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Items: 1 to 50 of 149

1.

Structural and mechanistic insights into the function of the unconventional class XIV myosin MyoA from Toxoplasma gondii.

Powell CJ, Ramaswamy R, Kelsen A, Hamelin DJ, Warshaw DM, Bosch J, Burke JE, Ward GE, Boulanger MJ.

Proc Natl Acad Sci U S A. 2018 Nov 6;115(45):E10548-E10555. doi: 10.1073/pnas.1811167115. Epub 2018 Oct 22.

PMID:
30348763
2.

Impact of egg handling and conditions during extended storage on egg quality.

Jones DR, Ward GE, Regmi P, Karcher DM.

Poult Sci. 2018 Feb 1;97(2):716-723. doi: 10.3382/ps/pex351.

PMID:
29253282
3.

Dissecting the molecular assembly of the Toxoplasma gondii MyoA motility complex.

Powell CJ, Jenkins ML, Parker ML, Ramaswamy R, Kelsen A, Warshaw DM, Ward GE, Burke JE, Boulanger MJ.

J Biol Chem. 2017 Nov 24;292(47):19469-19477. doi: 10.1074/jbc.M117.809632. Epub 2017 Sep 25.

PMID:
28972141
4.

Parasites lacking the micronemal protein MIC2 are deficient in surface attachment and host cell egress, but remain virulent in vivo.

Gras S, Jackson A, Woods S, Pall G, Whitelaw J, Leung JM, Ward GE, Roberts CW, Meissner M.

Wellcome Open Res. 2017 Jul 24;2:32. doi: 10.12688/wellcomeopenres.11594.2. eCollection 2017.

5.

Surface attachment, promoted by the actomyosin system of Toxoplasma gondii is important for efficient gliding motility and invasion.

Whitelaw JA, Latorre-Barragan F, Gras S, Pall GS, Leung JM, Heaslip A, Egarter S, Andenmatten N, Nelson SR, Warshaw DM, Ward GE, Meissner M.

BMC Biol. 2017 Jan 18;15(1):1. doi: 10.1186/s12915-016-0343-5.

6.

Not a Simple Tether: Binding of Toxoplasma gondii AMA1 to RON2 during Invasion Protects AMA1 from Rhomboid-Mediated Cleavage and Leads to Dephosphorylation of Its Cytosolic Tail.

Krishnamurthy S, Deng B, Del Rio R, Buchholz KR, Treeck M, Urban S, Boothroyd J, Lam YW, Ward GE.

MBio. 2016 Sep 13;7(5). pii: e00754-16. doi: 10.1128/mBio.00754-16.

7.

Global Analysis of Palmitoylated Proteins in Toxoplasma gondii.

Foe IT, Child MA, Majmudar JD, Krishnamurthy S, van der Linden WA, Ward GE, Martin BR, Bogyo M.

Cell Host Microbe. 2015 Oct 14;18(4):501-11. doi: 10.1016/j.chom.2015.09.006.

8.

Yeast three-hybrid screen identifies TgBRADIN/GRA24 as a negative regulator of Toxoplasma gondii bradyzoite differentiation.

Odell AV, Tran F, Foderaro JE, Poupart S, Pathak R, Westwood NJ, Ward GE.

PLoS One. 2015 Mar 19;10(3):e0120331. doi: 10.1371/journal.pone.0120331. eCollection 2015.

9.

A Toxoplasma gondii class XIV myosin, expressed in Sf9 cells with a parasite co-chaperone, requires two light chains for fast motility.

Bookwalter CS, Kelsen A, Leung JM, Ward GE, Trybus KM.

J Biol Chem. 2014 Oct 31;289(44):30832-41. doi: 10.1074/jbc.M114.572453. Epub 2014 Sep 17.

10.

Calcium-dependent phosphorylation alters class XIVa myosin function in the protozoan parasite Toxoplasma gondii.

Tang Q, Andenmatten N, Hortua Triana MA, Deng B, Meissner M, Moreno SN, Ballif BA, Ward GE.

Mol Biol Cell. 2014 Sep 1;25(17):2579-91. doi: 10.1091/mbc.E13-11-0648. Epub 2014 Jul 2.

11.

Identification of T. gondii myosin light chain-1 as a direct target of TachypleginA-2, a small-molecule inhibitor of parasite motility and invasion.

Leung JM, Tran F, Pathak RB, Poupart S, Heaslip AT, Ballif BA, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 3;9(6):e98056. doi: 10.1371/journal.pone.0098056. eCollection 2014.

12.

