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Base editor correction of COL7A1 in recessive dystrophic epidermolysis bullosa patient-derived fibroblasts and iPSCs.

Osborn MJ, Newby GA, McElroy AN, Knipping F, Nielsen SC, Riddle MJ, Xia L, Chen W, Eide CR, Webber BR, Wandall HH, Dabelsteen S, Blazar BR, Liu DR, Tolar J.

J Invest Dermatol. 2019 Aug 19. pii: S0022-202X(19)32698-3. doi: 10.1016/j.jid.2019.07.701. [Epub ahead of print]


Multiplexed Detection of Autoantibodies to Glycopeptides Using Microarray.

Pedersen JW, Nøstdal A, Wandall HH.

Methods Mol Biol. 2019;2024:199-211. doi: 10.1007/978-1-4939-9597-4_12.


Improved CRISPR/Cas9 gene editing by fluorescence activated cell sorting of green fluorescence protein tagged protoplasts.

Petersen BL, Möller SR, Mravec J, Jørgensen B, Christensen M, Liu Y, Wandall HH, Bennett EP, Yang Z.

BMC Biotechnol. 2019 Jun 17;19(1):36. doi: 10.1186/s12896-019-0530-x.


Fast and Quantitative Identification of Ex Vivo Precise Genome Targeting-Induced Indel Events by IDAA.

König S, Yang Z, Wandall HH, Mussolino C, Bennett EP.

Methods Mol Biol. 2019;1961:45-66. doi: 10.1007/978-1-4939-9170-9_4.


Galectin binding to cells and glycoproteins with genetically modified glycosylation reveals galectin-glycan specificities in a natural context.

Nielsen MI, Stegmayr J, Grant OC, Yang Z, Nilsson UJ, Boos I, Carlsson MC, Woods RJ, Unverzagt C, Leffler H, Wandall HH.

J Biol Chem. 2018 Dec 28;293(52):20249-20262. doi: 10.1074/jbc.RA118.004636. Epub 2018 Nov 1.


The glycosphingolipid MacCer promotes synaptic bouton formation in Drosophila by interacting with Wnt.

Huang Y, Huang S, Di Scala C, Wang Q, Wandall HH, Fantini J, Zhang YQ.

Elife. 2018 Oct 25;7. pii: e38183. doi: 10.7554/eLife.38183.


Genetically engineered cell factories produce glycoengineered vaccines that target antigen-presenting cells and reduce antigen-specific T-cell reactivity.

Mathiesen CBK, Carlsson MC, Brand S, Möller SR, Idorn M, Thor Straten P, Pedersen AE, Dabelsteen S, Halim A, Würtzen PA, Brimnes J, Ipsen H, Petersen BL, Wandall HH.

J Allergy Clin Immunol. 2018 Dec;142(6):1983-1987. doi: 10.1016/j.jaci.2018.07.030. Epub 2018 Aug 17. No abstract available.


Viral glycoproteomes: technologies for characterization and outlook for vaccine design.

Bagdonaite I, Vakhrushev SY, Joshi HJ, Wandall HH.

FEBS Lett. 2018 Dec;592(23):3898-3920. doi: 10.1002/1873-3468.13177. Epub 2018 Jul 12. Review.


TAILS N-terminomics and proteomics reveal complex regulation of proteolytic cleavage by O-glycosylation.

King SL, Goth CK, Eckhard U, Joshi HJ, Haue AD, Vakhrushev SY, Schjoldager KT, Overall CM, Wandall HH.

J Biol Chem. 2018 May 18;293(20):7629-7644. doi: 10.1074/jbc.RA118.001978. Epub 2018 Mar 28.


Global aspects of viral glycosylation.

Bagdonaite I, Wandall HH.

Glycobiology. 2018 Jul 1;28(7):443-467. doi: 10.1093/glycob/cwy021.


Glycosyltransferase genes that cause monogenic congenital disorders of glycosylation are distinct from glycosyltransferase genes associated with complex diseases.

Joshi HJ, Hansen L, Narimatsu Y, Freeze HH, Henrissat B, Bennett E, Wandall HH, Clausen H, Schjoldager KT.

Glycobiology. 2018 May 1;28(5):284-294. doi: 10.1093/glycob/cwy015.


A validated gRNA library for CRISPR/Cas9 targeting of the human glycosyltransferase genome.

