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Dual Actions of Ketorolac in Metastatic Ovarian Cancer.

Hudson LG, Cook LS, Grimes MM, Muller CY, Adams SF, Wandinger-Ness A.

Cancers (Basel). 2019 Jul 24;11(8). pii: E1049. doi: 10.3390/cancers11081049. Review.


Ovarian Tumor Microenvironment Signaling: Convergence on the Rac1 GTPase.

Hudson LG, Gillette JM, Kang H, Rivera MR, Wandinger-Ness A.

Cancers (Basel). 2018 Sep 27;10(10). pii: E358. doi: 10.3390/cancers10100358. Review.


Small-Volume Flow Cytometry-Based Multiplex Analysis of the Activity of Small GTPases.

Simons P, Bondu V, Wandinger-Ness A, Buranda T.

Methods Mol Biol. 2018;1821:177-195. doi: 10.1007/978-1-4939-8612-5_13.


Activation of Rho Family GTPases by Small Molecules.

Palsuledesai CC, Surviladze Z, Waller A, Miscioscia TF, Guo Y, Wu Y, Strouse J, Romero E, Salas VM, Curpan R, Young S, Carter M, Foutz T, Galochkina Z, Ames H, Haynes MK, Edwards BS, Nicolotti O, Luo L, Ursu O, Bologa CG, Oprea TI, Wandinger-Ness A, Sklar LA.

ACS Chem Biol. 2018 Jun 15;13(6):1514-1524. doi: 10.1021/acschembio.8b00038. Epub 2018 May 24.


The R-Enantiomer of Ketorolac Delays Mammary Tumor Development in Mouse Mammary Tumor Virus-Polyoma Middle T Antigen (MMTV-PyMT) Mice.

Peretti AS, Dominguez D, Grimes MM, Hathaway HJ, Prossnitz ER, Rivera MR, Wandinger-Ness A, Kusewitt DF, Hudson LG.

Am J Pathol. 2018 Feb;188(2):515-524. doi: 10.1016/j.ajpath.2017.10.018. Epub 2017 Nov 21.


Transcriptome analysis reveals manifold mechanisms of cyst development in ADPKD.

de Almeida RM, Clendenon SG, Richards WG, Boedigheimer M, Damore M, Rossetti S, Harris PC, Herbert BS, Xu WM, Wandinger-Ness A, Ward HH, Glazier JA, Bacallao RL.

Hum Genomics. 2016 Nov 21;10(1):37.


Constrained inference of protein interaction networks for invadopodium formation in cancer.

Wang H, Leung M, Wandinger-Ness A, Hudson LG, Song M.

IET Syst Biol. 2016 Apr;10(2):76-85. doi: 10.1049/iet-syb.2015.0009.


Novel Activities of Select NSAID R-Enantiomers against Rac1 and Cdc42 GTPases.

Oprea TI, Sklar LA, Agola JO, Guo Y, Silberberg M, Roxby J, Vestling A, Romero E, Surviladze Z, Murray-Krezan C, Waller A, Ursu O, Hudson LG, Wandinger-Ness A.

PLoS One. 2015 Nov 11;10(11):e0142182. doi: 10.1371/journal.pone.0142182. eCollection 2015.


Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development.

Uzarski JS, Su J, Xie Y, Zhang ZJ, Ward HH, Wandinger-Ness A, Miller WM, Wertheim JA.

J Vis Exp. 2015 Aug 10;(102):e53271. doi: 10.3791/53271.


A Pan-GTPase Inhibitor as a Molecular Probe.

Hong L, Guo Y, BasuRay S, Agola JO, Romero E, Simpson DS, Schroeder CE, Simons P, Waller A, Garcia M, Carter M, Ursu O, Gouveia K, Golden JE, Aubé J, Wandinger-Ness A, Sklar LA.

PLoS One. 2015 Aug 6;10(8):e0134317. doi: 10.1371/journal.pone.0134317. eCollection 2015.


R-Ketorolac Targets Cdc42 and Rac1 and Alters Ovarian Cancer Cell Behaviors Critical for Invasion and Metastasis.

Guo Y, Kenney SR, Muller CY, Adams S, Rutledge T, Romero E, Murray-Krezan C, Prekeris R, Sklar LA, Hudson LG, Wandinger-Ness A.

Mol Cancer Ther. 2015 Oct;14(10):2215-27. doi: 10.1158/1535-7163.MCT-15-0419. Epub 2015 Jul 23.


A Novel Pharmacologic Activity of Ketorolac for Therapeutic Benefit in Ovarian Cancer Patients.

Guo Y, Kenney SR, Cook L, Adams SF, Rutledge T, Romero E, Oprea TI, Sklar LA, Bedrick E, Wiggins CL, Kang H, Lomo L, Muller CY, Wandinger-Ness A, Hudson LG.

