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Items: 40

1.

The discovery of 2-fluoro-N-(3-fluoro-4-(5-((4-morpholinobutyl)amino)-1,3,4-oxadiazol-2-yl)phenyl)benzamide, a full agonist of the alpha-7 nicotinic acetylcholine receptor showing efficacy in the novel object recognition model of cognition enhancement.

Skidmore J, Atcha Z, Boucherat E, Castelletti L, Chen DW, Coppo FT, Cutler L, Dunsdon RM, Heath BM, Hutchings R, Hurst DN, Javed S, Martin S, Maskell ES, Norton D, Pemberton DJ, Redshaw S, Rutter R, Sehmi SS, Scoccitti T, Temple HE, Theobald P, Ward RW, Wilson DM.

Bioorg Med Chem Lett. 2012 May 15;22(10):3531-4. doi: 10.1016/j.bmcl.2012.03.062. Epub 2012 Mar 21.

PMID:
22503453
2.

Identification of a series of 1,3,4-oxadiazol-2-amines as potent alpha-7 agonists with efficacy in the novel object recognition model of cognition.

Skidmore J, Atcha Z, Boucherat E, Castelletti L, Chen DW, Coppo FT, Cutler L, Dunsdon RM, Heath BM, Hutchings R, Hurst DN, Javed S, Martin S, Maskell ES, Norton D, Pemberton DJ, Redshaw S, Rutter R, Sehmi SS, Scoccitti T, Temple HE, Theobald P, Ward RW, Wilson DM.

Bioorg Med Chem Lett. 2012 May 15;22(10):3560-3. doi: 10.1016/j.bmcl.2012.03.040. Epub 2012 Mar 16.

PMID:
22503248
3.

Aryl sulphonyl amides as potent agonists of the growth hormone secretagogue (ghrelin) receptor.

Witherington J, Abberley L, Bellenie BR, Boatman R, Collis K, Dean DK, Gaiba A, King NP, Shuker N, Steadman JG, Takle AK, Sanger G, Butler S, McKay F, Muir A, Winborn K, Ward RW, Heightman TD.

Bioorg Med Chem Lett. 2009 Feb 1;19(3):684-7. doi: 10.1016/j.bmcl.2008.12.042. Epub 2008 Dec 14.

PMID:
19128969
4.

QTL analysis of resistance to Fusarium head blight in the novel wheat germplasm CJ 9306. I. Resistance to fungal spread.

Jiang GL, Shi J, Ward RW.

Theor Appl Genet. 2007 Dec;116(1):3-13. Epub 2007 Sep 21.

PMID:
17898987
5.

Characterization of Seedling Infection Types and Adult Plant Infection Responses of Monogenic Sr Gene Lines to Race TTKS of Puccinia graminis f. sp. tritici.

Jin Y, Singh RP, Ward RW, Wanyera R, Kinyua M, Njau P, Fetch T, Pretorius ZA, Yahyaoui A.

Plant Dis. 2007 Sep;91(9):1096-1099. doi: 10.1094/PDIS-91-9-1096.

PMID:
30780647
6.
7.

Pyridone derivatives as potent, orally bioavailable VLA-4 integrin antagonists.

Witherington J, Blaney EL, Bordas V, Elliott RL, Gaiba A, Garton N, Green PM, Naylor A, Smith DG, Spalding DJ, Takle AK, Ward RW.

Bioorg Med Chem Lett. 2006 Nov 1;16(21):5538-41. Epub 2006 Aug 22.

PMID:
16931004
8.

Pyridone derivatives as potent and selective VLA-4 integrin antagonists.

Witherington J, Bordas V, Gaiba A, Green PM, Naylor A, Parr N, Smith DG, Takle AK, Ward RW.

Bioorg Med Chem Lett. 2006 Apr 15;16(8):2256-9. Epub 2006 Feb 7. Erratum in: Bioorg Med Chem Lett. 2006 Jun 15;16(12):3341.

PMID:
16455247
9.

TGF-beta1 causes airway fibrosis and increased collagen I and III mRNA in mice.

Kenyon NJ, Ward RW, McGrew G, Last JA.

Thorax. 2003 Sep;58(9):772-7.

10.

6-heteroaryl-pyrazolo[3,4-b]pyridines: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

Witherington J, Bordas V, Gaiba A, Naylor A, Rawlings AD, Slingsby BP, Smith DG, Takle AK, Ward RW.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3059-62.

PMID:
12941333
11.

