berge E, Caso V, Christensen H, Collins R, Czlonkowska A, El Etribi A, Farr TD, Gommans J, Laska AC, Ntaios G, Ozturk S, Pocock SJ, Prasad K, Wardlaw JM, Fone KC, Bath PM, Trueman RC; ENOS Trial investigators.

Transl Stroke Res. 2017 Dec;8(6):541-548. doi: 10.1007/s12975-017-0553-3. Epub 2017 Jul 27.


Detection, risk factors, and functional consequences of cerebral microinfarcts.

van Veluw SJ, Shih AY, Smith EE, Chen C, Schneider JA, Wardlaw JM, Greenberg SM, Biessels GJ.

Lancet Neurol. 2017 Sep;16(9):730-740. doi: 10.1016/S1474-4422(17)30196-5. Epub 2017 Jul 14. Review.


Advanced Neuroimaging of Cerebral Small Vessel Disease.

Blair GW, Hernandez MV, Thrippleton MJ, Doubal FN, Wardlaw JM.

Curr Treat Options Cardiovasc Med. 2017 Jul;19(7):56. doi: 10.1007/s11936-017-0555-1. Review.


Brain grey and white matter predictors of verbal ability traits in older age: The Lothian Birth Cohort 1936.

Hoffman P, Cox SR, Dykiert D, Muñoz Maniega S, Valdés Hernández MC, Bastin ME, Wardlaw JM, Deary IJ.

Neuroimage. 2017 Aug 1;156:394-402. doi: 10.1016/j.neuroimage.2017.05.052. Epub 2017 May 24.


Reliability of an automatic classifier for brain enlarged perivascular spaces burden and comparison with human performance.

González-Castro V, Valdés Hernández MDC, Chappell FM, Armitage PA, Makin S, Wardlaw JM.

Clin Sci (Lond). 2017 Jun 28;131(13):1465-1481. doi: 10.1042/CS20170051. Print 2017 Jul 1. Erratum in: Clin Sci (Lond). 2017 Dec 14;131(24):2959.


Lateral thinking - Interocular symmetry and asymmetry in neurovascular patterning, in health and disease.

Cameron JR, Megaw RD, Tatham AJ, McGrory S, MacGillivray TJ, Doubal FN, Wardlaw JM, Trucco E, Chandran S, Dhillon B.

Prog Retin Eye Res. 2017 Jul;59:131-157. doi: 10.1016/j.preteyeres.2017.04.003. Epub 2017 Apr 28. Review.


Brain age predicts mortality.

Cole JH, Ritchie SJ, Bastin ME, Valdés Hernández MC, Muñoz Maniega S, Royle N, Corley J, Pattie A, Harris SE, Zhang Q, Wray NR, Redmond P, Marioni RE, Starr JM, Cox SR, Wardlaw JM, Sharp DJ, Deary IJ.

Mol Psychiatry. 2018 May;23(5):1385-1392. doi: 10.1038/mp.2017.62. Epub 2017 Apr 25.


Risk and protective factors for structural brain ageing in the eighth decade of life.

Ritchie SJ, Tucker-Drob EM, Cox SR, Dickie DA, Del C Valdés Hernández M, Corley J, Royle NA, Redmond P, Muñoz Maniega S, Pattie A, Aribisala BS, Taylor AM, Clarke TK, Gow AJ, Starr JM, Bastin ME, Wardlaw JM, Deary IJ.

Brain Struct Funct. 2017 Nov;222(8):3477-3490. doi: 10.1007/s00429-017-1414-2. Epub 2017 Apr 19.

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