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Items: 1 to 50 of 133

1.

Special Issue in Honor of Professor Susan Band Horwitz.

Mooberry SL, Kingston DGI, Smith AB 3rd, Swanson SM, Wani MC.

J Nat Prod. 2018 Mar 23;81(3):449-450. doi: 10.1021/acs.jnatprod.8b00098. No abstract available.

PMID:
29566495
2.

Discovery of Anticancer Agents of Diverse Natural Origin.

Kinghorn AD, DE Blanco EJ, Lucas DM, Rakotondraibe HL, Orjala J, Soejarto DD, Oberlies NH, Pearce CJ, Wani MC, Stockwell BR, Burdette JE, Swanson SM, Fuchs JR, Phelps MA, Xu L, Zhang X, Shen YY.

Anticancer Res. 2016 Nov;36(11):5623-5637. Review.

3.

Spiroscytalin, a new tetramic acid and other metabolites of mixed biogenesis from Scytalidium cuboideum.

Sy-Cordero AA, Figueroa M, Raja HA, Meza Aviña ME, Croatt MP, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH.

Tetrahedron. 2015 Nov 25;71(47):8899-904. doi: 10.1016/j.tet.2015.09.073.

4.

Biosynthetically Distinct Cytotoxic Polyketides from Setophoma terrestris.

El-Elimat T, Figueroa M, Raja HA, Graf TN, Swanson SM, Falkinham JO 3rd, Wani MC, Pearce CJ, Oberlies NH.

European J Org Chem. 2015 Jan 1;2015(1):109-121.

5.

Sorbicillinoid analogs with cytotoxic and selective anti-Aspergillus activities from Scytalidium album.

El-Elimat T, Raja HA, Figueroa M, Swanson SM, Falkinham JO 3rd, Lucas DM, Grever MR, Wani MC, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2015 Mar;68(3):191-6. doi: 10.1038/ja.2014.125. Epub 2014 Sep 24.

6.

Nature as a remarkable chemist: a personal story of the discovery and development of Taxol.

Wani MC, Horwitz SB.

Anticancer Drugs. 2014 May;25(5):482-7. doi: 10.1097/CAD.0000000000000063. Review.

7.

Waol A, trans-dihydrowaol A, and cis-dihydrowaol A: polyketide-derived γ-lactones from a Volutella species.

El-Elimat T, Figueroa M, Raja HA, Adcock AF, Kroll DJ, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2013 Aug 7;54(32):4300-4302.

8.

Peptaibols, tetramic acid derivatives, isocoumarins, and sesquiterpenes from a Bionectria sp. (MSX 47401).

Figueroa M, Raja H, Falkinham JO 3rd, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2013 Jun 28;76(6):1007-15. doi: 10.1021/np3008842. Epub 2013 Jun 19.

9.

Benzoquinones and terphenyl compounds as phosphodiesterase-4B inhibitors from a fungus of the order Chaetothyriales (MSX 47445).

El-Elimat T, Figueroa M, Raja HA, Graf TN, Adcock AF, Kroll DJ, Day CS, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2013 Mar 22;76(3):382-7. doi: 10.1021/np300749w. Epub 2013 Jan 9.

10.

Enhanced bioactivity of silybin B methylation products.

Sy-Cordero AA, Graf TN, Runyon SP, Wani MC, Kroll DJ, Agarwal R, Brantley SJ, Paine MF, Polyak SJ, Oberlies NH.

Bioorg Med Chem. 2013 Feb 1;21(3):742-7. doi: 10.1016/j.bmc.2012.11.035. Epub 2012 Dec 5.

11.

Use of the hollow fiber assay for the discovery of novel anticancer agents from fungi.

Pearce CJ, Lantvit DD, Shen Q, Jarjoura D, Zhang X, Oberlies NH, Kroll DJ, Wani MC, Orjala J, Soejarto DD, Farnsworth NR, de Blanco EJ, Fuchs JR, Kinghorn AD, Swanson SM.

Methods Mol Biol. 2012;944:267-77. doi: 10.1007/978-1-62703-122-6_20.

PMID:
23065624
12.

Cytotoxic epipolythiodioxopiperazine alkaloids from filamentous fungi of the Bionectriaceae.

Figueroa M, Graf TN, Ayers S, Adcock AF, Kroll DJ, Yang J, Swanson SM, Munoz-Acuna U, Carcache de Blanco EJ, Agrawal R, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2012 Nov;65(11):559-64. doi: 10.1038/ja.2012.69. Epub 2012 Sep 12.

13.

Peptaibols from two unidentified fungi of the order Hypocreales with cytotoxic, antibiotic, and anthelmintic activities.

