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Items: 1 to 50 of 178

1.

Mild maternal hyperglycemia in INS C93S transgenic pigs causes impaired glucose tolerance and metabolic alterations in neonatal offspring.

Renner S, Martins AS, Streckel E, Braun-Reichhart C, Backman M, Prehn C, Klymiuk N, Bähr A, Blutke A, Landbrecht-Schessl C, Wünsch A, Kessler B, Kurome M, Hinrichs A, Koopmans SJ, Krebs S, Kemter E, Rathkolb B, Nagashima H, Blum H, Ritzmann M, Wanke R, Aigner B, Adamski J, Hrabě de Angelis M, Wolf E.

Dis Model Mech. 2019 Aug 12;12(8). pii: dmm039156. doi: 10.1242/dmm.039156.

2.

Multi-omics insights into functional alterations of the liver in insulin-deficient diabetes mellitus.

Backman M, Flenkenthaler F, Blutke A, Dahlhoff M, Ländström E, Renner S, Philippou-Massier J, Krebs S, Rathkolb B, Prehn C, Grzybek M, Coskun Ü, Rothe M, Adamski J, de Angelis MH, Wanke R, Fröhlich T, Arnold GJ, Blum H, Wolf E.

Mol Metab. 2019 Aug;26:30-44. doi: 10.1016/j.molmet.2019.05.011. Epub 2019 Jun 4.

3.

Novel Methinic Functionalized and Dendritic C-Scorpionates.

Martins LMDRS, Wanke R, Silva TFS, Pombeiro AJL, Servin P, Laurent R, Caminade AM.

Molecules. 2018 Nov 23;23(12). pii: E3066. doi: 10.3390/molecules23123066.

4.

Metabolic syndrome and extensive adipose tissue inflammation in morbidly obese Göttingen minipigs.

Renner S, Blutke A, Dobenecker B, Dhom G, Müller TD, Finan B, Clemmensen C, Bernau M, Novak I, Rathkolb B, Senf S, Zöls S, Roth M, Götz A, Hofmann SM, Hrabĕ de Angelis M, Wanke R, Kienzle E, Scholz AM, DiMarchi R, Ritzmann M, Tschöp MH, Wolf E.

Mol Metab. 2018 Oct;16:180-190. doi: 10.1016/j.molmet.2018.06.015. Epub 2018 Jun 28.

5.

Growth hormone receptor-deficient pigs resemble the pathophysiology of human Laron syndrome and reveal altered activation of signaling cascades in the liver.

Hinrichs A, Kessler B, Kurome M, Blutke A, Kemter E, Bernau M, Scholz AM, Rathkolb B, Renner S, Bultmann S, Leonhardt H, de Angelis MH, Nagashima H, Hoeflich A, Blum WF, Bidlingmaier M, Wanke R, Dahlhoff M, Wolf E.

Mol Metab. 2018 May;11:113-128. doi: 10.1016/j.molmet.2018.03.006. Epub 2018 Mar 15.

6.

Sampling Strategies and Processing of Biobank Tissue Samples from Porcine Biomedical Models.

Blutke A, Wanke R.

J Vis Exp. 2018 Mar 6;(133). doi: 10.3791/57276.

PMID:
29578524
7.

Practicable methods for histological section thickness measurement in quantitative stereological analyses.

Matenaers C, Popper B, Rieger A, Wanke R, Blutke A.

PLoS One. 2018 Feb 14;13(2):e0192879. doi: 10.1371/journal.pone.0192879. eCollection 2018.

8.

The Munich MIDY Pig Biobank - A unique resource for studying organ crosstalk in diabetes.

