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Items: 30

1.

Electrophysiological Analysis of human Pluripotent Stem Cell-derived Cardiomyocytes (hPSC-CMs) Using Multi-electrode Arrays (MEAs).

Sala L, Ward-van Oostwaard D, Tertoolen LGJ, Mummery CL, Bellin M.

J Vis Exp. 2017 May 12;(123). doi: 10.3791/55587.

2.

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes.

Chen Z, Xian W, Bellin M, Dorn T, Tian Q, Goedel A, Dreizehnter L, Schneider CM, Ward-van Oostwaard D, Ng JK, Hinkel R, Pane LS, Mummery CL, Lipp P, Moretti A, Laugwitz KL, Sinnecker D.

Eur Heart J. 2017 Jan 21;38(4):292-301. doi: 10.1093/eurheartj/ehw189. No abstract available.

3.

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells.

Sala L, Yu Z, Ward-van Oostwaard D, van Veldhoven JP, Moretti A, Laugwitz KL, Mummery CL, IJzerman AP, Bellin M.

EMBO Mol Med. 2016 Sep 1;8(9):1065-81. doi: 10.15252/emmm.201606260. Print 2016 Sep.

4.

Altered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure.

Kosmidis G, Bellin M, Ribeiro MC, van Meer B, Ward-van Oostwaard D, Passier R, Tertoolen LG, Mummery CL, Casini S.

Biochem Biophys Res Commun. 2015 Nov 27;467(4):998-1005. doi: 10.1016/j.bbrc.2015.10.026. Epub 2015 Oct 9.

PMID:
26456652
5.

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue.

Zhang M, D'Aniello C, Verkerk AO, Wrobel E, Frank S, Ward-van Oostwaard D, Piccini I, Freund C, Rao J, Seebohm G, Atsma DE, Schulze-Bahr E, Mummery CL, Greber B, Bellin M.

Proc Natl Acad Sci U S A. 2014 Dec 16;111(50):E5383-92. doi: 10.1073/pnas.1419553111. Epub 2014 Dec 1.

6.

BMP4 promotes EMT and mesodermal commitment in human embryonic stem cells via SLUG and MSX2.

Richter A, Valdimarsdottir L, Hrafnkelsdottir HE, Runarsson JF, Omarsdottir AR, Ward-van Oostwaard D, Mummery C, Valdimarsdottir G.

Stem Cells. 2014 Mar;32(3):636-48. doi: 10.1002/stem.1592.

7.

Isogenic human pluripotent stem cell pairs reveal the role of a KCNH2 mutation in long-QT syndrome.

Bellin M, Casini S, Davis RP, D'Aniello C, Haas J, Ward-van Oostwaard D, Tertoolen LG, Jung CB, Elliott DA, Welling A, Laugwitz KL, Moretti A, Mummery CL.

EMBO J. 2013 Dec 11;32(24):3161-75. doi: 10.1038/emboj.2013.240. Epub 2013 Nov 8.

8.

Screening ethnically diverse human embryonic stem cells identifies a chromosome 20 minimal amplicon conferring growth advantage.

International Stem Cell Initiative, Amps K, Andrews PW, Anyfantis G, Armstrong L, Avery S, Baharvand H, Baker J, Baker D, Munoz MB, Beil S, Benvenisty N, Ben-Yosef D, Biancotti JC, Bosman A, Brena RM, Brison D, Caisander G, Camarasa MV, Chen J, Chiao E, Choi YM, Choo AB, Collins D, Colman A, Crook JM, Daley GQ, Dalton A, De Sousa PA, Denning C, Downie J, Dvorak P, Montgomery KD, Feki A, Ford A, Fox V, Fraga AM, Frumkin T, Ge L, Gokhale PJ, Golan-Lev T, Gourabi H, Gropp M, Lu G, Hampl A, Harron K, Healy L, Herath W, Holm F, Hovatta O, Hyllner J, Inamdar MS, Irwanto AK, Ishii T, Jaconi M, Jin Y, Kimber S, Kiselev S, Knowles BB, Kopper O, Kukharenko V, Kuliev A, Lagarkova MA, Laird PW, Lako M, Laslett AL, Lavon N, Lee DR, Lee JE, Li C, Lim LS, Ludwig TE, Ma Y, Maltby E, Mateizel I, Mayshar Y, Mileikovsky M, Minger SL, Miyazaki T, Moon SY, Moore H, Mummery C, Nagy A, Nakatsuji N, Narwani K, Oh SK, Oh SK, Olson C, Otonkoski T, Pan F, Park IH, Pells S, Pera MF, Pereira LV, Qi O, Raj GS, Reubinoff B, Robins A, Robson P, Rossant J, Salekdeh GH, Schulz TC, Sermon K, Sheik Mohamed J, Shen H, Sherrer E, Sidhu K, Sivarajah S, Skottman H, Spits C, Stacey GN, Strehl R, Strelchenko N, Suemori H, Sun B, Suuronen R, Takahashi K, Tuuri T, Venu P, Verlinsky Y, Ward-van Oostwaard D, Weisenberger DJ, Wu Y, Yamanaka S, Young L, Zhou Q.

