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Transcriptional Programming of Human Mechanosensory Neuron Subtypes from Pluripotent Stem Cells.

Nickolls AR, Lee MM, Espinoza DF, Szczot M, Lam RM, Wang Q, Beers J, Zou J, Nguyen MQ, Solinski HJ, AlJanahi AA, Johnson KR, Ward ME, Chesler AT, Bönnemann CG.

Cell Rep. 2020 Jan 21;30(3):932-946.e7. doi: 10.1016/j.celrep.2019.12.062.


Acanthamoeba spp. and Balamuthia mandrillaris leading to fatal granulomatous amebic encephalitis.

Lee DC, Fiester SE, Madeline LA, Fulcher JW, Ward ME, Schammel CM, Hakimi RK.

Forensic Sci Med Pathol. 2019 Nov 26. doi: 10.1007/s12024-019-00202-6. [Epub ahead of print]


Coupling APEX labeling to imaging mass spectrometry of single organelles reveals heterogeneity in lysosomal protein turnover.

Narendra DP, Guillermier C, Gyngard F, Huang X, Ward ME, Steinhauser ML.

J Cell Biol. 2020 Jan 6;219(1). pii: e201901097. doi: 10.1083/jcb.201901097.


Lysosomal Dysfunction at the Centre of Parkinson's Disease and Frontotemporal Dementia/Amyotrophic Lateral Sclerosis.

Wallings RL, Humble SW, Ward ME, Wade-Martins R.

Trends Neurosci. 2019 Dec;42(12):899-912. doi: 10.1016/j.tins.2019.10.002. Epub 2019 Nov 5. Review.


A randomised controlled trial exploring the impact of a dedicated health and social care professionals team in the emergency department on the quality, safety, clinical and cost-effectiveness of care for older adults: a study protocol.

Cassarino M, Robinson K, O'Shaughnessy Í, Smalle E, White S, Devlin C, Quinn R, Trépel D, Boland F, Ward ME, McNamara R, O'Connor M, McCarthy G, Ryan D, Galvin R.

Trials. 2019 Oct 15;20(1):591. doi: 10.1186/s13063-019-3697-5.


ToolBox: Live Imaging of intracellular organelle transport in induced pluripotent stem cell-derived neurons.

Boecker CA, Olenick MA, Gallagher ER, Ward ME, Holzbaur ELF.

Traffic. 2020 Jan;21(1):138-155. doi: 10.1111/tra.12701. Epub 2019 Nov 15.


RNA Granules Hitchhike on Lysosomes for Long-Distance Transport, Using Annexin A11 as a Molecular Tether.

Liao YC, Fernandopulle MS, Wang G, Choi H, Hao L, Drerup CM, Patel R, Qamar S, Nixon-Abell J, Shen Y, Meadows W, Vendruscolo M, Knowles TPJ, Nelson M, Czekalska MA, Musteikyte G, Gachechiladze MA, Stephens CA, Pasolli HA, Forrest LR, St George-Hyslop P, Lippincott-Schwartz J, Ward ME.

Cell. 2019 Sep 19;179(1):147-164.e20. doi: 10.1016/j.cell.2019.08.050.


CRISPR Interference-Based Platform for Multimodal Genetic Screens in Human iPSC-Derived Neurons.

Tian R, Gachechiladze MA, Ludwig CH, Laurie MT, Hong JY, Nathaniel D, Prabhu AV, Fernandopulle MS, Patel R, Abshari M, Ward ME, Kampmann M.

Neuron. 2019 Oct 23;104(2):239-255.e12. doi: 10.1016/j.neuron.2019.07.014. Epub 2019 Aug 15.


Impact of early assessment and intervention by teams involving health and social care professionals in the emergency department: A systematic review.

Cassarino M, Robinson K, Quinn R, Naddy B, O'Regan A, Ryan D, Boland F, Ward ME, McNamara R, O'Connor M, McCarthy G, Galvin R.

PLoS One. 2019 Jul 31;14(7):e0220709. doi: 10.1371/journal.pone.0220709. eCollection 2019.