Blutke A, Renner S, Flenkenthaler F, Backman M, Haesner S, Kemter E, Ländström E, Braun-Reichhart C, Albl B, Streckel E, Rathkolb B, Prehn C, Palladini A, Grzybek M, Krebs S, Bauersachs S, Bähr A, Brühschwein A, Deeg CA, De Monte E, Dmochewitz M, Eberle C, Emrich D, Fux R, Groth F, Gumbert S, Heitmann A, Hinrichs A, Keßler B, Kurome M, Leipig-Rudolph M, Matiasek K, Öztürk H, Otzdorff C, Reichenbach M, Reichenbach HD, Rieger A, Rieseberg B, Rosati M, Saucedo MN, Schleicher A, Schneider MR, Simmet K, Steinmetz J, Übel N, Zehetmaier P, Jung A, Adamski J, Coskun Ü, Hrabě de Angelis M, Simmet C, Ritzmann M, Meyer-Lindenberg A, Blum H, Arnold GJ, Fröhlich T, Wanke R, Wolf E.

Mol Metab. 2017 Jun 13;6(8):931-940. doi: 10.1016/j.molmet.2017.06.004. eCollection 2017 Aug.

9.

Integration of cellular and molecular endpoints to assess the toxicity of polycyclic aromatic hydrocarbons in HepG2 cell line.

Morgado PI, Jose S, Wanke R, M Antunes AM, Cardoso AS, Jordao L.

Environ Toxicol Chem. 2017 Dec;36(12):3404-3414. doi: 10.1002/etc.3927. Epub 2017 Sep 8.

PMID:
28731233
10.

Mitochondrial Dysregulation Secondary to Endoplasmic Reticulum Stress in Autosomal Dominant Tubulointerstitial Kidney Disease - UMOD (ADTKD-UMOD).

Kemter E, Fröhlich T, Arnold GJ, Wolf E, Wanke R.

Sci Rep. 2017 Feb 21;7:42970. doi: 10.1038/srep42970.

11.

Progressive muscle proteome changes in a clinically relevant pig model of Duchenne muscular dystrophy.

Fröhlich T, Kemter E, Flenkenthaler F, Klymiuk N, Otte KA, Blutke A, Krause S, Walter MC, Wanke R, Wolf E, Arnold GJ.

Sci Rep. 2016 Sep 16;6:33362. doi: 10.1038/srep33362.

12.

Missense Mutation of POU Domain Class 3 Transcription Factor 3 in Pou3f3L423P Mice Causes Reduced Nephron Number and Impaired Development of the Thick Ascending Limb of the Loop of Henle.

Rieger A, Kemter E, Kumar S, Popper B, Aigner B, Wolf E, Wanke R, Blutke A.

PLoS One. 2016 Jul 15;11(7):e0158977. doi: 10.1371/journal.pone.0158977. eCollection 2016.

13.

Comparative aspects of rodent and nonrodent animal models for mechanistic and translational diabetes research.

Renner S, Dobenecker B, Blutke A, Zöls S, Wanke R, Ritzmann M, Wolf E.

Theriogenology. 2016 Jul 1;86(1):406-21. doi: 10.1016/j.theriogenology.2016.04.055. Epub 2016 Apr 21. Review.

PMID:
27180329
14.

Ribonuclease (RNase) Prolongs Survival of Grafts in Experimental Heart Transplantation.

Kleinert E, Langenmayer MC, Reichart B, Kindermann J, Griemert B, Blutke A, Troidl K, Mayr T, Grantzow T, Noyan F, Abicht JM, Fischer S, Preissner KT, Wanke R, Deindl E, Guethoff S.

J Am Heart Assoc. 2016 Apr 27;5(5). pii: e003429. doi: 10.1161/JAHA.116.003429.

15.
16.

Tissue Sampling Guides for Porcine Biomedical Models.

Albl B, Haesner S, Braun-Reichhart C, Streckel E, Renner S, Seeliger F, Wolf E, Wanke R, Blutke A.

Toxicol Pathol. 2016 Apr;44(3):414-20. doi: 10.1177/0192623316631023. Epub 2016 Feb 16.

PMID:
26883152
17.

