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Items: 1 to 50 of 134

1.

mHTT Seeding Activity: A Marker of Disease Progression and Neurotoxicity in Models of Huntington's Disease.

Ast A, Buntru A, Schindler F, Hasenkopf R, Schulz A, Brusendorf L, Klockmeier K, Grelle G, McMahon B, Niederlechner H, Jansen I, Diez L, Edel J, Boeddrich A, Franklin SA, Baldo B, Schnoegl S, Kunz S, Purfürst B, Gaertner A, Kampinga HH, Morton AJ, Petersén Å, Kirstein J, Bates GP, Wanker EE.

Mol Cell. 2018 Sep 6;71(5):675-688.e6. doi: 10.1016/j.molcel.2018.07.032.

PMID:
30193095
2.

LuTHy: a double-readout bioluminescence-based two-hybrid technology for quantitative mapping of protein-protein interactions in mammalian cells.

Trepte P, Kruse S, Kostova S, Hoffmann S, Buntru A, Tempelmeier A, Secker C, Diez L, Schulz A, Klockmeier K, Zenkner M, Golusik S, Rau K, Schnoegl S, Garner CC, Wanker EE.

Mol Syst Biol. 2018 Jul 11;14(7):e8071. doi: 10.15252/msb.20178071.

3.

A Filter Retardation Assay Facilitates the Detection and Quantification of Heat-Stable, Amyloidogenic Mutant Huntingtin Aggregates in Complex Biosamples.

Ast A, Schindler F, Buntru A, Schnoegl S, Wanker EE.

Methods Mol Biol. 2018;1780:31-40. doi: 10.1007/978-1-4939-7825-0_3.

PMID:
29856013
4.

Self-assembly of Mutant Huntingtin Exon-1 Fragments into Large Complex Fibrillar Structures Involves Nucleated Branching.

Wagner AS, Politi AZ, Ast A, Bravo-Rodriguez K, Baum K, Buntru A, Strempel NU, Brusendorf L, Hänig C, Boeddrich A, Plassmann S, Klockmeier K, Ramirez-Anguita JM, Sanchez-Garcia E, Wolf J, Wanker EE.

J Mol Biol. 2018 Jun 8;430(12):1725-1744. doi: 10.1016/j.jmb.2018.03.017. Epub 2018 Mar 28.

5.

A Novel RNA Editing Sensor Tool and a Specific Agonist Determine Neuronal Protein Expression of RNA-Edited Glycine Receptors and Identify a Genomic APOBEC1 Dimorphism as a New Genetic Risk Factor of Epilepsy.

Kankowski S, Förstera B, Winkelmann A, Knauff P, Wanker EE, You XA, Semtner M, Hetsch F, Meier JC.

Front Mol Neurosci. 2018 Jan 11;10:439. doi: 10.3389/fnmol.2017.00439. eCollection 2017.

6.

Epigallocatechin gallate (EGCG) reduces the intensity of pancreatic amyloid fibrils in human islet amyloid polypeptide (hIAPP) transgenic mice.

Franko A, Rodriguez Camargo DC, Böddrich A, Garg D, Rodriguez Camargo A, Rathkolb B, Janik D, Aichler M, Feuchtinger A, Neff F, Fuchs H, Wanker EE, Reif B, Häring HU, Peter A, Hrabě de Angelis M.

Sci Rep. 2018 Jan 18;8(1):1116. doi: 10.1038/s41598-017-18807-8.

7.

Complete suppression of Htt fibrilization and disaggregation of Htt fibrils by a trimeric chaperone complex.

Scior A, Buntru A, Arnsburg K, Ast A, Iburg M, Juenemann K, Pigazzini ML, Mlody B, Puchkov D, Priller J, Wanker EE, Prigione A, Kirstein J.

EMBO J. 2018 Jan 17;37(2):282-299. doi: 10.15252/embj.201797212. Epub 2017 Dec 6.

PMID:
29212816
8.

