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Items: 1 to 50 of 53

1.

Retraction: Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.

Amara K, Steen J, Murray F, Morbach H, Fernandez-Rodriguez BM, Joshua V, Engström M, Snir O, Israelsson L, Catrina AI, Wardemann H, Corti D, Meffre E, Klareskog L, Malmström V.

J Exp Med. 2019 Jan 7;216(1):245. doi: 10.1084/jem.2012148612112018r. Epub 2018 Dec 19. No abstract available.

2.

Assessing human B cell repertoire diversity and convergence.

Imkeller K, Wardemann H.

Immunol Rev. 2018 Jul;284(1):51-66. doi: 10.1111/imr.12670.

PMID:
29944762
3.

Antihomotypic affinity maturation improves human B cell responses against a repetitive epitope.

Imkeller K, Scally SW, Bosch A, Martí GP, Costa G, Triller G, Murugan R, Renna V, Jumaa H, Kremsner PG, Sim BKL, Hoffman SL, Mordmüller B, Levashina EA, Julien JP, Wardemann H.

Science. 2018 Jun 22;360(6395):1358-1362. doi: 10.1126/science.aar5304. Epub 2018 Jun 7.

PMID:
29880723
4.

Cross-specificity of protective human antibodies against Klebsiella pneumoniae LPS O-antigen.

Rollenske T, Szijarto V, Lukasiewicz J, Guachalla LM, Stojkovic K, Hartl K, Stulik L, Kocher S, Lasitschka F, Al-Saeedi M, Schröder-Braunstein J, von Frankenberg M, Gaebelein G, Hoffmann P, Klein S, Heeg K, Nagy E, Nagy G, Wardemann H.

Nat Immunol. 2018 Jun;19(6):617-624. doi: 10.1038/s41590-018-0106-2. Epub 2018 May 14.

PMID:
29760533
5.

From human antibody structure and function towards the design of a novel Plasmodium falciparum circumsporozoite protein malaria vaccine.

Wardemann H, Murugan R.

Curr Opin Immunol. 2018 Aug;53:119-123. doi: 10.1016/j.coi.2018.04.023. Epub 2018 May 8. Review.

PMID:
29751213
6.

Clonal selection drives protective memory B cell responses in controlled human malaria infection.

Murugan R, Buchauer L, Triller G, Kreschel C, Costa G, Pidelaserra Martí G, Imkeller K, Busse CE, Chakravarty S, Sim BKL, Hoffman SL, Levashina EA, Kremsner PG, Mordmüller B, Höfer T, Wardemann H.

Sci Immunol. 2018 Feb 16;3(20). pii: eaap8029. doi: 10.1126/sciimmunol.aap8029.

PMID:
29453292
7.

Natural Parasite Exposure Induces Protective Human Anti-Malarial Antibodies.

Triller G, Scally SW, Costa G, Pissarev M, Kreschel C, Bosch A, Marois E, Sack BK, Murugan R, Salman AM, Janse CJ, Khan SM, Kappe SHI, Adegnika AA, Mordmüller B, Levashina EA, Julien JP, Wardemann H.

Immunity. 2017 Dec 19;47(6):1197-1209.e10. doi: 10.1016/j.immuni.2017.11.007. Epub 2017 Nov 29.

8.

Rare PfCSP C-terminal antibodies induced by live sporozoite vaccination are ineffective against malaria infection.

Scally SW, Murugan R, Bosch A, Triller G, Costa G, Mordmüller B, Kremsner PG, Sim BKL, Hoffman SL, Levashina EA, Wardemann H, Julien JP.

J Exp Med. 2018 Jan 2;215(1):63-75. doi: 10.1084/jem.20170869. Epub 2017 Nov 22.

9.

Novel Approaches to Analyze Immunoglobulin Repertoires.

Wardemann H, Busse CE.

Trends Immunol. 2017 Jul;38(7):471-482. doi: 10.1016/j.it.2017.05.003. Epub 2017 May 26. Review.

PMID:
28566130
10.

