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A mathematical model demonstrating the role of interstitial fluid flow on the clearance and accumulation of amyloid β in the brain.

Chen CY, Tseng YH, Ward JP.

Math Biosci. 2019 Sep 25;317:108258. doi: 10.1016/j.mbs.2019.108258. [Epub ahead of print]


Circulating Tumor DNA Profiling in Small-Cell Lung Cancer Identifies Potentially Targetable Alterations.

Devarakonda S, Sankararaman S, Herzog BH, Gold KA, Waqar SN, Ward JP, Raymond VM, Lanman RB, Chaudhuri AA, Owonikoko TK, Li BT, Poirier JT, Rudin CM, Govindan R, Morgensztern D.

Clin Cancer Res. 2019 Oct 15;25(20):6119-6126. doi: 10.1158/1078-0432.CCR-19-0879. Epub 2019 Jul 12.


Mathematical modelling of contact dermatitis from nickel and chromium.

Ward JP, Franks SJ, Tindall MJ, King JR, Curtis A, Evans GS.

J Math Biol. 2019 Jul;79(2):595-630. doi: 10.1007/s00285-019-01371-2. Epub 2019 Jun 13.


Mujeres Fuertes y Corazones Saludables, a Culturally Tailored Physical Activity and Nutrition Program for Rural Latinas: Findings from a Pilot Study.

Seguin RA, Perry CK, Solanki E, McCalmont JC, Ward JP, Jackson C.

Int J Environ Res Public Health. 2019 Feb 21;16(4). pii: E630. doi: 10.3390/ijerph16040630.


High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.

Gubin MM, Esaulova E, Ward JP, Malkova ON, Runci D, Wong P, Noguchi T, Arthur CD, Meng W, Alspach E, Medrano RFV, Fronick C, Fehlings M, Newell EW, Fulton RS, Sheehan KCF, Oh ST, Schreiber RD, Artyomov MN.

Cell. 2018 Nov 15;175(5):1443. doi: 10.1016/j.cell.2018.11.003. No abstract available.


High-Dimensional Analysis Delineates Myeloid and Lymphoid Compartment Remodeling during Successful Immune-Checkpoint Cancer Therapy.

Gubin MM, Esaulova E, Ward JP, Malkova ON, Runci D, Wong P, Noguchi T, Arthur CD, Meng W, Alspach E, Medrano RFV, Fronick C, Fehlings M, Newell EW, Fulton RS, Sheehan KCF, Oh ST, Schreiber RD, Artyomov MN.

Cell. 2018 Nov 1;175(4):1014-1030.e19. doi: 10.1016/j.cell.2018.09.030. Epub 2018 Oct 18. Erratum in: Cell. 2018 Nov 15;175(5):1443.


Modelling the outbreak of infectious disease following mutation from a non-transmissible strain.

Chen CY, Ward JP, Xie WB.

Theor Popul Biol. 2019 Apr;126:1-18. doi: 10.1016/j.tpb.2018.08.002. Epub 2018 Aug 27.


Author Correction: Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells.

Fehlings M, Simoni Y, Penny HL, Becht E, Loh CY, Gubin MM, Ward JP, Wong SC, Schreiber RD, Newell EW.

Nat Commun. 2018 Jul 26;9(1):3000. doi: 10.1038/s41467-018-05468-y.


Profiling of healthy and asthmatic airway smooth muscle cells following interleukin-1β treatment: a novel role for CCL20 in chronic mucus hypersecretion.

Faiz A, Weckmann M, Tasena H, Vermeulen CJ, Van den Berge M, Ten Hacken NHT, Halayko AJ, Ward JPT, Lee TH, Tjin G, Black JL, Haghi M, Xu CJ, King GG, Farah CS, Oliver BG, Heijink IH, Burgess JK.

Eur Respir J. 2018 Aug 9;52(2). pii: 1800310. doi: 10.1183/13993003.00310-2018. Print 2018 Aug.


High Prevalence of Clinically Important Echocardiographic Abnormalities in Patients with a Normal Electrocardiogram Referred for Transthoracic Echocardiography.

Stone JR, Lee L, Ward JP, Ward RP.

J Am Soc Echocardiogr. 2018 Aug;31(8):926-932. doi: 10.1016/j.echo.2018.03.005. Epub 2018 May 31.


Role of reactive oxygen species and sulfide-quinone oxoreductase in hydrogen sulfide-induced contraction of rat pulmonary arteries.

Prieto-Lloret J, Snetkov VA, Shaifta Y, Docio I, Connolly MJ, MacKay CE, Knock GA, Ward JPT, Aaronson PI.