Inhibition of Huntingtin Exon-1 Aggregation by the Molecular Tweezer CLR01.

Vöpel T, Bravo-Rodriguez K, Mittal S, Vachharajani S, Gnutt D, Sharma A, Steinhof A, Fatoba O, Ellrichmann G, Nshanian M, Heid C, Loo JA, Klärner FG, Schrader T, Bitan G, Wanker EE, Ebbinghaus S, Sanchez-Garcia E.

J Am Chem Soc. 2017 Apr 26;139(16):5640-5643. doi: 10.1021/jacs.6b11039. Epub 2017 Apr 13.

9.

Identification of an RNA Polymerase III Regulator Linked to Disease-Associated Protein Aggregation.

Sin O, de Jong T, Mata-Cabana A, Kudron M, Zaini MA, Aprile FA, Seinstra RI, Stroo E, Prins RW, Martineau CN, Wang HH, Hogewerf W, Steinhof A, Wanker EE, Vendruscolo M, Calkhoven CF, Reinke V, Guryev V, Nollen EA.

Mol Cell. 2017 Mar 16;65(6):1096-1108.e6. doi: 10.1016/j.molcel.2017.02.022.

10.

The redox environment triggers conformational changes and aggregation of hIAPP in Type II Diabetes.

Rodriguez Camargo DC, Tripsianes K, Buday K, Franko A, Göbl C, Hartlmüller C, Sarkar R, Aichler M, Mettenleiter G, Schulz M, Böddrich A, Erck C, Martens H, Walch AK, Madl T, Wanker EE, Conrad M, de Angelis MH, Reif B.

Sci Rep. 2017 Mar 13;7:44041. doi: 10.1038/srep44041.

11.

Human iPSC-Derived Neural Progenitors Are an Effective Drug Discovery Model for Neurological mtDNA Disorders.

Lorenz C, Lesimple P, Bukowiecki R, Zink A, Inak G, Mlody B, Singh M, Semtner M, Mah N, Auré K, Leong M, Zabiegalov O, Lyras EM, Pfiffer V, Fauler B, Eichhorst J, Wiesner B, Huebner N, Priller J, Mielke T, Meierhofer D, Izsvák Z, Meier JC, Bouillaud F, Adjaye J, Schuelke M, Wanker EE, Lombès A, Prigione A.

Cell Stem Cell. 2017 May 4;20(5):659-674.e9. doi: 10.1016/j.stem.2016.12.013. Epub 2017 Jan 26.

12.

Aggregation-induced changes in the chemical exchange saturation transfer (CEST) signals of proteins.

Goerke S, Milde KS, Bukowiecki R, Kunz P, Klika KD, Wiglenda T, Mogk A, Wanker EE, Bukau B, Ladd ME, Bachert P, Zaiss M.

NMR Biomed. 2017 Jan;30(1). doi: 10.1002/nbm.3665. Epub 2016 Nov 11.

PMID:
27859838
13.

Organ-specific alteration in caspase expression and STK3 proteolysis during the aging process.

Lessard-Beaudoin M, Laroche M, Loudghi A, Demers MJ, Denault JB, Grenier G, Riechers SP, Wanker EE, Graham RK.

Neurobiol Aging. 2016 Nov;47:50-62. doi: 10.1016/j.neurobiolaging.2016.07.003. Epub 2016 Jul 15.

PMID:
27552481
14.

Quantitative interaction mapping reveals an extended UBX domain in ASPL that disrupts functional p97 hexamers.

Arumughan A, Roske Y, Barth C, Forero LL, Bravo-Rodriguez K, Redel A, Kostova S, McShane E, Opitz R, Faelber K, Rau K, Mielke T, Daumke O, Selbach M, Sanchez-Garcia E, Rocks O, Panáková D, Heinemann U, Wanker EE.

Nat Commun. 2016 Oct 20;7:13047. doi: 10.1038/ncomms13047.

15.

