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DP2 antagonism reduces airway smooth muscle mass in asthma by decreasing eosinophilia and myofibroblast recruitment.

Saunders R, Kaul H, Berair R, Gonem S, Singapuri A, Sutcliffe AJ, Chachi L, Biddle MS, Kaur D, Bourne M, Pavord ID, Wardlaw AJ, Siddiqui SH, Kay RA, Brook BS, Smallwood RH, Brightling CE.

Sci Transl Med. 2019 Feb 13;11(479). pii: eaao6451. doi: 10.1126/scitranslmed.aao6451.


Sexual Conflict and Sexually Transmitted Infections (STIs): Coevolution of Sexually Antagonistic Host Traits with an STI.

Wardlaw AM, Agrawal AF.

Am Nat. 2019 Jan;193(1):E1-E14. doi: 10.1086/700564. Epub 2018 Nov 29.


Exacerbations of severe asthma in patients treated with mepolizumab.

Shrimanker R, Pavord ID, Yancey S, Heaney LG, Green RH, Bradding P, Hargadon B, Brightling CE, Wardlaw AJ, Haldar P.

Eur Respir J. 2018 Dec 13;52(6). pii: 1801127. doi: 10.1183/13993003.01127-2018. Print 2018 Dec. No abstract available.


Revisiting the NIH Taskforce on the Research needs of Eosinophil-Associated Diseases (RE-TREAD).

Khoury P, Akuthota P, Ackerman SJ, Arron JR, Bochner BS, Collins MH, Kahn JE, Fulkerson PC, Gleich GJ, Gopal-Srivastava R, Jacobsen EA, Leiferman KM, Francesca LS, Mathur SK, Minnicozzi M, Prussin C, Rothenberg ME, Roufosse F, Sable K, Simon D, Simon HU, Spencer LA, Steinfeld J, Wardlaw AJ, Wechsler ME, Weller PF, Klion AD.

J Leukoc Biol. 2018 Jul;104(1):69-83. doi: 10.1002/JLB.5MR0118-028R. Epub 2018 Apr 19. Review.


Airway pathological heterogeneity in asthma: Visualization of disease microclusters using topological data analysis.

Siddiqui S, Shikotra A, Richardson M, Doran E, Choy D, Bell A, Austin CD, Eastham-Anderson J, Hargadon B, Arron JR, Wardlaw A, Brightling CE, Heaney LG, Bradding P.

J Allergy Clin Immunol. 2018 Nov;142(5):1457-1468. doi: 10.1016/j.jaci.2017.12.982. Epub 2018 Mar 14.


Minoxidil improves vascular compliance, restores cerebral blood flow, and alters extracellular matrix gene expression in a model of chronic vascular stiffness.

Knutsen RH, Beeman SC, Broekelmann TJ, Liu D, Tsang KM, Kovacs A, Ye L, Danback JR, Watson A, Wardlaw A, Wagenseil JE, Garbow JR, Shoykhet M, Kozel BA.

Am J Physiol Heart Circ Physiol. 2018 Jul 1;315(1):H18-H32. doi: 10.1152/ajpheart.00683.2017. Epub 2018 Mar 2.


rAsp f3 and rAsp f4 are associated with bronchiectasis in allergic fungal airways disease.

Woolnough K, Craner M, Pashley CH, Wardlaw AJ.

Ann Allergy Asthma Immunol. 2018 Mar;120(3):325-326. doi: 10.1016/j.anai.2017.10.026. Epub 2017 Dec 7. No abstract available.


The role of oral methotrexate as a steroid sparing agent in refractory eosinophilic asthma.

Bilocca D, Hargadon B, Pavord ID, Green RH, Brightling CE, Bradding P, Wardlaw AJ, Martin N, Murphy AC, Siddiqui S.

Chron Respir Dis. 2018 Feb;15(1):85-87. doi: 10.1177/1479972317709650. Epub 2017 Jun 1.


Responsiveness to oral prednisolone in severe asthma is related to the degree of eosinophilic airway inflammation.