6-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Witherington J, Bordas V, Gaiba A, Garton NS, Naylor A, Rawlings AD, Slingsby BP, Smith DG, Takle AK, Ward RW.

Bioorg Med Chem Lett. 2003 Sep 15;13(18):3055-7.

PMID:
12941332
12.

5-aryl-pyrazolo[3,4-b]pyridazines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Witherington J, Bordas V, Haigh D, Hickey DM, Ife RJ, Rawlings AD, Slingsby BP, Smith DG, Ward RW.

Bioorg Med Chem Lett. 2003 May 5;13(9):1581-4.

PMID:
12699760
13.

5-aryl-pyrazolo[3,4-b]pyridines: potent inhibitors of glycogen synthase kinase-3 (GSK-3).

Witherington J, Bordas V, Garland SL, Hickey DM, Ife RJ, Liddle J, Saunders M, Smith DG, Ward RW.

Bioorg Med Chem Lett. 2003 May 5;13(9):1577-80.

PMID:
12699759
14.

Airway fibrosis in a mouse model of airway inflammation.

Kenyon NJ, Ward RW, Last JA.

Toxicol Appl Pharmacol. 2003 Jan 15;186(2):90-100.

PMID:
12639500
15.

Steric acceleration of an uncatalysed ene reaction at room temperature.

Choony N, Sammes PG, Smith G, Ward RW.

Chem Commun (Camb). 2001 Oct 21;(20):2062-3.

PMID:
12240164
16.

3-Anilino-4-arylmaleimides: potent and selective inhibitors of glycogen synthase kinase-3 (GSK-3).

Smith DG, Buffet M, Fenwick AE, Haigh D, Ife RJ, Saunders M, Slingsby BP, Stacey R, Ward RW.

Bioorg Med Chem Lett. 2001 Mar 12;11(5):635-9.

PMID:
11266159
17.

Selective small molecule inhibitors of glycogen synthase kinase-3 modulate glycogen metabolism and gene transcription.

Coghlan MP, Culbert AA, Cross DA, Corcoran SL, Yates JW, Pearce NJ, Rausch OL, Murphy GJ, Carter PS, Roxbee Cox L, Mills D, Brown MJ, Haigh D, Ward RW, Smith DG, Murray KJ, Reith AD, Holder JC.

Chem Biol. 2000 Oct;7(10):793-803.

18.

Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides.

Chan WN, Hadley MS, Harling JD, Herdon HJ, Orlek BS, Riley GJ, Stead RE, Stean TO, Thompson M, Upton N, Ward RW.

Bioorg Med Chem. 2000 Aug;8(8):2085-94.

PMID:
11003154
19.

The inhibition of human cytomegalovirus (hCMV) protease by hydroxylamine derivatives.

Smith DG, Gribble AD, Haigh D, Ife RJ, Lavery P, Skett P, Slingsby BP, Stacey R, Ward RW, West A.

Bioorg Med Chem Lett. 1999 Nov 1;9(21):3137-42.

PMID:
10560740
20.

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity.

Chan WN, Hadley MS, Harling JD, Herdon HJ, Jerman JC, Orlek BS, Stean TO, Thompson M, Upton N, Ward RW.

Bioorg Med Chem Lett. 1998 Oct 20;8(20):2903-6.

PMID:
9873645
21.

The contribution of classical (beta1/2-) and atypical beta-adrenoceptors to the stimulation of human white adipocyte lipolysis and right atrial appendage contraction by novel beta3-adrenoceptor agonists of differing selectivities.

Sennitt MV, Kaumann AJ, Molenaar P, Beeley LJ, Young PW, Kelly J, Chapman H, Henson SM, Berge JM, Dean DK, Kotecha NR, Morgan HK, Rami HK, Ward RW, Thompson M, Wilson S, Smith SA, Cawthorne MA, Stock MJ, Arch JR.

J Pharmacol Exp Ther. 1998 Jun;285(3):1084-95. Erratum in: J Pharmacol Exp Ther 1998 Dec;287(3):1135.

PMID:
9618411
22.

Structure-based design of substituted diphenyl sulfones and sulfoxides as lipophilic inhibitors of thymidylate synthase.

Jones TR, Webber SE, Varney MD, Reddy MR, Lewis KK, Kathardekar V, Mazdiyasni H, Deal J, Nguyen D, Welsh KM, Webber S, Johnston A, Matthews DA, Smith WW, Janson CA, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Bartlett CA, Morse CA.