Reply: In vitro effects of a human monoclonal antibody against the N-methyl-d-aspartate receptor.

Kreye J, Wenke NK, Garner CC, Wardemann H, Prüss H.

Brain. 2017 Feb;140(2):e10. doi: 10.1093/brain/aww290. Epub 2016 Nov 17. No abstract available.

PMID:
27864269
11.

Human isotype-dependent inhibitory antibody responses against Mycobacterium tuberculosis.

Zimmermann N, Thormann V, Hu B, Köhler AB, Imai-Matsushima A, Locht C, Arnett E, Schlesinger LS, Zoller T, Schürmann M, Kaufmann SH, Wardemann H.

EMBO Mol Med. 2016 Nov 2;8(11):1325-1339. doi: 10.15252/emmm.201606330. Print 2016 Nov.

12.

Human cerebrospinal fluid monoclonal N-methyl-D-aspartate receptor autoantibodies are sufficient for encephalitis pathogenesis.

Kreye J, Wenke NK, Chayka M, Leubner J, Murugan R, Maier N, Jurek B, Ly LT, Brandl D, Rost BR, Stumpf A, Schulz P, Radbruch H, Hauser AE, Pache F, Meisel A, Harms L, Paul F, Dirnagl U, Garner C, Schmitz D, Wardemann H, Prüss H.

Brain. 2016 Oct;139(Pt 10):2641-2652. Epub 2016 Aug 20.

PMID:
27543972
13.

sciReptor: analysis of single-cell level immunoglobulin repertoires.

Imkeller K, Arndt PF, Wardemann H, Busse CE.

BMC Bioinformatics. 2016 Feb 4;17:67. doi: 10.1186/s12859-016-0920-1.

14.

Direct high-throughput amplification and sequencing of immunoglobulin genes from single human B cells.

Murugan R, Imkeller K, Busse CE, Wardemann H.

Eur J Immunol. 2015 Sep;45(9):2698-700. doi: 10.1002/eji.201545526. Epub 2015 Jul 20. No abstract available.

15.

The promise and challenge of high-throughput sequencing of the antibody repertoire.

Georgiou G, Ippolito GC, Beausang J, Busse CE, Wardemann H, Quake SR.

Nat Biotechnol. 2014 Feb;32(2):158-68. doi: 10.1038/nbt.2782. Epub 2014 Jan 19. Review.

16.

Single-cell based high-throughput sequencing of full-length immunoglobulin heavy and light chain genes.

Busse CE, Czogiel I, Braun P, Arndt PF, Wardemann H.

Eur J Immunol. 2014 Feb;44(2):597-603. doi: 10.1002/eji.201343917. Epub 2013 Oct 22.

17.

T cell-independent B cell activation induces immunosuppressive sialylated IgG antibodies.

Hess C, Winkler A, Lorenz AK, Holecska V, Blanchard V, Eiglmeier S, Schoen AL, Bitterling J, Stoehr AD, Petzold D, Schommartz T, Mertes MM, Schoen CT, Tiburzy B, Herrmann A, Köhl J, Manz RA, Madaio MP, Berger M, Wardemann H, Ehlers M.

J Clin Invest. 2013 Sep;123(9):3788-96. doi: 10.1172/JCI65938. Epub 2013 Aug 27.

18.

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition.

Amara K, Steen J, Murray F, Morbach H, Fernandez-Rodriguez BM, Joshua V, Engström M, Snir O, Israelsson L, Catrina AI, Wardemann H, Corti D, Meffre E, Klareskog L, Malmström V.

J Exp Med. 2013 Mar 11;210(3):445-55. doi: 10.1084/jem.20121486. Epub 2013 Feb 25. Retraction in: J Exp Med. 2019 Jan 7;216(1):245.

19.

Atypical and classical memory B cells produce Plasmodium falciparum neutralizing antibodies.

Muellenbeck MF, Ueberheide B, Amulic B, Epp A, Fenyo D, Busse CE, Esen M, Theisen M, Mordmüller B, Wardemann H.