Implementing an allied health team intervention to improve the care of older adults in the emergency department: protocol for a process evaluation.

Cassarino M, Cronin Ú, Robinson K, Quinn R, Boland F, Ward ME, MacNamara R, O'Connor M, McCarthy G, Ryan D, Galvin R.

BMJ Open. 2019 Jul 16;9(7):e032645. doi: 10.1136/bmjopen-2019-032645.


A biradical-tagged phospholipid as a polarizing agent for solid-state MAS Dynamic Nuclear Polarization NMR of membrane proteins.

Good DB, Voinov MA, Bolton D, Ward ME, Sergeyev IV, Caporini M, Scheffer P, Lo A, Rosay M, Marek A, Brown LS, I Smirnov A, Ladizhansky V.

Solid State Nucl Magn Reson. 2019 Aug;100:92-101. doi: 10.1016/j.ssnmr.2019.04.003. Epub 2019 Apr 17.


Heterochromatin anomalies and double-stranded RNA accumulation underlie C9orf72 poly(PR) toxicity.

Zhang YJ, Guo L, Gonzales PK, Gendron TF, Wu Y, Jansen-West K, O'Raw AD, Pickles SR, Prudencio M, Carlomagno Y, Gachechiladze MA, Ludwig C, Tian R, Chew J, DeTure M, Lin WL, Tong J, Daughrity LM, Yue M, Song Y, Andersen JW, Castanedes-Casey M, Kurti A, Datta A, Antognetti G, McCampbell A, Rademakers R, Oskarsson B, Dickson DW, Kampmann M, Ward ME, Fryer JD, Link CD, Shorter J, Petrucelli L.

Science. 2019 Feb 15;363(6428). pii: eaav2606. doi: 10.1126/science.aav2606.


Biosynthetic production of fully carbon-13 labeled retinal in E. coli for structural and functional studies of rhodopsins.

Munro RA, de Vlugt J, Ward ME, Kim SY, Lee KA, Jung KH, Ladizhansky V, Brown LS.

J Biomol NMR. 2019 Feb;73(1-2):49-58. doi: 10.1007/s10858-019-00225-9. Epub 2019 Feb 4.


Developing outcome, process and balancing measures for an emergency department longitudinal patient monitoring system using a modified Delphi.

Ward ME, Wakai A, McDowell R, Boland F, Coughlan E, Hamza M, Browne J, O'Sullivan R, Geary U, McDaid F, Ní Shé É, Drummond FJ, Deasy C, McAuliffe E.

BMC Emerg Med. 2019 Jan 14;19(1):7. doi: 10.1186/s12873-018-0220-3.


Genome Sequences of Nine Erwinia amylovora Bacteriophages.

Sharma R, Berg JA, Beatty NJ, Choi MC, Cowger AE, Cozzens BJR, Duncan SG, Fajardo CP, Ferguson HP, Galbraith T, Herring JA, Hoj TR, Durrant JL, Hyde JR, Jensen GL, Ke SY, Killpack S, Kruger JL, Lawrence EEK, Nwosu IO, Tam TC, Thompson DW, Tueller JA, Ward MEH, Webb CJ, Wood ME, Yeates EL, Baltrus DA, Breakwell DP, Hope S, Grose JH.

Microbiol Resour Announc. 2018 Oct 11;7(14). pii: e00944-18. doi: 10.1128/MRA.00944-18. eCollection 2018 Oct.


The Psychiatric Cell Map Initiative: A Convergent Systems Biological Approach to Illuminating Key Molecular Pathways in Neuropsychiatric Disorders.

Willsey AJ, Morris MT, Wang S, Willsey HR, Sun N, Teerikorpi N, Baum TB, Cagney G, Bender KJ, Desai TA, Srivastava D, Davis GW, Doudna J, Chang E, Sohal V, Lowenstein DH, Li H, Agard D, Keiser MJ, Shoichet B, von Zastrow M, Mucke L, Finkbeiner S, Gan L, Sestan N, Ward ME, Huttenhain R, Nowakowski TJ, Bellen HJ, Frank LM, Khokha MK, Lifton RP, Kampmann M, Ideker T, State MW, Krogan NJ.

