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Phase 2 study of efgartigimod, a novel FcRn antagonist, in adult patients with primary immune thrombocytopenia.

Newland AC, Sánchez-González B, Rejtő L, Egyed M, Romanyuk N, Godar M, Verschueren K, Gandini D, Ulrichts P, Beauchamp J, Dreier T, Ward ES, Michel M, Liebman HA, de Haard H, Leupin N, Kuter DJ.

Am J Hematol. 2020 Feb;95(2):178-187. doi: 10.1002/ajh.25680. Epub 2019 Dec 10.


A two-stage method for automated detection of ring-like endosomes in fluorescent microscopy images.

Lin D, Lin Z, Cao J, Velmurugan R, Ward ES, Ober RJ.

PLoS One. 2019 Jun 27;14(6):e0218931. doi: 10.1371/journal.pone.0218931. eCollection 2019.


Randomized phase 2 study of FcRn antagonist efgartigimod in generalized myasthenia gravis.

Howard JF Jr, Bril V, Burns TM, Mantegazza R, Bilinska M, Szczudlik A, Beydoun S, Garrido FJRR, Piehl F, Rottoli M, Van Damme P, Vu T, Evoli A, Freimer M, Mozaffar T, Ward ES, Dreier T, Ulrichts P, Verschueren K, Guglietta A, de Haard H, Leupin N, Verschuuren JJGM; Efgartigimod MG Study Group.

Neurology. 2019 Jun 4;92(23):e2661-e2673. doi: 10.1212/WNL.0000000000007600. Epub 2019 May 22.


Neonatal Fc receptor expression in macrophages is indispensable for IgG homeostasis.

Challa DK, Wang X, Montoyo HP, Velmurugan R, Ober RJ, Ward ES.

MAbs. 2019 Jul;11(5):848-860. doi: 10.1080/19420862.2019.1602459. Epub 2019 Apr 30.


Engineering a HER2-specific antibody-drug conjugate to increase lysosomal delivery and therapeutic efficacy.

Kang JC, Sun W, Khare P, Karimi M, Wang X, Shen Y, Ober RJ, Ward ES.

Nat Biotechnol. 2019 May;37(5):523-526. doi: 10.1038/s41587-019-0073-7. Epub 2019 Apr 1.


Targeting FcRn to Generate Antibody-Based Therapeutics.

Ward ES, Ober RJ.

Trends Pharmacol Sci. 2018 Oct;39(10):892-904. doi: 10.1016/ Epub 2018 Aug 22. Review.


BCAP links IL-1R to the PI3K-mTOR pathway and regulates pathogenic Th17 cell differentiation.

Deason K, Troutman TD, Jain A, Challa DK, Mandraju R, Brewer T, Ward ES, Pasare C.

J Exp Med. 2018 Sep 3;215(9):2413-2428. doi: 10.1084/jem.20171810. Epub 2018 Aug 9.


Neonatal Fc receptor antagonist efgartigimod safely and sustainably reduces IgGs in humans.

Ulrichts P, Guglietta A, Dreier T, van Bragt T, Hanssens V, Hofman E, Vankerckhoven B, Verheesen P, Ongenae N, Lykhopiy V, Enriquez FJ, Cho J, Ober RJ, Ward ES, de Haard H, Leupin N.

J Clin Invest. 2018 Oct 1;128(10):4372-4386. doi: 10.1172/JCI97911. Epub 2018 Jul 24.


Phagocytosis of antibody-opsonized tumor cells leads to the formation of a discrete vacuolar compartment in macrophages.

Velmurugan R, Ramakrishnan S, Kim M, Ober RJ, Ward ES.

Traffic. 2018 Apr;19(4):273-284. doi: 10.1111/tra.12552.


Myelin oligodendrocyte glycoprotein-specific antibodies from multiple sclerosis patients exacerbate disease in a humanized mouse model.

Khare P, Challa DK, Devanaboyina SC, Velmurugan R, Hughes S, Greenberg BM, Ober RJ, Ward ES.