Dissociation of somatic growth, time of sexual maturity, and life expectancy by overexpression of an RGD-deficient IGFBP-2 variant in female transgenic mice.

Hoeflich A, Reyer A, Ohde D, Schindler N, Brenmoehl J, Spitschak M, Langhammer M, Tuchscherer A, Wirthgen E, Renner-Müller I, Wanke R, Metzger F, Bielohuby M, Wolf E.

Aging Cell. 2016 Feb;15(1):111-7. doi: 10.1111/acel.12413. Epub 2015 Oct 28.

18.

Incretin actions and consequences of incretin-based therapies: lessons from complementary animal models.

Renner S, Blutke A, Streckel E, Wanke R, Wolf E.

J Pathol. 2016 Jan;238(2):345-58. doi: 10.1002/path.4655. Epub 2015 Nov 30. Review.

PMID:
26455904
19.

Effects of the glucagon-like peptide-1 receptor agonist liraglutide in juvenile transgenic pigs modeling a pre-diabetic condition.

Streckel E, Braun-Reichhart C, Herbach N, Dahlhoff M, Kessler B, Blutke A, Bähr A, Übel N, Eddicks M, Ritzmann M, Krebs S, Göke B, Blum H, Wanke R, Wolf E, Renner S.

J Transl Med. 2015 Feb 25;13:73. doi: 10.1186/s12967-015-0431-2.

20.

Attenuation of cardiac hypertrophy by G-CSF is associated with enhanced migration of bone marrow-derived cells.

Huber BC, Beetz NL, Laskowski A, Ziegler T, Grabmaier U, Kupatt C, Herbach N, Wanke R, Franz WM, Massberg S, Brunner S.

J Cell Mol Med. 2015 May;19(5):1033-41. doi: 10.1111/jcmm.12494. Epub 2015 Mar 8.

21.

Short-term inhibition of DPP-4 enhances endothelial regeneration after acute arterial injury via enhanced recruitment of circulating progenitor cells.

Brenner C, Kränkel N, Kühlenthal S, Israel L, Remm F, Fischer C, Herbach N, Speer T, Grabmaier U, Laskowski A, Gross L, Theiss H, Wanke R, Landmesser U, Franz WM.

Int J Cardiol. 2014 Nov 15;177(1):266-75. doi: 10.1016/j.ijcard.2014.09.016. Epub 2014 Sep 22.

PMID:
25499391
22.

Acaricide treatment prevents adrenocortical hyperplasia as a long-term stress reaction to psoroptic mange in cattle.

Blutke A, Börjes P, Herbach N, Pfister K, Hamel D, Rehbein S, Wanke R.

Vet Parasitol. 2015 Jan 15;207(1-2):125-33. doi: 10.1016/j.vetpar.2014.10.013. Epub 2014 Oct 24.

PMID:
25468014
23.

Inactivation of the ferroptosis regulator Gpx4 triggers acute renal failure in mice.

Friedmann Angeli JP, Schneider M, Proneth B, Tyurina YY, Tyurin VA, Hammond VJ, Herbach N, Aichler M, Walch A, Eggenhofer E, Basavarajappa D, Rådmark O, Kobayashi S, Seibt T, Beck H, Neff F, Esposito I, Wanke R, Förster H, Yefremova O, Heinrichmeyer M, Bornkamm GW, Geissler EK, Thomas SB, Stockwell BR, O'Donnell VB, Kagan VE, Schick JA, Conrad M.

Nat Cell Biol. 2014 Dec;16(12):1180-91. doi: 10.1038/ncb3064. Epub 2014 Nov 17.

24.

Location-specific expression of chemokines, TNF-α and S100 proteins in a teat explant model.

Lind M, Sipka AS, Schuberth HJ, Blutke A, Wanke R, Sauter-Louis C, Duda KA, Holst O, Rainard P, Germon P, Zerbe H, Petzl W.