Cell. 2018 Jul 26;174(3):505-520. doi: 10.1016/j.cell.2018.06.016. Review.


Effectiveness of early assessment and intervention by interdisciplinary teams including health and social care professionals in the emergency department: protocol for a systematic review.

Cassarino M, Robinson K, Quinn R, Naddy B, O'Regan A, Ryan D, Boland F, Ward ME, McNamara R, McCarthy G, Galvin R.

BMJ Open. 2018 Jul 16;8(7):e023464. doi: 10.1136/bmjopen-2018-023464.


Team interventions in acute hospital contexts: a systematic search of the literature using realist synthesis.

Cunningham U, Ward ME, De Brún A, McAuliffe E.

BMC Health Serv Res. 2018 Jul 11;18(1):536. doi: 10.1186/s12913-018-3331-3. Review.


Transcription Factor-Mediated Differentiation of Human iPSCs into Neurons.

Fernandopulle MS, Prestil R, Grunseich C, Wang C, Gan L, Ward ME.

Curr Protoc Cell Biol. 2018 Jun;79(1):e51. doi: 10.1002/cpcb.51. Epub 2018 May 18.


Using Co-Design to Develop a Collective Leadership Intervention for Healthcare Teams to Improve Safety Culture.

Ward ME, De Brún A, Beirne D, Conway C, Cunningham U, English A, Fitzsimons J, Furlong E, Kane Y, Kelly A, McDonnell S, McGinley S, Monaghan B, Myler A, Nolan E, O'Donovan R, O'Shea M, Shuhaiber A, McAuliffe E.

Int J Environ Res Public Health. 2018 Jun 5;15(6). pii: E1182. doi: 10.3390/ijerph15061182.


Investigations of dynamic amyloid-like structures of the Wnt signalling pathway by solid-state NMR.

Ward ME, Daniëls MA, van Kappel EC, Maurice MM, Baldus M.

Chem Commun (Camb). 2018 Apr 17;54(32):3959-3962. doi: 10.1039/C8CC01346B.


Reduced contrast sensitivity among older women is associated with increased risk of cognitive impairment.

Ward ME, Gelfand JM, Lui LY, Ou Y, Green AJ, Stone K, Pedula KL, Cummings SR, Yaffe K.

Ann Neurol. 2018 Apr;83(4):730-738. doi: 10.1002/ana.25196. Epub 2018 Apr 11.


Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons.

Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, Woolwine P, Huang M, Cowan MJ, Ge B, Koutsodendris N, Sandor KP, Komberg J, Vangoor VR, Senthilkumar K, Hennes V, Seah C, Nelson AR, Cheng TY, Lee SJ, August PR, Chen JA, Wisniewski N, Hanson-Smith V, Belgard TG, Zhang A, Coba M, Grunseich C, Ward ME, van den Berg LH, Pasterkamp RJ, Trotti D, Zlokovic BV, Ichida JK.

Nat Med. 2018 Mar;24(3):313-325. doi: 10.1038/nm.4490. Epub 2018 Feb 5.


Pulmonary Tumor Thrombotic Microangiopathy: Case Report and Review of Literature.

Hutchinson JC, Fulcher JW, Hanna J, Ward ME.

Am J Forensic Med Pathol. 2018 Mar;39(1):56-60. doi: 10.1097/PAF.0000000000000369. Review.


Systematic Three-Dimensional Coculture Rapidly Recapitulates Interactions between Human Neurons and Astrocytes.

Krencik R, Seo K, van Asperen JV, Basu N, Cvetkovic C, Barlas S, Chen R, Ludwig C, Wang C, Ward ME, Gan L, Horner PJ, Rowitch DH, Ullian EM.

Stem Cell Reports. 2017 Dec 12;9(6):1745-1753. doi: 10.1016/j.stemcr.2017.10.026. Epub 2017 Nov 30.


Genome Sequences of 19 Novel Erwinia amylovora Bacteriophages.

