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Items: 1 to 50 of 438

1.

The safety and sensitivity of a telemetric capsule to monitor gastrointestinal hydrogen production in vivo in healthy subjects: a pilot trial comparison to concurrent breath analysis.

Berean KJ, Ha N, Ou JZ, Chrimes AF, Grando D, Yao CK, Muir JG, Ward SA, Burgell RE, Gibson PR, Kalantar-Zadeh K.

Aliment Pharmacol Ther. 2018 Aug 1. doi: 10.1111/apt.14923. [Epub ahead of print]

PMID:
30067289
2.

Diagnosis of dementia in Australia: a narrative review of services and models of care.

Ng NSQ, Ward SA.

Aust Health Rev. 2018 Jul 27. doi: 10.1071/AH17167. [Epub ahead of print]

PMID:
30049298
3.

Exploring pancreatic pathology in Plasmodium falciparum malaria patients.

Glaharn S, Punsawad C, Ward SA, Viriyavejakul P.

Sci Rep. 2018 Jul 11;8(1):10456. doi: 10.1038/s41598-018-28797-w.

4.

Reservoirs of faecal indicator bacteria in well-head hand pumps in Bangladesh.

Osborne TH, Ward SA, Ahmed KM, Santini JM.

J Water Health. 2018 Jun;16(3):487-490. doi: 10.2166/wh.2018.042.

PMID:
29952337
5.

Synthesis and profiling of benzylmorpholine 1,2,4,5-tetraoxane analogue N205: Towards tetraoxane scaffolds with potential for single dose cure of malaria.

O' Neill PM, Stocks PA, Sabbani S, Roberts NL, Amewu RK, Shore ER, Aljayyoussi G, Angulo-Barturén I, Belén M, Jiménez-Díaz, Bazaga SF, Martínez MS, Campo B, Sharma R, Charman SA, Ryan E, Chen G, Shackleford DM, Davies J, Nixon GL, Biagini GA, Ward SA.

Bioorg Med Chem. 2018 Jul 15;26(11):2996-3005. doi: 10.1016/j.bmc.2018.05.006. Epub 2018 May 17.

PMID:
29779669
6.

Open-circuit respirometry: real-time, laboratory-based systems.

Ward SA.

Eur J Appl Physiol. 2018 May 4. doi: 10.1007/s00421-018-3860-9. [Epub ahead of print] Review.

PMID:
29728765
7.

Safety and mosquitocidal efficacy of high-dose ivermectin when co-administered with dihydroartemisinin-piperaquine in Kenyan adults with uncomplicated malaria (IVERMAL): a randomised, double-blind, placebo-controlled trial.

Smit MR, Ochomo EO, Aljayyoussi G, Kwambai TK, Abong'o BO, Chen T, Bousema T, Slater HC, Waterhouse D, Bayoh NM, Gimnig JE, Samuels AM, Desai MR, Phillips-Howard PA, Kariuki SK, Wang D, Ward SA, Ter Kuile FO.

Lancet Infect Dis. 2018 Jun;18(6):615-626. doi: 10.1016/S1473-3099(18)30163-4. Epub 2018 Mar 27.

PMID:
29602751
8.

Sexual Dimorphism of Resting-State Network Connectivity in Healthy Ageing.

Jamadar SD, Sforazzini F, Raniga P, Ferris NJ, Paton B, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Ward SA, Woods RL, Storey E, McNeil JJ, Egan GF; ASPREE Investigator Group.

J Gerontol B Psychol Sci Soc Sci. 2018 Feb 17. doi: 10.1093/geronb/gby004. [Epub ahead of print]

PMID:
29471348
9.

Population Pharmacokinetic Properties of Sulfadoxine and Pyrimethamine: a Pooled Analysis To Inform Optimal Dosing in African Children with Uncomplicated Malaria.

de Kock M, Tarning J, Workman L, Allen EN, Tekete MM, Djimde AA, Bell DJ, Ward SA, Barnes KI, Denti P.

