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Items: 1 to 50 of 158

1.

Chemo-enzymatic cascades to produce cycloalkenes from bio-based resources.

Wu S, Zhou Y, Gerngross D, Jeschek M, Ward TR.

Nat Commun. 2019 Nov 7;10(1):5060. doi: 10.1038/s41467-019-13071-y.

2.

Validation of a method to measure three-dimensional hip joint kinematics in subjects with femoroacetabular impingement.

Ward TR, Hussain MM, Pickering M, Perriman D, Burns A, Scarvell J, Smith PN.

Hip Int. 2019 Oct 17:1120700019883548. doi: 10.1177/1120700019883548. [Epub ahead of print]

PMID:
31623463
3.

Breaking Symmetry: Engineering Single-Chain Dimeric Streptavidin as Host for Artificial Metalloenzymes.

Wu S, Zhou Y, Rebelein JG, Kuhn M, Mallin H, Zhao J, Igareta NV, Ward TR.

J Am Chem Soc. 2019 Oct 9;141(40):15869-15878. doi: 10.1021/jacs.9b06923. Epub 2019 Sep 25.

4.

"Close-to-Release": Spontaneous Bioorthogonal Uncaging Resulting from Ring-Closing Metathesis.

Sabatino V, Rebelein JG, Ward TR.

J Am Chem Soc. 2019 Oct 30;141(43):17048-17052. doi: 10.1021/jacs.9b07193. Epub 2019 Sep 19.

5.

Artificial Metalloenzymes: Challenges and Opportunities.

Davis HJ, Ward TR.

ACS Cent Sci. 2019 Jul 24;5(7):1120-1136. doi: 10.1021/acscentsci.9b00397. Epub 2019 Jul 16. Review.

6.

Correction: E. coli surface display of streptavidin for directed evolution of an allylic deallylase.

Heinisch T, Schwizer F, Garabedian B, Csibra E, Jeschek M, Vallapurackal J, Pinheiro VB, Marlière P, Panke S, Ward TR.

Chem Sci. 2019 Jun 28;10(27):6735. doi: 10.1039/c9sc90139f. eCollection 2019 Jul 21.

7.

Cell-Penetrating Dynamic-Covalent Benzopolysulfane Networks.

Cheng Y, Zong L, López-Andarias J, Bartolami E, Okamoto Y, Ward TR, Sakai N, Matile S.

Angew Chem Int Ed Engl. 2019 Jul 8;58(28):9522-9526. doi: 10.1002/anie.201905003. Epub 2019 Jun 6.

8.

New "Cats" in the House: Chemistry Meets Biology in Artificial Metalloenzymes and Repurposed Metalloenzymes.

Hartwig JF, Ward TR.

Acc Chem Res. 2019 May 21;52(5):1145. doi: 10.1021/acs.accounts.9b00154. No abstract available.

9.

Chemical Optimization of Whole-Cell Transfer Hydrogenation Using Carbonic Anhydrase as Host Protein.

Rebelein JG, Cotelle Y, Garabedian B, Ward TR.

ACS Catal. 2019 May 3;9(5):4173-4178. doi: 10.1021/acscatal.9b01006. Epub 2019 Apr 5.

10.

Aqueous olefin metathesis: recent developments and applications.

Sabatino V, Ward TR.

Beilstein J Org Chem. 2019 Feb 14;15:445-468. doi: 10.3762/bjoc.15.39. eCollection 2019. Review.

11.

Diselenolane-Mediated Cellular Uptake: Efficient Cytosolic Delivery of Probes, Peptides, Proteins, Artificial Metalloenzymes and Protein-Coated Quantum Dots.

Bartolami E, Basagiannis D, Zong L, Martinent R, Okamoto Y, Laurent Q, Ward TR, Gonzalez-Gaitan M, Sakai N, Matile S.

Chemistry. 2019 Mar 15;25(16):4047-4051. doi: 10.1002/chem.201805900. Epub 2019 Feb 28.

PMID:
30815941
12.

Image intensifier distortion influences a surgeon's ability to aim guidewires during orthopaedic procedures.

Ward TR, Schwarz B, Le BTN, Smith GCS, Molnar RB, Smith PN.

Skeletal Radiol. 2019 Sep;48(9):1393-1398. doi: 10.1007/s00256-019-03171-7. Epub 2019 Feb 21.

PMID:
30790010
13.

Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology: Enzymatic Cascades and Directed Evolution.