Age-dependent differential expression of death-associated protein 6 (Daxx) in various peripheral tissues and different brain regions of C57BL/6 male mice.

Lessard-Beaudoin M, Laroche M, Demers MJ, Duclos C, Denault JB, Grenier G, Riechers SP, Wanker EE, Graham RK.

Biogerontology. 2016 Nov;17(5-6):817-828. Epub 2016 Jul 27.

PMID:
27465500
16.

Amyloid-β(1-42) Aggregation Initiates Its Cellular Uptake and Cytotoxicity.

Jin S, Kedia N, Illes-Toth E, Haralampiev I, Prisner S, Herrmann A, Wanker EE, Bieschke J.

J Biol Chem. 2016 Sep 9;291(37):19590-606. doi: 10.1074/jbc.M115.691840. Epub 2016 Jul 25.

17.

Current Approaches Toward Quantitative Mapping of the Interactome.

Buntru A, Trepte P, Klockmeier K, Schnoegl S, Wanker EE.

Front Genet. 2016 May 4;7:74. doi: 10.3389/fgene.2016.00074. eCollection 2016.

18.

Functional characterisation of human synaptic genes expressed in the Drosophila brain.

Zografos L, Tang J, Hesse F, Wanker EE, Li KW, Smit AB, Davies RW, Armstrong JD.

Biol Open. 2016 May 15;5(5):662-7. doi: 10.1242/bio.016261.

19.

Novel small molecules targeting ciliary transport of Smoothened and oncogenic Hedgehog pathway activation.

Jung B, Messias AC, Schorpp K, Geerlof A, Schneider G, Saur D, Hadian K, Sattler M, Wanker EE, Hasenöder S, Lickert H.

Sci Rep. 2016 Mar 2;6:22540. doi: 10.1038/srep22540.

20.

Interactome network analysis identifies multiple caspase-6 interactors involved in the pathogenesis of HD.

Riechers SP, Butland S, Deng Y, Skotte N, Ehrnhoefer DE, Russ J, Laine J, Laroche M, Pouladi MA, Wanker EE, Hayden MR, Graham RK.

Hum Mol Genet. 2016 Apr 15;25(8):1600-18. doi: 10.1093/hmg/ddw036. Epub 2016 Feb 11.

PMID:
26908611
21.

Corticotropin-Releasing Hormone Receptor Type 1 (CRHR1) Clustering with MAGUKs Is Mediated via Its C-Terminal PDZ Binding Motif.

Bender J, Engeholm M, Ederer MS, Breu J, Møller TC, Michalakis S, Rasko T, Wanker EE, Biel M, Martinez KL, Wurst W, Deussing JM.

PLoS One. 2015 Sep 9;10(9):e0136768. doi: 10.1371/journal.pone.0136768. eCollection 2015.

22.

DULIP: A Dual Luminescence-Based Co-Immunoprecipitation Assay for Interactome Mapping in Mammalian Cells.

Trepte P, Buntru A, Klockmeier K, Willmore L, Arumughan A, Secker C, Zenkner M, Brusendorf L, Rau K, Redel A, Wanker EE.

J Mol Biol. 2015 Oct 23;427(21):3375-88. doi: 10.1016/j.jmb.2015.08.003. Epub 2015 Aug 8.

PMID:
26264872
23.

Quantitative interaction proteomics of neurodegenerative disease proteins.

Hosp F, Vossfeldt H, Heinig M, Vasiljevic D, Arumughan A, Wyler E; Genetic and Environmental Risk for Alzheimer’s Disease GERAD1 Consortium, Landthaler M, Hubner N, Wanker EE, Lannfelt L, Ingelsson M, Lalowski M, Voigt A, Selbach M.

Cell Rep. 2015 May 19;11(7):1134-46. doi: 10.1016/j.celrep.2015.04.030. Epub 2015 May 7.

24.

Systematic interaction network filtering identifies CRMP1 as a novel suppressor of huntingtin misfolding and neurotoxicity.