Narimatsu Y, Joshi HJ, Yang Z, Gomes C, Chen YH, Lorenzetti FC, Furukawa S, Schjoldager KT, Hansen L, Clausen H, Bennett EP, Wandall HH.

Glycobiology. 2018 May 1;28(5):295-305. doi: 10.1093/glycob/cwx101.


Characterizing the O-glycosylation landscape of human plasma, platelets, and endothelial cells.

King SL, Joshi HJ, Schjoldager KT, Halim A, Madsen TD, Dziegiel MH, Woetmann A, Vakhrushev SY, Wandall HH.

Blood Adv. 2017 Feb 23;1(7):429-442. doi: 10.1182/bloodadvances.2016002121. eCollection 2017 Feb 28.


GlycoDomainViewer: a bioinformatics tool for contextual exploration of glycoproteomes.

Joshi HJ, Jørgensen A, Schjoldager KT, Halim A, Dworkin LA, Steentoft C, Wandall HH, Clausen H, Vakhrushev SY.

Glycobiology. 2018 Mar 1;28(3):131-136. doi: 10.1093/glycob/cwx104.


De novo expression of human polypeptide N-acetylgalactosaminyltransferase 6 (GalNAc-T6) in colon adenocarcinoma inhibits the differentiation of colonic epithelium.

Lavrsen K, Dabelsteen S, Vakhrushev SY, Levann AMR, Haue AD, Dylander A, Mandel U, Hansen L, Frödin M, Bennett EP, Wandall HH.

J Biol Chem. 2018 Jan 26;293(4):1298-1314. doi: 10.1074/jbc.M117.812826. Epub 2017 Nov 29.


Dynamics of Indel Profiles Induced by Various CRISPR/Cas9 Delivery Methods.

Kosicki M, Rajan SS, Lorenzetti FC, Wandall HH, Narimatsu Y, Metzakopian E, Bennett EP.

Prog Mol Biol Transl Sci. 2017;152:49-67. doi: 10.1016/bs.pmbts.2017.09.003. Epub 2017 Nov 6.


Reduced ferritin levels in individuals with non-O blood group: results from the Danish Blood Donor Study.

Rigas AS, Berkfors AA, Pedersen OB, Sørensen E, Nielsen KR, Larsen MH, Paarup HM, Wandall HH, Erikstrup C, Hjalgrim H, Ullum H.

Transfusion. 2017 Dec;57(12):2914-2919. doi: 10.1111/trf.14364. Epub 2017 Oct 8.


Glycosylation Engineering.

Clausen H, Wandall HH, Steentoft C, Stanley P, Schnaar RL.

In: Varki A, Cummings RD, Esko JD, Stanley P, Hart GW, Aebi M, Darvill AG, Kinoshita T, Packer NH, Prestegard JH, Schnaar RL, Seeberger PH, editors. Essentials of Glycobiology [Internet]. 3rd edition. Cold Spring Harbor (NY): Cold Spring Harbor Laboratory Press; 2015-2017. Chapter 56.


Corrigendum: Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PLM, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 May 23;7:46774. doi: 10.1038/srep46774.


Identification and evolution of a plant cell wall specific glycoprotein glycosyl transferase, ExAD.

Møller SR, Yi X, Velásquez SM, Gille S, Hansen PL, Poulsen CP, Olsen CE, Rejzek M, Parsons H, Yang Z, Wandall HH, Clausen H, Field RA, Pauly M, Estevez JM, Harholt J, Ulvskov P, Petersen BL.

Sci Rep. 2017 Mar 30;7:45341. doi: 10.1038/srep45341. Erratum in: Sci Rep. 2017 May 23;7:46774. Zhang, Yang [corrected to Yang, Zhang].


Genome editing using FACS enrichment of nuclease-expressing cells and indel detection by amplicon analysis.

Lonowski LA, Narimatsu Y, Riaz A, Delay CE, Yang Z, Niola F, Duda K, Ober EA, Clausen H, Wandall HH, Hansen SH, Bennett EP, Frödin M.

Nat Protoc. 2017 Mar;12(3):581-603. doi: 10.1038/nprot.2016.165. Epub 2017 Feb 16.


Mactosylceramide prevents glial cell overgrowth by inhibiting insulin and fibroblast growth factor receptor signaling.

Gerdøe-Kristensen S, Lund VK, Wandall HH, Kjaerulff O.

