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Items: 1 to 50 of 450

1.

Short-course, oral flubendazole does not mediate significant efficacy against Onchocerca adult male worms or Brugia microfilariae in murine infection models.

Sjoberg HT, Pionnier N, Aljayyoussi G, Metuge HM, Njouendou AJ, Chunda VC, Fombad FF, Tayong DB, Gandjui NVT, Akumtoh DN, Chounna PWN, Ndzeshang BL, Lachaud S, Tekle F, Quirynen L, Engelen M, Baeten B, Steven A, Ward SA, Taylor MJ, Wanji S, Turner JD.

PLoS Negl Trop Dis. 2019 Jan 16;13(1):e0006356. doi: 10.1371/journal.pntd.0006356. eCollection 2019 Jan.

2.

Cohort Profile: The ASPREE Longitudinal Study of Older Persons (ALSOP).

McNeil JJ, Woods RL, Ward SA, Britt CJ, Lockery JE, Beilin LJ, Owen AJ.

Int J Epidemiol. 2019 Jan 8. doi: 10.1093/ije/dyy279. [Epub ahead of print] No abstract available.

PMID:
30624660
3.

AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.

Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.

Proc Natl Acad Sci U S A. 2019 Jan 7. pii: 201816585. doi: 10.1073/pnas.1816585116. [Epub ahead of print]

4.

Potent Antimalarial 2-Pyrazolyl Quinolone bc 1 (Qi) Inhibitors with Improved Drug-like Properties.

David Hong W, Leung SC, Amporndanai K, Davies J, Priestley RS, Nixon GL, Berry NG, Samar Hasnain S, Antonyuk S, Ward SA, Biagini GA, O'Neill PM.

ACS Med Chem Lett. 2018 Oct 19;9(12):1205-1210. doi: 10.1021/acsmedchemlett.8b00371. eCollection 2018 Dec 13.

PMID:
30613327
5.

Industrial scale high-throughput screening delivers multiple fast acting macrofilaricides.

Clare RH, Bardelle C, Harper P, Hong WD, Börjesson U, Johnston KL, Collier M, Myhill L, Cassidy A, Plant D, Plant H, Clark R, Cook DAN, Steven A, Archer J, McGillan P, Charoensutthivarakul S, Bibby J, Sharma R, Nixon GL, Slatko BE, Cantin L, Wu B, Turner J, Ford L, Rich K, Wigglesworth M, Berry NG, O'Neill PM, Taylor MJ, Ward SA.

Nat Commun. 2019 Jan 2;10(1):11. doi: 10.1038/s41467-018-07826-2.

6.

Human Direct Skin Feeding versus Membrane Feeding to Assess the Mosquitocidal Efficacy of High-Dose Ivermectin (IVERMAL Trial).

Smit MR, Ochomo EO, Aljayyoussi G, Kwambai TK, Abong'o BO, Bousema T, Waterhouse D, Bayoh NM, Gimnig JE, Samuels AM, Desai MR, Phillips-Howard PA, Kariuki SK, Wang D, Ward SA, Ter Kuile FO.

Clin Infect Dis. 2018 Dec 22. doi: 10.1093/cid/ciy1063. [Epub ahead of print]

PMID:
30590537
7.

The biological evaluation of fusidic acid and its hydrogenation derivative as antimicrobial and anti-inflammatory agents.

Wu PP, He H, Hong WD, Wu TR, Huang GY, Zhong YY, Tu BR, Gao M, Zhou J, Zhao SQ, Li DL, Xu XT, Sheng ZJ, Ward SA, O'Neill PM, Zhang K.

Infect Drug Resist. 2018 Oct 24;11:1945-1957. doi: 10.2147/IDR.S176390. eCollection 2018.

8.

Intra-individual effects of food upon the pharmacokinetics of rifampicin and isoniazid.

Requena-Méndez A, Davies G, Waterhouse D, Ardrey A, Jave O, López-Romero SL, Ward SA, Moore DAJ.

J Antimicrob Chemother. 2019 Feb 1;74(2):416-424. doi: 10.1093/jac/dky444.

PMID:
30412245
9.

The COSMIC Cancer Gene Census: describing genetic dysfunction across all human cancers.

Sondka Z, Bamford S, Cole CG, Ward SA, Dunham I, Forbes SA.