Identification of TgCBAP, a novel cytoskeletal protein that localizes to three distinct subcompartments of the Toxoplasma gondii pellicle.

Tilley LD, Krishnamurthy S, Westwood NJ, Ward GE.

PLoS One. 2014 Jun 2;9(6):e98492. doi: 10.1371/journal.pone.0098492. eCollection 2014.

13.

Identification of Cryptosporidium parvum active chemical series by Repurposing the open access malaria box.

Bessoff K, Spangenberg T, Foderaro JE, Jumani RS, Ward GE, Huston CD.

Antimicrob Agents Chemother. 2014 May;58(5):2731-9. doi: 10.1128/AAC.02641-13. Epub 2014 Feb 24.

14.

Disruption of TgPHIL1 alters specific parameters of Toxoplasma gondii motility measured in a quantitative, three-dimensional live motility assay.

Leung JM, Rould MA, Konradt C, Hunter CA, Ward GE.

PLoS One. 2014 Jan 29;9(1):e85763. doi: 10.1371/journal.pone.0085763. eCollection 2014.

15.

A modular approach to triazole-containing chemical inducers of dimerisation for yeast three-hybrid screening.

Tran F, Odell AV, Ward GE, Westwood NJ.

Molecules. 2013 Sep 23;18(9):11639-57. doi: 10.3390/molecules180911639.

16.

Intramembrane proteolysis of Toxoplasma apical membrane antigen 1 facilitates host-cell invasion but is dispensable for replication.

Parussini F, Tang Q, Moin SM, Mital J, Urban S, Ward GE.

Proc Natl Acad Sci U S A. 2012 May 8;109(19):7463-8. doi: 10.1073/pnas.1114661109. Epub 2012 Apr 20.

17.

Targeted disruption of TgPhIL1 in Toxoplasma gondii results in altered parasite morphology and fitness.

Barkhuff WD, Gilk SD, Whitmarsh R, Tilley LD, Hunter C, Ward GE.

PLoS One. 2011;6(8):e23977. doi: 10.1371/journal.pone.0023977. Epub 2011 Aug 25.

18.

Chemical genetic screen identifies Toxoplasma DJ-1 as a regulator of parasite secretion, attachment, and invasion.

Hall CI, Reese ML, Weerapana E, Child MA, Bowyer PW, Albrow VE, Haraldsen JD, Phillips MR, Sandoval ED, Ward GE, Cravatt BF, Boothroyd JC, Bogyo M.

Proc Natl Acad Sci U S A. 2011 Jun 28;108(26):10568-73. doi: 10.1073/pnas.1105622108. Epub 2011 Jun 13.

19.

Toxoplasma gondii transmembrane microneme proteins and their modular design.

Sheiner L, Santos JM, Klages N, Parussini F, Jemmely N, Friedrich N, Ward GE, Soldati-Favre D.

Mol Microbiol. 2010 Aug;77(4):912-29. doi: 10.1111/j.1365-2958.2010.07255.x. Epub 2010 Jun 9.

20.

A small-molecule inhibitor of T. gondii motility induces the posttranslational modification of myosin light chain-1 and inhibits myosin motor activity.

Heaslip AT, Leung JM, Carey KL, Catti F, Warshaw DM, Westwood NJ, Ballif BA, Ward GE.

PLoS Pathog. 2010 Jan 15;6(1):e1000720. doi: 10.1371/journal.ppat.1000720.

21.

IDENTIFICATION OF CONOIDIN A AS A COVALENT INHIBITOR OF PEROXIREDOXIN II.

Haraldsen JD, Liu G, Botting CH, Walton JG, Storm J, Phalen TJ, Kwok LY, Soldati-Favre D, Heintz NH, Müller S, Westwood NJ, Ward GE.

Org Biomol Chem. 2009;7:3040-3048.

22.

GAP45 phosphorylation controls assembly of the Toxoplasma myosin XIV complex.

Gilk SD, Gaskins E, Ward GE, Beckers CJ.

Eukaryot Cell. 2009 Feb;8(2):190-6. doi: 10.1128/EC.00201-08. Epub 2008 Dec 1.

23.

Current and emerging approaches to studying invasion in apicomplexan parasites.

Mital J, Ward GE.

Subcell Biochem. 2008;47:1-32. Review.

PMID:
18512338
24.

Gene expression signatures and small-molecule compounds link a protein kinase to Plasmodium falciparum motility.