J Autoimmun. 2018 Jan;86:104-115. doi: 10.1016/j.jaut.2017.09.002. Epub 2017 Sep 28.


Targeting Phosphatidylserine with Calcium-Dependent Protein-Drug Conjugates for the Treatment of Cancer.

Li R, Chiguru S, Li L, Kim D, Velmurugan R, Kim D, Devanaboyina SC, Tian H, Schroit A, Mason RP, Ober RJ, Ward ES.

Mol Cancer Ther. 2018 Jan;17(1):169-182. doi: 10.1158/1535-7163.MCT-17-0092. Epub 2017 Sep 22.


Hepatic function of FcRn revealed: Implications for overcoming drug-mediated hepatotoxicity.

Ward ES, Ober RJ.

Hepatology. 2017 Dec;66(6):2083-2085. doi: 10.1002/hep.29476. Epub 2017 Nov 8. No abstract available.


A state space based approach to localizing single molecules from multi-emitter images.

Vahid MR, Chao J, Ward ES, Ober RJ.

Proc SPIE Int Soc Opt Eng. 2017 Jan 28;10070. pii: 100700J. doi: 10.1117/12.2253175. Epub 2017 Feb 17.


State space approach to single molecule localization in fluorescence microscopy.

Vahid MR, Chao J, Kim D, Ward ES, Ober RJ.

Biomed Opt Express. 2017 Feb 6;8(3):1332-1355. doi: 10.1364/BOE.8.001332. eCollection 2017 Mar 1.


Remote focusing multifocal plane microscopy for the imaging of 3D single molecule dynamics with cellular context.

Chao J, Velmurugan R, You S, Kim D, Ward ES, Ober RJ.

Proc SPIE Int Soc Opt Eng. 2017 Jan 28;10070. pii: 100700L. doi: 10.1117/12.2251218. Epub 2017 Feb 17.


Engineered clearing agents for the selective depletion of antigen-specific antibodies.

Devanaboyina SC, Khare P, Challa DK, Ober RJ, Ward ES.

Nat Commun. 2017 May 31;8:15314. doi: 10.1038/ncomms15314.


Intensity-based axial localization approaches for multifocal plane microscopy.

Velmurugan R, Chao J, Ram S, Ward ES, Ober RJ.

Opt Express. 2017 Feb 20;25(4):3394-3410. doi: 10.1364/OE.25.003394.


Detection of phosphatidylserine-positive exosomes as a diagnostic marker for ovarian malignancies: a proof of concept study.

Lea J, Sharma R, Yang F, Zhu H, Ward ES, Schroit AJ.

Oncotarget. 2017 Feb 28;8(9):14395-14407. doi: 10.18632/oncotarget.14795.


Loss of expression of the recycling receptor, FcRn, promotes tumor cell growth by increasing albumin consumption.

Swiercz R, Mo M, Khare P, Schneider Z, Ober RJ, Ward ES.

Oncotarget. 2017 Jan 10;8(2):3528-3541. doi: 10.18632/oncotarget.13869.


Antigen dynamics govern the induction of CD4(+) T cell tolerance during autoimmunity.

Challa DK, Mi W, Lo ST, Ober RJ, Ward ES.

J Autoimmun. 2016 Aug;72:84-94. doi: 10.1016/j.jaut.2016.05.007. Epub 2016 May 25.


Macrophage-Mediated Trogocytosis Leads to Death of Antibody-Opsonized Tumor Cells.

Velmurugan R, Challa DK, Ram S, Ober RJ, Ward ES.

Mol Cancer Ther. 2016 Aug;15(8):1879-89. doi: 10.1158/1535-7163.MCT-15-0335. Epub 2016 May 25.


Investigating the usage of point spread functions in point source and microsphere localization.

Chao J, Ram S, Ward ES, Ober RJ.

Proc SPIE Int Soc Opt Eng. 2016 Feb 13;9713. pii: 97131M. Epub 2016 Mar 9.