J Med Chem. 1997 Feb 28;40(5):677-83.

PMID:
9057854
23.

Structure-based design of lipophilic quinazoline inhibitors of thymidylate synthase.

Jones TR, Varney MD, Webber SE, Lewis KK, Marzoni GP, Palmer CL, Kathardekar V, Welsh KM, Webber S, Matthews DA, Appelt K, Smith WW, Janson CA, Villafranca JE, Bacquet RJ, Howland EF, Booth CL, Herrmann SM, Ward RW, White J, Moomaw EW, Bartlett CA, Morse CA.

J Med Chem. 1996 Feb 16;39(4):904-17.

PMID:
8632414
24.

Digital clubbing. Demonstration with positron emission tomography.

Ward RW, Chin R Jr, Keyes JW Jr, Haponik EF.

Chest. 1995 Apr;107(4):1172-3.

PMID:
7705135
25.

Synthesis of novel N-phosphonoalkyl dipeptide inhibitors of human collagenase.

Bird J, De Mello RC, Harper GP, Hunter DJ, Karran EH, Markwell RE, Miles-Williams AJ, Rahman SS, Ward RW.

J Med Chem. 1994 Jan 7;37(1):158-69.

PMID:
8289190
26.

Characterization of a Cold-Regulated Wheat Gene Related to Arabidopsis cor47.

Guo W, Ward RW, Thomashow MF.

Plant Physiol. 1992 Oct;100(2):915-22.

27.

Experimental evidence for mode shape influence on acceleration-induced frequency shifts in quartz resonators.

Eernisse EP, Ward RW, Watts MH, Wiggins RB, Wood OL.

IEEE Trans Ultrason Ferroelectr Freq Control. 1990;37(6):566-70.

PMID:
18285079
28.

Survey of quartz bulk resonator sensor technologies.

Eernisse EP, Ward RW, Wiggins RB.

IEEE Trans Ultrason Ferroelectr Freq Control. 1988;35(3):323-30.

PMID:
18290158
29.

7-Aroyl-2,3-dihydrobenzo[b]furan-3-carboxylic acids and 7-benzoyl-2,3-dihydrobenzo[b]thiophene-3-carboxylic acids as analgesic agents.

Boyle EA, Mangan FR, Markwell RE, Smith SA, Thomson MJ, Ward RW, Wyman PA.

J Med Chem. 1986 Jun;29(6):894-8.

PMID:
3086559
30.

Responses of alloplasmic (cytoplasm=Triticum timopheevii) and euplasmic wheats (Triticum aestivum) to photoperiod and vernalization.

Ward RW, Heyne EG, Paulsen GM.

Theor Appl Genet. 1983 Jul;66(1):61-6. doi: 10.1007/BF00281850.

PMID:
24263632
31.
32.
33.

Spontaneous myocardial cholesterol embolization.

Pschibul F, Ward RW.

J Med Soc N J. 1980 Jan;77(1):37-40. No abstract available.

PMID:
6928211
34.

Residual toxicity of several disinfectants in domestic wastewater.

Ward RW, DeGraeve GM.

J Water Pollut Control Fed. 1978 Jan;50(1):46-60. No abstract available.

PMID:
621828
35.

Acclimation of fathead minnows and lake trout to residual chlorine and bromine chloride.

DeGraeve GM, Ward RW.

J Water Pollut Control Fed. 1977 Oct;49(10):2172-8. No abstract available.

PMID:
916131
36.

Thermally induced stresses and rapid temperature changes in teeth.

Barker RE Jr, Rafoth RF, Ward RW.

J Biomed Mater Res. 1972 Sep;6(5):305-25. No abstract available.

PMID:
5072345
37.

Rupture of aortic aneurysm into the pulmonary artery.

Ward RW, Kalbfleisch JM.

South Med J. 1968 Apr;61(4):408-10. No abstract available.

PMID:
5644076
38.

Antimalarials in the treatment of dermatomyositis.

WARD RW.

J Med Soc N J. 1960 Jun;57:317-21. No abstract available.

PMID:
13842877
39.

Tumors of the small intestine.

WARD RW, GERE JB.

J Med Soc N J. 1960 Mar;57:121-3. No abstract available.

PMID:
13842876
40.

Anomalous return of the pulmonary veins.

SAREWITZ AB, WARD RW.

J Med Soc N J. 1959 Oct;56:611-3. No abstract available.

PMID:
14441726

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