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Items: 1 to 50 of 69


Development of a multicellular pancreatic tumor microenvironment system using patient-derived tumor cells.

Gioeli D, Snow CJ, Simmers MB, Hoang SA, Figler RA, Allende JA, Roller DG, Parsons JT, Wulfkuhle JD, Petricoin EF, Bauer TW, Wamhoff BR.

Lab Chip. 2019 Mar 27;19(7):1193-1204. doi: 10.1039/c8lc00755a.


Non-alcoholic fatty liver disease (NAFLD) models in drug discovery.

Cole BK, Feaver RE, Wamhoff BR, Dash A.

Expert Opin Drug Discov. 2018 Feb;13(2):193-205. doi: 10.1080/17460441.2018.1410135. Epub 2017 Dec 6. Review.


Exposure of Induced Pluripotent Stem Cell-Derived Vascular Endothelial and Smooth Muscle Cells in Coculture to Hemodynamics Induces Primary Vascular Cell-Like Phenotypes.

Collado MS, Cole BK, Figler RA, Lawson M, Manka D, Simmers MB, Hoang S, Serrano F, Blackman BR, Sinha S, Wamhoff BR.

Stem Cells Transl Med. 2017 Aug;6(8):1673-1683. doi: 10.1002/sctm.17-0004. Epub 2017 Jun 19.


Development of an in vitro human liver system for interrogating nonalcoholic steatohepatitis.

Feaver RE, Cole BK, Lawson MJ, Hoang SA, Marukian S, Blackman BR, Figler RA, Sanyal AJ, Wamhoff BR, Dash A.

JCI Insight. 2016 Dec 8;1(20):e90954. doi: 10.1172/jci.insight.90954.


Pharmacotoxicology of clinically-relevant concentrations of obeticholic acid in an organotypic human hepatocyte system.

Dash A, Figler RA, Blackman BR, Marukian S, Collado MS, Lawson MJ, Hoang SA, Mackey AJ, Manka D, Cole BK, Feaver RE, Sanyal AJ, Wamhoff BR.

Toxicol In Vitro. 2017 Mar;39:93-103. doi: 10.1016/j.tiv.2016.11.014. Epub 2016 Dec 7.


Drug-induced steatohepatitis.

Dash A, Figler RA, Sanyal AJ, Wamhoff BR.

Expert Opin Drug Metab Toxicol. 2017 Feb;13(2):193-204. doi: 10.1080/17425255.2017.1246534. Epub 2016 Oct 27. Review.


Hemodynamics associated with atrial fibrillation directly alters thrombotic potential of endothelial cells.

Simmers MB, Cole BK, Ogletree ML, Chen Z, Xu Y, Kong LJ, Mackman N, Blackman BR, Wamhoff BR.

Thromb Res. 2016 Jul;143:34-9. doi: 10.1016/j.thromres.2016.04.022. Epub 2016 Apr 27.


Recapitulation of metabolic defects in a model of propionic acidemia using patient-derived primary hepatocytes.

Chapman KA, Collado MS, Figler RA, Hoang SA, Armstrong AJ, Cui W, Purdy M, Simmers MB, Yazigi NA, Summar ML, Wamhoff BR, Dash A.

Mol Genet Metab. 2016 Mar;117(3):355-362. doi: 10.1016/j.ymgme.2015.12.008. Epub 2015 Dec 24.


Transcriptional profiling suggests that Nevirapine and Ritonavir cause drug induced liver injury through distinct mechanisms in primary human hepatocytes.

Terelius Y, Figler RA, Marukian S, Collado MS, Lawson MJ, Mackey AJ, Manka D, Qualls CW Jr, Blackman BR, Wamhoff BR, Dash A.

Chem Biol Interact. 2016 Aug 5;255:31-44. doi: 10.1016/j.cbi.2015.11.023. Epub 2015 Dec 2.


Microbubble-mediated intravascular ultrasound imaging and drug delivery.

Dixon AJ, Kilroy JP, Dhanaliwala AH, Chen JL, Phillips LC, Ragosta M, Klibanov AL, Wamhoff BR, Hossack JA.

IEEE Trans Ultrason Ferroelectr Freq Control. 2015 Sep;62(9):1674-85. doi: 10.1109/TUFFC.2015.007143.


An In Vitro Cynomolgus Vascular Surrogate System for Preclinical Drug Assessment and Human Translation.

Cole BK, Simmers MB, Feaver R, Qualls CW Jr, Collado MS, Berzin E, Figler RA, Pryor AW Jr, Lawson M, Mackey A, Manka D, Wamhoff BR, Turk JR, Blackman BR.

Arterioscler Thromb Vasc Biol. 2015 Oct;35(10):2185-95. doi: 10.1161/ATVBAHA.115.306245. Epub 2015 Aug 20.


Reducing Neointima Formation in a Swine Model with IVUS and Sirolimus Microbubbles.

Kilroy JP, Dhanaliwala AH, Klibanov AL, Bowles DK, Wamhoff BR, Hossack JA.

Ann Biomed Eng. 2015 Nov;43(11):2642-51. doi: 10.1007/s10439-015-1315-6. Epub 2015 Apr 17.