Am J Physiol Lung Cell Mol Physiol. 2018 Apr 1;314(4):L670-L685. doi: 10.1152/ajplung.00283.2016. Epub 2017 Dec 28.


Phenotype and Functional Features of Human Telomerase Reverse Transcriptase Immortalized Human Airway Smooth Muscle Cells from Asthmatic and Non-Asthmatic Donors.

Burgess JK, Ketheson A, Faiz A, Limbert Rempel KA, Oliver BG, Ward JPT, Halayko AJ.

Sci Rep. 2018 Jan 16;8(1):805. doi: 10.1038/s41598-017-18429-0.


Mujeres Fuertes y Corazones Saludables: adaptation of the StrongWomen -healthy hearts program for rural Latinas using an intervention mapping approach.

Perry CK, McCalmont JC, Ward JP, Menelas HK, Jackson C, De Witz JR, Solanki E, Seguin RA.

BMC Public Health. 2017 Dec 28;17(1):982. doi: 10.1186/s12889-017-4842-2.


Numerical Modelling of Effects of Biphasic Layers of Corrosion Products to the Degradation of Magnesium Metal In Vitro.

Ahmed SK, Ward JP, Liu Y.

Materials (Basel). 2017 Dec 21;11(1). pii: E1. doi: 10.3390/ma11010001.


Transforming growth factor-β enhances Rho-kinase activity and contraction in airway smooth muscle via the nucleotide exchange factor ARHGEF1.

Shaifta Y, MacKay CE, Irechukwu N, O'Brien KA, Wright DB, Ward JPT, Knock GA.

J Physiol. 2018 Jan 1;596(1):47-66. doi: 10.1113/JP275033. Epub 2017 Nov 23.


From Physiological Redox Signalling to Oxidant Stress.

Ward JPT.

Adv Exp Med Biol. 2017;967:335-342. doi: 10.1007/978-3-319-63245-2_21.


Checkpoint blockade immunotherapy reshapes the high-dimensional phenotypic heterogeneity of murine intratumoural neoantigen-specific CD8+ T cells.

Fehlings M, Simoni Y, Penny HL, Becht E, Loh CY, Gubin MM, Ward JP, Wong SC, Schreiber RD, Newell EW.

Nat Commun. 2017 Sep 15;8(1):562. doi: 10.1038/s41467-017-00627-z. Erratum in: Nat Commun. 2018 Jul 26;9(1):3000.


ROS-dependent activation of RhoA/Rho-kinase in pulmonary artery: Role of Src-family kinases and ARHGEF1.

MacKay CE, Shaifta Y, Snetkov VV, Francois AA, Ward JPT, Knock GA.

Free Radic Biol Med. 2017 Sep;110:316-331. doi: 10.1016/j.freeradbiomed.2017.06.022. Epub 2017 Jul 1.


Steerable Wavelet Machines (SWM): Learning Moving Frames for Texture Classification.

Depeursinge A, Puspoki Z, Ward JP, Unser M.

IEEE Trans Image Process. 2017 Apr;26(4):1626-1636. doi: 10.1109/TIP.2017.2655438. Epub 2017 Jan 18.


Temporally Distinct PD-L1 Expression by Tumor and Host Cells Contributes to Immune Escape.

Noguchi T, Ward JP, Gubin MM, Arthur CD, Lee SH, Hundal J, Selby MJ, Graziano RF, Mardis ER, Korman AJ, Schreiber RD.

Cancer Immunol Res. 2017 Feb;5(2):106-117. doi: 10.1158/2326-6066.CIR-16-0391. Epub 2017 Jan 10.


Physiological redox signalling and regulation of ion channels: implications for pulmonary hypertension.

Ward JPT.

Exp Physiol. 2017 Sep 1;102(9):1078-1082. doi: 10.1113/EP086040. Epub 2017 Jan 13. Review.


Endogenous Neoantigen-Specific CD8 T Cells Identified in Two Glioblastoma Models Using a Cancer Immunogenomics Approach.

Johanns TM, Ward JP, Miller CA, Wilson C, Kobayashi DK, Bender D, Fu Y, Alexandrov A, Mardis ER, Artyomov MN, Schreiber RD, Dunn GP.

Cancer Immunol Res. 2016 Dec;4(12):1007-1015. Epub 2016 Oct 31.


Sigmatropic Rearrangement of Vinyl Aziridines: Expedient Synthesis of Cyclic Sulfoximines from Chiral Sulfinimines.

Moragas T, Liffey RM, Regentová D, Ward JP, Dutton J, Lewis W, Churcher I, Walton L, Souto JA, Stockman RA.