Nat Biotechnol. 2011 Nov 27;29(12):1132-44. doi: 10.1038/nbt.2051.

9.

NKX2-5(eGFP/w) hESCs for isolation of human cardiac progenitors and cardiomyocytes.

Elliott DA, Braam SR, Koutsis K, Ng ES, Jenny R, Lagerqvist EL, Biben C, Hatzistavrou T, Hirst CE, Yu QC, Skelton RJ, Ward-van Oostwaard D, Lim SM, Khammy O, Li X, Hawes SM, Davis RP, Goulburn AL, Passier R, Prall OW, Haynes JM, Pouton CW, Kaye DM, Mummery CL, Elefanty AG, Stanley EG.

Nat Methods. 2011 Oct 23;8(12):1037-40. doi: 10.1038/nmeth.1740.

PMID:
22020065
10.

Inhibition of ROCK improves survival of human embryonic stem cell-derived cardiomyocytes after dissociation.

Braam SR, Nauw R, Ward-van Oostwaard D, Mummery C, Passier R.

Ann N Y Acad Sci. 2010 Feb;1188:52-7. doi: 10.1111/j.1749-6632.2009.05083.x.

PMID:
20201886
11.

The first reported generation of human induced pluripotent stem cells (iPS cells) and iPS cell-derived cardiomyocytes in the Netherlands.

Freund C, Davis RP, Gkatzis K, Ward-van Oostwaard D, Mummery CL.

Neth Heart J. 2010 Jan;18(1):51-4.

12.

Identification of cell surface proteins for antibody-based selection of human embryonic stem cell-derived cardiomyocytes.

Van Hoof D, Dormeyer W, Braam SR, Passier R, Monshouwer-Kloots J, Ward-van Oostwaard D, Heck AJ, Krijgsveld J, Mummery CL.

J Proteome Res. 2010 Mar 5;9(3):1610-8. doi: 10.1021/pr901138a.

PMID:
20088484
13.

Improvement of mouse cardiac function by hESC-derived cardiomyocytes correlates with vascularity but not graft size.

van Laake LW, Passier R, den Ouden K, Schreurs C, Monshouwer-Kloots J, Ward-van Oostwaard D, van Echteld CJ, Doevendans PA, Mummery CL.

Stem Cell Res. 2009 Sep-Nov;3(2-3):106-12. doi: 10.1016/j.scr.2009.05.004. Epub 2009 Jun 2.

14.

Feeder-free monolayer cultures of human embryonic stem cells express an epithelial plasma membrane protein profile.

Van Hoof D, Braam SR, Dormeyer W, Ward-van Oostwaard D, Heck AJ, Krijgsveld J, Mummery CL.

Stem Cells. 2008 Nov;26(11):2777-81. doi: 10.1634/stemcells.2008-0365. Epub 2008 Aug 14.

15.

Recombinant vitronectin is a functionally defined substrate that supports human embryonic stem cell self-renewal via alphavbeta5 integrin.

Braam SR, Zeinstra L, Litjens S, Ward-van Oostwaard D, van den Brink S, van Laake L, Lebrin F, Kats P, Hochstenbach R, Passier R, Sonnenberg A, Mummery CL.

Stem Cells. 2008 Sep;26(9):2257-65. doi: 10.1634/stemcells.2008-0291. Epub 2008 Jul 3.

16.

Insulin redirects differentiation from cardiogenic mesoderm and endoderm to neuroectoderm in differentiating human embryonic stem cells.

Freund C, Ward-van Oostwaard D, Monshouwer-Kloots J, van den Brink S, van Rooijen M, Xu X, Zweigerdt R, Mummery C, Passier R.

Stem Cells. 2008 Mar;26(3):724-33. Epub 2007 Dec 20.

17.

Gene-specific vulnerability to imprinting variability in human embryonic stem cell lines.

Kim KP, Thurston A, Mummery C, Ward-van Oostwaard D, Priddle H, Allegrucci C, Denning C, Young L.

Genome Res. 2007 Dec;17(12):1731-42. Epub 2007 Nov 7.

18.

Monitoring of cell therapy and assessment of cardiac function using magnetic resonance imaging in a mouse model of myocardial infarction.

van Laake LW, Passier R, Monshouwer-Kloots J, Nederhoff MG, Ward-van Oostwaard D, Field LJ, van Echteld CJ, Doevendans PA, Mummery CL.