Ayers S, Ehrmann BM, Adcock AF, Kroll DJ, Carcache de Blanco EJ, Shen Q, Swanson SM, Falkinham JO 3rd, Wani MC, Mitchell SM, Pearce CJ, Oberlies NH.

J Pept Sci. 2012 Aug;18(8):500-10. doi: 10.1002/psc.2425. Epub 2012 Jun 29.

14.

Thielavin B methyl ester: a cytotoxic benzoate trimer from an unidentified fungus (MSX 55526) from the Order Sordariales.

Ayers S, Ehrmann BM, Adcock AF, Kroll DJ, Wani MC, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2011 Nov 2;52(44):5733-5735.

15.

Cytotoxic xanthone-anthraquinone heterodimers from an unidentified fungus of the order Hypocreales (MSX 17022).

Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Matthew S, Carcache de Blanco EJ, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2012 Jan;65(1):3-8. doi: 10.1038/ja.2011.95. Epub 2011 Nov 9.

16.

Obionin B: An o-pyranonaphthoquinone decaketide from an unidentified fungus (MSX 63619) from the Order Pleosporales.

Ayers S, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Darveaux BA, Pearce CJ, Oberlies NH.

Tetrahedron Lett. 2011 Oct 5;52(40):5128-5230.

17.

Cyclodepsipeptides, sesquiterpenoids, and other cytotoxic metabolites from the filamentous fungus Trichothecium sp. (MSX 51320).

Sy-Cordero AA, Graf TN, Adcock AF, Kroll DJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2011 Oct 28;74(10):2137-42. doi: 10.1021/np2004243. Epub 2011 Oct 6. Erratum in: J Nat Prod. 2012 Feb 24;75(2):307.

18.

Resorcylic acid lactones with cytotoxic and NF-κB inhibitory activities and their structure-activity relationships.

Ayers S, Graf TN, Adcock AF, Kroll DJ, Matthew S, Carcache de Blanco EJ, Shen Q, Swanson SM, Wani MC, Pearce CJ, Oberlies NH.

J Nat Prod. 2011 May 27;74(5):1126-31. doi: 10.1021/np200062x. Epub 2011 Apr 22.

19.

Dereplication of macrocyclic trichothecenes from extracts of filamentous fungi through UV and NMR profiles.

Sy-Cordero AA, Graf TN, Wani MC, Kroll DJ, Pearce CJ, Oberlies NH.

J Antibiot (Tokyo). 2010 Sep;63(9):539-44. doi: 10.1038/ja.2010.77. Epub 2010 Jul 21.

20.

BACPTDP: a water-soluble camptothecin pro-drug with enhanced activity in hypoxic/acidic tumors.

Adams DJ, Waud WR, Wani MC, Manikumar G, Flowers JL, Driscoll TA, Morgan LR.

Cancer Chemother Pharmacol. 2011 Apr;67(4):855-65. doi: 10.1007/s00280-010-1388-8. Epub 2010 Jun 22.

21.

Discovery of anticancer agents of diverse natural origin.

Kinghorn AD, Carcache de Blanco EJ, Chai HB, Orjala J, Farnsworth NR, Soejarto DD, Oberlies NH, Wani MC, Kroll DJ, Pearce CJ, Swanson SM, Kramer RA, Rose WC, Fairchild CR, Vite GD, Emanuel S, Jarjoura D, Cope FO.

Pure Appl Chem. 2009 Jan 1;81(6):1051-1063.

22.

Large-scale isolation of flavonolignans from Silybum marianum extract affords new minor constituents and preliminary structure-activity relationships.

Sy-Cordero A, Graf TN, Nakanishi Y, Wani MC, Agarwal R, Kroll DJ, Oberlies NH.

Planta Med. 2010 Apr;76(6):644-7. doi: 10.1055/s-0029-1240624. Epub 2009 Nov 25.

23.

Bioactive constituents of the stem bark of Mitrephora glabra.

Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO 3rd, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH.

J Nat Prod. 2009 Nov;72(11):1949-53. doi: 10.1021/np900572g.

24.

Design, synthesis, and biological evaluation of antibody-drug conjugates comprised of potent camptothecin analogues.

Burke PJ, Senter PD, Meyer DW, Miyamoto JB, Anderson M, Toki BE, Manikumar G, Wani MC, Kroll DJ, Jeffrey SC.

Bioconjug Chem. 2009 Jun;20(6):1242-50. doi: 10.1021/bc9001097.

PMID:
19469529
25.

Use of the in vivo hollow fiber assay in natural products anticancer drug discovery.

Mi Q, Pezzuto JM, Farnsworth NR, Wani MC, Kinghorn AD, Swanson SM.

J Nat Prod. 2009 Mar 27;72(3):573-80. doi: 10.1021/np800767a. Review.

26.
27.