Stroedicke M, Bounab Y, Strempel N, Klockmeier K, Yigit S, Friedrich RP, Chaurasia G, Li S, Hesse F, Riechers SP, Russ J, Nicoletti C, Boeddrich A, Wiglenda T, Haenig C, Schnoegl S, Fournier D, Graham RK, Hayden MR, Sigrist S, Bates GP, Priller J, Andrade-Navarro MA, Futschik ME, Wanker EE.

Genome Res. 2015 May;25(5):701-13. doi: 10.1101/gr.182444.114.

25.

Reduced SNAP-25 increases PSD-95 mobility and impairs spine morphogenesis.

Fossati G, Morini R, Corradini I, Antonucci F, Trepte P, Edry E, Sharma V, Papale A, Pozzi D, Defilippi P, Meier JC, Brambilla R, Turco E, Rosenblum K, Wanker EE, Ziv NE, Menna E, Matteoli M.

Cell Death Differ. 2015 Sep;22(9):1425-36. doi: 10.1038/cdd.2014.227. Epub 2015 Feb 13.

26.

The green tea polyphenol (-)-epigallocatechin gallate prevents the aggregation of tau protein into toxic oligomers at substoichiometric ratios.

Wobst HJ, Sharma A, Diamond MI, Wanker EE, Bieschke J.

FEBS Lett. 2015 Jan 2;589(1):77-83. doi: 10.1016/j.febslet.2014.11.026. Epub 2014 Nov 29.

27.

Modulation of human IAPP fibrillation: cosolutes, crowders and chaperones.

Gao M, Estel K, Seeliger J, Friedrich RP, Dogan S, Wanker EE, Winter R, Ebbinghaus S.

Phys Chem Chem Phys. 2015 Apr 7;17(13):8338-48. doi: 10.1039/c4cp04682j. Epub 2014 Nov 19.

PMID:
25406896
28.

Spontaneous self-assembly of pathogenic huntingtin exon 1 protein into amyloid structures.

Trepte P, Strempel N, Wanker EE.

Essays Biochem. 2014;56:167-80. doi: 10.1042/bse0560167. Review.

PMID:
25131594
29.

Prion-like proteins sequester and suppress the toxicity of huntingtin exon 1.

Kayatekin C, Matlack KE, Hesse WR, Guan Y, Chakrabortee S, Russ J, Wanker EE, Shah JV, Lindquist S.

Proc Natl Acad Sci U S A. 2014 Aug 19;111(33):12085-90. doi: 10.1073/pnas.1412504111. Epub 2014 Aug 4.

30.

In utero gene therapy rescues microcephaly caused by Pqbp1-hypofunction in neural stem progenitor cells.

Ito H, Shiwaku H, Yoshida C, Homma H, Luo H, Chen X, Fujita K, Musante L, Fischer U, Frints SG, Romano C, Ikeuchi Y, Shimamura T, Imoto S, Miyano S, Muramatsu SI, Kawauchi T, Hoshino M, Sudol M, Arumughan A, Wanker EE, Rich T, Schwartz C, Matsuzaki F, Bonni A, Kalscheuer VM, Okazawa H.

Mol Psychiatry. 2015 Apr;20(4):459-71. doi: 10.1038/mp.2014.69. Epub 2014 Jul 29.

31.

The palmitoyl acyltransferase HIP14 shares a high proportion of interactors with huntingtin: implications for a role in the pathogenesis of Huntington's disease.

Butland SL, Sanders SS, Schmidt ME, Riechers SP, Lin DT, Martin DD, Vaid K, Graham RK, Singaraja RR, Wanker EE, Conibear E, Hayden MR.

Hum Mol Genet. 2014 Aug 1;23(15):4142-60. doi: 10.1093/hmg/ddu137. Epub 2014 Apr 4.

32.

HDAC4 reduction: a novel therapeutic strategy to target cytoplasmic huntingtin and ameliorate neurodegeneration.