A Distinct Class of Antibodies May Be an Indicator of Gray Matter Autoimmunity in Early and Established Relapsing Remitting Multiple Sclerosis Patients.

Ligocki AJ, Rivas JR, Rounds WH, Guzman AA, Li M, Spadaro M, Lahey L, Chen D, Henson PM, Graves D, Greenberg BM, Frohman EM, Ward ES, Robinson W, Meinl E, White CL 3rd, Stowe AM, Monson NL.

ASN Neuro. 2015 Oct 21;7(5). pii: 1759091415609613. doi: 10.1177/1759091415609613. Print 2015 Sep-Oct.


New results on the single molecule localization problem in two and three dimensions.

Tahmasb A, Ward ES, Ober RJ.

Proc SPIE Int Soc Opt Eng. 2015 Aug 9;9554. pii: 955402.


Commentary: "There's been a Flaw in Our Thinking".

Ward ES, Ober RJ.

Front Immunol. 2015 Jul 16;6:351. doi: 10.3389/fimmu.2015.00351. eCollection 2015. No abstract available.


Fluorescent Microspheres as Point Sources: A Localization Study.

Chao J, Lee T, Ward ES, Ober RJ.

PLoS One. 2015 Jul 28;10(7):e0134112. doi: 10.1371/journal.pone.0134112. eCollection 2015.


Investigation of the numerics of point spread function integration in single molecule localization.

Chao J, Ram S, Lee T, Ward ES, Ober RJ.

Opt Express. 2015 Jun 29;23(13):16866-83. doi: 10.1364/OE.23.016866.


Quantitative Aspects of Single Molecule Microscopy.

Ober RJ, Tahmasbi A, Ram S, Lin Z, Ward ES.

IEEE Signal Process Mag. 2015 Jan;32(1):58-69.


An information-theoretic approach to designing the plane spacing for multifocal plane microscopy.

Tahmasbi A, Ram S, Chao J, Abraham AV, Ward ES, Ober RJ.

Proc SPIE Int Soc Opt Eng. 2015 Feb 7;9330. pii: 933011.


Determination of localization accuracy based on experimentally acquired image sets: applications to single molecule microscopy.

Tahmasbi A, Ward ES, Ober RJ.

Opt Express. 2015 Mar 23;23(6):7630-52. doi: 10.1364/OE.23.007630.


Targeting FcRn for the modulation of antibody dynamics.

Ward ES, Devanaboyina SC, Ober RJ.

Mol Immunol. 2015 Oct;67(2 Pt A):131-41. doi: 10.1016/j.molimm.2015.02.007. Epub 2015 Mar 9. Review.


The level of HER2 expression is a predictor of antibody-HER2 trafficking behavior in cancer cells.

Ram S, Kim D, Ober RJ, Ward ES.

MAbs. 2014;6(5):1211-9. doi: 10.4161/mabs.29865.


Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer.

Poovassery JS, Kang JC, Kim D, Ober RJ, Ward ES.

Int J Cancer. 2015 Jul 15;137(2):267-77. doi: 10.1002/ijc.29378. Epub 2014 Dec 19.


Designing the focal plane spacing for multifocal plane microscopy.

Tahmasbi A, Ram S, Chao J, Abraham AV, Tang FW, Ward ES, Ober RJ.

Opt Express. 2014 Jul 14;22(14):16706-21. doi: 10.1364/OE.22.016706.


Use of Fc-Engineered Antibodies as Clearing Agents to Increase Contrast During PET.

Swiercz R, Chiguru S, Tahmasbi A, Ramezani SM, Hao G, Challa DK, Lewis MA, Kulkarni PV, Sun X, Ober RJ, Mason RP, Ward ES.

J Nucl Med. 2014 Jul;55(7):1204-7. doi: 10.2967/jnumed.113.136481. Epub 2014 May 27.


Targeting FcRn for therapy: from live cell imaging to in vivo studies in mice.

Ward ES, Velmurugan R, Ober RJ.