Alvaradoins E-N, antitumor and cytotoxic anthracenone C-glycosides from the leaves of Alvaradoa haitiensis.

Phifer SS, Lee D, Seo EK, Kim NC, Graf TN, Kroll DJ, Navarro HA, Izydore RA, Jiménez F, Garcia R, Rose WC, Fairchild CR, Wild R, Soejarto DD, Farnsworth NR, Kinghorn AD, Oberlies NH, Wall ME, Wani MC.

J Nat Prod. 2007 Jun;70(6):954-61. Epub 2007 Jun 7.

28.

Variability in the yield of benzophenanthridine alkaloids in wildcrafted vs cultivated bloodroot (Sanguinaria canadensis L.).

Graf TN, Levine KE, Andrews ME, Perlmutter JM, Nielsen SJ, Davis JM, Wani MC, Oberlies NH.

J Agric Food Chem. 2007 Feb 21;55(4):1205-11. Epub 2007 Jan 25.

PMID:
17253712
29.

Dendrimer-encapsulated camptothecins: increased solubility, cellular uptake, and cellular retention affords enhanced anticancer activity in vitro.

Morgan MT, Nakanishi Y, Kroll DJ, Griset AP, Carnahan MA, Wathier M, Oberlies NH, Manikumar G, Wani MC, Grinstaff MW.

Cancer Res. 2006 Dec 15;66(24):11913-21.

30.

Phytochemical studies and cytotoxicity evaluations of Colchicum tunicatum Feinbr and Colchicum hierosolymitanum Feinbr (Colchicaceae): two native Jordanian meadow saffrons.

Alali FQ, Tawaha K, El-Elimat T, Qasaymeh R, Li C, Burgess J, Nakanishi Y, Kroll DJ, Wani MC, Oberlies NH.

Nat Prod Res. 2006 May 20;20(6):558-66.

PMID:
16835088
31.

A hexacyclic ent-trachylobane diterpenoid possessing an oxetane ring from Mitrephora glabra.

Li C, Lee D, Graf TN, Phifer SS, Nakanishi Y, Burgess JP, Riswan S, Setyowati FM, Saribi AM, Soejarto DD, Farnsworth NR, Falkinham JO 3rd, Kroll DJ, Kinghorn AD, Wani MC, Oberlies NH.

Org Lett. 2005 Dec 8;7(25):5709-12.

32.

Novel fluoro-substituted camptothecins: in vivo antitumor activity, reduced gastrointestinal toxicity and pharmacokinetic characterization.

Rose WC, Marathe PH, Jang GR, Monticello TM, Balasubramanian BN, Long B, Fairchild CR, Wall ME, Wani MC.

Cancer Chemother Pharmacol. 2006 Jul;58(1):73-85. Epub 2005 Oct 14.

PMID:
16228206
33.

Camptothecin analogs with enhanced activity against human breast cancer cells. I. Correlation of potency with lipophilicity and persistence in the cleavage complex.

Adams DJ, da Silva MW, Flowers JL, Kohlhagen G, Pommier Y, Colvin OM, Manikumar G, Wani MC.

Cancer Chemother Pharmacol. 2006 Jan;57(2):135-44. Epub 2005 Aug 23.

PMID:
16151810
34.

Diterpene glycosides from Egletes viscosa.

Lee D, Li C, Graf TN, Vigo JS, Graham JG, Cabieses F, Farnsworth NR, Cordell GA, Kinghorn AD, Kroll DJ, Wani MC, Oberlies NH.

Planta Med. 2005 Aug;71(8):792-4.

PMID:
16142652
35.

Camptothecin analogs with enhanced activity against human breast cancer cells. II. Impact of the tumor pH gradient.

Adams DJ, Wahl ML, Flowers JL, Sen B, Colvin M, Dewhirst MW, Manikumar G, Wani MC.

Cancer Chemother Pharmacol. 2006 Jan;57(2):145-54. Epub 2005 Jul 5.

PMID:
16001167
36.

Milk thistle and prostate cancer: differential effects of pure flavonolignans from Silybum marianum on antiproliferative end points in human prostate carcinoma cells.

Davis-Searles PR, Nakanishi Y, Kim NC, Graf TN, Oberlies NH, Wani MC, Wall ME, Agarwal R, Kroll DJ.

Cancer Res. 2005 May 15;65(10):4448-57.

37.

Apoptotic anticancer effect of alvaradoin E isolated from Alvaradoa haitiensis.

Mi Q, Lantvit D, Reyes-Lim E, Chai H, Phifer SS, Wani MC, Wall ME, Tan GT, Cordell GA, Farnsworth NR, Kinghorn AD, Pezzuto JM.

Anticancer Res. 2005 Mar-Apr;25(2A):779-87.

