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Items: 1 to 50 of 105

1.

Pharmacokinetics and pharmacodynamics of the novel Nrf2 activator omaveloxolone in primates.

Reisman SA, Gahir SS, Lee CI, Proksch JW, Sakamoto M, Ward KW.

Drug Des Devel Ther. 2019 Apr 17;13:1259-1270. doi: 10.2147/DDDT.S193889. eCollection 2019.

2.

Nrf2 Activation Is a Potential Therapeutic Approach to Attenuate Diabetic Retinopathy.

Deliyanti D, Alrashdi SF, Tan SM, Meyer C, Ward KW, de Haan JB, Wilkinson-Berka JL.

Invest Ophthalmol Vis Sci. 2018 Feb 1;59(2):815-825. doi: 10.1167/iovs.17-22920.

PMID:
29411009
3.

The nuclear factor (erythroid-derived 2)-like 2 (Nrf2) activator dh404 protects against diabetes-induced endothelial dysfunction.

Sharma A, Rizky L, Stefanovic N, Tate M, Ritchie RH, Ward KW, de Haan JB.

Cardiovasc Diabetol. 2017 Mar 3;16(1):33. doi: 10.1186/s12933-017-0513-y.

4.

A potent Nrf2 activator, dh404, bolsters antioxidant capacity in glial cells and attenuates ischaemic retinopathy.

Deliyanti D, Lee JY, Petratos S, Meyer CJ, Ward KW, Wilkinson-Berka JL, de Haan JB.

Clin Sci (Lond). 2016 Aug 1;130(15):1375-87. doi: 10.1042/CS20160068. Epub 2016 Mar 22.

PMID:
27005782
5.

First Report of Ceftazidime-Avibactam Resistance in a KPC-3-Expressing Klebsiella pneumoniae Isolate.

Humphries RM, Yang S, Hemarajata P, Ward KW, Hindler JA, Miller SA, Gregson A.

Antimicrob Agents Chemother. 2015 Oct;59(10):6605-7. doi: 10.1128/AAC.01165-15. Epub 2015 Jul 20.

6.

Topical application of RTA 408 lotion activates Nrf2 in human skin and is well-tolerated by healthy human volunteers.

Reisman SA, Goldsberry AR, Lee CY, O'Grady ML, Proksch JW, Ward KW, Meyer CJ.

BMC Dermatol. 2015 Jul 14;15:10. doi: 10.1186/s12895-015-0029-7.

7.

Photo quiz: A child with fever after hematopoietic stem cell transplantation.

Dharia NV, Miller SA, Ward KW, Yeganeh N, Humphries RM.

J Clin Microbiol. 2015 May;53(5):1463, 1788. doi: 10.1128/JCM.01318-13. No abstract available.

8.

Mechanisms contributing to adverse cardiovascular events in patients with type 2 diabetes mellitus and stage 4 chronic kidney disease treated with bardoxolone methyl.

Chin MP, Reisman SA, Bakris GL, O'Grady M, Linde PG, McCullough PA, Packham D, Vaziri ND, Ward KW, Warnock DG, Meyer CJ.

Am J Nephrol. 2014;39(6):499-508. doi: 10.1159/000362906. Epub 2014 Jun 3.

9.

Targeting Nrf2 by dihydro-CDDO-trifluoroethyl amide enhances autophagic clearance and viability of β-cells in a setting of oxidative stress.

Li W, Wu W, Song H, Wang F, Li H, Chen L, Lai Y, Janicki JS, Ward KW, Meyer CJ, Wang XL, Tang D, Cui T.

FEBS Lett. 2014 Jun 5;588(12):2115-24. doi: 10.1016/j.febslet.2014.04.046. Epub 2014 May 8.

10.

Derivative of bardoxolone methyl, dh404, in an inverse dose-dependent manner lessens diabetes-associated atherosclerosis and improves diabetic kidney disease.

Tan SM, Sharma A, Stefanovic N, Yuen DY, Karagiannis TC, Meyer C, Ward KW, Cooper ME, de Haan JB.

Diabetes. 2014 Sep;63(9):3091-103. doi: 10.2337/db13-1743. Epub 2014 Apr 16.

11.

Topical application of the synthetic triterpenoid RTA 408 protects mice from radiation-induced dermatitis.

Reisman SA, Lee CY, Meyer CJ, Proksch JW, Sonis ST, Ward KW.

Radiat Res. 2014 May;181(5):512-20. doi: 10.1667/RR13578.1. Epub 2014 Apr 10.

PMID:
24720753
12.

Dihydro-CDDO-trifluoroethyl amide suppresses inflammatory responses in macrophages via activation of Nrf2.