Innate Immun. 2015 Apr;21(3):322-31. doi: 10.1177/1753425914539820. Epub 2014 Aug 17.

PMID:
25134520
25.

Genetic dissection of IGF1-dependent and -independent effects of permanent GH excess on postnatal growth and organ pathology of mice.

Blutke A, Schneider MR, Renner-Müller I, Herbach N, Wanke R, Wolf E.

Mol Cell Endocrinol. 2014 Aug 25;394(1-2):88-98. doi: 10.1016/j.mce.2014.07.002. Epub 2014 Jul 10.

PMID:
25017732
26.

No amelioration of uromodulin maturation and trafficking defect by sodium 4-phenylbutyrate in vivo: studies in mouse models of uromodulin-associated kidney disease.

Kemter E, Sklenak S, Rathkolb B, Hrabě de Angelis M, Wolf E, Aigner B, Wanke R.

J Biol Chem. 2014 Apr 11;289(15):10715-26. doi: 10.1074/jbc.M113.537035. Epub 2014 Feb 24.

27.

The phenolic metabolites of the anti-HIV drug efavirenz: evidence for distinct reactivities upon oxidation with Frémy's salt.

Harjivan SG, Wanke R, Ferreira da Silva JL, Marques MM, Antunes AM.

Eur J Med Chem. 2014 Mar 3;74:7-11. doi: 10.1016/j.ejmech.2013.12.022. Epub 2013 Dec 31.

PMID:
24440376
28.

Regulatory sequences of the porcine THBD gene facilitate endothelial-specific expression of bioactive human thrombomodulin in single- and multitransgenic pigs.

Wuensch A, Baehr A, Bongoni AK, Kemter E, Blutke A, Baars W, Haertle S, Zakhartchenko V, Kurome M, Kessler B, Faber C, Abicht JM, Reichart B, Wanke R, Schwinzer R, Nagashima H, Rieben R, Ayares D, Wolf E, Klymiuk N.

Transplantation. 2014 Jan 27;97(2):138-47. doi: 10.1097/TP.0b013e3182a95cbc.

29.

The role of competitive binding to human serum albumin on efavirenz-warfarin interaction: a nuclear magnetic resonance study.

Wanke R, Harjivan SG, Pereira SA, Marques MM, Antunes AM.

Int J Antimicrob Agents. 2013 Nov;42(5):443-6. doi: 10.1016/j.ijantimicag.2013.06.023. Epub 2013 Sep 1.

PMID:
24051055
30.

Impaired glucose tolerance in rats fed low-carbohydrate, high-fat diets.

Bielohuby M, Sisley S, Sandoval D, Herbach N, Zengin A, Fischereder M, Menhofer D, Stoehr BJ, Stemmer K, Wanke R, Tschöp MH, Seeley RJ, Bidlingmaier M.

Am J Physiol Endocrinol Metab. 2013 Nov 1;305(9):E1059-70. doi: 10.1152/ajpendo.00208.2013. Epub 2013 Aug 27.

31.

Polycystic kidney disease in a European roe deer (Capreolus capreolus).

Blutke A, März K, Matenaers C, Oswald K, Hermanns W, Wanke R.

J Zoo Wildl Med. 2013 Jun;44(2):487-90.

PMID:
23805573
32.

Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle.

Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A, Krebs S, Kessler B, Zakhartchenko V, Kurome M, Kemter E, Nagashima H, Schoser B, Herbach N, Blum H, Wanke R, Aartsma-Rus A, Thirion C, Lochmüller H, Walter MC, Wolf E.

Hum Mol Genet. 2013 Nov 1;22(21):4368-82. doi: 10.1093/hmg/ddt287. Epub 2013 Jun 19.

PMID:
23784375
33.

Type of uromodulin mutation and allelic status influence onset and severity of uromodulin-associated kidney disease in mice.

Kemter E, Prueckl P, Sklenak S, Rathkolb B, Habermann FA, Hans W, Gailus-Durner V, Fuchs H, Hrabě de Angelis M, Wolf E, Aigner B, Wanke R.

