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Items: 1 to 50 of 152

1.

Cell-Penetrating Dynamic-Covalent Benzopolysulfane Networks.

Cheng Y, Zong L, López-Andarias J, Bartolami E, Okamoto Y, Ward TR, Sakai N, Matile S.

Angew Chem Int Ed Engl. 2019 Jun 6. doi: 10.1002/anie.201905003. [Epub ahead of print]

PMID:
31168906
2.

New "Cats" in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed Metalloenzymes.

Hartwig JF, Ward TR.

Acc Chem Res. 2019 May 21;52(5):1145. doi: 10.1021/acs.accounts.9b00154. No abstract available.

PMID:
31117418
3.

Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein.

Rebelein JG, Cotelle Y, Garabedian B, Ward TR.

ACS Catal. 2019 May 3;9(5):4173-4178. doi: 10.1021/acscatal.9b01006. Epub 2019 Apr 5.

4.

Aqueous olefin metathesis: recent developments and applications.

Sabatino V, Ward TR.

Beilstein J Org Chem. 2019 Feb 14;15:445-468. doi: 10.3762/bjoc.15.39. eCollection 2019. Review.

5.

Diselenolane-Mediated Cellular Uptake: Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein-Coated Quantum Dots.

Bartolami E, Basagiannis D, Zong L, Martinent R, Okamoto Y, Laurent Q, Ward TR, Gonzalez-Gaitan M, Sakai N, Matile S.

Chemistry. 2019 Mar 15;25(16):4047-4051. doi: 10.1002/chem.201805900. Epub 2019 Feb 28.

PMID:
30815941
6.

Image intensifier distortion influences a surgeon's ability to aim guidewires during orthopaedic procedures.

Ward TR, Schwarz B, Le BTN, Smith GCS, Molnar RB, Smith PN.

Skeletal Radiol. 2019 Feb 21. doi: 10.1007/s00256-019-03171-7. [Epub ahead of print]

PMID:
30790010
7.

Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology: Enzymatic Cascades and Directed Evolution.

Liang AD, Serrano-Plana J, Peterson RL, Ward TR.

Acc Chem Res. 2019 Mar 19;52(3):585-595. doi: 10.1021/acs.accounts.8b00618. Epub 2019 Feb 8.

8.

Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli's Periplasm.

Zhao J, Rebelein JG, Mallin H, Trindler C, Pellizzoni MM, Ward TR.

J Am Chem Soc. 2018 Oct 17;140(41):13171-13175. doi: 10.1021/jacs.8b07189. Epub 2018 Oct 3.

PMID:
30272972
9.

E. coli surface display of streptavidin for directed evolution of an allylic deallylase.

Heinisch T, Schwizer F, Garabedian B, Csibra E, Jeschek M, Vallapurackal J, Pinheiro VB, Marlière P, Panke S, Ward TR.

Chem Sci. 2018 May 24;9(24):5383-5388. doi: 10.1039/c8sc00484f. eCollection 2018 Jun 28.

10.

Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase.

Hestericová M, Heinisch T, Lenz M, Ward TR.

Dalton Trans. 2018 Aug 14;47(32):10837-10841. doi: 10.1039/c8dt02224k.

PMID:
30019062
11.

Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network.

Guo X, Okamoto Y, Schreier MR, Ward TR, Wenger OS.

Chem Sci. 2018 May 17;9(22):5052-5056. doi: 10.1039/c8sc01561a. eCollection 2018 Jun 14.

12.

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell.

Okamoto Y, Kojima R, Schwizer F, Bartolami E, Heinisch T, Matile S, Fussenegger M, Ward TR.

Nat Commun. 2018 May 16;9(1):1943. doi: 10.1038/s41467-018-04440-0.

13.

Coordination chemistry within a protein host: regulation of the secondary coordination sphere.

Mann SI, Heinisch T, Ward TR, Borovik AS.