Antimicrob Agents Chemother. 2018 Apr 26;62(5). pii: e01370-17. doi: 10.1128/AAC.01370-17. Print 2018 May.

10.

Perioperative cardiopulmonary exercise testing (CPET): consensus clinical guidelines on indications, organization, conduct, and physiological interpretation.

Levett DZH, Jack S, Swart M, Carlisle J, Wilson J, Snowden C, Riley M, Danjoux G, Ward SA, Older P, Grocott MPW; Perioperative Exercise Testing and Training Society (POETTS).

Br J Anaesth. 2018 Mar;120(3):484-500. doi: 10.1016/j.bja.2017.10.020. Epub 2017 Nov 24.

PMID:
29452805
11.

Author Correction: Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.

Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA.

Sci Rep. 2018 Jan 18;8(1):1384. doi: 10.1038/s41598-018-19723-1.

12.

Corrigendum: Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.

Sharma R, Aljayyoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DAN, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ.

Sci Rep. 2018 Jan 8;8:46934. doi: 10.1038/srep46934.

13.

The Study of Neurocognitive Outcomes, Radiological and Retinal Effects of Aspirin in Sleep Apnoea- rationale and methodology of the SNORE-ASA study.

Ward SA, Storey E, Woods RL, Hamilton GS, Kawasaki R, Janke AL, Naughton MT, O'Donoghue F, Wolfe R, Wong TY, Reid CM, Abhayaratna WP, Stocks N, Trevaks R, Fitzgerald S, Hodgson LAB, Robman L, Workman B, McNeil JJ; ASPREE Study Group.

Contemp Clin Trials. 2018 Jan;64:101-111. doi: 10.1016/j.cct.2017.10.016. Epub 2017 Oct 31.

PMID:
29097299
14.

Albendazole and antibiotics synergize to deliver short-course anti-Wolbachia curative treatments in preclinical models of filariasis.

Turner JD, Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Priestley RS, Murphy EA, Davies J, Waterhouse D, Cook DAN, Clare RH, Cassidy A, Steven A, Johnston KL, McCall J, Ford L, Hemingway J, Ward SA, Taylor MJ.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9712-E9721. doi: 10.1073/pnas.1710845114. Epub 2017 Oct 23.

15.

Identification and prioritization of novel anti-Wolbachia chemotypes from screening a 10,000-compound diversity library.

Johnston KL, Cook DAN, Berry NG, David Hong W, Clare RH, Goddard M, Ford L, Nixon GL, O'Neill PM, Ward SA, Taylor MJ.

Sci Adv. 2017 Sep 27;3(9):eaao1551. doi: 10.1126/sciadv.aao1551. eCollection 2017 Sep.

16.

Exercise Testing, Supplemental Oxygen, and Hypoxia.

Ward SA, Grocott MPW, Levett DZH.

Ann Am Thorac Soc. 2017 Jul;14(Supplement_1):S140-S148. doi: 10.1513/AnnalsATS.201701-043OT. Review.

PMID:
28590162
17.

A Novel Triethylphosphonium Charge Tag on Peptides: Synthesis, Derivatization, and Fragmentation.

DeGraan-Weber N, Ward SA, Reilly JP.

J Am Soc Mass Spectrom. 2017 Sep;28(9):1889-1900. doi: 10.1007/s13361-017-1694-z. Epub 2017 May 30.

PMID:
28560565
18.

A tetraoxane-based antimalarial drug candidate that overcomes PfK13-C580Y dependent artemisinin resistance.

O'Neill PM, Amewu RK, Charman SA, Sabbani S, Gnädig NF, Straimer J, Fidock DA, Shore ER, Roberts NL, Wong MH, Hong WD, Pidathala C, Riley C, Murphy B, Aljayyoussi G, Gamo FJ, Sanz L, Rodrigues J, Cortes CG, Herreros E, Angulo-Barturén I, Jiménez-Díaz MB, Bazaga SF, Martínez-Martínez MS, Campo B, Sharma R, Ryan E, Shackleford DM, Campbell S, Smith DA, Wirjanata G, Noviyanti R, Price RN, Marfurt J, Palmer MJ, Copple IM, Mercer AE, Ruecker A, Delves MJ, Sinden RE, Siegl P, Davies J, Rochford R, Kocken CHM, Zeeman AM, Nixon GL, Biagini GA, Ward SA.