J Cell Physiol. 2017 Nov;232(11):3112-3127. doi: 10.1002/jcp.25762. Epub 2017 Mar 31.


Loss of Function of GALNT2 Lowers High-Density Lipoproteins in Humans, Nonhuman Primates, and Rodents.

Khetarpal SA, Schjoldager KT, Christoffersen C, Raghavan A, Edmondson AC, Reutter HM, Ahmed B, Ouazzani R, Peloso GM, Vitali C, Zhao W, Somasundara AV, Millar JS, Park Y, Fernando G, Livanov V, Choi S, Noé E, Patel P, Ho SP; Myocardial Infarction Exome Sequencing Study, Kirchgessner TG, Wandall HH, Hansen L, Bennett EP, Vakhrushev SY, Saleheen D, Kathiresan S, Brown CD, Abou Jamra R, LeGuern E, Clausen H, Rader DJ.

Cell Metab. 2016 Aug 9;24(2):234-45. doi: 10.1016/j.cmet.2016.07.012.


Global Mapping of O-Glycosylation of Varicella Zoster Virus, Human Cytomegalovirus, and Epstein-Barr Virus.

Bagdonaite I, Nordén R, Joshi HJ, King SL, Vakhrushev SY, Olofsson S, Wandall HH.

J Biol Chem. 2016 Jun 3;291(23):12014-28. doi: 10.1074/jbc.M116.721746. Epub 2016 Apr 15.


An innate antiviral pathway acting before interferons at epithelial surfaces.

Iversen MB, Reinert LS, Thomsen MK, Bagdonaite I, Nandakumar R, Cheshenko N, Prabakaran T, Vakhrushev SY, Krzyzowska M, Kratholm SK, Ruiz-Perez F, Petersen SV, Goriely S, Bibby BM, Eriksson K, Ruland J, Thomsen AR, Herold BC, Wandall HH, Frische S, Holm CK, Paludan SR.

Nat Immunol. 2016 Feb;17(2):150-8. doi: 10.1038/ni.3319. Epub 2015 Nov 30.


Deconstruction of O-glycosylation--GalNAc-T isoforms direct distinct subsets of the O-glycoproteome.

Schjoldager KT, Joshi HJ, Kong Y, Goth CK, King SL, Wandall HH, Bennett EP, Vakhrushev SY, Clausen H.

EMBO Rep. 2015 Dec;16(12):1713-22. doi: 10.15252/embr.201540796. Epub 2015 Nov 13.


Viral O-GalNAc peptide epitopes: a novel potential target in viral envelope glycoproteins.

Olofsson S, Blixt O, Bergström T, Frank M, Wandall HH.

Rev Med Virol. 2016 Jan;26(1):34-48. doi: 10.1002/rmv.1859. Epub 2015 Nov 2. Review.


Engineered CHO cells for production of diverse, homogeneous glycoproteins.

Yang Z, Wang S, Halim A, Schulz MA, Frodin M, Rahman SH, Vester-Christensen MB, Behrens C, Kristensen C, Vakhrushev SY, Bennett EP, Wandall HH, Clausen H.

Nat Biotechnol. 2015 Aug;33(8):842-4. doi: 10.1038/nbt.3280. Epub 2015 Jul 20.


Ectopic expression of a novel CD22 splice-variant regulates survival and proliferation in malignant T cells from cutaneous T cell lymphoma (CTCL) patients.

Bagdonaite I, Wandall HH, Litvinov IV, Nastasi C, Becker JC, Dabelsteen S, Geisler C, Bonefeld CM, Zhang Q, Wasik MA, Zhou Y, Sasseville D, Ødum N, Woetmann A.

Oncotarget. 2015 Jun 10;6(16):14374-84.


A strategy for O-glycoproteomics of enveloped viruses--the O-glycoproteome of herpes simplex virus type 1.

Bagdonaite I, Nordén R, Joshi HJ, Dabelsteen S, Nyström K, Vakhrushev SY, Olofsson S, Wandall HH.

PLoS Pathog. 2015 Apr 1;11(4):e1004784. doi: 10.1371/journal.ppat.1004784. eCollection 2015 Apr.


Auto-reactive T cells revised. Overestimation based on methodology?

Thorlacius-Ussing G, Sørensen JF, Wandall HH, Pedersen AE.

J Immunol Methods. 2015 May;420:56-9. doi: 10.1016/j.jim.2015.03.010. Epub 2015 Mar 27. Review.