Sousa AR, Marshall RP, Warnock LC, Bolton S, Hastie A, Symon F, Hargadon B, Marshall H, Richardson M, Brightling CE, Haldar P, Milone R, Chalk P, Williamson R, Panettieri R Jr, Knowles R, Bleecker ER, Wardlaw AJ.

Clin Exp Allergy. 2017 Jul;47(7):890-899. doi: 10.1111/cea.12954. Epub 2017 Jun 16.


Associations in asthma between quantitative computed tomography and bronchial biopsy-derived airway remodelling.

Berair R, Hartley R, Mistry V, Sheshadri A, Gupta S, Singapuri A, Gonem S, Marshall RP, Sousa AR, Shikotra A, Kay R, Wardlaw A, Bradding P, Siddiqui S, Castro M, Brightling CE.

Eur Respir J. 2017 May 1;49(5). pii: 1601507. doi: 10.1183/13993003.01507-2016. Print 2017 May.


Sputum Inflammatory Mediators Are Increased in Aspergillus fumigatus Culture-Positive Asthmatics.

Ghebre MA, Desai D, Singapuri A, Woods J, Rapley L, Cohen S, Herath A, Wardlaw AJ, Pashley CH, May R, Brightling CE.

Allergy Asthma Immunol Res. 2017 Mar;9(2):177-181. doi: 10.4168/aair.2017.9.2.177.


Allergic Fungal Airway Disease.

Rick EM, Woolnough K, Pashley CH, Wardlaw AJ.

J Investig Allergol Clin Immunol. 2016;26(6):344-354. doi: 10.18176/jiaci.0122. Review.


Experimental Investigation of Cavitation as a Possible Damage Mechanism in Blast-Induced Traumatic Brain Injury in Post-Mortem Human Subject Heads.

Salzar RS, Treichler D, Wardlaw A, Weiss G, Goeller J.

J Neurotrauma. 2017 Apr 15;34(8):1589-1602. doi: 10.1089/neu.2016.4600. Epub 2017 Jan 13.


The relationship between biomarkers of fungal allergy and lung damage in asthma.

Woolnough KF, Richardson M, Newby C, Craner M, Bourne M, Monteiro W, Siddiqui S, Bradding P, Pashley CH, Wardlaw AJ.

Clin Exp Allergy. 2017 Jan;47(1):48-56. doi: 10.1111/cea.12848. Epub 2016 Dec 2.


The Ser82 RAGE Variant Affects Lung Function and Serum RAGE in Smokers and sRAGE Production In Vitro.

Miller S, Henry AP, Hodge E, Kheirallah AK, Billington CK, Rimington TL, Bhaker SK, Obeidat M, Melén E, Merid SK, Swan C, Gowland C, Nelson CP, Stewart CE, Bolton CE, Kilty I, Malarstig A, Parker SG, Moffatt MF, Wardlaw AJ, Hall IP, Sayers I.

PLoS One. 2016 Oct 18;11(10):e0164041. doi: 10.1371/journal.pone.0164041. eCollection 2016.


Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre, randomised, double-blind, parallel-group, placebo-controlled trial.

Gonem S, Berair R, Singapuri A, Hartley R, Laurencin MFM, Bacher G, Holzhauer B, Bourne M, Mistry V, Pavord ID, Mansur AH, Wardlaw AJ, Siddiqui SH, Kay RA, Brightling CE.

Lancet Respir Med. 2016 Sep;4(9):699-707. doi: 10.1016/S2213-2600(16)30179-5. Epub 2016 Aug 5.


Protein phosphatase 5 mediates corticosteroid insensitivity in airway smooth muscle in patients with severe asthma.

Chachi L, Abbasian M, Gavrila A, Alzahrani A, Tliba O, Bradding P, Wardlaw AJ, Brightling C, Amrani Y.

Allergy. 2017 Jan;72(1):126-136. doi: 10.1111/all.13003. Epub 2016 Sep 15.


Impaired P2X1 Receptor-Mediated Adhesion in Eosinophils from Asthmatic Patients.

Wright A, Mahaut-Smith M, Symon F, Sylvius N, Ran S, Bafadhel M, Muessel M, Bradding P, Wardlaw A, Vial C.

J Immunol. 2016 Jun 15;196(12):4877-84. doi: 10.4049/jimmunol.1501585. Epub 2016 May 9.