Localized in vivo model drug delivery with intravascular ultrasound and microbubbles.

Kilroy JP, Klibanov AL, Wamhoff BR, Bowles DK, Hossack JA.

Ultrasound Med Biol. 2014 Oct;40(10):2458-67. doi: 10.1016/j.ultrasmedbio.2014.04.007. Epub 2014 Aug 15.


Hemodynamic flow improves rat hepatocyte morphology, function, and metabolic activity in vitro.

Dash A, Simmers MB, Deering TG, Berry DJ, Feaver RE, Hastings NE, Pruett TL, LeCluyse EL, Blackman BR, Wamhoff BR.

Am J Physiol Cell Physiol. 2013 Jun 1;304(11):C1053-63. doi: 10.1152/ajpcell.00331.2012. Epub 2013 Mar 13.


Intravascular ultrasound catheter to enhance microbubble-based drug delivery via acoustic radiation force.

Kilroy JP, Klibanov AL, Wamhoff BR, Hossack J.

IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Oct;59(10):2156-66. doi: 10.1109/TUFFC.2012.2442.


NFAT5 expression in bone marrow-derived cells enhances atherosclerosis and drives macrophage migration.

Halterman JA, Kwon HM, Leitinger N, Wamhoff BR.

Front Physiol. 2012 Aug 3;3:313. doi: 10.3389/fphys.2012.00313. eCollection 2012.


Intravascular ultrasound detection and delivery of molecularly targeted microbubbles for gene delivery.

Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA.

IEEE Trans Ultrason Ferroelectr Freq Control. 2012 Jul;59(7):1596-601. doi: 10.1109/TUFFC.2012.2359.


Organotypic systems in drug metabolism and toxicity: challenges and opportunities.

Dash A, Blackman BR, Wamhoff BR.

Expert Opin Drug Metab Toxicol. 2012 Aug;8(8):999-1014. doi: 10.1517/17425255.2012.693161. Epub 2012 May 26. Review.


Chromatin immunoprecipitation (ChIP): revisiting the efficacy of sample preparation, sonication, quantification of sheared DNA, and analysis via PCR.

Schoppee Bortz PD, Wamhoff BR.

PLoS One. 2011;6(10):e26015. doi: 10.1371/journal.pone.0026015. Epub 2011 Oct 25.


Tonicity-independent regulation of the osmosensitive transcription factor TonEBP (NFAT5).

Halterman JA, Kwon HM, Wamhoff BR.

Am J Physiol Cell Physiol. 2012 Jan 1;302(1):C1-8. doi: 10.1152/ajpcell.00327.2011. Epub 2011 Oct 12. Review.


Focused ultrasound-mediated drug delivery from microbubbles reduces drug dose necessary for therapeutic effect on neointima formation--brief report.

Phillips LC, Dhanaliwala AH, Klibanov AL, Hossack JA, Wamhoff BR.

Arterioscler Thromb Vasc Biol. 2011 Dec;31(12):2853-5. doi: 10.1161/ATVBAHA.111.238170. Epub 2011 Sep 29.


Nuclear factor of activated T cells 5 regulates vascular smooth muscle cell phenotypic modulation.

Halterman JA, Kwon HM, Zargham R, Bortz PD, Wamhoff BR.

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2287-96. doi: 10.1161/ATVBAHA.111.232165. Epub 2011 Jul 14.


Localized ultrasound enhances delivery of rapamycin from microbubbles to prevent smooth muscle proliferation.

Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA.

J Control Release. 2011 Aug 25;154(1):42-9. doi: 10.1016/j.jconrel.2011.04.020. Epub 2011 Apr 23.


Hemodynamic activation of beta-catenin and T-cell-specific transcription factor signaling in vascular endothelium regulates fibronectin expression.

Gelfand BD, Meller J, Pryor AW, Kahn M, Bortz PD, Wamhoff BR, Blackman BR.

Arterioscler Thromb Vasc Biol. 2011 Jul;31(7):1625-33. doi: 10.1161/ATVBAHA.111.227827. Epub 2011 Apr 28.


Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth.

Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA.

Tissue Eng Part A. 2011 Mar;17(5-6):617-29. doi: 10.1089/ten.TEA.2010.0404. Epub 2010 Nov 9.


Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery.

Phillips LC, Klibanov AL, Wamhoff BR, Hossack JA.

Ultrasound Med Biol. 2010 Sep;36(9):1470-80. doi: 10.1016/j.ultrasmedbio.2010.06.010.


Identification of a novel macrophage phenotype that develops in response to atherogenic phospholipids via Nrf2.

Kadl A, Meher AK, Sharma PR, Lee MY, Doran AC, Johnstone SR, Elliott MR, Gruber F, Han J, Chen W, Kensler T, Ravichandran KS, Isakson BE, Wamhoff BR, Leitinger N.

Circ Res. 2010 Sep 17;107(6):737-46. doi: 10.1161/CIRCRESAHA.109.215715. Epub 2010 Jul 22.


Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors.

Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL.