Liang AD, Serrano-Plana J, Peterson RL, Ward TR.

Acc Chem Res. 2019 Mar 19;52(3):585-595. doi: 10.1021/acs.accounts.8b00618. Epub 2019 Feb 8.

14.

Genetic Engineering of an Artificial Metalloenzyme for Transfer Hydrogenation of a Self-Immolative Substrate in Escherichia coli's Periplasm.

Zhao J, Rebelein JG, Mallin H, Trindler C, Pellizzoni MM, Ward TR.

J Am Chem Soc. 2018 Oct 17;140(41):13171-13175. doi: 10.1021/jacs.8b07189. Epub 2018 Oct 3.

PMID:
30272972
15.

E. coli surface display of streptavidin for directed evolution of an allylic deallylase.

Heinisch T, Schwizer F, Garabedian B, Csibra E, Jeschek M, Vallapurackal J, Pinheiro VB, Marlière P, Panke S, Ward TR.

Chem Sci. 2018 May 24;9(24):5383-5388. doi: 10.1039/c8sc00484f. eCollection 2018 Jun 28. Erratum in: Chem Sci. 2019 Jun 28;10(27):6735.

16.

Ferritin encapsulation of artificial metalloenzymes: engineering a tertiary coordination sphere for an artificial transfer hydrogenase.

Hestericová M, Heinisch T, Lenz M, Ward TR.

Dalton Trans. 2018 Aug 14;47(32):10837-10841. doi: 10.1039/c8dt02224k.

PMID:
30019062
17.

Enantioselective synthesis of amines by combining photoredox and enzymatic catalysis in a cyclic reaction network.

Guo X, Okamoto Y, Schreier MR, Ward TR, Wenger OS.

Chem Sci. 2018 May 17;9(22):5052-5056. doi: 10.1039/c8sc01561a. eCollection 2018 Jun 14.

18.

A cell-penetrating artificial metalloenzyme regulates a gene switch in a designer mammalian cell.

Okamoto Y, Kojima R, Schwizer F, Bartolami E, Heinisch T, Matile S, Fussenegger M, Ward TR.

Nat Commun. 2018 May 16;9(1):1943. doi: 10.1038/s41467-018-04440-0.

19.

Coordination chemistry within a protein host: regulation of the secondary coordination sphere.

Mann SI, Heinisch T, Ward TR, Borovik AS.

Chem Commun (Camb). 2018 Apr 26;54(35):4413-4416. doi: 10.1039/c8cc01931b.

20.

In vivo catalyzed new-to-nature reactions.

Rebelein JG, Ward TR.

Curr Opin Biotechnol. 2018 Oct;53:106-114. doi: 10.1016/j.copbio.2017.12.008. Epub 2018 Jan 4. Review.

PMID:
29306675
21.

Directed Evolution of an Artificial Imine Reductase.

Hestericová M, Heinisch T, Alonso-Cotchico L, Maréchal JD, Vidossich P, Ward TR.

Angew Chem Int Ed Engl. 2018 Feb 12;57(7):1863-1868. doi: 10.1002/anie.201711016. Epub 2018 Jan 16.

PMID:
29265726
22.

Peroxide Activation Regulated by Hydrogen Bonds within Artificial Cu Proteins.

Mann SI, Heinisch T, Ward TR, Borovik AS.

J Am Chem Soc. 2017 Dec 6;139(48):17289-17292. doi: 10.1021/jacs.7b10452. Epub 2017 Nov 15.

23.

Artificial Metalloenzymes on the Verge of New-to-Nature Metabolism.

Jeschek M, Panke S, Ward TR.

Trends Biotechnol. 2018 Jan;36(1):60-72. doi: 10.1016/j.tibtech.2017.10.003. Epub 2017 Oct 20. Review.

PMID:
29061328
24.

Streptavidin as a Scaffold for Light-Induced Long-Lived Charge Separation.

Keller SG, Pannwitz A, Mallin H, Wenger OS, Ward TR.

Chemistry. 2017 Dec 19;23(71):18019-18024. doi: 10.1002/chem.201703885. Epub 2017 Nov 20.

PMID:
29024136
25.

Transfer Hydrogenation Catalyzed by Organometallic Complexes Using NADH as a Reductant in a Biochemical Context.

Okamoto Y, Ward TR.

Biochemistry. 2017 Oct 10;56(40):5223-5224. doi: 10.1021/acs.biochem.7b00809. Epub 2017 Sep 27. No abstract available.

PMID:
28953358
26.

