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Items: 40

1.

Loss of PTEN expression does not contribute to PDK-1 activity and PKC activation-loop phosphorylation in Jurkat leukaemic T cells.

Freeley M, Park J, Yang KJ, Wange RL, Volkov Y, Kelleher D, Long A.

Cell Signal. 2007 Dec;19(12):2444-57. Epub 2007 Aug 3.

PMID:
17826953
2.

Negative regulation of CXCR4-mediated chemotaxis by the lipid phosphatase activity of tumor suppressor PTEN.

Gao P, Wange RL, Zhang N, Oppenheim JJ, Howard OM.

Blood. 2005 Oct 15;106(8):2619-26. Epub 2005 Jun 30.

3.

Deficiency of ADAP/Fyb/SLAP-130 destabilizes SKAP55 in Jurkat T cells.

Huang Y, Norton DD, Precht P, Martindale JL, Burkhardt JK, Wange RL.

J Biol Chem. 2005 Jun 24;280(25):23576-83. Epub 2005 Apr 22.

4.

Modulation of specific protein expression levels by PTEN: identification of AKAP121, DHFR, G3BP, Rap1, and RCC1 as potential targets of PTEN.

Huang Y, Wernyj RP, Norton DD, Precht P, Seminario MC, Wange RL.

Oncogene. 2005 May 26;24(23):3819-29.

PMID:
15782128
5.

Kinase-independent functions for Itk in TCR-induced regulation of Vav and the actin cytoskeleton.

Dombroski D, Houghtling RA, Labno CM, Precht P, Takesono A, Caplen NJ, Billadeau DD, Wange RL, Burkhardt JK, Schwartzberg PL.

J Immunol. 2005 Feb 1;174(3):1385-92.

6.

PTEN permits acute increases in D3-phosphoinositide levels following TCR stimulation but inhibits distal signaling events by reducing the basal activity of Akt.

Seminario MC, Precht P, Bunnell SC, Warren SE, Morris CM, Taub D, Wange RL.

Eur J Immunol. 2004 Nov;34(11):3165-75.

7.

TCR signaling: another Abl-bodied kinase joins the cascade.

Wange RL.

Curr Biol. 2004 Jul 27;14(14):R562-4. Review.

8.

T cell receptor signaling: beyond complex complexes.

Huang Y, Wange RL.

J Biol Chem. 2004 Jul 9;279(28):28827-30. Epub 2004 Apr 14. Review. No abstract available.

9.

The missing link(er): a return to symmetry in antigen receptor signaling?

Wange RL.

Mol Interv. 2003 Mar;3(2):75-8, 50. Review.

PMID:
14993428
10.

PTEN expression in PTEN-null leukaemic T cell lines leads to reduced proliferation via slowed cell cycle progression.

Seminario MC, Precht P, Wersto RP, Gorospe M, Wange RL.

Oncogene. 2003 Nov 6;22(50):8195-204.

PMID:
14603260
11.

Lipid phosphatases in the regulation of T cell activation: living up to their PTEN-tial.

Seminario MC, Wange RL.

Immunol Rev. 2003 Apr;192:80-97. Review.

PMID:
12670397
12.

Signaling pathways of D3-phosphoinositide-binding kinases in T cells and their regulation by PTEN.

Seminario MC, Wange RL.

Semin Immunol. 2002 Feb;14(1):27-36. Review.

PMID:
11884228
13.
14.

Zap-70-independent Ca(2+) mobilization and Erk activation in Jurkat T cells in response to T-cell antigen receptor ligation.

Shan X, Balakir R, Criado G, Wood JS, Seminario MC, Madrenas J, Wange RL.

Mol Cell Biol. 2001 Nov;21(21):7137-49.

15.

Membrane raft-dependent regulation of phospholipase Cgamma-1 activation in T lymphocytes.

Verí MC, DeBell KE, Seminario MC, DiBaldassarre A, Reischl I, Rawat R, Graham L, Noviello C, Rellahan BL, Miscia S, Wange RL, Bonvini E.

Mol Cell Biol. 2001 Oct;21(20):6939-50.

16.
17.

Involvement of hematopoietic progenitor kinase 1 in T cell receptor signaling.

Ling P, Meyer CF, Redmond LP, Shui JW, Davis B, Rich RR, Hu MC, Wange RL, Tan TH.