Fast and sensitive detection of indels induced by precise gene targeting.

Yang Z, Steentoft C, Hauge C, Hansen L, Thomsen AL, Niola F, Vester-Christensen MB, Frödin M, Clausen H, Wandall HH, Bennett EP.

Nucleic Acids Res. 2015 May 19;43(9):e59. doi: 10.1093/nar/gkv126. Epub 2015 Mar 9.


Glycoproteomic analysis of seven major allergenic proteins reveals novel post-translational modifications.

Halim A, Carlsson MC, Madsen CB, Brand S, Møller SR, Olsen CE, Vakhrushev SY, Brimnes J, Wurtzen PA, Ipsen H, Petersen BL, Wandall HH.

Mol Cell Proteomics. 2015 Jan;14(1):191-204. doi: 10.1074/mcp.M114.042614. Epub 2014 Nov 11.


A glycogene mutation map for discovery of diseases of glycosylation.

Hansen L, Lind-Thomsen A, Joshi HJ, Pedersen NB, Have CT, Kong Y, Wang S, Sparso T, Grarup N, Vester-Christensen MB, Schjoldager K, Freeze HH, Hansen T, Pedersen O, Henrissat B, Mandel U, Clausen H, Wandall HH, Bennett EP.

Glycobiology. 2015 Feb;25(2):211-24. doi: 10.1093/glycob/cwu104. Epub 2014 Sep 28.


Probing polypeptide GalNAc-transferase isoform substrate specificities by in vitro analysis.

Kong Y, Joshi HJ, Schjoldager KT, Madsen TD, Gerken TA, Vester-Christensen MB, Wandall HH, Bennett EP, Levery SB, Vakhrushev SY, Clausen H.

Glycobiology. 2015 Jan;25(1):55-65. doi: 10.1093/glycob/cwu089. Epub 2014 Aug 25.


Immature truncated O-glycophenotype of cancer directly induces oncogenic features.

Radhakrishnan P, Dabelsteen S, Madsen FB, Francavilla C, Kopp KL, Steentoft C, Vakhrushev SY, Olsen JV, Hansen L, Bennett EP, Woetmann A, Yin G, Chen L, Song H, Bak M, Hlady RA, Peters SL, Opavsky R, Thode C, Qvortrup K, Schjoldager KT, Clausen H, Hollingsworth MA, Wandall HH.

Proc Natl Acad Sci U S A. 2014 Sep 30;111(39):E4066-75. doi: 10.1073/pnas.1406619111. Epub 2014 Aug 12.


Malignant T cells secrete galectins and induce epidermal hyperproliferation and disorganized stratification in a skin model of cutaneous T-cell lymphoma.

Thode C, Woetmann A, Wandall HH, Carlsson MC, Qvortrup K, Kauczok CS, Wobser M, Printzlau A, Ødum N, Dabelsteen S.

J Invest Dermatol. 2015 Jan;135(1):238-246. doi: 10.1038/jid.2014.284. Epub 2014 Jul 9.


Precision genome editing: a small revolution for glycobiology.

Steentoft C, Bennett EP, Schjoldager KT, Vakhrushev SY, Wandall HH, Clausen H.

Glycobiology. 2014 Aug;24(8):663-80. doi: 10.1093/glycob/cwu046. Epub 2014 May 26. Review.


Induction of Bcl-xL-specific cytotoxic T lymphocytes in mice.

Larsen HL, Andersen MH, Wandall HH, Madsen CB, Christensen RE, Petersen TR, Pedersen AE.

Scand J Immunol. 2014 Aug;80(2):111-20. doi: 10.1111/sji.12192.


Microvesicle cargo of tumor-associated MUC1 to dendritic cells allows cross-presentation and specific carbohydrate processing.

Rughetti A, Rahimi H, Belleudi F, Napoletano C, Battisti F, Zizzari IG, Antonilli M, Bellati F, Wandall HH, Benedetti Panici P, Burchell JM, Torrisi MR, Nuti M.

Cancer Immunol Res. 2014 Feb;2(2):177-86. doi: 10.1158/2326-6066.CIR-13-0112-T. Epub 2013 Oct 28.


High-efficiency genome editing via 2A-coupled co-expression of fluorescent proteins and zinc finger nucleases or CRISPR/Cas9 nickase pairs.