Nat Commun. 2017 May 24;8:15159. doi: 10.1038/ncomms15159.

19.

Genetic Determinants of the Pharmacokinetic Variability of Rifampin in Malawian Adults with Pulmonary Tuberculosis.

Sloan DJ, McCallum AD, Schipani A, Egan D, Mwandumba HC, Ward SA, Waterhouse D, Banda G, Allain TJ, Owen A, Khoo SH, Davies GR.

Antimicrob Agents Chemother. 2017 Jun 27;61(7). pii: e00210-17. doi: 10.1128/AAC.00210-17. Print 2017 Jul.

20.

Pharmacokinetic-Pharmacodynamic modelling of intracellular Mycobacterium tuberculosis growth and kill rates is predictive of clinical treatment duration.

Aljayyoussi G, Jenkins VA, Sharma R, Ardrey A, Donnellan S, Ward SA, Biagini GA.

Sci Rep. 2017 Mar 29;7(1):502. doi: 10.1038/s41598-017-00529-6.

21.

Rational Design, Synthesis, and Biological Evaluation of Heterocyclic Quinolones Targeting the Respiratory Chain of Mycobacterium tuberculosis.

Hong WD, Gibbons PD, Leung SC, Amewu R, Stocks PA, Stachulski A, Horta P, Cristiano MLS, Shone AE, Moss D, Ardrey A, Sharma R, Warman AJ, Bedingfield PTP, Fisher NE, Aljayyoussi G, Mead S, Caws M, Berry NG, Ward SA, Biagini GA, O'Neill PM, Nixon GL.

J Med Chem. 2017 May 11;60(9):3703-3726. doi: 10.1021/acs.jmedchem.6b01718. Epub 2017 Apr 25.

22.

Short-Course, High-Dose Rifampicin Achieves Wolbachia Depletion Predictive of Curative Outcomes in Preclinical Models of Lymphatic Filariasis and Onchocerciasis.

Aljayyoussi G, Tyrer HE, Ford L, Sjoberg H, Pionnier N, Waterhouse D, Davies J, Gamble J, Metuge H, Cook DAN, Steven A, Sharma R, Guimaraes AF, Clare RH, Cassidy A, Johnston KL, Myhill L, Hayward L, Wanji S, Turner JD, Taylor MJ, Ward SA.

Sci Rep. 2017 Mar 16;7(1):210. doi: 10.1038/s41598-017-00322-5. Erratum in: Sci Rep. 2018 Jan 18;8(1):1384.

23.

Suboptimal Exposure to Anti-TB Drugs in a TBM/HIV+ Population Is Not Related to Antiretroviral Therapy.

Török ME, Aljayyoussi G, Waterhouse D, Chau T, Mai N, Phu NH, Hien TT, Hope W, Farrar JJ, Ward SA.

Clin Pharmacol Ther. 2018 Mar;103(3):449-457. doi: 10.1002/cpt.646. Epub 2017 Dec 6.

PMID:
28160272
24.

Influence of the pfmdr1 Gene on In Vitro Sensitivities of Piperaquine in Thai Isolates of Plasmodium falciparum.

Mungthin M, Watanatanasup E, Sitthichot N, Suwandittakul N, Khositnithikul R, Ward SA.

Am J Trop Med Hyg. 2017 Mar;96(3):624-629. doi: 10.4269/ajtmh.16-0668. Epub 2017 Apr 6.

25.

Reprogramming Medulloblastoma-Propagating Cells by a Combined Antagonism of Sonic Hedgehog and CXCR4.

Ward SA, Warrington NM, Taylor S, Kfoury N, Luo J, Rubin JB.

