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Items: 36

1.

Metabolomic profiling of the excretory-secretory products of hookworm and whipworm.

Wangchuk P, Kouremenos K, Eichenberger RM, Pearson M, Susianto A, Wishart DS, McConville MJ, Loukas A.

Metabolomics. 2019 Jun 28;15(7):101. doi: 10.1007/s11306-019-1561-y.

PMID:
31254203
2.

Characterization of Tapeworm Metabolites and Their Reported Biological Activities.

Wangchuk P, Constantinoiu C, Eichenberger RM, Field M, Loukas A.

Molecules. 2019 Apr 15;24(8). pii: E1480. doi: 10.3390/molecules24081480.

3.

Hookworm-Derived Metabolites Suppress Pathology in a Mouse Model of Colitis and Inhibit Secretion of Key Inflammatory Cytokines in Primary Human Leukocytes.

Wangchuk P, Shepherd C, Constantinoiu C, Ryan RYM, Kouremenos KA, Becker L, Jones L, Buitrago G, Giacomin P, Wilson D, Daly N, McConville MJ, Miles JJ, Loukas A.

Infect Immun. 2019 Mar 25;87(4). pii: e00851-18. doi: 10.1128/IAI.00851-18. Print 2019 Apr.

4.

Defined Small Molecules Produced by Himalayan Medicinal Plants Display Immunomodulatory Properties.

Wangchuk P, Apte SH, Smout MJ, Groves PL, Loukas A, Doolan DL.

Int J Mol Sci. 2018 Nov 6;19(11). pii: E3490. doi: 10.3390/ijms19113490.

5.

Engineering of an Anti-Inflammatory Peptide Based on the Disulfide-Rich Linaclotide Scaffold.

Cobos C, Bansal PS, Jones L, Wangchuk P, Wilson D, Loukas A, Daly NL.

Biomedicines. 2018 Oct 6;6(4). pii: E97. doi: 10.3390/biomedicines6040097.

6.

Burden of Alcoholic Liver Disease: Bhutan Scenario.

Wangchuk P.

Euroasian J Hepatogastroenterol. 2018 Jan-Jun;8(1):81-82. doi: 10.5005/jp-journals-10018-1267. Epub 2018 May 1. Review.

7.

Geopharmaceuticals of Himalayan Sowa Rigpa medicine: Ethnopharmacological uses, mineral diversity, chemical identification and current utilization in Bhutan.

Yeshi K, Wangdi T, Qusar N, Nettles J, Craig SR, Schrempf M, Wangchuk P.

J Ethnopharmacol. 2018 Sep 15;223:99-112. doi: 10.1016/j.jep.2018.05.007. Epub 2018 May 8.

PMID:
29751124
8.

Characterization of Trichuris muris secreted proteins and extracellular vesicles provides new insights into host-parasite communication.

Eichenberger RM, Talukder MH, Field MA, Wangchuk P, Giacomin P, Loukas A, Sotillo J.

J Extracell Vesicles. 2018 Jan 21;7(1):1428004. doi: 10.1080/20013078.2018.1428004. eCollection 2018.

9.

Of dogs and hookworms: man's best friend and his parasites as a model for translational biomedical research.

Shepherd C, Wangchuk P, Loukas A.

Parasit Vectors. 2018 Jan 25;11(1):59. doi: 10.1186/s13071-018-2621-2. Review.

10.

Sertraline, Paroxetine, and Chlorpromazine Are Rapidly Acting Anthelmintic Drugs Capable of Clinical Repurposing.

Weeks JC, Roberts WM, Leasure C, Suzuki BM, Robinson KJ, Currey H, Wangchuk P, Eichenberger RM, Saxton AD, Bird TD, Kraemer BC, Loukas A, Hawdon JM, Caffrey CR, Liachko NF.

Sci Rep. 2018 Jan 17;8(1):975. doi: 10.1038/s41598-017-18457-w.

11.

Pharmacological, ethnopharmacological, and botanical evaluation of subtropical medicinal plants of Lower Kheng region in Bhutan.

Wangchuk P, Yeshi K, Jamphel K.

Integr Med Res. 2017 Dec;6(4):372-387. doi: 10.1016/j.imr.2017.08.002. Epub 2017 Sep 1.

12.

Polypyridylruthenium(II) complexes exert anti-schistosome activity and inhibit parasite acetylcholinesterases.

Sundaraneedi MK, Tedla BA, Eichenberger RM, Becker L, Pickering D, Smout MJ, Rajan S, Wangchuk P, Keene FR, Loukas A, Collins JG, Pearson MS.