38.

New colchicinoids from a native Jordanian meadow saffron, colchicum brachyphyllum: isolation of the first naturally occurring dextrorotatory colchicinoid.

Alali FQ, El-Elimat T, Li C, Qandil A, Alkofahi A, Tawaha K, Burgess JP, Nakanishi Y, Kroll DJ, Navarro HA, Falkinham JO 3rd, Wani MC, Oberlies NH.

J Nat Prod. 2005 Feb;68(2):173-8.

PMID:
15730238
39.
40.

Camptothecin analogs with bulky, hydrophobic substituents at the 7-position via a Grignard reaction.

Manikumar G, Wadkins RM, Bearss D, Von Hoff DD, Wani MC, Wall ME.

Bioorg Med Chem Lett. 2004 Nov 1;14(21):5377-81.

PMID:
15454230
41.

Hydrophilic camptothecin analogs that form extremely stable cleavable complexes with DNA and topoisomerase I.

Wadkins RM, Bearss D, Manikumar G, Wani MC, Wall ME, Von Hoff DD.

Cancer Res. 2004 Sep 15;64(18):6679-83.

42.

Topoisomerase I-DNA complex stability induced by camptothecins and its role in drug activity.

Wadkins RM, Bearss D, Manikumar G, Wani MC, Wall ME, Von Hoff DD.

Curr Med Chem Anticancer Agents. 2004 Jul;4(4):327-34.

PMID:
15281905
43.

Cytotoxic and antimicrobial constituents of the bark of Diospyros maritima collected in two geographical locations in Indonesia.

Gu JQ, Graf TN, Lee D, Chai HB, Mi Q, Kardono LB, Setyowati FM, Ismail R, Riswan S, Farnsworth NR, Cordell GA, Pezzuto JM, Swanson SM, Kroll DJ, Falkinham JO 3rd, Wall ME, Wani MC, Kinghorn AD, Oberlies NH.

J Nat Prod. 2004 Jul;67(7):1156-61.

PMID:
15270571
44.

Complete isolation and characterization of silybins and isosilybins from milk thistle (Silybum marianum).

Kim NC, Graf TN, Sparacino CM, Wani MC, Wall ME.

Org Biomol Chem. 2003 May 21;1(10):1684-9. Erratum in: Org Biomol Chem. 2003 Oct 7;1(19):3470.

PMID:
12926355
45.

Synergistic antimicrobial activity of metabolites produced by a nonobligate bacterial predator.

Cain CC, Lee D, Waldo RH 3rd, Henry AT, Casida EJ Jr, Wani MC, Wall ME, Oberlies NH, Falkinham JO 3rd.

Antimicrob Agents Chemother. 2003 Jul;47(7):2113-7.

46.

The activity of camptothecin analogues is enhanced in histocultures of human tumors and human tumor xenografts by modulation of extracellular pH.

Flowers JL, Hoffman RM, Driscoll TA, Wall ME, Wani MC, Manikumar G, Friedman HS, Dewhirst M, Colvin OM, Adams DJ.

Cancer Chemother Pharmacol. 2003 Sep;52(3):253-61. Epub 2003 Jun 3.

PMID:
12783198
47.

Camptothecin analogs in malignant gliomas: comparative analysis and characterization.

Sampath P, Amundson E, Wall ME, Tyler BM, Wani MC, Alderson LM, Colvin M, Brem H, Weingart JD.

J Neurosurg. 2003 Mar;98(3):570-7.

PMID:
12650430
48.

Bioactive prenylated flavonoids from the stem bark of Artocarpus kemando.

Seo EK, Lee D, Shin YG, Chai HB, Navarro HA, Kardono LB, Rahman I, Cordell GA, Farnsworth NR, Pezzuto JM, Kinghorn AD, Wani MC, Wall ME.

Arch Pharm Res. 2003 Feb;26(2):124-7.

PMID:
12643587
49.

Cytotoxic prenylated xanthones and the unusual compounds anthraquinobenzophenones from Cratoxylum sumatranum.

Seo EK, Kim NC, Wani MC, Wall ME, Navarro HA, Burgess JP, Kawanishi K, Kardono LB, Riswan S, Rose WC, Fairchild CR, Farnsworth NR, Kinghorn AD.

J Nat Prod. 2002 Mar;65(3):299-305.

PMID:
11908969
50.

Novel bioactive clerodane diterpenoids from the leaves and twigs of Casearia sylvestris.

Oberlies NH, Burgess JP, Navarro HA, Pinos RE, Fairchild CR, Peterson RW, Soejarto DD, Farnsworth NR, Kinghorn AD, Wani MC, Wall ME.

J Nat Prod. 2002 Feb;65(2):95-9.

PMID:
11858737

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