J Exp Med. 2013 Feb 11;210(2):389-99. doi: 10.1084/jem.20121970. Epub 2013 Jan 14.

20.

Expression cloning of human B cell immunoglobulins.

Wardemann H, Kofer J.

Methods Mol Biol. 2013;971:93-111. doi: 10.1007/978-1-62703-269-8_5.

PMID:
23296959
21.

Highly restricted usage of Ig H chain VH14 family gene segments in Slp65-deficient pre-B cell leukemia in mice.

Ta VB, de Bruijn MJ, Matheson L, Zoller M, Bach MP, Wardemann H, Jumaa H, Corcoran A, Hendriks RW.

J Immunol. 2012 Nov 15;189(10):4842-51. doi: 10.4049/jimmunol.1201440. Epub 2012 Oct 12.

22.

Chronic lymphocytic leukaemia is driven by antigen-independent cell-autonomous signalling.

Dühren-von Minden M, Übelhart R, Schneider D, Wossning T, Bach MP, Buchner M, Hofmann D, Surova E, Follo M, Köhler F, Wardemann H, Zirlik K, Veelken H, Jumaa H.

Nature. 2012 Sep 13;489(7415):309-12. doi: 10.1038/nature11309.

PMID:
22885698
23.

Tolerance induction with T cell-dependent protein antigens induces regulatory sialylated IgGs.

Oefner CM, Winkler A, Hess C, Lorenz AK, Holecska V, Huxdorf M, Schommartz T, Petzold D, Bitterling J, Schoen AL, Stoehr AD, Vu Van D, Darcan-Nikolaisen Y, Blanchard V, Schmudde I, Laumonnier Y, Ströver HA, Hegazy AN, Eiglmeier S, Schoen CT, Mertes MM, Loddenkemper C, Löhning M, König P, Petersen A, Luger EO, Collin M, Köhl J, Hutloff A, Hamelmann E, Berger M, Wardemann H, Ehlers M.

J Allergy Clin Immunol. 2012 Jun;129(6):1647-55.e13. doi: 10.1016/j.jaci.2012.02.037. Epub 2012 Apr 12.

PMID:
22502800
24.

Rituximab induces sustained reduction of pathogenic B cells in patients with peripheral nervous system autoimmunity.

Maurer MA, Rakocevic G, Leung CS, Quast I, Lukačišin M, Goebels N, Münz C, Wardemann H, Dalakas M, Lünemann JD.

J Clin Invest. 2012 Apr;122(4):1393-402. doi: 10.1172/JCI58743. Epub 2012 Mar 19.

25.

Differential regulation of self-reactivity discriminates between IgG+ human circulating memory B cells and bone marrow plasma cells.

Scheid JF, Mouquet H, Kofer J, Yurasov S, Nussenzweig MC, Wardemann H.

Proc Natl Acad Sci U S A. 2011 Nov 1;108(44):18044-8. doi: 10.1073/pnas.1113395108. Epub 2011 Oct 24.

26.

TLR9 in peritoneal B-1b cells is essential for production of protective self-reactive IgM to control Th17 cells and severe autoimmunity.

Stoehr AD, Schoen CT, Mertes MM, Eiglmeier S, Holecska V, Lorenz AK, Schommartz T, Schoen AL, Hess C, Winkler A, Wardemann H, Ehlers M.

J Immunol. 2011 Sep 15;187(6):2953-65. doi: 10.4049/jimmunol.1003340. Epub 2011 Aug 22.

27.

The majority of intestinal IgA+ and IgG+ plasmablasts in the human gut are antigen-specific.

Benckert J, Schmolka N, Kreschel C, Zoller MJ, Sturm A, Wiedenmann B, Wardemann H.

J Clin Invest. 2011 May;121(5):1946-55. doi: 10.1172/JCI44447. Epub 2011 Apr 1.

28.

Development of self-reactive germinal center B cells and plasma cells in autoimmune Fc gammaRIIB-deficient mice.