Angew Chem Int Ed Engl. 2016 Aug 16;55(34):10047-51. doi: 10.1002/anie.201604188. Epub 2016 Jul 13.


Total Hip Arthroplasty After Proximal Femoral Osteotomy: A Technique That Can Be Used to Address Presence of a Retained Intracortical Plate.

Uquillas CA, Ward JP, Zuckerman JD.

Am J Orthop (Belle Mead NJ). 2016 May-Jun;45(4):E224-6.


Latrophilin receptors: novel bronchodilator targets in asthma.

Faiz A, Donovan C, Nieuwenhuis MA, van den Berge M, Postma DS, Yao S, Park CY, Hirsch R, Fredberg JJ, Tjin G, Halayko AJ, Rempel KL, Ward JP, Lee T, Bossé Y, Nickle DC, Obeidat M, Vonk JM, Black JL, Oliver BG, Krishnan R, McParland B, Bourke JE, Burgess JK.

Thorax. 2017 Jan;72(1):74-82. doi: 10.1136/thoraxjnl-2015-207236. Epub 2016 Jun 20.


Predicting tyrosinaemia: a mathematical model of 4-hydroxyphenylpyruvate dioxygenase inhibition by nitisinone in rats.

Ward JP, Dunster JL, Derks G, Mistry P, Salazar JD.

Math Med Biol. 2017 Sep 1;34(3):335-390. doi: 10.1093/imammb/dqw006.


CD155 on HIV-Infected Cells Is Not Modulated by HIV-1 Vpu and Nef but Synergizes with NKG2D Ligands to Trigger NK Cell Lysis of Autologous Primary HIV-Infected Cells.

Davis ZB, Sowrirajan B, Cogswell A, Ward JP, Planelles V, Barker E.

AIDS Res Hum Retroviruses. 2017 Feb;33(2):93-100. doi: 10.1089/AID.2015.0375. Epub 2016 Jul 20.


The Role of Neoantigens in Naturally Occurring and Therapeutically Induced Immune Responses to Cancer.

Ward JP, Gubin MM, Schreiber RD.

Adv Immunol. 2016;130:25-74. doi: 10.1016/ Epub 2016 Feb 10. Review.


SpotCaliper: fast wavelet-based spot detection with accurate size estimation.

Püspöki Z, Sage D, Ward JP, Unser M.

Bioinformatics. 2016 Apr 15;32(8):1278-80. doi: 10.1093/bioinformatics/btv728. Epub 2015 Dec 10.


Divergent modulation of Rho-kinase and Ca(2+) influx pathways by Src family kinases and focal adhesion kinase in airway smooth muscle.

Shaifta Y, Irechukwu N, Prieto-Lloret J, MacKay CE, Marchon KA, Ward JP, Knock GA.

Br J Pharmacol. 2015 Nov;172(22):5265-80. doi: 10.1111/bph.13313. Epub 2015 Oct 23.


Wound Closure in Nonidiopathic Scoliosis: Does Closure Matter?

Ward JP, Feldman DS, Paul J, Sala DA, Errico TJ, Otsuka NY, Margiotta MS.

J Pediatr Orthop. 2017 Apr/May;37(3):166-170. doi: 10.1097/BPO.0000000000000610.


Optimized Kaiser-Bessel Window Functions for Computed Tomography.

Nilchian M, Ward JP, Vonesch C, Unser M.

IEEE Trans Image Process. 2015 Nov;24(11):3826-33. doi: 10.1109/TIP.2015.2451955. Epub 2015 Jul 1.


Sphingosylphosphorylcholine potentiates vasoreactivity and voltage-gated Ca2+ entry via NOX1 and reactive oxygen species.

Shaifta Y, Snetkov VA, Prieto-Lloret J, Knock GA, Smirnov SV, Aaronson PI, Ward JP.

Cardiovasc Res. 2015 Apr 1;106(1):121-30. doi: 10.1093/cvr/cvv029. Epub 2015 Feb 6.


Hypoxic pulmonary vasoconstriction in isolated rat pulmonary arteries is not inhibited by antagonists of H2 S-synthesizing pathways.

Prieto-Lloret J, Shaifta Y, Ward JP, Aaronson PI.

J Physiol. 2015 Jan 15;593(2):385-401. doi: 10.1113/jphysiol.2014.277046.


A mathematical model of the growth of uterine myomas.

Chen CY, Ward JP.

Bull Math Biol. 2014 Dec;76(12):3088-121. doi: 10.1007/s11538-014-0045-5. Epub 2014 Dec 3.


Checkpoint blockade cancer immunotherapy targets tumour-specific mutant antigens.