Hum Mol Genet. 2013 Oct 15;22(20):4148-63. doi: 10.1093/hmg/ddt263. Epub 2013 Jun 6.

PMID:
23748428
34.

Divergent functions of the Rho GTPases Rac1 and Cdc42 in podocyte injury.

Blattner SM, Hodgin JB, Nishio M, Wylie SA, Saha J, Soofi AA, Vining C, Randolph A, Herbach N, Wanke R, Atkins KB, Gyung Kang H, Henger A, Brakebusch C, Holzman LB, Kretzler M.

Kidney Int. 2013 Nov;84(5):920-30. doi: 10.1038/ki.2013.175. Epub 2013 May 15.

35.

Permanent neonatal diabetes in INS(C94Y) transgenic pigs.

Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E, Wünsch A, Kessler B, Kurome M, Bähr A, Klymiuk N, Krebs S, Puk O, Nagashima H, Graw J, Blum H, Wanke R, Wolf E.

Diabetes. 2013 May;62(5):1505-11. doi: 10.2337/db12-1065. Epub 2012 Dec 28.

36.

Exploration of global gene expression changes during the estrous cycle in equine endometrium.

Gebhardt S, Merkl M, Herbach N, Wanke R, Handler J, Bauersachs S.

Biol Reprod. 2012 Dec 13;87(6):136. doi: 10.1095/biolreprod.112.103226. Print 2012 Jun.

PMID:
23077167
37.

A novel di-compartmental bis-(2-hydroxyisophtalamide) macrocyclic ligand and its mononuclear Cu(II) and Ni(II) complexes.

Eckshtain-Levi M, Lavi R, Yufit D, Orio M, Wanke R, Benisvy L.

Dalton Trans. 2012 Oct 28;41(40):12457-67.

PMID:
22948228
38.

Induction of oxazolone-mediated features of atopic dermatitis in NOD-scid IL2Rγ(null) mice engrafted with human peripheral blood mononuclear cells.

Nolte T, Zadeh-Khorasani M, Safarov O, Rueff F, Varga R, Herbach N, Wanke R, Wollenberg A, Mueller T, Gropp R, Wolf E, Siebeck M.

Dis Model Mech. 2013 Jan;6(1):125-34. doi: 10.1242/dmm.009167. Epub 2012 Jul 19.

39.

Enhanced oxidative stress and endocrine pancreas alterations are linked to a novel glucokinase missense mutation in ENU-derived Munich Gck(D217V) mutants.

van Buerck L, Schuster M, Rathkolb B, Sabrautzki S, Hrabě de Angelis M, Wolf E, Aigner B, Wanke R, Herbach N.

Mol Cell Endocrinol. 2012 Oct 15;362(1-2):139-48. doi: 10.1016/j.mce.2012.06.001. Epub 2012 Jun 12.

PMID:
22698525
40.

Biomimetic oxidation of aromatic xenobiotics: synthesis of the phenolic metabolites from the anti-HIV drug efavirenz.

Wanke R, Novais DA, Harjivan SG, Marques MM, Antunes AM.

Org Biomol Chem. 2012 Jun 21;10(23):4554-61. doi: 10.1039/c2ob25212k. Epub 2012 May 8.

PMID:
22569890
41.

Xenografted islet cell clusters from INSLEA29Y transgenic pigs rescue diabetes and prevent immune rejection in humanized mice.

Klymiuk N, van Buerck L, Bähr A, Offers M, Kessler B, Wuensch A, Kurome M, Thormann M, Lochner K, Nagashima H, Herbach N, Wanke R, Seissler J, Wolf E.

Diabetes. 2012 Jun;61(6):1527-32. doi: 10.2337/db11-1325. Epub 2012 Apr 20.

42.

First inducible transgene expression in porcine large animal models.