Li B, Abdalrahman A, Lai Y, Janicki JS, Ward KW, Meyer CJ, Wang XL, Tang D, Cui T.

Biochem Biophys Res Commun. 2014 Feb 21;444(4):555-61. doi: 10.1016/j.bbrc.2014.01.101. Epub 2014 Jan 29.

PMID:
24486487
13.

Topical application of the synthetic triterpenoid RTA 408 activates Nrf2 and induces cytoprotective genes in rat skin.

Reisman SA, Lee CY, Meyer CJ, Proksch JW, Ward KW.

Arch Dermatol Res. 2014 Jul;306(5):447-54. doi: 10.1007/s00403-013-1433-7. Epub 2013 Dec 22.

PMID:
24362512
14.

Bardoxolone methyl analogs RTA 405 and dh404 are well tolerated and exhibit efficacy in rodent models of Type 2 diabetes and obesity.

Chin M, Lee CY, Chuang JC, Bumeister R, Wigley WC, Sonis ST, Ward KW, Meyer C.

Am J Physiol Renal Physiol. 2013 Jun 15;304(12):F1438-46. doi: 10.1152/ajprenal.00387.2012. Epub 2013 Apr 17.

15.

CDDO-9,11-dihydro-trifluoroethyl amide (CDDO-dhTFEA) induces hepatic cytoprotective genes and increases bile flow in rats.

Reisman SA, Ward KW, Klaassen CD, Meyer CJ.

Xenobiotica. 2013 Jul;43(7):571-8. doi: 10.3109/00498254.2012.750022. Epub 2012 Dec 17.

PMID:
23244591
16.

Bardoxolone methyl decreases megalin and activates nrf2 in the kidney.

Reisman SA, Chertow GM, Hebbar S, Vaziri ND, Ward KW, Meyer CJ.

J Am Soc Nephrol. 2012 Oct;23(10):1663-73. Epub 2012 Aug 2.

17.

In vitro biocompatibility assessment of multipurpose contact lens solutions: effects on human corneal epithelial viability and barrier function.

Cavet ME, Harrington KL, VanDerMeid KR, Ward KW, Zhang JZ.

Cont Lens Anterior Eye. 2012 Aug;35(4):163-70. doi: 10.1016/j.clae.2012.02.003. Epub 2012 Mar 20.

PMID:
22436848
18.

Correlation of tear inflammatory cytokines and matrix metalloproteinases with four dry eye diagnostic tests.

VanDerMeid KR, Su SP, Ward KW, Zhang JZ.

Invest Ophthalmol Vis Sci. 2012 Mar 21;53(3):1512-8. doi: 10.1167/iovs.11-7627.

PMID:
22323462
19.

The use of the African green monkey as a preclinical model for ocular pharmacokinetic studies.

Glogowski S, Ward KW, Lawrence MS, Goody RJ, Proksch JW.

J Ocul Pharmacol Ther. 2012 Jun;28(3):290-8. doi: 10.1089/jop.2011.0164. Epub 2012 Jan 11.

PMID:
22235843
20.

Eosinophil as a cellular target of the ocular anti-allergic action of mapracorat, a novel selective glucocorticoid receptor agonist.

Baiula M, Spartà A, Bedini A, Carbonari G, Bucolo C, Ward KW, Zhang JZ, Govoni P, Spampinato S.

Mol Vis. 2011;17:3208-23. Epub 2011 Dec 14.

21.

Legionella steelei sp. nov., isolated from human respiratory specimens in California, USA, and South Australia.

Edelstein PH, Edelstein MA, Shephard LJ, Ward KW, Ratcliff RM.

Int J Syst Evol Microbiol. 2012 Aug;62(Pt 8):1766-71. doi: 10.1099/ijs.0.035709-0. Epub 2011 Sep 23.

PMID:
21948093
22.

A method to extract cytokines and matrix metalloproteinases from Schirmer strips and analyze using Luminex.

VanDerMeid KR, Su SP, Krenzer KL, Ward KW, Zhang JZ.

Mol Vis. 2011 Apr 27;17:1056-63.

23.

Ocular pharmacokinetics of mapracorat, a novel, selective glucocorticoid receptor agonist, in rabbits and monkeys.

Proksch JW, Lowe ER, Ward KW.

Drug Metab Dispos. 2011 Jul;39(7):1181-7. doi: 10.1124/dmd.111.039099. Epub 2011 Mar 25.

PMID:
21441467
24.
25.

New Delhi metallo-β-lactamase (NDM-1)-producing Klebsiella pneumoniae: case report and laboratory detection strategies.

Mochon AB, Garner OB, Hindler JA, Krogstad P, Ward KW, Lewinski MA, Rasheed JK, Anderson KF, Limbago BM, Humphries RM.