PLoS Negl Trop Dis. 2017 Dec 14;11(12):e0006134. doi: 10.1371/journal.pntd.0006134. eCollection 2017 Dec.

13.

Polypyridylruthenium(II) complexes exert in vitro and in vivo nematocidal activity and show significant inhibition of parasite acetylcholinesterases.

Sundaraneedi M, Eichenberger RM, Al-Hallaf R, Yang D, Sotillo J, Rajan S, Wangchuk P, Giacomin PR, Keene FR, Loukas A, Collins JG, Pearson MS.

Int J Parasitol Drugs Drug Resist. 2018 Apr;8(1):1-7. doi: 10.1016/j.ijpddr.2017.11.005. Epub 2017 Nov 29.

14.

A medicinal plant compound, capnoidine, prevents the onset of inflammation in a mouse model of colitis.

Shepherd C, Giacomin P, Navarro S, Miller C, Loukas A, Wangchuk P.

J Ethnopharmacol. 2018 Jan 30;211:17-28. doi: 10.1016/j.jep.2017.09.024. Epub 2017 Sep 21.

PMID:
28942135
15.

Animal-derived natural products of Sowa Rigpa medicine: Their pharmacopoeial description, current utilization and zoological identification.

Yeshi K, Morisco P, Wangchuk P.

J Ethnopharmacol. 2017 Jul 31;207:192-202. doi: 10.1016/j.jep.2017.06.009. Epub 2017 Jun 9. Review.

PMID:
28606809
16.

Anti-inflammatory, Anti-bacterial and Anti-acetylcholinesterase Activities of two Isoquinoline Alkaloids-Scoulerine and Cheilanthifoline.

Wangchuk P, Sastraruji T, Taweechotipatr M, Keller PA, Pyne SG.

Nat Prod Commun. 2016 Dec;11(12):1801-1804.

PMID:
30508337
17.

Identification of lead chemotherapeutic agents from medicinal plants against blood flukes and whipworms.

Wangchuk P, Giacomin PR, Pearson MS, Smout MJ, Loukas A.

Sci Rep. 2016 Aug 30;6:32101. doi: 10.1038/srep32101.

18.
19.

Compounds Derived from the Bhutanese Daisy, Ajania nubigena, Demonstrate Dual Anthelmintic Activity against Schistosoma mansoni and Trichuris muris.

Wangchuk P, Pearson MS, Giacomin PR, Becker L, Sotillo J, Pickering D, Smout MJ, Loukas A.

PLoS Negl Trop Dis. 2016 Aug 4;10(8):e0004908. doi: 10.1371/journal.pntd.0004908. eCollection 2016 Aug.

20.

Medicinal plants of Dagala region in Bhutan: their diversity, distribution, uses and economic potential.

Wangchuk P, Namgay K, Gayleg K, Dorji Y.

J Ethnobiol Ethnomed. 2016 Jun 24;12(1):28. doi: 10.1186/s13002-016-0098-7.

21.

Diterpenoid alkaloids of Aconitum laciniatum and mitigation of inflammation by 14-O-acetylneoline in a murine model of ulcerative colitis.

Wangchuk P, Navarro S, Shepherd C, Keller PA, Pyne SG, Loukas A.

Sci Rep. 2015 Aug 4;5:12845. doi: 10.1038/srep12845.

22.

Contributions of medicinal plants to the Gross National Happiness and Biodiscovery in Bhutan.

Wangchuk P, Tobgay T.

J Ethnobiol Ethnomed. 2015 Jun 3;11:48. doi: 10.1186/s13002-015-0035-1.

23.

Identifying the immunomodulatory components of helminths.

Shepherd C, Navarro S, Wangchuk P, Wilson D, Daly NL, Loukas A.

Parasite Immunol. 2015 Jun;37(6):293-303. doi: 10.1111/pim.12192. Review.

24.

Phenylpropanoids and furanocoumarins as antibacterial and antimalarial constituents of the Bhutanese medicinal plant Pleurospermum amabile.

Wangchuk P, Pyne SG, Keller PA, Taweechotipatr M, Kamchonwongpaisane S.

Nat Prod Commun. 2014 Jul;9(7):957-60.

PMID:
25230503
25.

GC/GC-MS analysis, isolation and identification of bioactive essential oil components from the Bhutanese medicinal plant, Pleurospermum amabile.

Wangchuk P, Keller PA, Pyne SG, Taweechotipatr M, Kamchonwongpaisan S.