Immunol Lett. 2014 Aug;160(2):158-62. doi: 10.1016/j.imlet.2014.02.008. Epub 2014 Feb 23. Review.


The effect of pH dependence of antibody-antigen interactions on subcellular trafficking dynamics.

Devanaboyina SC, Lynch SM, Ober RJ, Ram S, Kim D, Puig-Canto A, Breen S, Kasturirangan S, Fowler S, Peng L, Zhong H, Jermutus L, Wu H, Webster C, Ward ES, Gao C.

MAbs. 2013 Nov-Dec;5(6):851-9. doi: 10.4161/mabs.26389.


Engineering multivalent antibodies to target heregulin-induced HER3 signaling in breast cancer cells.

Kang JC, Poovassery JS, Bansal P, You S, Manjarres IM, Ober RJ, Ward ES.

MAbs. 2014 Mar-Apr;6(2):340-53. doi: 10.4161/mabs.27658. Epub 2013 Dec 26.


3D single molecule tracking and superresolution microscopy using multifocal plane microscopy.

Ram S, Ward ES, Ober RJ.

Proc IEEE Int Symp Biomed Imaging. 2012 Dec 31;2012:914-915.


Autoantibody depletion ameliorates disease in murine experimental autoimmune encephalomyelitis.

Challa DK, Bussmeyer U, Khan T, Montoyo HP, Bansal P, Ober RJ, Ward ES.

MAbs. 2013 Sep-Oct;5(5):655-9. doi: 10.4161/mabs.25439. Epub 2013 Jun 19.


The encephalitogenic, human myelin oligodendrocyte glycoprotein-induced antibody repertoire is directed toward multiple epitopes in C57BL/6-immunized mice.

Bansal P, Khan T, Bussmeyer U, Challa DK, Swiercz R, Velmurugan R, Ober RJ, Ward ES.

J Immunol. 2013 Aug 1;191(3):1091-101. doi: 10.4049/jimmunol.1300019. Epub 2013 Jul 1.


Ultrahigh accuracy imaging modality for super-localization microscopy.

Chao J, Ram S, Ward ES, Ober RJ.

Nat Methods. 2013 Apr;10(4):335-8. doi: 10.1038/nmeth.2396. Epub 2013 Mar 3.


Using multifocal plane microscopy to reveal novel trafficking processes in the recycling pathway.

Gan Z, Ram S, Ober RJ, Ward ES.

J Cell Sci. 2013 Mar 1;126(Pt 5):1176-88. doi: 10.1242/jcs.116327. Epub 2013 Jan 23.


3D single molecule tracking with multifocal plane microscopy reveals rapid intercellular transferrin transport at epithelial cell barriers.

Ram S, Kim D, Ober RJ, Ward ES.

Biophys J. 2012 Oct 3;103(7):1594-603. doi: 10.1016/j.bpj.2012.08.054. Epub 2012 Oct 2.


Inhibitory receptors bind ANGPTLs and support blood stem cells and leukaemia development.

Zheng J, Umikawa M, Cui C, Li J, Chen X, Zhang C, Huynh H, Kang X, Silvany R, Wan X, Ye J, Cantó AP, Chen SH, Wang HY, Ward ES, Zhang CC.

Nature. 2012 May 30;485(7400):656-60. doi: 10.1038/nature11095. Erratum in: Nature. 2012 Aug 30;488(7413):684. Hyunh, Hoangdinh [corrected to Huynh, HoangDinh].


Localization accuracy in single molecule microscopy using electron-multiplying charge-coupled device cameras.

Chao J, Ward ES, Ober RJ.

Proc SPIE Int Soc Opt Eng. 2012 Mar 15;8227. doi: 10.1117/12.908951.


Robotic radical prostatectomy at a teaching community hospital: outcomes and safety.

Padavano J, Shaffer L, Fannin E, Burgers J, Poll W, Ward ES, Banks K, Bell JG.

JSLS. 2011 Apr-Jun;15(2):193-9. doi: 10.4293/108680811X13022985131930.

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