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OATP1A/1B, CYP3A, ABCB1, and ABCG2 limit oral availability of NTRK inhibitor larotrectinib, while ABCB1 and ABCG2 also restrict its brain accumulation.
Wang Y, Sparidans RW, Li W, Lebre MC, Beijnen JH, Schinkel AH.
Br J Pharmacol. 2020 Feb 22. doi: 10.1111/bph.15034. [Epub ahead of print]
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