Klymiuk N, Böcker W, Schönitzer V, Bähr A, Radic T, Fröhlich T, Wünsch A, Keßler B, Kurome M, Schilling E, Herbach N, Wanke R, Nagashima H, Mutschler W, Arnold GJ, Schwinzer R, Schieker M, Wolf E.

FASEB J. 2012 Mar;26(3):1086-99. doi: 10.1096/fj.11-185041. Epub 2011 Dec 1.

PMID:
22138035
43.

Early insulin therapy prevents beta cell loss in a mouse model for permanent neonatal diabetes (Munich Ins2(C95S)).

Kautz S, van Bürck L, Schuster M, Wolf E, Wanke R, Herbach N.

Diabetologia. 2012 Feb;55(2):382-91. doi: 10.1007/s00125-011-2362-7. Epub 2011 Nov 18.

PMID:
22095234
44.

The cardioprotective effects of parathyroid hormone are independent of endogenous granulocyte-colony stimulating factor release.

Brunner S, Weinberger T, Huber BC, Segeth A, Zaruba MM, Theiss HD, Assmann G, Herbach N, Wanke R, Mueller-Hoecker J, Franz WM.

Cardiovasc Res. 2012 Feb 1;93(2):330-9. doi: 10.1093/cvr/cvr303. Epub 2011 Nov 10.

PMID:
22080594
45.

Gene expression profiling of bovine peripartal placentomes: detection of molecular pathways potentially involved in the release of foetal membranes.

Streyl D, Kenngott R, Herbach N, Wanke R, Blum H, Sinowatz F, Wolf E, Zerbe H, Bauersachs S.

Reproduction. 2012 Jan 1;143(1):85-105. doi: 10.1530/REP-11-0204. Epub 2011 Oct 26.

PMID:
22031715
46.

In vivo evidence for epidermal growth factor receptor (EGFR)-mediated release of prolactin from the pituitary gland.

Dahlhoff M, Blutke A, Wanke R, Wolf E, Schneider MR.

J Biol Chem. 2011 Nov 11;286(45):39297-306. doi: 10.1074/jbc.M111.243493. Epub 2011 Sep 13.

47.

Persistent hydrogen-bonded and non-hydrogen-bonded phenoxyl radicals.

Wanke R, Benisvy L, Kuznetsov ML, da Silva MF, Pombeiro AJ.

Chemistry. 2011 Oct 10;17(42):11882-92. doi: 10.1002/chem.201101509. Epub 2011 Sep 5.

PMID:
21898619
48.

Postnatal development of numbers and mean sizes of pancreatic islets and beta-cells in healthy mice and GIPR(dn) transgenic diabetic mice.

Herbach N, Bergmayr M, Göke B, Wolf E, Wanke R.

PLoS One. 2011;6(7):e22814. doi: 10.1371/journal.pone.0022814. Epub 2011 Jul 26.

49.

Role of mTOR in podocyte function and diabetic nephropathy in humans and mice.

Gödel M, Hartleben B, Herbach N, Liu S, Zschiedrich S, Lu S, Debreczeni-Mór A, Lindenmeyer MT, Rastaldi MP, Hartleben G, Wiech T, Fornoni A, Nelson RG, Kretzler M, Wanke R, Pavenstädt H, Kerjaschki D, Cohen CD, Hall MN, Rüegg MA, Inoki K, Walz G, Huber TB.

J Clin Invest. 2011 Jun;121(6):2197-209. doi: 10.1172/JCI44774. Epub 2011 May 23.

50.

Differential glomerular proteome analysis of two murine nephropathy models at onset of albuminuria.

Blutke A, Block C, Berendt F, Herbach N, Kemter E, Amann K, Fröhlich T, Arnold GJ, Wanke R.

Proteomics Clin Appl. 2011 Jun;5(5-6):375-81. doi: 10.1002/prca.201000103. Epub 2011 Apr 29.

PMID:
21538912

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