Nat Rev Cancer. 2018 Nov;18(11):696-705. doi: 10.1038/s41568-018-0060-1. Review.

PMID:
30293088
10.

Reply to Garcia-Tabar et al.: Quality control of open-circuit respirometry: real-time, laboratory-based systems. Let us spread "good practice".

Ward SA.

Eur J Appl Physiol. 2018 Dec;118(12):2721-2722. doi: 10.1007/s00421-018-3991-z. Epub 2018 Sep 20.

PMID:
30238249
11.

Intra-host dynamics of co-infecting parasite genotypes in asymptomatic malaria patients.

Nkhoma SC, Banda RL, Khoswe S, Dzoole-Mwale TJ, Ward SA.

Infect Genet Evol. 2018 Nov;65:414-424. doi: 10.1016/j.meegid.2018.08.018. Epub 2018 Aug 23.

12.

Pharmacokinetics-Pharmacodynamics of High-Dose Ivermectin with Dihydroartemisinin-Piperaquine on Mosquitocidal Activity and QT-Prolongation (IVERMAL).

Smit MR, Ochomo EO, Waterhouse D, Kwambai TK, Abong'o BO, Bousema T, Bayoh NM, Gimnig JE, Samuels AM, Desai MR, Phillips-Howard PA, Kariuki SK, Wang D, Ter Kuile FO, Ward SA, Aljayyoussi G.

Clin Pharmacol Ther. 2018 Aug 20. doi: 10.1002/cpt.1219. [Epub ahead of print]

PMID:
30125353
13.

The safety and sensitivity of a telemetric capsule to monitor gastrointestinal hydrogen production in vivo in healthy subjects: a pilot trial comparison to concurrent breath analysis.

Berean KJ, Ha N, Ou JZ, Chrimes AF, Grando D, Yao CK, Muir JG, Ward SA, Burgell RE, Gibson PR, Kalantar-Zadeh K.

Aliment Pharmacol Ther. 2018 Sep;48(6):646-654. doi: 10.1111/apt.14923. Epub 2018 Aug 1.

PMID:
30067289
14.

Diagnosis of dementia in Australia: a narrative review of services and models of care.

Ng NSQ, Ward SA.

Aust Health Rev. 2018 Jul 27. doi: 10.1071/AH17167. [Epub ahead of print]

PMID:
30049298
15.

Exploring pancreatic pathology in Plasmodium falciparum malaria patients.

Glaharn S, Punsawad C, Ward SA, Viriyavejakul P.

Sci Rep. 2018 Jul 11;8(1):10456. doi: 10.1038/s41598-018-28797-w.

16.

Reservoirs of faecal indicator bacteria in well-head hand pumps in Bangladesh.

Osborne TH, Ward SA, Ahmed KM, Santini JM.

J Water Health. 2018 Jun;16(3):487-490. doi: 10.2166/wh.2018.042.

PMID:
29952337
17.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

O' Neill PM, Stocks PA, Sabbani S, Roberts NL, Amewu RK, Shore ER, Aljayyoussi G, Angulo-Barturén I, Belén M, Jiménez-Díaz, Bazaga SF, Martínez MS, Campo B, Sharma R, Charman SA, Ryan E, Chen G, Shackleford DM, Davies J, Nixon GL, Biagini GA, Ward SA.

Bioorg Med Chem. 2018 Jul 15;26(11):2996-3005. doi: 10.1016/j.bmc.2018.05.006. Epub 2018 May 17.

PMID:
29779669
18.

Open-circuit respirometry: real-time, laboratory-based systems.

Ward SA.

Eur J Appl Physiol. 2018 May 4. doi: 10.1007/s00421-018-3860-9. [Epub ahead of print] Review.

PMID:
29728765
19.

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

Smit MR, Ochomo EO, Aljayyoussi G, Kwambai TK, Abong'o BO, Chen T, Bousema T, Slater HC, Waterhouse D, Bayoh NM, Gimnig JE, Samuels AM, Desai MR, Phillips-Howard PA, Kariuki SK, Wang D, Ward SA, Ter Kuile FO.

Lancet Infect Dis. 2018 Jun;18(6):615-626. doi: 10.1016/S1473-3099(18)30163-4. Epub 2018 Mar 27.

20.

Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing.

Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF; ASPREE Investigator Group.