Artificial Metalloenzymes: Reaction Scope and Optimization Strategies.

Schwizer F, Okamoto Y, Heinisch T, Gu Y, Pellizzoni MM, Lebrun V, Reuter R, Köhler V, Lewis JC, Ward TR.

Chem Rev. 2018 Jan 10;118(1):142-231. doi: 10.1021/acs.chemrev.7b00014. Epub 2017 Jul 17. Review.

PMID:
28714313
27.

Correction to BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.

J Med Chem. 2017 Jul 27;60(14):6458. doi: 10.1021/acs.jmedchem.7b00943. Epub 2017 Jul 11. No abstract available.

PMID:
28696689
28.

Anion-π catalysis: bicyclic products with four contiguous stereogenic centers from otherwise elusive diastereospecific domino reactions on π-acidic surfaces.

Liu L, Cotelle Y, Klehr J, Sakai N, Ward TR, Matile S.

Chem Sci. 2017 May 1;8(5):3770-3774. doi: 10.1039/c7sc00525c. Epub 2017 Mar 17.

29.

BET Bromodomain Inhibitors with One-Step Synthesis Discovered from Virtual Screen.

Ayoub AM, Hawk LML, Herzig RJ, Jiang J, Wisniewski AJ, Gee CT, Zhao P, Zhu JY, Berndt N, Offei-Addo NK, Scott TG, Qi J, Bradner JE, Ward TR, Schönbrunn E, Georg GI, Pomerantz WCK.

J Med Chem. 2017 Jun 22;60(12):4805-4817. doi: 10.1021/acs.jmedchem.6b01336. Epub 2017 Jun 7. Erratum in: J Med Chem. 2017 Jul 27;60(14):6458.

30.

Cross-Regulation of an Artificial Metalloenzyme.

Okamoto Y, Ward TR.

Angew Chem Int Ed Engl. 2017 Aug 14;56(34):10156-10160. doi: 10.1002/anie.201702181. Epub 2017 May 31.

31.

Biotin-independent strains of Escherichia coli for enhanced streptavidin production.

Jeschek M, Bahls MO, Schneider V, Marlière P, Ward TR, Panke S.

Metab Eng. 2017 Mar;40:33-40. doi: 10.1016/j.ymben.2016.12.013. Epub 2017 Jan 3.

PMID:
28062280
32.

Directed Evolution of Iridium-Substituted Myoglobin Affords Versatile Artificial Metalloenzymes for Enantioselective C-C Bond-Forming Reactions.

Ward TR.

Angew Chem Int Ed Engl. 2016 Nov 21;55(48):14909-14911. doi: 10.1002/anie.201607222. Epub 2016 Oct 4.

PMID:
27699968
33.

Periplasmic Screening for Artificial Metalloenzymes.

Jeschek M, Panke S, Ward TR.

Methods Enzymol. 2016;580:539-56. doi: 10.1016/bs.mie.2016.05.037. Epub 2016 Jun 15.

PMID:
27586348
34.

Directed evolution of artificial metalloenzymes for in vivo metathesis.

Jeschek M, Reuter R, Heinisch T, Trindler C, Klehr J, Panke S, Ward TR.

Nature. 2016 Sep 29;537(7622):661-665. doi: 10.1038/nature19114. Epub 2016 Aug 29.

PMID:
27571282
35.

Artificial Metalloenzymes Based on the Biotin-Streptavidin Technology: Challenges and Opportunities.

Heinisch T, Ward TR.

Acc Chem Res. 2016 Sep 20;49(9):1711-21. doi: 10.1021/acs.accounts.6b00235. Epub 2016 Aug 16.

PMID:
27529561
36.

Upregulation of an Artificial Zymogen by Proteolysis.

Liu Z, Lebrun V, Kitanosono T, Mallin H, Köhler V, Häussinger D, Hilvert D, Kobayashi S, Ward TR.

Angew Chem Int Ed Engl. 2016 Sep 12;55(38):11587-90. doi: 10.1002/anie.201605010. Epub 2016 Aug 16.

PMID:
27529471
37.

Anion-π Enzymes.

Cotelle Y, Lebrun V, Sakai N, Ward TR, Matile S.

ACS Cent Sci. 2016 Jun 22;2(6):388-93. doi: 10.1021/acscentsci.6b00097. Epub 2016 May 23.

38.

Light-driven electron injection from a biotinylated triarylamine donor to [Ru(diimine)3](2+)-labeled streptavidin.