Esplin IND, Berg JA, Sharma R, Allen RC, Arens DK, Ashcroft CR, Bairett SR, Beatty NJ, Bickmore M, Bloomfield TJ, Brady TS, Bybee RN, Carter JL, Choi MC, Duncan S, Fajardo CP, Foy BB, Fuhriman DA, Gibby PD, Grossarth SE, Harbaugh K, Harris N, Hilton JA, Hurst E, Hyde JR, Ingersoll K, Jacobson CM, James BD, Jarvis TM, Jaen-Anieves D, Jensen GL, Knabe BK, Kruger JL, Merrill BD, Pape JA, Payne Anderson AM, Payne DE, Peck MD, Pollock SV, Putnam MJ, Ransom EK, Ririe DB, Robinson DM, Rogers SL, Russell KA, Schoenhals JE, Shurtleff CA, Simister AR, Smith HG, Stephenson MB, Staley LA, Stettler JM, Stratton ML, Tateoka OB, Tatlow PJ, Taylor AS, Thompson SE, Townsend MH, Thurgood TL, Usher BK, Whitley KV, Ward AT, Ward MEH, Webb CJ, Wienclaw TM, Williamson TL, Wells MJ, Wright CK, Breakwell DP, Hope S, Grose JH.

Genome Announc. 2017 Nov 16;5(46). pii: e00931-17. doi: 10.1128/genomeA.00931-17.


Scalable Production of iPSC-Derived Human Neurons to Identify Tau-Lowering Compounds by High-Content Screening.

Wang C, Ward ME, Chen R, Liu K, Tracy TE, Chen X, Xie M, Sohn PD, Ludwig C, Meyer-Franke A, Karch CM, Ding S, Gan L.

Stem Cell Reports. 2017 Oct 10;9(4):1221-1233. doi: 10.1016/j.stemcr.2017.08.019. Epub 2017 Sep 28.


Team Approach: Single-Event Multilevel Surgery in Ambulatory Patients with Cerebral Palsy.

Georgiadis AG, Schwartz MH, Walt K, Ward ME, Kim PD, Novacheck TF.

JBJS Rev. 2017 Aug;5(8):e10. doi: 10.2106/JBJS.RVW.16.00101. Review. No abstract available.


Oligomeric Structure of Anabaena Sensory Rhodopsin in a Lipid Bilayer Environment by Combining Solid-State NMR and Long-range DEER Constraints.

Milikisiyants S, Wang S, Munro RA, Donohue M, Ward ME, Bolton D, Brown LS, Smirnova TI, Ladizhansky V, Smirnov AI.

J Mol Biol. 2017 Jun 16;429(12):1903-1920. doi: 10.1016/j.jmb.2017.05.005. Epub 2017 May 10.


Microglial NFκB-TNFα hyperactivation induces obsessive-compulsive behavior in mouse models of progranulin-deficient frontotemporal dementia.

Krabbe G, Minami SS, Etchegaray JI, Taneja P, Djukic B, Davalos D, Le D, Lo I, Zhan L, Reichert MC, Sayed F, Merlini M, Ward ME, Perry DC, Lee SE, Sias A, Parkhurst CN, Gan WB, Akassoglou K, Miller BL, Farese RV Jr, Gan L.

Proc Natl Acad Sci U S A. 2017 May 9;114(19):5029-5034. doi: 10.1073/pnas.1700477114. Epub 2017 Apr 24.


Individuals with progranulin haploinsufficiency exhibit features of neuronal ceroid lipofuscinosis.

Ward ME, Chen R, Huang HY, Ludwig C, Telpoukhovskaia M, Taubes A, Boudin H, Minami SS, Reichert M, Albrecht P, Gelfand JM, Cruz-Herranz A, Cordano C, Alavi MV, Leslie S, Seeley WW, Miller BL, Bigio E, Mesulam MM, Bogyo MS, Mackenzie IR, Staropoli JF, Cotman SL, Huang EJ, Gan L, Green AJ.

Sci Transl Med. 2017 Apr 12;9(385). pii: eaah5642. doi: 10.1126/scitranslmed.aah5642.


Retinal thinning is uniquely associated with medial temporal lobe atrophy in neurologically normal older adults.