Mielcarek M, Landles C, Weiss A, Bradaia A, Seredenina T, Inuabasi L, Osborne GF, Wadel K, Touller C, Butler R, Robertson J, Franklin SA, Smith DL, Park L, Marks PA, Wanker EE, Olson EN, Luthi-Carter R, van der Putten H, Beaumont V, Bates GP.

PLoS Biol. 2013 Nov;11(11):e1001717. doi: 10.1371/journal.pbio.1001717. Epub 2013 Nov 26.

33.

HIF1α modulates cell fate reprogramming through early glycolytic shift and upregulation of PDK1-3 and PKM2.

Prigione A, Rohwer N, Hoffmann S, Mlody B, Drews K, Bukowiecki R, Blümlein K, Wanker EE, Ralser M, Cramer T, Adjaye J.

Stem Cells. 2014 Feb;32(2):364-76. doi: 10.1002/stem.1552.

34.

Myc inhibition impairs autophagosome formation.

Toh PP, Luo S, Menzies FM, Raskó T, Wanker EE, Rubinsztein DC.

Hum Mol Genet. 2013 Dec 20;22(25):5237-48. doi: 10.1093/hmg/ddt381. Epub 2013 Aug 9.

35.

SUMO-2 and PIAS1 modulate insoluble mutant huntingtin protein accumulation.

O'Rourke JG, Gareau JR, Ochaba J, Song W, Raskó T, Reverter D, Lee J, Monteys AM, Pallos J, Mee L, Vashishtha M, Apostol BL, Nicholson TP, Illes K, Zhu YZ, Dasso M, Bates GP, Difiglia M, Davidson B, Wanker EE, Marsh JL, Lima CD, Steffan JS, Thompson LM.

Cell Rep. 2013 Jul 25;4(2):362-75. doi: 10.1016/j.celrep.2013.06.034. Epub 2013 Jul 18.

36.

A functional deficiency of TERA/VCP/p97 contributes to impaired DNA repair in multiple polyglutamine diseases.

Fujita K, Nakamura Y, Oka T, Ito H, Tamura T, Tagawa K, Sasabe T, Katsuta A, Motoki K, Shiwaku H, Sone M, Yoshida C, Katsuno M, Eishi Y, Murata M, Taylor JP, Wanker EE, Kono K, Tashiro S, Sobue G, La Spada AR, Okazawa H.

Nat Commun. 2013;4:1816. doi: 10.1038/ncomms2828.

37.

Dynamic circadian protein-protein interaction networks predict temporal organization of cellular functions.

Wallach T, Schellenberg K, Maier B, Kalathur RK, Porras P, Wanker EE, Futschik ME, Kramer A.

PLoS Genet. 2013 Mar;9(3):e1003398. doi: 10.1371/journal.pgen.1003398. Epub 2013 Mar 28.

38.

Aggregation of polyQ-extended proteins is promoted by interaction with their natural coiled-coil partners.

Petrakis S, Schaefer MH, Wanker EE, Andrade-Navarro MA.

Bioessays. 2013 Jun;35(6):503-7. doi: 10.1002/bies.201300001. Epub 2013 Mar 11.

39.

A Y2H-seq approach defines the human protein methyltransferase interactome.

Weimann M, Grossmann A, Woodsmith J, Özkan Z, Birth P, Meierhofer D, Benlasfer N, Valovka T, Timmermann B, Wanker EE, Sauer S, Stelzl U.

Nat Methods. 2013 Apr;10(4):339-42. doi: 10.1038/nmeth.2397. Epub 2013 Mar 3.

PMID:
23455924
40.

Epigallocatechin-3-gallate: a useful, effective and safe clinical approach for targeted prevention and individualised treatment of neurological diseases?

Mähler A, Mandel S, Lorenz M, Ruegg U, Wanker EE, Boschmann M, Paul F.

EPMA J. 2013 Feb 18;4(1):5. doi: 10.1186/1878-5085-4-5.

41.

Development and application of a DNA microarray-based yeast two-hybrid system.