Exome-wide analysis of rare coding variation identifies novel associations with COPD and airflow limitation in MOCS3, IFIT3 and SERPINA12.

Jackson VE, Ntalla I, Sayers I, Morris R, Whincup P, Casas JP, Amuzu A, Choi M, Dale C, Kumari M, Engmann J, Kalsheker N, Chappell S, Guetta-Baranes T, McKeever TM, Palmer CN, Tavendale R, Holloway JW, Sayer AA, Dennison EM, Cooper C, Bafadhel M, Barker B, Brightling C, Bolton CE, John ME, Parker SG, Moffat MF, Wardlaw AJ, Connolly MJ, Porteous DJ, Smith BH, Padmanabhan S, Hocking L, Stirrups KE, Deloukas P, Strachan DP, Hall IP, Tobin MD, Wain LV.

Thorax. 2016 Jun;71(6):501-9. doi: 10.1136/thoraxjnl-2015-207876. Epub 2016 Feb 25.


NADPH Oxidase-4 Overexpression Is Associated With Epithelial Ciliary Dysfunction in Neutrophilic Asthma.

Wan WY, Hollins F, Haste L, Woodman L, Hirst RA, Bolton S, Gomez E, Sutcliffe A, Desai D, Chachi L, Mistry V, Szyndralewiez C, Wardlaw A, Saunders R, O'Callaghan C, Andrew PW, Brightling CE.

Chest. 2016 Jun;149(6):1445-59. doi: 10.1016/j.chest.2016.01.024. Epub 2016 Feb 2.


Lassoing a chimera: the semantics of allergic fungal airway disease.

Wardlaw AJ, Woolnough K, Pashley CH.

Clin Exp Allergy. 2015 Dec;45(12):1746-9. doi: 10.1111/cea.12659. No abstract available.



Corrigan CJ, Hamid Q, O'Hehir RE, Wardlaw AJ.

Clin Exp Allergy. 2015 Dec;45(12):1721-2. doi: 10.1111/cea.12662. No abstract available.


Developments in the field of allergy in 2014 through the eyes of Clinical and Experimental Allergy.

Hales BJ, Hizawa N, Jenmalm M, Sverremark-Ekström E, Wardlaw AJ.

Clin Exp Allergy. 2015 Dec;45(12):1723-45. doi: 10.1111/cea.12663.


Eosinophilia in Pulmonary Disorders.

Woolnough K, Wardlaw AJ.

Immunol Allergy Clin North Am. 2015 Aug;35(3):477-92. doi: 10.1016/j.iac.2015.05.002. Epub 2015 Jun 18. Review.


The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels.

Martin KJ, Muessel MJ, Pullar CE, Willars GB, Wardlaw AJ.

PLoS One. 2015 Feb 6;10(2):e0116250. doi: 10.1371/journal.pone.0116250. eCollection 2015. Erratum in: PLoS One. 2015;10(7):e0134924.


A special issue on risk factors for the development of allergic disease.

Wardlaw A.

Clin Exp Allergy. 2015 Jan;45(1):1-2. doi: 10.1111/cea.12469. No abstract available.


Allergic fungal airway disease: pathophysiologic and diagnostic considerations.

Woolnough K, Fairs A, Pashley CH, Wardlaw AJ.

Curr Opin Pulm Med. 2015 Jan;21(1):39-47. doi: 10.1097/MCP.0000000000000129. Review.


Developments in the field of allergy in 2013 through the eyes of Clinical and Experimental Allergy.

Blankestijn MA, Boyle RJ, Gore R, Hawrylowicz C, Jarvis D, Knulst AC, Wardlaw AJ.

Clin Exp Allergy. 2014 Dec;44(12):1436-57. doi: 10.1111/cea.12442. Review.


Fungal allergy in asthma-state of the art and research needs.

Denning DW, Pashley C, Hartl D, Wardlaw A, Godet C, Del Giacco S, Delhaes L, Sergejeva S.

Clin Transl Allergy. 2014 Apr 15;4:14. doi: 10.1186/2045-7022-4-14. eCollection 2014.