Keller SG, Pannwitz A, Schwizer F, Klehr J, Wenger OS, Ward TR.

Org Biomol Chem. 2016 Jul 26;14(30):7197-201. doi: 10.1039/c6ob01273f.

PMID:
27411288
39.

Modular Artificial Cupredoxins.

Mann SI, Heinisch T, Weitz AC, Hendrich MP, Ward TR, Borovik AS.

J Am Chem Soc. 2016 Jul 27;138(29):9073-6. doi: 10.1021/jacs.6b05428. Epub 2016 Jul 14.

40.

Immobilization of an artificial imine reductase within silica nanoparticles improves its performance.

Hestericová M, Correro MR, Lenz M, Corvini PF, Shahgaldian P, Ward TR.

Chem Commun (Camb). 2016 Aug 4;52(60):9462-5. doi: 10.1039/c6cc04604e. Epub 2016 Jul 6.

PMID:
27380900
41.

Interfacing Functional Systems.

Cotelle Y, Chuard N, Lascano S, Lebrun V, Wehlauch R, Bohni N, Lörcher S, Postupalenko V, Reddy ST, Meier W, Palivan CG, Gademann K, Ward TR, Matile S.

Chimia (Aarau). 2016;70(6):418-23. doi: 10.2533/chimia.2016.418. Review.

PMID:
27363370
42.

From Photodriven Charge Accumulation to Fueling Enzyme Cascades in Molecular Factories.

Okamoto Y, Ward TR, Wenger OS.

Chimia (Aarau). 2016;70(6):395-7. doi: 10.2533/chimia.2016.395. Review.

PMID:
27363366
43.

An NAD(P)H-Dependent Artificial Transfer Hydrogenase for Multienzymatic Cascades.

Okamoto Y, Köhler V, Ward TR.

J Am Chem Soc. 2016 May 11;138(18):5781-4. doi: 10.1021/jacs.6b02470. Epub 2016 Apr 28.

PMID:
27100673
44.

Library design and screening protocol for artificial metalloenzymes based on the biotin-streptavidin technology.

Mallin H, Hestericová M, Reuter R, Ward TR.

Nat Protoc. 2016 May;11(5):835-52. doi: 10.1038/nprot.2016.019. Epub 2016 Mar 31.

PMID:
27031496
45.

Genetic Optimization of Metalloenzymes: Enhancing Enzymes for Non-Natural Reactions.

Hyster TK, Ward TR.

Angew Chem Int Ed Engl. 2016 Jun 20;55(26):7344-57. doi: 10.1002/anie.201508816. Epub 2016 Mar 11. Review.

PMID:
26971363
46.

Anion-π Catalysis of Enolate Chemistry: Rigidified Leonard Turns as a General Motif to Run Reactions on Aromatic Surfaces.

Cotelle Y, Benz S, Avestro AJ, Ward TR, Sakai N, Matile S.

Angew Chem Int Ed Engl. 2016 Mar 18;55(13):4275-9. doi: 10.1002/anie.201600831. Epub 2016 Feb 24.

PMID:
26916316
47.

An enantioselective artificial Suzukiase based on the biotin-streptavidin technology.

Chatterjee A, Mallin H, Klehr J, Vallapurackal J, Finke AD, Vera L, Marsh M, Ward TR.

Chem Sci. 2016 Jan 1;7(1):673-677. doi: 10.1039/c5sc03116h. Epub 2015 Oct 19.

48.

Profluorescent substrates for the screening of olefin metathesis catalysts.

Reuter R, Ward TR.

Beilstein J Org Chem. 2015 Oct 12;11:1886-92. doi: 10.3762/bjoc.11.203. eCollection 2015.

49.

Improving the Catalytic Performance of an Artificial Metalloenzyme by Computational Design.

Heinisch T, Pellizzoni M, Dürrenberger M, Tinberg CE, Köhler V, Klehr J, Häussinger D, Baker D, Ward TR.

J Am Chem Soc. 2015 Aug 19;137(32):10414-9. doi: 10.1021/jacs.5b06622. Epub 2015 Aug 7.

PMID:
26226626
50.

Enzyme repurposing of a hydrolase as an emergent peroxidase upon metal binding.

Fujieda N, Schätti J, Stuttfeld E, Ohkubo K, Maier T, Fukuzumi S, Ward TR.

Chem Sci. 2015 Jul 1;6(7):4060-4065. doi: 10.1039/c5sc01065a. Epub 2015 May 7.

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