Duda K, Lonowski LA, Kofoed-Nielsen M, Ibarra A, Delay CM, Kang Q, Yang Z, Pruett-Miller SM, Bennett EP, Wandall HH, Davis GD, Hansen SH, Frödin M.

Nucleic Acids Res. 2014 Jun;42(10):e84. doi: 10.1093/nar/gku251. Epub 2014 Apr 21.


Cancer-associated autoantibodies to MUC1 and MUC4--a blinded case–control study of colorectal cancer in UK collaborative trial of ovarian cancer screening.

Pedersen JW, Gentry-Maharaj A, Nøstdal A, Fourkala EO, Dawnay A, Burnell M, Zaikin A, Burchell J, Papadimitriou JT, Clausen H, Jacobs I, Menon U, Wandall HH.

Int J Cancer. 2014 May 1;134(9):2180-88.


Potential for novel MUC1 glycopeptide-specific antibody in passive cancer immunotherapy.

Madsen CB, Wandall HH, Pedersen AE.

Immunopharmacol Immunotoxicol. 2013 Dec;35(6):649-52. doi: 10.3109/08923973.2013.837060. Epub 2013 Sep 24. Review.


Glycan elongation beyond the mucin associated Tn antigen protects tumor cells from immune-mediated killing.

Madsen CB, Lavrsen K, Steentoft C, Vester-Christensen MB, Clausen H, Wandall HH, Pedersen AE.

PLoS One. 2013 Sep 6;8(9):e72413. doi: 10.1371/journal.pone.0072413. eCollection 2013. Erratum in: PLoS One. 2013;8(10). doi:10.1371/annotation/81b54c99-e47f-4128-8aeb-b6b3e8c02562.


Chemo-enzymatic production of O-glycopeptides for the detection of serum glycopeptide antibodies.

Nøstdal A, Wandall HH.

Methods Mol Biol. 2013;1061:167-79. doi: 10.1007/978-1-62703-589-7_10.


Carbon anhydrase IX specific immune responses in patients with metastatic renal cell carcinoma potentially cured by interleukin-2 based immunotherapy.

Rasmussen S, Donskov F, Pedersen JW, Wandall HH, Buus S, Harndahl M, Braendstrup P, Claesson MH, Pedersen AE.

Immunopharmacol Immunotoxicol. 2013 Aug;35(4):487-96. doi: 10.3109/08923973.2013.802802. Epub 2013 Jun 27.


Glycan-mediated modification of the immune response.

Madsen CB, Pedersen AE, Wandall HH.

Oncoimmunology. 2013 Apr 1;2(4):e23659.


Autoantibodies to MUC1 glycopeptides cannot be used as a screening assay for early detection of breast, ovarian, lung or pancreatic cancer.

Burford B, Gentry-Maharaj A, Graham R, Allen D, Pedersen JW, Nudelman AS, Blixt O, Fourkala EO, Bueti D, Dawnay A, Ford J, Desai R, David L, Trinder P, Acres B, Schwientek T, Gammerman A, Reis CA, Silva L, Osório H, Hallett R, Wandall HH, Mandel U, Hollingsworth MA, Jacobs I, Fentiman I, Clausen H, Taylor-Papadimitriou J, Menon U, Burchell JM.

Br J Cancer. 2013 May 28;108(10):2045-55. doi: 10.1038/bjc.2013.214. Epub 2013 May 7.


Precision mapping of the human O-GalNAc glycoproteome through SimpleCell technology.

Steentoft C, Vakhrushev SY, Joshi HJ, Kong Y, Vester-Christensen MB, Schjoldager KT, Lavrsen K, Dabelsteen S, Pedersen NB, Marcos-Silva L, Gupta R, Bennett EP, Mandel U, Brunak S, Wandall HH, Levery SB, Clausen H.

EMBO J. 2013 May 15;32(10):1478-88. doi: 10.1038/emboj.2013.79. Epub 2013 Apr 12.


Aberrant expression of mucin core proteins and o-linked glycans associated with progression of pancreatic cancer.

Remmers N, Anderson JM, Linde EM, DiMaio DJ, Lazenby AJ, Wandall HH, Mandel U, Clausen H, Yu F, Hollingsworth MA.

Clin Cancer Res. 2013 Apr 15;19(8):1981-93. doi: 10.1158/1078-0432.CCR-12-2662. Epub 2013 Feb 27.

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