J Clin Microbiol. 2011 Apr;49(4):1667-70. doi: 10.1128/JCM.00183-11. Epub 2011 Feb 16. Erratum in: J Clin Microbiol. 2011 Jun;49(6):2386.

26.

Effect of a novel multipurpose contact lens solution on human corneal epithelial barrier function.

Cavet ME, VanDerMeid KR, Harrington KL, Tchao R, Ward KW, Zhang JZ.

Cont Lens Anterior Eye. 2010 Dec;33 Suppl 1:S18-23. doi: 10.1016/j.clae.2010.06.012. Epub 2010 Nov 4.

PMID:
21051274
27.

Enteric fever in a 6-year-old traveler caused by Salmonella enterica serotypes Typhi and Paratyphi A: laboratory detection strategies and treatment options.

Humphries RM, Yeganeh N, Ward KW, Lewinski MA, Ching N.

J Clin Microbiol. 2011 Jan;49(1):452-4. doi: 10.1128/JCM.01316-10. Epub 2010 Oct 27.

28.

WY-14 643, a selective PPAR{alpha} agonist, induces proinflammatory and proangiogenic responses in human ocular cells.

Zhang JZ, Ward KW.

Int J Toxicol. 2010 Sep-Oct;29(5):496-504. doi: 10.1177/1091581810376674.

PMID:
20884859
29.

In vivo ocular efficacy profile of mapracorat, a novel selective glucocorticoid receptor agonist, in rabbit models of ocular disease.

Shafiee A, Bucolo C, Budzynski E, Ward KW, López FJ.

Invest Ophthalmol Vis Sci. 2011 Mar 14;52(3):1422-30. doi: 10.1167/iovs.10-5598.

PMID:
20881303
30.

Ocular pharmacokinetics/pharmacodynamics of besifloxacin, moxifloxacin, and gatifloxacin following topical administration to pigmented rabbits.

Proksch JW, Ward KW.

J Ocul Pharmacol Ther. 2010 Oct;26(5):449-58. doi: 10.1089/jop.2010.0054.

PMID:
20874668
32.

Successful treatment of pan-resistant Klebsiella pneumoniae pneumonia and bacteraemia with a combination of high-dose tigecycline and colistin.

Humphries RM, Kelesidis T, Dien Bard J, Ward KW, Bhattacharya D, Lewinski MA.

J Med Microbiol. 2010 Nov;59(Pt 11):1383-6. doi: 10.1099/jmm.0.023010-0. Epub 2010 Aug 5.

PMID:
20688947
33.

Comparative effects of besifloxacin and other fluoroquinolones on corneal reepithelialization in the rabbit.

Zhang JZ, Krenzer KL, López FJ, Ward KW.

J Cataract Refract Surg. 2010 Jun;36(6):1049-50. doi: 10.1016/j.jcrs.2010.03.034. No abstract available.

PMID:
20494783
34.

BOL-303242-X, a novel selective glucocorticoid receptor agonist, with full anti-inflammatory properties in human ocular cells.

Zhang JZ, Cavet ME, VanderMeid KR, Salvador-Silva M, López FJ, Ward KW.

Mol Vis. 2009 Dec 8;15:2606-16.

35.

Antagonists of the calcium receptor. 2. Amino alcohol-based parathyroid hormone secretagogues.

Marquis RW, Lago AM, Callahan JF, Rahman A, Dong X, Stroup GB, Hoffman S, Gowen M, DelMar EG, Van Wagenen BC, Logan S, Shimizu S, Fox J, Nemeth EF, Roethke T, Smith BR, Ward KW, Bhatnagar P.

J Med Chem. 2009 Nov 12;52(21):6599-605. doi: 10.1021/jm900563e.

PMID:
19821575
36.

Reduced myocilin expression in cultured monkey trabecular meshwork cells induced by a selective glucocorticoid receptor agonist: comparison with steroids.

Pfeffer BA, DeWitt CA, Salvador-Silva M, Cavet ME, López FJ, Ward KW.

Invest Ophthalmol Vis Sci. 2010 Jan;51(1):437-46. doi: 10.1167/iovs.09-4202. Epub 2009 Aug 20.

PMID:
19696178
37.

Comparison of the effect of multipurpose contact lens solutions on the viability of cultured corneal epithelial cells.

Cavet ME, Harrington KL, VanDerMeid KR, Ward KW, Zhang JZ.

Cont Lens Anterior Eye. 2009 Aug;32(4):171-5. doi: 10.1016/j.clae.2009.05.002. Epub 2009 Jun 21.

PMID:
19540795
38.

Vulnerability to (+)-methamphetamine effects and the relationship to drug disposition in pregnant rats during chronic infusion.