Tiller T, Kofer J, Kreschel C, Busse CE, Riebel S, Wickert S, Oden F, Mertes MM, Ehlers M, Wardemann H.

J Exp Med. 2010 Nov 22;207(12):2767-78. doi: 10.1084/jem.20100171. Epub 2010 Nov 15.

29.

Polyreactivity increases the apparent affinity of anti-HIV antibodies by heteroligation.

Mouquet H, Scheid JF, Zoller MJ, Krogsgaard M, Ott RG, Shukair S, Artyomov MN, Pietzsch J, Connors M, Pereyra F, Walker BD, Ho DD, Wilson PC, Seaman MS, Eisen HN, Chakraborty AK, Hope TJ, Ravetch JV, Wardemann H, Nussenzweig MC.

Nature. 2010 Sep 30;467(7315):591-5. doi: 10.1038/nature09385.

30.

Homeostatic expansion of autoreactive immunoglobulin-secreting cells in the Rag2 mouse model of Omenn syndrome.

Cassani B, Poliani PL, Marrella V, Schena F, Sauer AV, Ravanini M, Strina D, Busse CE, Regenass S, Wardemann H, Martini A, Facchetti F, van der Burg M, Rolink AG, Vezzoni P, Grassi F, Traggiai E, Villa A.

J Exp Med. 2010 Jul 5;207(7):1525-40. doi: 10.1084/jem.20091928. Epub 2010 Jun 14.

31.

Cloning and expression of murine Ig genes from single B cells.

Tiller T, Busse CE, Wardemann H.

J Immunol Methods. 2009 Oct 31;350(1-2):183-93. doi: 10.1016/j.jim.2009.08.009. Epub 2009 Aug 27.

PMID:
19716372
32.

Broad diversity of neutralizing antibodies isolated from memory B cells in HIV-infected individuals.

Scheid JF, Mouquet H, Feldhahn N, Seaman MS, Velinzon K, Pietzsch J, Ott RG, Anthony RM, Zebroski H, Hurley A, Phogat A, Chakrabarti B, Li Y, Connors M, Pereyra F, Walker BD, Wardemann H, Ho D, Wyatt RT, Mascola JR, Ravetch JV, Nussenzweig MC.

Nature. 2009 Apr 2;458(7238):636-40. doi: 10.1038/nature07930. Epub 2009 Mar 15.

PMID:
19287373
33.

A method for identification of HIV gp140 binding memory B cells in human blood.

Scheid JF, Mouquet H, Feldhahn N, Walker BD, Pereyra F, Cutrell E, Seaman MS, Mascola JR, Wyatt RT, Wardemann H, Nussenzweig MC.

J Immunol Methods. 2009 Apr 15;343(2):65-7. doi: 10.1016/j.jim.2008.11.012. Epub 2008 Dec 25.

34.

Autoreactive B cell receptors mimic autonomous pre-B cell receptor signaling and induce proliferation of early B cells.

Köhler F, Hug E, Eschbach C, Meixlsperger S, Hobeika E, Kofer J, Wardemann H, Jumaa H.

Immunity. 2008 Dec 19;29(6):912-21. doi: 10.1016/j.immuni.2008.10.013. Epub 2008 Dec 11.

35.

B-cell tolerance checkpoints in health and autoimmunity.

Meffre E, Wardemann H.

Curr Opin Immunol. 2008 Dec;20(6):632-8. doi: 10.1016/j.coi.2008.09.001. Epub 2008 Oct 25.

PMID:
18848883
36.

Autoreactive IgG memory antibodies in patients with systemic lupus erythematosus arise from nonreactive and polyreactive precursors.

Mietzner B, Tsuiji M, Scheid J, Velinzon K, Tiller T, Abraham K, Gonzalez JB, Pascual V, Stichweh D, Wardemann H, Nussenzweig MC.

Proc Natl Acad Sci U S A. 2008 Jul 15;105(28):9727-32. doi: 10.1073/pnas.0803644105. Epub 2008 Jul 9.