Kato N, Sakata T, Breton G, Le Roch KG, Nagle A, Andersen C, Bursulaya B, Henson K, Johnson J, Kumar KA, Marr F, Mason D, McNamara C, Plouffe D, Ramachandran V, Spooner M, Tuntland T, Zhou Y, Peters EC, Chatterjee A, Schultz PG, Ward GE, Gray N, Harper J, Winzeler EA.

Nat Chem Biol. 2008 Jun;4(6):347-56. doi: 10.1038/nchembio.87. Epub 2008 May 4.

PMID:
18454143
25.

Synthesis and chemical characterisation of target identification reagents based on an inhibitor of human cell invasion by the parasite Toxoplasma gondii.

Evans KM, Haraldsen JD, Pearson RJ, Slawin AM, Ward GE, Westwood NJ.

Org Biomol Chem. 2007 Jul 7;5(13):2063-9. Epub 2007 May 31.

PMID:
17581649
26.

Targeting invasion and egress: from tools to drugs?

Morgan RE, Evans KM, Patterson S, Catti F, Ward GE, Westwood NJ.

Curr Drug Targets. 2007 Jan;8(1):61-74. Review.

PMID:
17266531
27.
28.

Targeted deletion of MIC5 enhances trimming proteolysis of Toxoplasma invasion proteins.

Brydges SD, Zhou XW, Huynh MH, Harper JM, Mital J, Adjogble KD, Däubener W, Ward GE, Carruthers VB.

Eukaryot Cell. 2006 Dec;5(12):2174-83. Epub 2006 Sep 15.

29.
30.

Identification of the moving junction complex of Toxoplasma gondii: a collaboration between distinct secretory organelles.

Alexander DL, Mital J, Ward GE, Bradley P, Boothroyd JC.

PLoS Pathog. 2005 Oct;1(2):e17. Epub 2005 Oct 21.

31.
32.
33.

A small-molecule approach to studying invasive mechanisms of Toxoplasma gondii.

Carey KL, Westwood NJ, Mitchison TJ, Ward GE.

Proc Natl Acad Sci U S A. 2004 May 11;101(19):7433-8. Epub 2004 May 3.

35.

Using small molecules to study big questions in cellular microbiology.

Ward GE, Carey KL, Westwood NJ.

Cell Microbiol. 2002 Aug;4(8):471-82. Review.

PMID:
12174082
37.
38.

Identification and molecular characterization of GRA8, a novel, proline-rich, dense granule protein of Toxoplasma gondii.

Carey KL, Donahue CG, Ward GE.

Mol Biochem Parasitol. 2000 Jan 5;105(1):25-37.

PMID:
10613696
40.

Novel secretory pathways in Plasmodium?

Mattei D, Ward GE, Langsley G, Lingelbach K.

Parasitol Today. 1999 Jun;15(6):235-7. Review.

PMID:
10366830
41.
42.

Rab GTPases and the unusual secretory pathway of plasmodium.

Ward GE, Tilney LG, Langsley G.

Parasitol Today. 1997 Feb;13(2):57-62.

PMID:
15275124
43.

Identification of a family of Rab G-proteins in Plasmodium falciparum and a detailed characterisation of pfrab6.

de Castro FA, Ward GE, Jambou R, Attal G, Mayau V, Jaureguiberry G, Braun-Breton C, Chakrabarti D, Langsley G.

Mol Biochem Parasitol. 1996 Sep;80(1):77-88.

PMID:
8885224
44.
45.

Staurosporine inhibits invasion of erythrocytes by malarial merozoites.

Ward GE, Fujioka H, Aikawa M, Miller LH.

Exp Parasitol. 1994 Nov;79(3):480-7.

PMID:
7957765
46.

Specific in situ hybridization of the intracellular organism of porcine proliferative enteropathy.

Gebhart CJ, McOrist S, Lawson GH, Collins JE, Ward GE.

Vet Pathol. 1994 Jul;31(4):462-7.

PMID:
7941236
47.

Relationship between Ileal symbiont intracellularis and porcine proliferative enteritis.

Jones GF, Ward GE, Murtaugh MP, Rose R, Gebhart CJ.

Infect Immun. 1993 Dec;61(12):5237-44.

48.

Comparison of techniques for diagnosis of proliferative enteritis of swine.

Jones GF, Davies PR, Rose R, Ward GE, Murtaugh MP.

Am J Vet Res. 1993 Dec;54(12):1980-5.

PMID:
7509582
49.
50.

Use of a DNA probe to detect the intracellular organism of proliferative enteritis in swine feces.

Jones GF, Ward GE, Gebhart CJ, Murtaugh MP, Collins JE.

Am J Vet Res. 1993 Oct;54(10):1585-90.

PMID:
8250381

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