Outcomes after cessation of mepolizumab therapy in severe eosinophilic asthma: a 12-month follow-up analysis.

Haldar P, Brightling CE, Singapuri A, Hargadon B, Gupta S, Monteiro W, Bradding P, Green RH, Wardlaw AJ, Ortega H, Pavord ID.

J Allergy Clin Immunol. 2014 Mar;133(3):921-3. doi: 10.1016/j.jaci.2013.11.026. Epub 2014 Jan 10. No abstract available.


Effectiveness of voriconazole in the treatment of Aspergillus fumigatus-associated asthma (EVITA3 study).

Agbetile J, Bourne M, Fairs A, Hargadon B, Desai D, Broad C, Morley J, Bradding P, Brightling CE, Green RH, Haldar P, Pashley CH, Pavord ID, Wardlaw AJ.

J Allergy Clin Immunol. 2014 Jul;134(1):33-9. doi: 10.1016/j.jaci.2013.09.050. Epub 2013 Nov 28.


Genome-wide protein QTL mapping identifies human plasma kallikrein as a post-translational regulator of serum uPAR levels.

Portelli MA, Siedlinski M, Stewart CE, Postma DS, Nieuwenhuis MA, Vonk JM, Nurnberg P, Altmuller J, Moffatt MF, Wardlaw AJ, Parker SG, Connolly MJ, Koppelman GH, Sayers I.

FASEB J. 2014 Feb;28(2):923-34. doi: 10.1096/fj.13-240879. Epub 2013 Nov 18.


Developments in the field of allergy in 2012 through the eyes of Clinical & Experimental Allergy.

Mari A, Antonietta Ciardiello M, Passalacqua G, Vliagoftis H, Wardlaw AJ, Wickman M.

Clin Exp Allergy. 2013 Dec;43(12):1309-32. doi: 10.1111/cea.12212. Review.


Aspergillus fumigatus during stable state and exacerbations of COPD.

Bafadhel M, McKenna S, Agbetile J, Fairs A, Desai D, Mistry V, Morley JP, Pancholi M, Pavord ID, Wardlaw AJ, Pashley CH, Brightling CE.

Eur Respir J. 2014 Jan;43(1):64-71. doi: 10.1183/09031936.00162912. Epub 2013 Apr 18.


Elevated sputum interleukin-5 and submucosal eosinophilia in obese individuals with severe asthma.

Desai D, Newby C, Symon FA, Haldar P, Shah S, Gupta S, Bafadhel M, Singapuri A, Siddiqui S, Woods J, Herath A, Anderson IK, Bradding P, Green R, Kulkarni N, Pavord I, Marshall RP, Sousa AR, May RD, Wardlaw AJ, Brightling CE.

Am J Respir Crit Care Med. 2013 Sep 15;188(6):657-63. doi: 10.1164/rccm.201208-1470OC.


Real-time multi-marker measurement of organic compounds in human breath: towards fingerprinting breath.

White IR, Willis KA, Whyte C, Cordell R, Blake RS, Wardlaw AJ, Rao S, Grigg J, Ellis AM, Monks PS.

J Breath Res. 2013 Mar;7(1):017112. doi: 10.1088/1752-7155/7/1/017112. Epub 2013 Feb 27.


Isolation of Aspergillus fumigatus from sputum is associated with elevated airborne levels in homes of patients with asthma.

Fairs A, Agbetile J, Bourne M, Hargadon B, Monteiro WR, Morley JP, Edwards RE, Wardlaw AJ, Pashley CH.

Indoor Air. 2013 Aug;23(4):275-84. doi: 10.1111/ina.12020. Epub 2013 Jan 25.


Developments in the field of allergy in 2011 through the eyes of Clinical and Experimental Allergy.

Arshad SH, Dharmage SC, Ferreira F, Fixman ED, Gadermaier G, Hauser M, Sampson AP, Teran LM, Wallner M, Wardlaw AJ.

Clin Exp Allergy. 2012 Dec;42(12):1697-723. doi: 10.1111/cea.12037. Review.


Phenotyping airways disease: an A to E approach.

Gonem S, Raj V, Wardlaw AJ, Pavord ID, Green R, Siddiqui S.