Suter B, Fontaine JF, Yildirimman R, Raskó T, Schaefer MH, Rasche A, Porras P, Vázquez-Álvarez BM, Russ J, Rau K, Foulle R, Zenkner M, Saar K, Herwig R, Andrade-Navarro MA, Wanker EE.

Nucleic Acids Res. 2013 Feb 1;41(3):1496-507. doi: 10.1093/nar/gks1329. Epub 2012 Dec 28.

42.

Identification of human proteins that modify misfolding and proteotoxicity of pathogenic ataxin-1.

Petrakis S, Raskó T, Russ J, Friedrich RP, Stroedicke M, Riechers SP, Muehlenberg K, Möller A, Reinhardt A, Vinayagam A, Schaefer MH, Boutros M, Tricoire H, Andrade-Navarro MA, Wanker EE.

PLoS Genet. 2012;8(8):e1002897. doi: 10.1371/journal.pgen.1002897. Epub 2012 Aug 16.

43.

Green tea halts progression of cardiac transthyretin amyloidosis: an observational report.

Kristen AV, Lehrke S, Buss S, Mereles D, Steen H, Ehlermann P, Hardt S, Giannitsis E, Schreiner R, Haberkorn U, Schnabel PA, Linke RP, Röcken C, Wanker EE, Dengler TJ, Altland K, Katus HA.

Clin Res Cardiol. 2012 Oct;101(10):805-13. Epub 2012 May 15.

44.

Phosphorylation-regulated axonal dependent transport of syntaxin 1 is mediated by a Kinesin-1 adapter.

Chua JJ, Butkevich E, Worseck JM, Kittelmann M, Grønborg M, Behrmann E, Stelzl U, Pavlos NJ, Lalowski MM, Eimer S, Wanker EE, Klopfenstein DR, Jahn R.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5862-7. doi: 10.1073/pnas.1113819109. Epub 2012 Mar 26.

45.

HIPPIE: Integrating protein interaction networks with experiment based quality scores.

Schaefer MH, Fontaine JF, Vinayagam A, Porras P, Wanker EE, Andrade-Navarro MA.

PLoS One. 2012;7(2):e31826. doi: 10.1371/journal.pone.0031826. Epub 2012 Feb 14.

46.
47.

Structural properties of EGCG-induced, nontoxic Alzheimer's disease Aβ oligomers.

Lopez del Amo JM, Fink U, Dasari M, Grelle G, Wanker EE, Bieschke J, Reif B.

J Mol Biol. 2012 Aug 24;421(4-5):517-24. doi: 10.1016/j.jmb.2012.01.013. Epub 2012 Jan 28.

PMID:
22300765
48.

Evolution and function of CAG/polyglutamine repeats in protein-protein interaction networks.

Schaefer MH, Wanker EE, Andrade-Navarro MA.

Nucleic Acids Res. 2012 May;40(10):4273-87. doi: 10.1093/nar/gks011. Epub 2012 Jan 28.

49.

A novel multiplex cell viability assay for high-throughput RNAi screening.

Gilbert DF, Erdmann G, Zhang X, Fritzsche A, Demir K, Jaedicke A, Muehlenberg K, Wanker EE, Boutros M.

PLoS One. 2011;6(12):e28338. doi: 10.1371/journal.pone.0028338. Epub 2011 Dec 5.

50.

Small-molecule conversion of toxic oligomers to nontoxic β-sheet-rich amyloid fibrils.

Bieschke J, Herbst M, Wiglenda T, Friedrich RP, Boeddrich A, Schiele F, Kleckers D, Lopez del Amo JM, Grüning BA, Wang Q, Schmidt MR, Lurz R, Anwyl R, Schnoegl S, Fändrich M, Frank RF, Reif B, Günther S, Walsh DM, Wanker EE.

Nat Chem Biol. 2011 Nov 20;8(1):93-101. doi: 10.1038/nchembio.719.

PMID:
22101602

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