Clin Cancer Res. 2015 Nov 15;21(22):5064-72. doi: 10.1158/1078-0432.CCR-15-0461. Epub 2015 Jun 12.


Dual-Purpose Bioreactors to Monitor Noninvasive Physical and Biochemical Markers of Kidney and Liver Scaffold Recellularization.

Uzarski JS, Bijonowski BM, Wang B, Ward HH, Wandinger-Ness A, Miller WM, Wertheim JA.

Tissue Eng Part C Methods. 2015 Oct;21(10):1032-43. doi: 10.1089/ten.TEC.2014.0665. Epub 2015 Jun 26. Erratum in: Tissue Eng Part C Methods. 2018 Jul 1;24(7):441-442.


Quantitative bead-based flow cytometry for assaying Rab7 GTPase interaction with the Rab-interacting lysosomal protein (RILP) effector protein.

Agola JO, Sivalingam D, Cimino DF, Simons PC, Buranda T, Sklar LA, Wandinger-Ness A.

Methods Mol Biol. 2015;1298:331-54. doi: 10.1007/978-1-4939-2569-8_28.


Optimization and critical evaluation of decellularization strategies to develop renal extracellular matrix scaffolds as biological templates for organ engineering and transplantation.

Caralt M, Uzarski JS, Iacob S, Obergfell KP, Berg N, Bijonowski BM, Kiefer KM, Ward HH, Wandinger-Ness A, Miller WM, Zhang ZJ, Abecassis MM, Wertheim JA.

Am J Transplant. 2015 Jan;15(1):64-75. doi: 10.1111/ajt.12999. Epub 2014 Nov 17. Erratum in: Am J Transplant. 2017 May;17 (5):1429.


Rab proteins and the compartmentalization of the endosomal system.

Wandinger-Ness A, Zerial M.

Cold Spring Harb Perspect Biol. 2014 Oct 23;6(11):a022616. doi: 10.1101/cshperspect.a022616. Review.


OFD1 and flotillins are integral components of a ciliary signaling protein complex organized by polycystins in renal epithelia and odontoblasts.

Jerman S, Ward HH, Lee R, Lopes CA, Fry AM, MacDougall M, Wandinger-Ness A.

PLoS One. 2014 Sep 2;9(9):e106330. doi: 10.1371/journal.pone.0106330. eCollection 2014.


Meeting report - Arf and Rab family G proteins.

Casanova JE, Hsu VW, Jackson CL, Kahn RA, Roy CR, Stow JL, Wandinger-Ness A, Sztul E.

J Cell Sci. 2013 Dec 1;126(Pt 23):5313-6. doi: 10.1242/jcs.143610.


Rapid parallel flow cytometry assays of active GTPases using effector beads.

Buranda T, BasuRay S, Swanson S, Agola J, Bondu V, Wandinger-Ness A.

Anal Biochem. 2013 Nov 15;442(2):149-57. doi: 10.1016/j.ab.2013.07.039. Epub 2013 Aug 6.


A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7.

Hong L, Simons P, Waller A, Strouse J, Surviladze Z, Ursu O, Bologa C, Gouveia K, Agola JO, BasuRay S, Wandinger-Ness A, Sklar L, Simpson DS, Schroeder CE, Golden JE, Aubé J.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Dec 16 [updated 2013 Mar 7].


A telomerase immortalized human proximal tubule cell line with a truncation mutation (Q4004X) in polycystin-1.

Herbert BS, Grimes BR, Xu WM, Werner M, Ward C, Rossetti S, Harris P, Bello-Reuss E, Ward HH, Miller C, Gattone VH 2nd, Phillips CL, Wandinger-Ness A, Bacallao RL.

PLoS One. 2013;8(1):e55191. doi: 10.1371/journal.pone.0055191. Epub 2013 Jan 28.


Characterization of a Cdc42 protein inhibitor and its use as a molecular probe.

Hong L, Kenney SR, Phillips GK, Simpson D, Schroeder CE, Nöth J, Romero E, Swanson S, Waller A, Strouse JJ, Carter M, Chigaev A, Ursu O, Oprea T, Hjelle B, Golden JE, Aubé J, Hudson LG, Buranda T, Sklar LA, Wandinger-Ness A.

J Biol Chem. 2013 Mar 22;288(12):8531-43. doi: 10.1074/jbc.M112.435941. Epub 2013 Feb 4. Erratum in: J Biol Chem. 2014 Mar 7;289(10):6837.


Rab7 mutants associated with Charcot-Marie-Tooth disease cause delayed growth factor receptor transport and altered endosomal and nuclear signaling.

BasuRay S, Mukherjee S, Romero EG, Seaman MN, Wandinger-Ness A.

J Biol Chem. 2013 Jan 11;288(2):1135-49. doi: 10.1074/jbc.M112.417766. Epub 2012 Nov 27.