Cancer Res. 2017 Mar 15;77(6):1416-1426. doi: 10.1158/0008-5472.CAN-16-0847. Epub 2016 Dec 28.

26.

Studies of Azetidin-2-one as a Reactive Enolate Synthon of β-Alanine for Condensations with Aldehydes and Ketones.

Williams DR, Donnell AF, Kammler DC, Ward SA, Taylor L 4th.

J Org Chem. 2016 Nov 4;81(21):10463-10475. Epub 2016 Sep 23.

PMID:
27627106
27.

ASPREE-NEURO study protocol: A randomized controlled trial to determine the effect of low-dose aspirin on cerebral microbleeds, white matter hyperintensities, cognition, and stroke in the healthy elderly.

Ward SA, Raniga P, Ferris NJ, Woods RL, Storey E, Bailey MJ, Brodtmann A, Yates PA, Donnan GA, Trevaks RE, Wolfe R, Egan GF, McNeil JJ; (Joint Senior authorship); on behalf of the ASPREE investigator group.

Int J Stroke. 2017 Jan;12(1):108-113. doi: 10.1177/1747493016669848. Epub 2016 Sep 24.

PMID:
27634976
28.

Potential of in vivo real-time gastric gas profiling: a pilot evaluation of heat-stress and modulating dietary cinnamon effect in an animal model.

Ou JZ, Cottrell JJ, Ha N, Pillai N, Yao CK, Berean KJ, Ward SA, Grando D, Muir JG, Harrison CJ, Wijesiriwardana U, Dunshea FR, Gibson PR, Kalantar-Zadeh K.

Sci Rep. 2016 Sep 16;6:33387. doi: 10.1038/srep33387.

29.

Corrigendum: A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM.

Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10548. doi: 10.1002/anie.201607032. No abstract available.

PMID:
27552550
30.

A simple breath test for tuberculosis using ion mobility: A pilot study.

Sahota AS, Gowda R, Arasaradnam RP, Daulton E, Savage RS, Skinner JR, Adams E, Ward SA, Covington JA.

Tuberculosis (Edinb). 2016 Jul;99:143-6. doi: 10.1016/j.tube.2016.05.005. Epub 2016 May 29.

31.

PFMDR1 POLYMORPHISMS INFLUENCE ON IN VITRO SENSITIVITY OF THAI PLASMODIUM FALCIPARUM ISOLATES TO PRIMAQUINE, SITAMAQUINE AND TAFENOQUINE.

Kaewpruk N, Tan-ariya P, Ward SA, Sitthichot N, Suwandittakul N, Mungthin M.

Southeast Asian J Trop Med Public Health. 2016 May;47(3):366-76.

PMID:
27405118
32.

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM.

Angew Chem Weinheim Bergstr Ger. 2016 May 23;128(22):6511-6515. Epub 2016 Apr 18.

33.

OptiMal-PK: an internet-based, user-friendly interface for the mathematical-based design of optimized anti-malarial treatment regimens.

Aljayyoussi G, Kay K, Ward SA, Biagini GA.

Malar J. 2016 Jul 7;15(1):344. doi: 10.1186/s12936-016-1401-8.

34.

A Click Chemistry-Based Proteomic Approach Reveals that 1,2,4-Trioxolane and Artemisinin Antimalarials Share a Common Protein Alkylation Profile.

Ismail HM, Barton VE, Panchana M, Charoensutthivarakul S, Biagini GA, Ward SA, O'Neill PM.

Angew Chem Int Ed Engl. 2016 May 23;55(22):6401-5. doi: 10.1002/anie.201512062. Epub 2016 Apr 18. Erratum in: Angew Chem Int Ed Engl. 2016 Aug 26;55(36):10548.

35.

Relationship between eating behaviors and physical activity of preschoolers and their peers: a systematic review.

Ward SA, Bélanger MF, Donovan D, Carrier N.

Int J Behav Nutr Phys Act. 2016 Apr 14;13:50. doi: 10.1186/s12966-016-0374-x. Review.

36.