Nat Prod Commun. 2013 Sep;8(9):1305-8.

PMID:
24273872
26.

A new protoberberine alkaloid from Meconopsis simplicifolia (D. Don) Walpers with potent antimalarial activity against a multidrug resistant Plasmodium falciparum strain.

Wangchuk P, Keller PA, Pyne SG, Lie W, Willis AC, Rattanajak R, Kamchonwongpaisan S.

J Ethnopharmacol. 2013 Dec 12;150(3):953-9. doi: 10.1016/j.jep.2013.09.052. Epub 2013 Oct 9. Erratum in: J Ethnopharmacol. 2014 May 14;153(3):934. Phurpa, Wangchuk [corrected to Wangchuk, Phurpa].

PMID:
24120516
27.

Inhibition of TNF-α production in LPS-activated THP-1 monocytic cells by the crude extracts of seven Bhutanese medicinal plants.

Wangchuk P, Keller PA, Pyne SG, Taweechotipatr M.

J Ethnopharmacol. 2013 Jul 30;148(3):1013-7. doi: 10.1016/j.jep.2013.05.055. Epub 2013 Jun 12.

PMID:
23769984
28.

An assessment of the Bhutanese traditional medicine for its ethnopharmacology, ethnobotany and ethnoquality: Textual understanding and the current practices.

Wangchuk P, Pyne SG, Keller PA.

J Ethnopharmacol. 2013 Jun 21;148(1):305-10. doi: 10.1016/j.jep.2013.04.030. Epub 2013 Apr 24.

PMID:
23624200
29.

Phytochemical and biological activity studies of the Bhutanese medicinal plant Corydalis crispa.

Wangchuk P, Keller PA, Pyne SG, Sastraruji T, Taweechotipatr M, Rattanajak R, Tonsomboon A, Kamchonwongpaisan S.

Nat Prod Commun. 2012 May;7(5):575-80.

PMID:
22799079
30.

Antimalarial alkaloids from a Bhutanese traditional medicinal plant Corydalis dubia.

Wangchuk P, Keller PA, Pyne SG, Willis AC, Kamchonwongpaisan S.

J Ethnopharmacol. 2012 Aug 30;143(1):310-3. doi: 10.1016/j.jep.2012.06.037. Epub 2012 Jul 14.

PMID:
22796506
31.

Evaluation of an ethnopharmacologically selected Bhutanese medicinal plants for their major classes of phytochemicals and biological activities.

Wangchuk P, Keller PA, Pyne SG, Taweechotipatr M, Tonsomboon A, Rattanajak R, Kamchonwongpaisan S.

J Ethnopharmacol. 2011 Sep 1;137(1):730-42. doi: 10.1016/j.jep.2011.06.032. Epub 2011 Jun 28.

PMID:
21741462
32.

Ethnobotanical authentication and identification of Khrog-sman (Lower Elevation Medicinal Plants) of Bhutan.

Wangchuk P, Pyne SG, Keller PA.

J Ethnopharmacol. 2011 Apr 12;134(3):813-23. doi: 10.1016/j.jep.2011.01.034. Epub 2011 Feb 1.

PMID:
21291989
33.

Antiplasmodial activity of atisinium chloride from the Bhutanese medicinal plant, Aconitum orochryseum.

Wangchuk P, Bremner JB, Samten, Skelton BW, White AH, Rattanajak R, Kamchonwongpaisan S.

J Ethnopharmacol. 2010 Aug 9;130(3):559-62. doi: 10.1016/j.jep.2010.05.057. Epub 2010 Jun 2.

PMID:
20561926
34.

Antiplasmodial agents from the Bhutanese medicinal plant Corydalis calliantha.

Wangchuk P, Bremner JB; Samten, Rattanajak R, Kamchonwongpaisan S.

Phytother Res. 2010 Apr;24(4):481-5. doi: 10.1002/ptr.2893.

PMID:
19496064
35.

Hetisine-type diterpenoid alkaloids from the Bhutanese medicinal plant Aconitum orochryseum.

Wangchuk P, Bremner JB, Samosorn S.

J Nat Prod. 2007 Nov;70(11):1808-11. Epub 2007 Oct 30.

PMID:
17966986
36.

Traditional Bhutanese medicine (gSo-BA Rig-PA): an integrated part of the formal health care services.

Wangchuk P, Wangchuk D, Aagaard-Hansen J.

Southeast Asian J Trop Med Public Health. 2007 Jan;38(1):161-7. Review.

PMID:
17539263

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