White SJ, Laurenzana EM, Gentry WB, Hendrickson HP, Williams DK, Ward KW, Owens SM.

Toxicol Sci. 2009 Sep;111(1):27-36. doi: 10.1093/toxsci/kfp127. Epub 2009 Jun 10.

39.

Ocular pharmacokinetics of besifloxacin following topical administration to rabbits, monkeys, and humans.

Proksch JW, Granvil CP, Siou-Mermet R, Comstock TL, Paterno MR, Ward KW.

J Ocul Pharmacol Ther. 2009 Aug;25(4):335-44. doi: 10.1089/jop.2008.0116.

PMID:
19492955
40.

Antagonists of the calcium receptor I. Amino alcohol-based parathyroid hormone secretagogues.

Marquis RW, Lago AM, Callahan JF, Trout RE, Gowen M, DelMar EG, Van Wagenen BC, Logan S, Shimizu S, Fox J, Nemeth EF, Yang Z, Roethke T, Smith BR, Ward KW, Lee J, Keenan RM, Bhatnagar P.

J Med Chem. 2009 Jul 9;52(13):3982-93. doi: 10.1021/jm900364m.

PMID:
19492813
41.

Exploration of the African green monkey as a preclinical pharmacokinetic model: oral pharmacokinetic parameters and drug-drug interactions.

Ward KW, Coon DJ, Magiera D, Bhadresa S, Struharik M, Lawrence MS.

Xenobiotica. 2009 Mar;39(3):266-72. doi: 10.1080/00498250802657718.

PMID:
19280525
42.

Protective effects of a coumarin derivative in diabetic rats.

Bucolo C, Ward KW, Mazzon E, Cuzzocrea S, Drago F.

Invest Ophthalmol Vis Sci. 2009 Aug;50(8):3846-52. doi: 10.1167/iovs.08-3328. Epub 2009 Mar 11.

PMID:
19279317
43.

Anti-inflammatory effects of besifloxacin, a novel fluoroquinolone, in primary human corneal epithelial cells.

Zhang JZ, Cavet ME, Ward KW.

Curr Eye Res. 2008 Nov;33(11):923-32. doi: 10.1080/02713680802478704.

PMID:
19085374
44.

New coumarin-based anti-inflammatory drug: putative antagonist of the integrins alphaLbeta2 and alphaMbeta2.

Bucolo C, Maltese A, Maugeri F, Ward KW, Baiula M, Spartà A, Spampinato S.

J Pharm Pharmacol. 2008 Nov;60(11):1473-9. doi: 10.1211/jpp.60.11.0008.

PMID:
18957168
45.

Nonclinical safety and pharmacokinetics of intravitreally administered human-derived plasmin in rabbits and minipigs.

Proksch JW, Driot JY, Vandeberg P, Ward KW.

J Ocul Pharmacol Ther. 2008 Jun;24(3):320-32. doi: 10.1089/jop.2007.0120.

PMID:
18476803
46.

Rabbit models of contact lens--associated corneal hypoxia: a review of the literature.

McCanna DJ, Driot JY, Hartsook R, Ward KW.

Eye Contact Lens. 2008 May;34(3):160-5. doi: 10.1097/ICL.0b013e31815788d7. Review.

PMID:
18463481
47.

Experimental determination and allometric prediction of vitreous volume, and retina and lens weights in Göttingen minipigs.

Shafiee A, McIntire GL, Sidebotham LC, Ward KW.

Vet Ophthalmol. 2008 May-Jun;11(3):193-6. doi: 10.1111/j.1463-5224.2008.00619.x.

PMID:
18435662
48.

Quantitative determination of besifloxacin, a novel fluoroquinolone antimicrobial agent, in human tears by liquid chromatography-tandem mass spectrometry.

Arnold DR, Granvil CP, Ward KW, Proksch JW.

J Chromatogr B Analyt Technol Biomed Life Sci. 2008 May 1;867(1):105-10. doi: 10.1016/j.jchromb.2008.03.025. Epub 2008 Apr 1.

PMID:
18417430
49.

Exploration of the African green monkey as a preclinical pharmacokinetic model: intravenous pharmacokinetic parameters.

Ward KW, Coon DJ, Magiera D, Bhadresa S, Nisbett E, Lawrence MS.

Drug Metab Dispos. 2008 Apr;36(4):715-20. doi: 10.1124/dmd.107.019315. Epub 2008 Jan 28.

PMID:
18227143
50.

Use of a human corneal epithelial cell line for screening the safety of contact lens care solutions in vitro.

McCanna DJ, Harrington KL, Driot JY, Ward KW, Tchao R.

Eye Contact Lens. 2008 Jan;34(1):6-12. doi: 10.1097/ICL.0b013e31804fa141.

PMID:
18180675

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