Minocycline as a re-purposed anti-Wolbachia macrofilaricide: superiority compared with doxycycline regimens in a murine infection model of human lymphatic filariasis.

Sharma R, Al Jayoussi G, Tyrer HE, Gamble J, Hayward L, Guimaraes AF, Davies J, Waterhouse D, Cook DA, Myhill LJ, Clare RH, Cassidy A, Steven A, Johnston KL, Ford L, Turner JD, Ward SA, Taylor MJ.

Sci Rep. 2016 Mar 21;6:23458. doi: 10.1038/srep23458. Erratum in: Sci Rep. 2018 Jan 08;8:46934.

37.

Artemisinin activity-based probes identify multiple molecular targets within the asexual stage of the malaria parasites Plasmodium falciparum 3D7.

Ismail HM, Barton V, Phanchana M, Charoensutthivarakul S, Wong MH, Hemingway J, Biagini GA, O'Neill PM, Ward SA.

Proc Natl Acad Sci U S A. 2016 Feb 23;113(8):2080-5. doi: 10.1073/pnas.1600459113. Epub 2016 Feb 8.

38.

A simultaneous population pharmacokinetic analysis of rifampicin in Malawian adults and children.

Schipani A, Pertinez H, Mlota R, Molyneux E, Lopez N, Dzinjalamala FK, van Oosterhout JJ, Ward SA, Khoo S, Davies G.

Br J Clin Pharmacol. 2016 Apr;81(4):679-87. doi: 10.1111/bcp.12848. Epub 2016 Jan 30.

39.

Lymphocyte Perturbations in Malawian Children with Severe and Uncomplicated Malaria.

Mandala WL, Msefula CL, Gondwe EN, Gilchrist JJ, Graham SM, Pensulo P, Mwimaniwa G, Banda M, Taylor TE, Molyneux EE, Drayson MT, Ward SA, Molyneux ME, MacLennan CA.

Clin Vaccine Immunol. 2015 Nov 18;23(2):95-103. doi: 10.1128/CVI.00564-15.

40.

Reflections on the Nobel Prize for Medicine 2015--The Public Health Legacy and Impact of Avermectin and Artemisinin.

Molyneux DH, Ward SA.

Trends Parasitol. 2015 Dec;31(12):605-607. doi: 10.1016/j.pt.2015.10.008. Epub 2015 Nov 6.

PMID:
26552892
41.

Intestinal Gas Capsules: A Proof-of-Concept Demonstration.

Kalantar-Zadeh K, Yao CK, Berean KJ, Ha N, Ou JZ, Ward SA, Pillai N, Hill J, Cottrell JJ, Dunshea FR, McSweeney C, Muir JG, Gibson PR.

Gastroenterology. 2016 Jan;150(1):37-9. doi: 10.1053/j.gastro.2015.07.072. Epub 2015 Oct 28. No abstract available.

PMID:
26518389
42.

A Quinoline Carboxamide Antimalarial Drug Candidate Uniquely Targets Plasmodia at Three Stages of the Parasite Life Cycle.

O'Neill PM, Ward SA.

Angew Chem Int Ed Engl. 2015 Nov 9;54(46):13504-6. doi: 10.1002/anie.201507264. Epub 2015 Oct 1. No abstract available.

PMID:
26426264
43.

Baseline data of parasite clearance in patients with falciparum malaria treated with an artemisinin derivative: an individual patient data meta-analysis.

WWARN Parasite Clearance Study Group, Abdulla S, Ashley EA, Bassat Q, Bethell D, Björkman A, Borrmann S, D'Alessandro U, Dahal P, Day NP, Diakite M, Djimde AA, Dondorp AM, Duong S, Edstein MD, Fairhurst RM, Faiz MA, Falade C, Flegg JA, Fogg C, Gonzalez R, Greenwood B, Guérin PJ, Guthmann JP, Hamed K, Hien TT, Htut Y, Juma E, Lim P, Mårtensson A, Mayxay M, Mokuolu OA, Moreira C, Newton P, Noedl H, Nosten F, Ogutu BR, Onyamboko MA, Owusu-Agyei S, Phyo AP, Premji Z, Price RN, Pukrittayakamee S, Ramharter M, Sagara I, Se Y, Suon S, Stepniewska K, Ward SA, White NJ, Winstanley PA.