Clin Exp Allergy. 2012 Dec;42(12):1664-83. doi: 10.1111/j.1365-2222.2012.04008.x. Review.


Advances in the management of severe asthma.

Siddiqui S, Gonem S, Wardlaw AJ.

Semin Respir Crit Care Med. 2012 Dec;33(6):666-84. doi: 10.1055/s-0032-1326964. Epub 2012 Oct 9.


Novel targeted therapies for eosinophilic disorders.

Wechsler ME, Fulkerson PC, Bochner BS, Gauvreau GM, Gleich GJ, Henkel T, Kolbeck R, Mathur SK, Ortega H, Patel J, Prussin C, Renzi P, Rothenberg ME, Roufosse F, Simon D, Simon HU, Wardlaw A, Weller PF, Klion AD.

J Allergy Clin Immunol. 2012 Sep;130(3):563-71. doi: 10.1016/j.jaci.2012.07.027. Review.


Immune response modifiers in the treatment of asthma: A PRACTALL document of the American Academy of Allergy, Asthma & Immunology and the European Academy of Allergy and Clinical Immunology.

Ballow M, Akdis CA, Casale TB, Wardlaw AJ, Wenzel SE, Ballas Z, Lötvall J.

J Allergy Clin Immunol. 2012 Aug;130(2):311-24. doi: 10.1016/j.jaci.2012.04.046. Epub 2012 Jun 17. No abstract available.


Temporal variation in selection accelerates mutational decay by Muller's ratchet.

Wardlaw AM, Agrawal AF.

Genetics. 2012 Jul;191(3):907-16. doi: 10.1534/genetics.112.140962. Epub 2012 Apr 27.


Isolation of filamentous fungi from sputum in asthma is associated with reduced post-bronchodilator FEV1.

Agbetile J, Fairs A, Desai D, Hargadon B, Bourne M, Mutalithas K, Edwards R, Morley JP, Monteiro WR, Kulkarni NS, Green RH, Pavord ID, Bradding P, Brightling CE, Wardlaw AJ, Pashley CH.

Clin Exp Allergy. 2012 May;42(5):782-91. doi: 10.1111/j.1365-2222.2012.03987.x.


What is severe asthma?

Blakey JD, Wardlaw AJ.

Clin Exp Allergy. 2012 May;42(5):617-24. doi: 10.1111/j.1365-2222.2012.03962.x. Review.


Special issue on severe asthma.

Wardlaw AJ, O'Hehir RE, Corrigan CJ, Hamid QA.

Clin Exp Allergy. 2012 May;42(5):611. doi: 10.1111/j.1365-2222.2012.03999.x. No abstract available.


Investigation of cavitation as a possible damage mechanism in blast-induced traumatic brain injury.

Goeller J, Wardlaw A, Treichler D, O'Bruba J, Weiss G.

J Neurotrauma. 2012 Jul 1;29(10):1970-81. doi: 10.1089/neu.2011.2224. Epub 2012 May 14.


The relationship between clinical outcomes and medication adherence in difficult-to-control asthma.

Murphy AC, Proeschal A, Brightling CE, Wardlaw AJ, Pavord I, Bradding P, Green RH.

Thorax. 2012 Aug;67(8):751-3. doi: 10.1136/thoraxjnl-2011-201096. Epub 2012 Mar 21.


DNA analysis of outdoor air reveals a high degree of fungal diversity, temporal variability, and genera not seen by spore morphology.

Pashley CH, Fairs A, Free RC, Wardlaw AJ.

Fungal Biol. 2012 Feb;116(2):214-24. doi: 10.1016/j.funbio.2011.11.004. Epub 2011 Nov 20.


Fungi and allergic lower respiratory tract diseases.

Knutsen AP, Bush RK, Demain JG, Denning DW, Dixit A, Fairs A, Greenberger PA, Kariuki B, Kita H, Kurup VP, Moss RB, Niven RM, Pashley CH, Slavin RG, Vijay HM, Wardlaw AJ.

J Allergy Clin Immunol. 2012 Feb;129(2):280-91; quiz 292-3. doi: 10.1016/j.jaci.2011.12.970. Review.


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