J Gerontol B Psychol Sci Soc Sci. 2018 Feb 17. doi: 10.1093/geronb/gby004. [Epub ahead of print]

PMID:
29471348
21.

Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: a Pooled Analysis To Inform Optimal Dosing in African Children with Uncomplicated Malaria.

de Kock M, Tarning J, Workman L, Allen EN, Tekete MM, Djimde AA, Bell DJ, Ward SA, Barnes KI, Denti P.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01370-17. doi: 10.1128/AAC.01370-17. Print 2018 May.

22.

Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation.

Levett DZH, Jack S, Swart M, Carlisle J, Wilson J, Snowden C, Riley M, Danjoux G, Ward SA, Older P, Grocott MPW; Perioperative Exercise Testing and Training Society (POETTS).

Br J Anaesth. 2018 Mar;120(3):484-500. doi: 10.1016/j.bja.2017.10.020. Epub 2017 Nov 24.

PMID:
29452805
23.

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.

Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA.

Sci Rep. 2018 Jan 18;8(1):1384. doi: 10.1038/s41598-018-19723-1.

24.

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.

Sharma R, Aljayyoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DAN, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ.

Sci Rep. 2018 Jan 8;8:46934. doi: 10.1038/srep46934.

25.

The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.

Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O'Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L, Workman B, McNeil JJ; ASPREE Study Group.

Contemp Clin Trials. 2018 Jan;64:101-111. doi: 10.1016/j.cct.2017.10.016. Epub 2017 Oct 31.

PMID:
29097299
26.

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.

Turner JD, Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Priestley RS, Murphy EA, Davies J, Waterhouse D, Cook DAN, Clare RH, Cassidy A, Steven A, Johnston KL, McCall J, Ford L, Hemingway J, Ward SA, Taylor MJ.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9712-E9721. doi: 10.1073/pnas.1710845114. Epub 2017 Oct 23.

27.

Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library.

Johnston KL, Cook DAN, Berry NG, David Hong W, Clare RH, Goddard M, Ford L, Nixon GL, O'Neill PM, Ward SA, Taylor MJ.

Sci Adv. 2017 Sep 27;3(9):eaao1551. doi: 10.1126/sciadv.aao1551. eCollection 2017 Sep.

28.

Exercise Testing, Supplemental Oxygen, and Hypoxia.

Ward SA, Grocott MPW, Levett DZH.

Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S140-S148. doi: 10.1513/AnnalsATS.201701-043OT. Review.

PMID:
28590162
29.

A Novel Triethylphosphonium Charge Tag on Peptides: Synthesis, Derivatization, and Fragmentation.

DeGraan-Weber N, Ward SA, Reilly JP.

J Am Soc Mass Spectrom. 2017 Sep;28(9):1889-1900. doi: 10.1007/s13361-017-1694-z. Epub 2017 May 30.

30.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA.

Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159.

31.

Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.

Sloan DJ, McCallum AD, Schipani A, Egan D, Mwandumba HC, Ward SA, Waterhouse D, Banda G, Allain TJ, Owen A, Khoo SH, Davies GR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00210-17. doi: 10.1128/AAC.00210-17. Print 2017 Jul.

32.

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.

Aljayyoussi G, Jenkins VA, Sharma R, Ardrey A, Donnellan S, Ward SA, Biagini GA.

Sci Rep. 2017 Mar 29;7(1):502. doi: 10.1038/s41598-017-00529-6.

33.

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

Hong WD, Gibbons PD, Leung SC, Amewu R, Stocks PA, Stachulski A, Horta P, Cristiano MLS, Shone AE, Moss D, Ardrey A, Sharma R, Warman AJ, Bedingfield PTP, Fisher NE, Aljayyoussi G, Mead S, Caws M, Berry NG, Ward SA, Biagini GA, O'Neill PM, Nixon GL.

J Med Chem. 2017 May 11;60(9):3703-3726. doi: 10.1021/acs.jmedchem.6b01718. Epub 2017 Apr 25.

34.

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.

Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA.

Sci Rep. 2017 Mar 16;7(1):210. doi: 10.1038/s41598-017-00322-5. Erratum in: Sci Rep. 2018 Jan 18;8(1):1384.

35.

Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy.

Török ME, Aljayyoussi G, Waterhouse D, Chau T, Mai N, Phu NH, Hien TT, Hope W, Farrar JJ, Ward SA.