Malar J. 2015 Sep 22;14:359. doi: 10.1186/s12936-015-0874-1.

44.

Not so Fast: Co-Requirements for Sonic Hedgehog Induced Brain Tumorigenesis.

Ward SA, Rubin JB.

Cancers (Basel). 2015 Aug 6;7(3):1484-98. doi: 10.3390/cancers7030848. Review.

45.

Carbamoyl Triazoles, Known Serine Protease Inhibitors, Are a Potent New Class of Antimalarials.

McConville M, Fernández J, Angulo-Barturen Í, Bahamontes-Rosa N, Ballell-Pages L, Castañeda P, de Cózar C, Crespo B, Guijarro L, Jiménez-Díaz MB, Martínez-Martínez MS, de Mercado J, Santos-Villarejo Á, Sanz LM, Frigerio M, Washbourn G, Ward SA, Nixon GL, Biagini GA, Berry NG, Blackman MJ, Calderón F, O'Neill PM.

J Med Chem. 2015 Aug 27;58(16):6448-55. doi: 10.1021/acs.jmedchem.5b00434. Epub 2015 Aug 17.

PMID:
26222445
46.

Commentaries on Viewpoint: Precedence and autocracy in breathing control.

Torday JS, Zuo L, Chuang CC, Huszczuk A, Poon CS, Del Rio R, Andrade DC, Schultz HD, Nicolò A, Sacchetti M, Marcora SM, Ward SA.

J Appl Physiol (1985). 2015 Jun 15;118(12):1557-9. doi: 10.1152/japplphysiol.00229.2015. No abstract available.

47.

A randomised controlled trial of low-dose aspirin for the prevention of fractures in healthy older people: protocol for the ASPREE-Fracture substudy.

Barker AL, McNeil JJ, Seeman E, Ward SA, Sanders KM, Khosla S, Cumming RG, Pasco JA, Bohensky MA, Ebeling PR, Woods RL, Lockery JE, Wolfe R, Talevski J; ASPREE Investigator Group.

Inj Prev. 2016 Aug;22(4):297-301. doi: 10.1136/injuryprev-2015-041655. Epub 2015 May 21.

48.

Commentaries on Viewpoint: The two-hour marathon: what's the equivalent for women?

Bishop D, Christiansen D, Bartlett J, Gardner D, Craigon J, Goodall S, Thomas K, Temesi J, Millet GY, Cattagni T, Lepers R, Deaner RO, Guenette JA, Pageaux B, Lepers R, Lepers R, Stapley PJ, Cattagni T, Sparling PB, Santos-Lozano A, Garatachea N, Sanchis-Gomar F, Pareja-Galeano H, Fiuza-Luces C, Lucia A, Ward SA.

J Appl Physiol (1985). 2015 May 15;118(10):1324-8. doi: 10.1152/japplphysiol.00158.2015. No abstract available.

49.

Antimalarial 4(1H)-pyridones bind to the Qi site of cytochrome bc1.

Capper MJ, O'Neill PM, Fisher N, Strange RW, Moss D, Ward SA, Berry NG, Lawrenson AS, Hasnain SS, Biagini GA, Antonyuk SV.

Proc Natl Acad Sci U S A. 2015 Jan 20;112(3):755-60. doi: 10.1073/pnas.1416611112. Epub 2015 Jan 6.

50.

Development and validation of a high-throughput anti-Wolbachia whole-cell screen: a route to macrofilaricidal drugs against onchocerciasis and lymphatic filariasis.

Clare RH, Cook DA, Johnston KL, Ford L, Ward SA, Taylor MJ.

J Biomol Screen. 2015 Jan;20(1):64-9. doi: 10.1177/1087057114551518. Epub 2014 Oct 2.

PMID:
25278497

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