Nat Protoc. 2007;2(10):2551-67.

PMID:
17947998
19.

Human embryonic stem cell-derived cardiomyocytes survive and mature in the mouse heart and transiently improve function after myocardial infarction.

van Laake LW, Passier R, Monshouwer-Kloots J, Verkleij AJ, Lips DJ, Freund C, den Ouden K, Ward-van Oostwaard D, Korving J, Tertoolen LG, van Echteld CJ, Doevendans PA, Mummery CL.

Stem Cell Res. 2007 Oct;1(1):9-24. doi: 10.1016/j.scr.2007.06.001. Epub 2007 Aug 17.

20.

Restriction landmark genome scanning identifies culture-induced DNA methylation instability in the human embryonic stem cell epigenome.

Allegrucci C, Wu YZ, Thurston A, Denning CN, Priddle H, Mummery CL, Ward-van Oostwaard D, Andrews PW, Stojkovic M, Smith N, Parkin T, Jones ME, Warren G, Yu L, Brena RM, Plass C, Young LE.

Hum Mol Genet. 2007 May 15;16(10):1253-68. Epub 2007 Apr 4.

PMID:
17409196
21.

Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes.

Beqqali A, Kloots J, Ward-van Oostwaard D, Mummery C, Passier R.

Stem Cells. 2006 Aug;24(8):1956-67. Epub 2006 May 4.

22.

A quest for human and mouse embryonic stem cell-specific proteins.

Van Hoof D, Passier R, Ward-Van Oostwaard D, Pinkse MW, Heck AJ, Mummery CL, Krijgsveld J.

Mol Cell Proteomics. 2006 Jul;5(7):1261-73. Epub 2006 Apr 6.

23.

Human embryonic stem cells: towards therapies for cardiac disease. Derivation of a Dutch human embryonic stem cell line.

van de Stolpe A, van den Brink S, van Rooijen M, Ward-van Oostwaard D, van Inzen W, Slaper-Cortenbach I, Fauser B, van den Hout N, Weima S, Passier R, Smith N, Denning C, Mummery C.

Reprod Biomed Online. 2005 Oct;11(4):476-85.

PMID:
16274613
24.

Regulation of human embryonic stem cell differentiation by BMP-2 and its antagonist noggin.

Pera MF, Andrade J, Houssami S, Reubinoff B, Trounson A, Stanley EG, Ward-van Oostwaard D, Mummery C.

J Cell Sci. 2004 Mar 1;117(Pt 7):1269-80.

25.

Differentiation of human embryonic stem cells to cardiomyocytes: role of coculture with visceral endoderm-like cells.

Mummery C, Ward-van Oostwaard D, Doevendans P, Spijker R, van den Brink S, Hassink R, van der Heyden M, Opthof T, Pera M, de la Riviere AB, Passier R, Tertoolen L.

Circulation. 2003 Jun 3;107(21):2733-40. Epub 2003 May 12.

PMID:
12742992
26.

Bone morphogenetic proteins (BMPs) induce epithelial differentiation of NT2D1 human embryonal carcinoma cells.

Caricasole A, Ward-van Oostwaard D, Zeinstra L, van den Eijnden-van Raaij A, Mummery C.

Int J Dev Biol. 2000 Aug;44(5):443-50.

27.

Bone morphogenetic proteins and retinoic acid induce human endogenous retrovirus HERV-K expression in NT2D1 human embryonal carcinoma cells.

Caricasole A, Ward-van Oostwaard D, Mummery C, van den Eijnden-van Raaij A.

Dev Growth Differ. 2000 Aug;42(4):407-11.

PMID:
10969740
28.

Snail is an immediate early target gene of parathyroid hormone related peptide signaling in parietal endoderm formation.

Veltmaat JM, Orelio CC, Ward-Van Oostwaard D, Van Rooijen MA, Mummery CL, Defize LH.

Int J Dev Biol. 2000 Apr;44(3):297-307.

29.

Expression of the alpha 6A integrin splice variant in developing mouse embryonic stem cell aggregates and correlation with cardiac muscle differentiation.

Thorsteinsdóttir S, Roelen BA, Goumans MJ, Ward-van Oostwaard D, Gaspar AC, Mummery CL.

Differentiation. 1999 Mar;64(3):173-84.

PMID:
10234814
30.

Mouse embryonic stem cells with aberrant transforming growth factor beta signalling exhibit impaired differentiation in vitro and in vivo.

Goumans MJ, Ward-van Oostwaard D, Wianny F, Savatier P, Zwijsen A, Mummery C.

Differentiation. 1998 Jul;63(3):101-13.

PMID:
9697304

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