Bacterial pathogens commandeer Rab GTPases to establish intracellular niches.

Stein MP, Müller MP, Wandinger-Ness A.

Traffic. 2012 Dec;13(12):1565-88. doi: 10.1111/tra.12000. Epub 2012 Sep 13. Review.


A competitive nucleotide binding inhibitor: in vitro characterization of Rab7 GTPase inhibition.

Agola JO, Hong L, Surviladze Z, Ursu O, Waller A, Strouse JJ, Simpson DS, Schroeder CE, Oprea TI, Golden JE, Aubé J, Buranda T, Sklar LA, Wandinger-Ness A.

ACS Chem Biol. 2012 Jun 15;7(6):1095-108. doi: 10.1021/cb3001099. Epub 2012 Apr 23.


Drug Repurposing from an Academic Perspective.

Oprea TI, Bauman JE, Bologa CG, Buranda T, Chigaev A, Edwards BS, Jarvik JW, Gresham HD, Haynes MK, Hjelle B, Hromas R, Hudson L, Mackenzie DA, Muller CY, Reed JC, Simons PC, Smagley Y, Strouse J, Surviladze Z, Thompson T, Ursu O, Waller A, Wandinger-Ness A, Winter SS, Wu Y, Young SM, Larson RS, Willman C, Sklar LA.

Drug Discov Today Ther Strateg. 2011 Winter;8(3-4):61-69.


Differential downregulation of e-cadherin and desmoglein by epidermal growth factor.

Chavez MG, Buhr CA, Petrie WK, Wandinger-Ness A, Kusewitt DF, Hudson LG.

Dermatol Res Pract. 2012;2012:309587. doi: 10.1155/2012/309587. Epub 2012 Jan 16.


A conserved signal and GTPase complex are required for the ciliary transport of polycystin-1.

Ward HH, Brown-Glaberman U, Wang J, Morita Y, Alper SL, Bedrick EJ, Gattone VH 2nd, Deretic D, Wandinger-Ness A.

Mol Biol Cell. 2011 Sep;22(18):3289-305. doi: 10.1091/mbc.E11-01-0082. Epub 2011 Jul 20.


Rab GTPases as regulators of endocytosis, targets of disease and therapeutic opportunities.

Agola JO, Jim PA, Ward HH, Basuray S, Wandinger-Ness A.

Clin Genet. 2011 Oct;80(4):305-18. doi: 10.1111/j.1399-0004.2011.01724.x. Epub 2011 Jul 13. Review.


A Potent and Selective Inhibitor of Cdc42 GTPase.

Surviladze Z, Waller A, Strouse JJ, Bologa C, Ursu O, Salas V, Parkinson JF, Phillips GK, Romero E, Wandinger-Ness A, Sklar LA, Schroeder C, Simpson D, Nöth J, Wang J, Golden J, Aubé J.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Feb 27 [updated 2010 Dec 16].


Three small molecule pan activator families of Ras-related GTPases.

Surviladze Z, Ursu O, Miscioscia F, Curpan R, Halip L, Bologa C, Oprea T, Waller A, Strouse J, Salas V, Wu Y, Edwards B, Wandinger-Ness A, Sklar L.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2009 May 18 [updated 2010 Sep 2].


Ectopic expression of cadherin 8 is sufficient to cause cyst formation in a novel 3D collagen matrix renal tubule culture.

Kher R, Sha EC, Escobar MR, Andreoli EM, Wang P, Xu WM, Wandinger-Ness A, Bacallao RL.

Am J Physiol Cell Physiol. 2011 Jul;301(1):C99-C105. doi: 10.1152/ajpcell.00151.2010. Epub 2011 Mar 9.


Adult human CD133/1(+) kidney cells isolated from papilla integrate into developing kidney tubules.

Ward HH, Romero E, Welford A, Pickett G, Bacallao R, Gattone VH 2nd, Ness SA, Wandinger-Ness A, Roitbak T.

Biochim Biophys Acta. 2011 Oct;1812(10):1344-57. doi: 10.1016/j.bbadis.2011.01.010. Epub 2011 Jan 19.


Rab7 mutants associated with Charcot-Marie-Tooth disease exhibit enhanced NGF-stimulated signaling.

BasuRay S, Mukherjee S, Romero E, Wilson MC, Wandinger-Ness A.

PLoS One. 2010 Dec 9;5(12):e15351. doi: 10.1371/journal.pone.0015351.


Receptor protein tyrosine phosphatases are novel components of a polycystin complex.

Boucher CA, Ward HH, Case RL, Thurston KS, Li X, Needham A, Romero E, Hyink D, Qamar S, Roitbak T, Powell S, Ward C, Wilson PD, Wandinger-Ness A, Sandford RN.