37.

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning.

Tiller T, Meffre E, Yurasov S, Tsuiji M, Nussenzweig MC, Wardemann H.

J Immunol Methods. 2008 Jan 1;329(1-2):112-24. Epub 2007 Oct 31. Erratum in: J Immunol Methods. 2008 May 20;334(1-2):142.

38.

B-cell self-tolerance in humans.

Wardemann H, Nussenzweig MC.

Adv Immunol. 2007;95:83-110. Review.

PMID:
17869611
39.

Autoreactivity in human IgG+ memory B cells.

Tiller T, Tsuiji M, Yurasov S, Velinzon K, Nussenzweig MC, Wardemann H.

Immunity. 2007 Feb;26(2):205-13.

40.

Persistent expression of autoantibodies in SLE patients in remission.

Yurasov S, Tiller T, Tsuiji M, Velinzon K, Pascual V, Wardemann H, Nussenzweig MC.

J Exp Med. 2006 Oct 2;203(10):2255-61. Epub 2006 Sep 11.

41.

B-cell tolerance checkpoints in healthy humans and patients with systemic lupus erythematosus.

Yurasov S, Hammersen J, Tiller T, Tsuiji M, Wardemann H.

Ann N Y Acad Sci. 2005 Dec;1062:165-74. Review.

PMID:
16461799
42.

A checkpoint for autoreactivity in human IgM+ memory B cell development.

Tsuiji M, Yurasov S, Velinzon K, Thomas S, Nussenzweig MC, Wardemann H.

J Exp Med. 2006 Feb 20;203(2):393-400. Epub 2006 Jan 30.

43.

Runx3 regulates integrin alpha E/CD103 and CD4 expression during development of CD4-/CD8+ T cells.

Grueter B, Petter M, Egawa T, Laule-Kilian K, Aldrian CJ, Wuerch A, Ludwig Y, Fukuyama H, Wardemann H, Waldschuetz R, Möröy T, Taniuchi I, Steimle V, Littman DR, Ehlers M.

J Immunol. 2005 Aug 1;175(3):1694-705. Erratum in: J Immunol. 2005 Nov 1;175(9):6238.

44.

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

Hervé M, Xu K, Ng YS, Wardemann H, Albesiano E, Messmer BT, Chiorazzi N, Meffre E.

J Clin Invest. 2005 Jun;115(6):1636-43. Epub 2005 May 2.

45.

Defective B cell tolerance checkpoints in systemic lupus erythematosus.

Yurasov S, Wardemann H, Hammersen J, Tsuiji M, Meffre E, Pascual V, Nussenzweig MC.

J Exp Med. 2005 Mar 7;201(5):703-11. Epub 2005 Feb 28.

46.

Visualizing dendritic cell networks in vivo.

Lindquist RL, Shakhar G, Dudziak D, Wardemann H, Eisenreich T, Dustin ML, Nussenzweig MC.

Nat Immunol. 2004 Dec;5(12):1243-50. Epub 2004 Nov 14.

PMID:
15543150
47.

Bruton's tyrosine kinase is essential for human B cell tolerance.

Ng YS, Wardemann H, Chelnis J, Cunningham-Rundles C, Meffre E.

J Exp Med. 2004 Oct 4;200(7):927-34.

48.

Human autoantibody silencing by immunoglobulin light chains.

Wardemann H, Hammersen J, Nussenzweig MC.

J Exp Med. 2004 Jul 19;200(2):191-9.

49.

RAGs and regulation of autoantibodies.

Jankovic M, Casellas R, Yannoutsos N, Wardemann H, Nussenzweig MC.

Annu Rev Immunol. 2004;22:485-501. Review.

PMID:
15032586
50.

Surrogate light chain expressing human peripheral B cells produce self-reactive antibodies.

Meffre E, Schaefer A, Wardemann H, Wilson P, Davis E, Nussenzweig MC.

J Exp Med. 2004 Jan 5;199(1):145-50. Epub 2003 Dec 29.

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