J Biol Chem. 2001 Jun 1;276(22):18908-14. Epub 2001 Mar 13.

18.

Deficiency of PTEN in Jurkat T cells causes constitutive localization of Itk to the plasma membrane and hyperresponsiveness to CD3 stimulation.

Shan X, Czar MJ, Bunnell SC, Liu P, Liu Y, Schwartzberg PL, Wange RL.

Mol Cell Biol. 2000 Sep;20(18):6945-57.

19.

Structure/function relationship of activating Ly-49D and inhibitory Ly-49G2 NK receptors.

Ortaldo JR, Winkler-Pickett R, Willette-Brown J, Wange RL, Anderson SK, Palumbo GJ, Mason LH, McVicar DW.

J Immunol. 1999 Nov 15;163(10):5269-77.

21.

Specific CD3 epsilon association of a phosphodiesterase 4B isoform determines its selective tyrosine phosphorylation after CD3 ligation.

Baroja ML, Cieslinski LB, Torphy TJ, Wange RL, Madrenas J.

J Immunol. 1999 Feb 15;162(4):2016-23.

22.
23.

Genetic evidence for differential coupling of Syk family kinases to the T-cell receptor: reconstitution studies in a ZAP-70-deficient Jurkat T-cell line.

Williams BL, Schreiber KL, Zhang W, Wange RL, Samelson LE, Leibson PJ, Abraham RT.

Mol Cell Biol. 1998 Mar;18(3):1388-99.

24.

Distinct tyrosine phosphorylation sites in JAK3 kinase domain positively and negatively regulate its enzymatic activity.

Zhou YJ, Hanson EP, Chen YQ, Magnuson K, Chen M, Swann PG, Wange RL, Changelian PS, O'Shea JJ.

Proc Natl Acad Sci U S A. 1997 Dec 9;94(25):13850-5.

25.

Identification and characterization of a substrate specific for the T cell protein tyrosine kinase ZAP-70.

Watts JD, Brabb T, Bures EJ, Wange RL, Samelson LE, Aebersold R.

FEBS Lett. 1996 Dec 2;398(2-3):217-22.

26.

Complex complexes: signaling at the TCR.

Wange RL, Samelson LE.

Immunity. 1996 Sep;5(3):197-205. Review. No abstract available.

27.

Purification and characterization of human ZAP-70 protein-tyrosine kinase from a baculovirus expression system.

Isakov N, Wange RL, Watts JD, Aebersold R, Samelson LE.

J Biol Chem. 1996 Jun 28;271(26):15753-61.

28.

Signal transduction mediated by the T-cell antigen receptor.

Samelson LE, Donovan JA, Isakov N, Ota Y, Wange RL.

Ann N Y Acad Sci. 1995 Sep 7;766:157-72. Review. No abstract available.

PMID:
7486652
29.

Activating and inhibitory mutations in adjacent tyrosines in the kinase domain of ZAP-70.

Wange RL, Guitián R, Isakov N, Watts JD, Aebersold R, Samelson LE.

J Biol Chem. 1995 Aug 11;270(32):18730-3.

30.

Zeta phosphorylation without ZAP-70 activation induced by TCR antagonists or partial agonists.

Madrenas J, Wange RL, Wang JL, Isakov N, Samelson LE, Germain RN.

Science. 1995 Jan 27;267(5197):515-8.

PMID:
7824949
31.

F2(Pmp)2-TAM zeta 3, a novel competitive inhibitor of the binding of ZAP-70 to the T cell antigen receptor, blocks early T cell signaling.

Wange RL, Isakov N, Burke TR Jr, Otaka A, Roller PP, Watts JD, Aebersold R, Samelson LE.

J Biol Chem. 1995 Jan 13;270(2):944-8.

33.
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36.

Tandem SH2 domains of ZAP-70 bind to T cell antigen receptor zeta and CD3 epsilon from activated Jurkat T cells.

Wange RL, Malek SN, Desiderio S, Samelson LE.

J Biol Chem. 1993 Sep 15;268(26):19797-801.

38.

The T cell antigen receptor tyrosine kinase pathway.

Samelson LE, Egerton M, Thomas PM, Wange RL.

Adv Exp Med Biol. 1992;323:9-16. Review. No abstract available.

PMID:
1485569

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