Casaletto KB, Ward ME, Baker NS, Bettcher BM, Gelfand JM, Li Y, Chen R, Dutt S, Miller B, Kramer JH, Green AJ.

Neurobiol Aging. 2017 Mar;51:141-147. doi: 10.1016/j.neurobiolaging.2016.12.011. Epub 2016 Dec 21.


Strangulation by Feeding Tube in a 23-Month-Old With Down Syndrome: Case Report and Review of Literature.

Woodham PC, Fulcher JW, Ward ME.

Am J Forensic Med Pathol. 2016 Dec;37(4):245-247. Review.


DNA Methylation and BMI: Investigating Identified Methylation Sites at HIF3A in a Causal Framework.

Richmond RC, Sharp GC, Ward ME, Fraser A, Lyttleton O, McArdle WL, Ring SM, Gaunt TR, Lawlor DA, Davey Smith G, Relton CL.

Diabetes. 2016 May;65(5):1231-44. doi: 10.2337/db15-0996. Epub 2016 Feb 9.


Proton detection for signal enhancement in solid-state NMR experiments on mobile species in membrane proteins.

Ward ME, Ritz E, Ahmed MAM, Bamm VV, Harauz G, Brown LS, Ladizhansky V.

J Biomol NMR. 2015 Dec;63(4):375-388. doi: 10.1007/s10858-015-9997-5. Epub 2015 Oct 22.


Cysteine-Specific Labeling of Proteins with a Nitroxide Biradical for Dynamic Nuclear Polarization NMR.

Voinov MA, Good DB, Ward ME, Milikisiyants S, Marek A, Caporini MA, Rosay M, Munro RA, Ljumovic M, Brown LS, Ladizhansky V, Smirnov AI.

J Phys Chem B. 2015 Aug 13;119(32):10180-90. doi: 10.1021/acs.jpcb.5b05230. Epub 2015 Jul 31.


In situ structural studies of Anabaena sensory rhodopsin in the E. coli membrane.

Ward ME, Wang S, Munro R, Ritz E, Hung I, Gor'kov PL, Jiang Y, Liang H, Brown LS, Ladizhansky V.

Biophys J. 2015 Apr 7;108(7):1683-1696. doi: 10.1016/j.bpj.2015.02.018.


Expedited diagnosis and management of inpatient hyperosmolar hyperglycemic nonketotic syndrome.

McCombs DG, Appel SJ, Ward ME.

J Am Assoc Nurse Pract. 2015 Aug;27(8):426-32. doi: 10.1002/2327-6924.12205. Epub 2015 Jan 30.


Advanced solid-state NMR techniques for characterization of membrane protein structure and dynamics: application to Anabaena Sensory Rhodopsin.

Ward ME, Brown LS, Ladizhansky V.

J Magn Reson. 2015 Apr;253:119-28. doi: 10.1016/j.jmr.2014.11.017. Epub 2014 Dec 26. Review.


SIRT1 deficiency in microglia contributes to cognitive decline in aging and neurodegeneration via epigenetic regulation of IL-1β.

Cho SH, Chen JA, Sayed F, Ward ME, Gao F, Nguyen TA, Krabbe G, Sohn PD, Lo I, Minami S, Devidze N, Zhou Y, Coppola G, Gan L.

J Neurosci. 2015 Jan 14;35(2):807-18. doi: 10.1523/JNEUROSCI.2939-14.2015.


Progranulin protects against amyloid β deposition and toxicity in Alzheimer's disease mouse models.

Minami SS, Min SW, Krabbe G, Wang C, Zhou Y, Asgarov R, Li Y, Martens LH, Elia LP, Ward ME, Mucke L, Farese RV Jr, Gan L.

Nat Med. 2014 Oct;20(10):1157-64. doi: 10.1038/nm.3672. Epub 2014 Sep 28.


Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.