Chem Commun (Camb). 2018 Apr 26;54(35):4413-4416. doi: 10.1039/c8cc01931b.

14.

In vivo catalyzed new-to-nature reactions.

Rebelein JG, Ward TR.

Curr Opin Biotechnol. 2018 Oct;53:106-114. doi: 10.1016/j.copbio.2017.12.008. Epub 2018 Jan 4. Review.

PMID:
29306675
15.

Directed Evolution of an Artificial Imine Reductase.

Hestericová M, Heinisch T, Alonso-Cotchico L, Maréchal JD, Vidossich P, Ward TR.

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1863-1868. doi: 10.1002/anie.201711016. Epub 2018 Jan 16.

PMID:
29265726
16.

Peroxide Activation Regulated by Hydrogen Bonds within Artificial Cu Proteins.

Mann SI, Heinisch T, Ward TR, Borovik AS.

J Am Chem Soc. 2017 Dec 6;139(48):17289-17292. doi: 10.1021/jacs.7b10452. Epub 2017 Nov 15.

17.

Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism.

Jeschek M, Panke S, Ward TR.

Trends Biotechnol. 2018 Jan;36(1):60-72. doi: 10.1016/j.tibtech.2017.10.003. Epub 2017 Oct 20. Review.

PMID:
29061328
18.

Streptavidin as a Scaffold for Light-Induced Long-Lived Charge Separation.

Keller SG, Pannwitz A, Mallin H, Wenger OS, Ward TR.

Chemistry. 2017 Dec 19;23(71):18019-18024. doi: 10.1002/chem.201703885. Epub 2017 Nov 20.

PMID:
29024136
19.

Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context.

Okamoto Y, Ward TR.

Biochemistry. 2017 Oct 10;56(40):5223-5224. doi: 10.1021/acs.biochem.7b00809. Epub 2017 Sep 27. No abstract available.

PMID:
28953358
20.

Artificial Metalloenzymes: Reaction Scope and Optimization Strategies.

Schwizer F, Okamoto Y, Heinisch T, Gu Y, Pellizzoni MM, Lebrun V, Reuter R, Köhler V, Lewis JC, Ward TR.

Chem Rev. 2018 Jan 10;118(1):142-231. doi: 10.1021/acs.chemrev.7b00014. Epub 2017 Jul 17. Review.

PMID:
28714313
21.

Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.

J Med Chem. 2017 Jul 27;60(14):6458. doi: 10.1021/acs.jmedchem.7b00943. Epub 2017 Jul 11. No abstract available.

PMID:
28696689
22.

Anion-π catalysis: bicyclic products with four contiguous stereogenic centers from otherwise elusive diastereospecific domino reactions on π-acidic surfaces.

Liu L, Cotelle Y, Klehr J, Sakai N, Ward TR, Matile S.

Chem Sci. 2017 May 1;8(5):3770-3774. doi: 10.1039/c7sc00525c. Epub 2017 Mar 17.

23.

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.

J Med Chem. 2017 Jun 22;60(12):4805-4817. doi: 10.1021/acs.jmedchem.6b01336. Epub 2017 Jun 7. Erratum in: J Med Chem. 2017 Jul 27;60(14):6458.

24.

Cross-Regulation of an Artificial Metalloenzyme.

Okamoto Y, Ward TR.

Angew Chem Int Ed Engl. 2017 Aug 14;56(34):10156-10160. doi: 10.1002/anie.201702181. Epub 2017 May 31.

25.

Biotin-independent strains of Escherichia coli for enhanced streptavidin production.

Jeschek M, Bahls MO, Schneider V, Marlière P, Ward TR, Panke S.

Metab Eng. 2017 Mar;40:33-40. doi: 10.1016/j.ymben.2016.12.013. Epub 2017 Jan 3.

PMID:
28062280
26.

Directed Evolution of Iridium-Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C-C Bond-Forming Reactions.