Biochim Biophys Acta. 2011 Oct;1812(10):1225-38. doi: 10.1016/j.bbadis.2010.11.006. Epub 2010 Nov 29.


Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay.

Surviladze Z, Waller A, Wu Y, Romero E, Edwards BS, Wandinger-Ness A, Sklar LA.

J Biomol Screen. 2010 Jan;15(1):10-20. doi: 10.1177/1087057109352240. Epub 2009 Dec 11.


Attenuated, flow-induced ATP release contributes to absence of flow-sensitive, purinergic Cai2+ signaling in human ADPKD cyst epithelial cells.

Xu C, Shmukler BE, Nishimura K, Kaczmarek E, Rossetti S, Harris PC, Wandinger-Ness A, Bacallao RL, Alper SL.

Am J Physiol Renal Physiol. 2009 Jun;296(6):F1464-76. doi: 10.1152/ajprenal.90542.2008. Epub 2009 Feb 25.


Caveolin-1-dependent infectious entry of human papillomavirus type 31 in human keratinocytes proceeds to the endosomal pathway for pH-dependent uncoating.

Smith JL, Campos SK, Wandinger-Ness A, Ozbun MA.

J Virol. 2008 Oct;82(19):9505-12. doi: 10.1128/JVI.01014-08. Epub 2008 Jul 30.


Flow cytometry for real-time measurement of guanine nucleotide binding and exchange by Ras-like GTPases.

Schwartz SL, Tessema M, Buranda T, Pylypenko O, Rak A, Simons PC, Surviladze Z, Sklar LA, Wandinger-Ness A.

Anal Biochem. 2008 Oct 15;381(2):258-66. doi: 10.1016/j.ab.2008.06.039. Epub 2008 Jul 8.


Sequential actions of myotubularin lipid phosphatases regulate endosomal PI(3)P and growth factor receptor trafficking.

Cao C, Backer JM, Laporte J, Bedrick EJ, Wandinger-Ness A.

Mol Biol Cell. 2008 Aug;19(8):3334-46. doi: 10.1091/mbc.E08-04-0367. Epub 2008 Jun 4.


Rab GTPases at a glance.

Schwartz SL, Cao C, Pylypenko O, Rak A, Wandinger-Ness A.

J Cell Sci. 2007 Nov 15;120(Pt 22):3905-10. No abstract available. Erratum in: J Cell Sci. 2008 Jan 15;121(Pt 2):246.


Myotubularin lipid phosphatase binds the hVPS15/hVPS34 lipid kinase complex on endosomes.

Cao C, Laporte J, Backer JM, Wandinger-Ness A, Stein MP.

Traffic. 2007 Aug;8(8):1052-67.


Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins.

Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K.

Traffic. 2007 Mar;8(3):297-309.


Human ADPKD primary cyst epithelial cells with a novel, single codon deletion in the PKD1 gene exhibit defective ciliary polycystin localization and loss of flow-induced Ca2+ signaling.

Xu C, Rossetti S, Jiang L, Harris PC, Brown-Glaberman U, Wandinger-Ness A, Bacallao R, Alper SL.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F930-45. Epub 2006 Nov 7.


Glutathione-S-transferase-green fluorescent protein fusion protein reveals slow dissociation from high site density beads and measures free GSH.

Tessema M, Simons PC, Cimino DF, Sanchez L, Waller A, Posner RG, Wandinger-Ness A, Prossnitz ER, Sklar LA.

Cytometry A. 2006 May;69(5):326-34.


Vesicular trafficking of tyrosine kinase receptors and associated proteins in the regulation of signaling and vascular function.

Mukherjee S, Tessema M, Wandinger-Ness A.

Circ Res. 2006 Mar 31;98(6):743-56. Review.


Functional analyses and interaction of the XAPC7 proteasome subunit with Rab7.

Mukherjee S, Dong J, Heincelman C, Lenhart M, Welford A, Wandinger-Ness A.

Methods Enzymol. 2005;403:650-63.


Interaction and functional analyses of human VPS34/p150 phosphatidylinositol 3-kinase complex with Rab7.

Stein MP, Cao C, Tessema M, Feng Y, Romero E, Welford A, Wandinger-Ness A.

Methods Enzymol. 2005;403:628-49.


A polycystin multiprotein complex constitutes a cholesterol-containing signalling microdomain in human kidney epithelia.

Roitbak T, Surviladze Z, Tikkanen R, Wandinger-Ness A.

Biochem J. 2005 Nov 15;392(Pt 1):29-38.


Mispolarization of desmosomal proteins and altered intercellular adhesion in autosomal dominant polycystic kidney disease.

Silberberg M, Charron AJ, Bacallao R, Wandinger-Ness A.

Am J Physiol Renal Physiol. 2005 Jun;288(6):F1153-63. Epub 2005 Feb 8.

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