Gubin MM, Zhang X, Schuster H, Caron E, Ward JP, Noguchi T, Ivanova Y, Hundal J, Arthur CD, Krebber WJ, Mulder GE, Toebes M, Vesely MD, Lam SS, Korman AJ, Allison JP, Freeman GJ, Sharpe AH, Pearce EL, Schumacher TN, Aebersold R, Rammensee HG, Melief CJ, Mardis ER, Gillanders WE, Artyomov MN, Schreiber RD.

Nature. 2014 Nov 27;515(7528):577-81. doi: 10.1038/nature13988.


Protective role of p450 epoxyeicosanoids in subarachnoid hemorrhage.

Siler DA, Martini RP, Ward JP, Nelson JW, Borkar RN, Zuloaga KL, Liu JJ, Fairbanks SL, Raskin JS, Anderson VC, Dogan A, Wang RK, Alkayed NJ, Cetas JS.

Neurocrit Care. 2015 Apr;22(2):306-19. doi: 10.1007/s12028-014-0011-y.


Ruptures of the distal biceps tendon.

Ward JP, Shreve MC, Youm T, Strauss EJ.

Bull Hosp Jt Dis (2013). 2014;72(1):110-9. Review.


Bidirectional cross-regulation between the endothelial nitric oxide synthase and β-catenin signalling pathways.

Warboys CM, Chen N, Zhang Q, Shaifta Y, Vanderslott G, Passacquale G, Hu Y, Xu Q, Ward JP, Ferro A.

Cardiovasc Res. 2014 Oct 1;104(1):116-26. doi: 10.1093/cvr/cvu173. Epub 2014 Jul 25.


Sphingosine-1-phosphate induces pro-remodelling response in airway smooth muscle cells.

Fuerst E, Foster HR, Ward JP, Corrigan CJ, Cousins DJ, Woszczek G.

Allergy. 2014 Nov;69(11):1531-9. doi: 10.1111/all.12489. Epub 2014 Sep 6.


Ca2+ handling and sensitivity in airway smooth muscle: emerging concepts for mechanistic understanding and therapeutic targeting.

Koopmans T, Anaparti V, Castro-Piedras I, Yarova P, Irechukwu N, Nelson C, Perez-Zoghbi J, Tan X, Ward JP, Wright DB.

Pulm Pharmacol Ther. 2014 Dec;29(2):108-20. doi: 10.1016/j.pupt.2014.05.001. Epub 2014 May 14. Review.


Adaptive image resizing based on continuous-domain stochastic modeling.

Kirshner H, Bourquard A, Ward JP, Porat M, Unser M.

IEEE Trans Image Process. 2014 Jan;23(1):413-23.


Decision making in the in-season athlete with shoulder instability.

Ward JP, Bradley JP.

Clin Sports Med. 2013 Oct;32(4):685-96. doi: 10.1016/j.csm.2013.07.005. Epub 2013 Aug 17. Review.


Complete Dissociation of the Polyethylene Component in a Newly Available Dual-Mobility Bearing Used in Total Hip Arthroplasty: A Case Report.

Ward JP, McCardel BR, Hallstrom BR.

JBJS Case Connect. 2013 Sep 25;3(3 Suppl 9):e941-4. doi: 10.2106/JBJS.CC.L.00213. No abstract available.


Is prophylactic surgery for femoroacetabular impingement indicated? A systematic review.

Collins JA, Ward JP, Youm T.

Am J Sports Med. 2014 Dec;42(12):3009-15. doi: 10.1177/0363546513499227. Epub 2013 Aug 21. Review.


Hypoxic pulmonary hypertension; the load on the right ventricle. Introduction.

McLoughlin P, Ward JP.

Exp Physiol. 2013 Aug;98(8):1244-6. doi: 10.1113/expphysiol.2012.068940. No abstract available.


Hypoxic pulmonary vasoconstriction in the absence of pretone: essential role for intracellular Ca2+ release.

Connolly MJ, Prieto-Lloret J, Becker S, Ward JP, Aaronson PI.

J Physiol. 2013 Sep 15;591(18):4473-98. doi: 10.1113/jphysiol.2013.253682. Epub 2013 Jun 17.


Gap junctions support the sustained phase of hypoxic pulmonary vasoconstriction by facilitating calcium sensitization.

Kizub IV, Strielkov IV, Shaifta Y, Becker S, Prieto-Lloret J, Snetkov VA, Soloviev AI, Aaronson PI, Ward JP.

Cardiovasc Res. 2013 Aug 1;99(3):404-11. doi: 10.1093/cvr/cvt129. Epub 2013 May 25.

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