Ward TR.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14909-14911. doi: 10.1002/anie.201607222. Epub 2016 Oct 4.

PMID:
27699968
27.

Periplasmic Screening for Artificial Metalloenzymes.

Jeschek M, Panke S, Ward TR.

Methods Enzymol. 2016;580:539-56. doi: 10.1016/bs.mie.2016.05.037. Epub 2016 Jun 15.

PMID:
27586348
28.

Directed evolution of artificial metalloenzymes for in vivo metathesis.

Jeschek M, Reuter R, Heinisch T, Trindler C, Klehr J, Panke S, Ward TR.

Nature. 2016 Sep 29;537(7622):661-665. doi: 10.1038/nature19114. Epub 2016 Aug 29.

PMID:
27571282
29.

Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology: Challenges and Opportunities.

Heinisch T, Ward TR.

Acc Chem Res. 2016 Sep 20;49(9):1711-21. doi: 10.1021/acs.accounts.6b00235. Epub 2016 Aug 16.

PMID:
27529561
30.

Upregulation of an Artificial Zymogen by Proteolysis.

Liu Z, Lebrun V, Kitanosono T, Mallin H, Köhler V, Häussinger D, Hilvert D, Kobayashi S, Ward TR.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11587-90. doi: 10.1002/anie.201605010. Epub 2016 Aug 16.

PMID:
27529471
31.

Anion-π Enzymes.

Cotelle Y, Lebrun V, Sakai N, Ward TR, Matile S.

ACS Cent Sci. 2016 Jun 22;2(6):388-93. doi: 10.1021/acscentsci.6b00097. Epub 2016 May 23.

32.

Light-driven electron injection from a biotinylated triarylamine donor to [Ru(diimine)3](2+)-labeled streptavidin.

Keller SG, Pannwitz A, Schwizer F, Klehr J, Wenger OS, Ward TR.

Org Biomol Chem. 2016 Jul 26;14(30):7197-201. doi: 10.1039/c6ob01273f.

PMID:
27411288
33.

Modular Artificial Cupredoxins.

Mann SI, Heinisch T, Weitz AC, Hendrich MP, Ward TR, Borovik AS.

J Am Chem Soc. 2016 Jul 27;138(29):9073-6. doi: 10.1021/jacs.6b05428. Epub 2016 Jul 14.

34.

Immobilization of an artificial imine reductase within silica nanoparticles improves its performance.

Hestericová M, Correro MR, Lenz M, Corvini PF, Shahgaldian P, Ward TR.

Chem Commun (Camb). 2016 Aug 4;52(60):9462-5. doi: 10.1039/c6cc04604e. Epub 2016 Jul 6.

PMID:
27380900
35.

Interfacing Functional Systems.

Cotelle Y, Chuard N, Lascano S, Lebrun V, Wehlauch R, Bohni N, Lörcher S, Postupalenko V, Reddy ST, Meier W, Palivan CG, Gademann K, Ward TR, Matile S.

Chimia (Aarau). 2016;70(6):418-23. doi: 10.2533/chimia.2016.418. Review.

PMID:
27363370
36.

From Photodriven Charge Accumulation to Fueling Enzyme Cascades in Molecular Factories.

Okamoto Y, Ward TR, Wenger OS.

Chimia (Aarau). 2016;70(6):395-7. doi: 10.2533/chimia.2016.395. Review.

PMID:
27363366
37.

An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades.

Okamoto Y, Köhler V, Ward TR.

J Am Chem Soc. 2016 May 11;138(18):5781-4. doi: 10.1021/jacs.6b02470. Epub 2016 Apr 28.

PMID:
27100673
38.

Library design and screening protocol for artificial metalloenzymes based on the biotin-streptavidin technology.

Mallin H, Hestericová M, Reuter R, Ward TR.

Nat Protoc. 2016 May;11(5):835-52. doi: 10.1038/nprot.2016.019. Epub 2016 Mar 31.

PMID:
27031496
39.

Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions.

Hyster TK, Ward TR.

Angew Chem Int Ed Engl. 2016 Jun 20;55(26):7344-57. doi: 10.1002/anie.201508816. Epub 2016 Mar 11. Review.

PMID:
26971363
40.

Anion-π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces.

Cotelle Y, Benz S, Avestro AJ, Ward TR, Sakai N, Matile S.

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4275-9. doi: 10.1002/anie.201600831. Epub 2016 Feb 24.

PMID:
26916316
41.

An enantioselective artificial Suzukiase based on the biotin-streptavidin technology.

Chatterjee A, Mallin H, Klehr J, Vallapurackal J, Finke AD, Vera L, Marsh M, Ward TR.

Chem Sci. 2016 Jan 1;7(1):673-677. doi: 10.1039/c5sc03116h. Epub 2015 Oct 19.

42.

Profluorescent substrates for the screening of olefin metathesis catalysts.

Reuter R, Ward TR.

Beilstein J Org Chem. 2015 Oct 12;11:1886-92. doi: 10.3762/bjoc.11.203. eCollection 2015.

43.

Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design.

Heinisch T, Pellizzoni M, Dürrenberger M, Tinberg CE, Köhler V, Klehr J, Häussinger D, Baker D, Ward TR.

J Am Chem Soc. 2015 Aug 19;137(32):10414-9. doi: 10.1021/jacs.5b06622. Epub 2015 Aug 7.

PMID:
26226626
44.

Enzyme repurposing of a hydrolase as an emergent peroxidase upon metal binding.

Fujieda N, Schätti J, Stuttfeld E, Ohkubo K, Maier T, Fukuzumi S, Ward TR.

Chem Sci. 2015 Jul 1;6(7):4060-4065. doi: 10.1039/c5sc01065a. Epub 2015 May 7.

45.

Carbonic anhydrase II as host protein for the creation of a biocompatible artificial metathesase.

Zhao J, Kajetanowicz A, Ward TR.

Org Biomol Chem. 2015 May 28;13(20):5652-5. doi: 10.1039/c5ob00428d. Epub 2015 Apr 20.

PMID:
25894419
46.

Editorial overview: Biocatalysis and biotransformation: bio-inspired, bio-based and bio-linked catalysis.

Ward TR, Köhler V.

Curr Opin Chem Biol. 2015 Apr;25:v-vi. doi: 10.1016/j.cbpa.2015.02.022. Epub 2015 Mar 9. No abstract available.

PMID:
25765737
47.

Artificial metalloenzymes for the diastereoselective reduction of NAD(+) to NAD(2)H.

Quinto T, Häussinger D, Köhler V, Ward TR.

Org Biomol Chem. 2015 Jan 14;13(2):357-60. doi: 10.1039/c4ob02071e. Epub 2014 Nov 7.

PMID:
25379837
48.

Structural, kinetic, and docking studies of artificial imine reductases based on biotin-streptavidin technology: an induced lock-and-key hypothesis.

Robles VM, Dürrenberger M, Heinisch T, Lledós A, Schirmer T, Ward TR, Maréchal JD.

J Am Chem Soc. 2014 Nov 5;136(44):15676-83. doi: 10.1021/ja508258t. Epub 2014 Oct 28.

PMID:
25317660
49.

Neutralizing the detrimental effect of glutathione on precious metal catalysts.

Wilson YM, Dürrenberger M, Nogueira ES, Ward TR.

J Am Chem Soc. 2014 Jun 25;136(25):8928-32. doi: 10.1021/ja500613n. Epub 2014 Jun 11.

PMID:
24918731
50.

Recent achievments in the design and engineering of artificial metalloenzymes.

Dürrenberger M, Ward TR.

Curr Opin Chem Biol. 2014 Apr;19:99-106. doi: 10.1016/j.cbpa.2014.01.018. Epub 2014 Mar 5. Review.

PMID:
24608081

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