Rietveld CA, Esko T, Davies G, Pers TH, Turley P, Benyamin B, Chabris CF, Emilsson V, Johnson AD, Lee JJ, de Leeuw C, Marioni RE, Medland SE, Miller MB, Rostapshova O, van der Lee SJ, Vinkhuyzen AA, Amin N, Conley D, Derringer J, van Duijn CM, Fehrmann R, Franke L, Glaeser EL, Hansell NK, Hayward C, Iacono WG, Ibrahim-Verbaas C, Jaddoe V, Karjalainen J, Laibson D, Lichtenstein P, Liewald DC, Magnusson PK, Martin NG, McGue M, McMahon G, Pedersen NL, Pinker S, Porteous DJ, Posthuma D, Rivadeneira F, Smith BH, Starr JM, Tiemeier H, Timpson NJ, Trzaskowski M, Uitterlinden AG, Verhulst FC, Ward ME, Wright MJ, Davey Smith G, Deary IJ, Johannesson M, Plomin R, Visscher PM, Benjamin DJ, Cesarini D, Koellinger PD.

Proc Natl Acad Sci U S A. 2014 Sep 23;111(38):13790-4. doi: 10.1073/pnas.1404623111. Epub 2014 Sep 8. Erratum in: Proc Natl Acad Sci U S A. 2015 Jan 27;112(4):E380.


Early retinal neurodegeneration and impaired Ran-mediated nuclear import of TDP-43 in progranulin-deficient FTLD.

Ward ME, Taubes A, Chen R, Miller BL, Sephton CF, Gelfand JM, Minami S, Boscardin J, Martens LH, Seeley WW, Yu G, Herz J, Filiano AJ, Arrant AE, Roberson ED, Kraft TW, Farese RV Jr, Green A, Gan L.

J Exp Med. 2014 Sep 22;211(10):1937-45. doi: 10.1084/jem.20140214. Epub 2014 Aug 25.


Genetic variation associated with differential educational attainment in adults has anticipated associations with school performance in children.

Ward ME, McMahon G, St Pourcain B, Evans DM, Rietveld CA, Benjamin DJ, Koellinger PD, Cesarini D; Social Science Genetic Association Consortium, Davey Smith G, Timpson NJ.

PLoS One. 2014 Jul 17;9(7):e100248. doi: 10.1371/journal.pone.0100248. eCollection 2014.


Conformational dynamics of a seven transmembrane helical protein Anabaena Sensory Rhodopsin probed by solid-state NMR.

Good DB, Wang S, Ward ME, Struppe J, Brown LS, Lewandowski JR, Ladizhansky V.

J Am Chem Soc. 2014 Feb 19;136(7):2833-42. doi: 10.1021/ja411633w. Epub 2014 Feb 5.


High-resolution paramagnetically enhanced solid-state NMR spectroscopy of membrane proteins at fast magic angle spinning.

Ward ME, Wang S, Krishnamurthy S, Hutchins H, Fey M, Brown LS, Ladizhansky V.

J Biomol NMR. 2014 Jan;58(1):37-47. doi: 10.1007/s10858-013-9802-2. Epub 2013 Dec 13.


Swelling-activated Cl- currents and intracellular CLC-3 are involved in proliferation of human pulmonary artery smooth muscle cells.

Liang W, Huang L, Zhao D, He JZ, Sharma P, Liu J, Gramolini AO, Ward ME, Cho HC, Backx PH.

J Hypertens. 2014 Feb;32(2):318-30. doi: 10.1097/HJH.0000000000000013.


Glaucoma and dementia: more than meets the eye?

Ward ME, Petersen RC.

Ann Neurol. 2013 Aug;74(2):155-7. doi: 10.1002/ana.23949. No abstract available.


A cautionary tale of technology: not a substitute for careful collaboration and effective communication.

Ward ME.

JONAS Healthc Law Ethics Regul. 2012 Jul-Sep;14(3):77-80. doi: 10.1097/NHL.0b013e318263eb0e.


Selective targeting of microglia by quantum dots.

Minami SS, Sun B, Popat K, Kauppinen T, Pleiss M, Zhou Y, Ward ME, Floreancig P, Mucke L, Desai T, Gan L.

J Neuroinflammation. 2012 Jan 24;9:22. doi: 10.1186/1742-2094-9-22.

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