Clin Pharmacol Ther. 2018 Mar;103(3):449-457. doi: 10.1002/cpt.646. Epub 2017 Dec 6.

PMID:
28160272
36.

Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.

Mungthin M, Watanatanasup E, Sitthichot N, Suwandittakul N, Khositnithikul R, Ward SA.

Am J Trop Med Hyg. 2017 Mar;96(3):624-629. doi: 10.4269/ajtmh.16-0668. Epub 2017 Apr 6.

37.

Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.

Ward SA, Warrington NM, Taylor S, Kfoury N, Luo J, Rubin JB.

Cancer Res. 2017 Mar 15;77(6):1416-1426. doi: 10.1158/0008-5472.CAN-16-0847. Epub 2016 Dec 28.

38.

Studies of Azetidin-2-one as a Reactive Enolate Synthon of β-Alanine for Condensations with Aldehydes and Ketones.

Williams DR, Donnell AF, Kammler DC, Ward SA, Taylor L 4th.

J Org Chem. 2016 Nov 4;81(21):10463-10475. Epub 2016 Sep 23.

PMID:
27627106
39.

ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly.

Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship); on behalf of the ASPREE investigator group.

Int J Stroke. 2017 Jan;12(1):108-113. doi: 10.1177/1747493016669848. Epub 2016 Sep 24.

PMID:
27634976
40.

Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model.

Ou JZ, Cottrell JJ, Ha N, Pillai N, Yao CK, Berean KJ, Ward SA, Grando D, Muir JG, Harrison CJ, Wijesiriwardana U, Dunshea FR, Gibson PR, Kalantar-Zadeh K.

Sci Rep. 2016 Sep 16;6:33387. doi: 10.1038/srep33387.

41.

Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10548. doi: 10.1002/anie.201607032. No abstract available.

PMID:
27552550
42.

A simple breath test for tuberculosis using ion mobility: A pilot study.

Sahota AS, Gowda R, Arasaradnam RP, Daulton E, Savage RS, Skinner JR, Adams E, Ward SA, Covington JA.

Tuberculosis (Edinb). 2016 Jul;99:143-6. doi: 10.1016/j.tube.2016.05.005. Epub 2016 May 29.

43.

PFMDR1 POLYMORPHISMS INFLUENCE ON IN VITRO SENSITIVITY OF THAI PLASMODIUM FALCIPARUM ISOLATES TO PRIMAQUINE, SITAMAQUINE AND TAFENOQUINE.

Kaewpruk N, Tan-ariya P, Ward SA, Sitthichot N, Suwandittakul N, Mungthin M.

Southeast Asian J Trop Med Public Health. 2016 May;47(3):366-76.

PMID:
27405118
44.

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM.

Angew Chem Weinheim Bergstr Ger. 2016 May 23;128(22):6511-6515. Epub 2016 Apr 18.

45.

OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.

Aljayyoussi G, Kay K, Ward SA, Biagini GA.

Malar J. 2016 Jul 7;15(1):344. doi: 10.1186/s12936-016-1401-8.

46.

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM.

Angew Chem Int Ed Engl. 2016 May 23;55(22):6401-5. doi: 10.1002/anie.201512062. Epub 2016 Apr 18. Erratum in: Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10548.

47.

Relationship between eating behaviors and physical activity of preschoolers and their peers: a systematic review.

Ward SA, Bélanger MF, Donovan D, Carrier N.

Int J Behav Nutr Phys Act. 2016 Apr 14;13:50. doi: 10.1186/s12966-016-0374-x. Review.

48.

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.

Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DA, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ.

Sci Rep. 2016 Mar 21;6:23458. doi: 10.1038/srep23458. Erratum in: Sci Rep. 2018 Jan 08;8:46934.

49.

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2080-5. doi: 10.1073/pnas.1600459113. Epub 2016 Feb 8.

50.

A simultaneous population pharmacokinetic analysis of rifampicin in Malawian adults and children.

Schipani A, Pertinez H, Mlota R, Molyneux E, Lopez N, Dzinjalamala FK, van Oosterhout JJ, Ward SA, Khoo S, Davies G.

Br J Clin Pharmacol. 2016 Apr;81(4):679-87. doi: 10.1111/bcp.12848. Epub 2016 Jan 30.

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