J Med Chem. 2010 Apr 8;53(7):2766-78. doi: 10.1021/jm901860h.


Cyclosporine up-regulates Krüppel-like factor-4 (KLF4) in vascular smooth muscle cells and drives phenotypic modulation in vivo.

Garvey SM, Sinden DS, Schoppee Bortz PD, Wamhoff BR.

J Pharmacol Exp Ther. 2010 Apr;333(1):34-42. doi: 10.1124/jpet.109.163949. Epub 2010 Jan 20.


FTY720 promotes local microvascular network formation and regeneration of cranial bone defects.

Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA.

Tissue Eng Part A. 2010 Jun;16(6):1801-9. doi: 10.1089/ten.TEA.2009.0539.


Nuclear factor of activated T cells regulates osteopontin expression in arterial smooth muscle in response to diabetes-induced hyperglycemia.

Nilsson-Berglund LM, Zetterqvist AV, Nilsson-Ohman J, Sigvardsson M, González Bosc LV, Smith ML, Salehi A, Agardh E, Fredrikson GN, Agardh CD, Nilsson J, Wamhoff BR, Hultgårdh-Nilsson A, Gomez MF.

Arterioscler Thromb Vasc Biol. 2010 Feb;30(2):218-24. doi: 10.1161/ATVBAHA.109.199299. Epub 2009 Dec 3.


Integrative genomics identifies DSCR1 (RCAN1) as a novel NFAT-dependent mediator of phenotypic modulation in vascular smooth muscle cells.

Lee MY, Garvey SM, Baras AS, Lemmon JA, Gomez MF, Schoppee Bortz PD, Daum G, LeBoeuf RC, Wamhoff BR.

Hum Mol Genet. 2010 Feb 1;19(3):468-79. doi: 10.1093/hmg/ddp511. Epub 2009 Nov 19.


Focused in vivo delivery of plasmid DNA to the porcine vascular wall via intravascular ultrasound destruction of microbubbles.

Phillips LC, Klibanov AL, Bowles DK, Ragosta M, Hossack JA, Wamhoff BR.

J Vasc Res. 2010;47(3):270-4. doi: 10.1159/000258905. Epub 2009 Nov 18.


Complex regulation and function of the inflammatory smooth muscle cell phenotype in atherosclerosis.

Orr AW, Hastings NE, Blackman BR, Wamhoff BR.

J Vasc Res. 2010;47(2):168-80. doi: 10.1159/000250095. Epub 2009 Oct 22. Review.


The smooth muscle cell-restricted KCNMB1 ion channel subunit is a direct transcriptional target of serum response factor and myocardin.

Long X, Tharp DL, Georger MA, Slivano OJ, Lee MY, Wamhoff BR, Bowles DK, Miano JM.

J Biol Chem. 2009 Nov 27;284(48):33671-82. doi: 10.1074/jbc.M109.050419. Epub 2009 Oct 1.


Human IL-8 regulates smooth muscle cell VCAM-1 expression in response to endothelial cells exposed to atheroprone flow.

Hastings NE, Feaver RE, Lee MY, Wamhoff BR, Blackman BR.

Arterioscler Thromb Vasc Biol. 2009 May;29(5):725-31. doi: 10.1161/ATVBAHA.109.184382. Epub 2009 Feb 19.


PDGF-DD, a novel mediator of smooth muscle cell phenotypic modulation, is upregulated in endothelial cells exposed to atherosclerosis-prone flow patterns.

Thomas JA, Deaton RA, Hastings NE, Shang Y, Moehle CW, Eriksson U, Topouzis S, Wamhoff BR, Blackman BR, Owens GK.

Am J Physiol Heart Circ Physiol. 2009 Feb;296(2):H442-52. doi: 10.1152/ajpheart.00165.2008. Epub 2008 Nov 21.


Molecular mechanisms of collagen isotype-specific modulation of smooth muscle cell phenotype.

Orr AW, Lee MY, Lemmon JA, Yurdagul A Jr, Gomez MF, Bortz PD, Wamhoff BR.

Arterioscler Thromb Vasc Biol. 2009 Feb;29(2):225-31. doi: 10.1161/ATVBAHA.108.178749. Epub 2008 Nov 20.


"FRNKly, smooth muscle, I don't give a CArG!": a novel mechanism for smooth muscle cell differentiation.

Lemmon JA, Wamhoff BR.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2091-3. doi: 10.1161/ATVBAHA.108.176875. No abstract available.


Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype.

Wamhoff BR, Lynch KR, Macdonald TL, Owens GK.

Arterioscler Thromb Vasc Biol. 2008 Aug;28(8):1454-61. doi: 10.1161/ATVBAHA.107.159392. Epub 2008 Jun 5. Erratum in: Arterioscler Thromb Vasc Biol. 2011 Jan;31(1):e3.


Local delivery of the KCa3.1 blocker, TRAM-34, prevents acute angioplasty-induced coronary smooth muscle phenotypic modulation and limits stenosis.

Tharp DL, Wamhoff BR, Wulff H, Raman G, Cheong A, Bowles DK.

Arterioscler Thromb Vasc Biol. 2008 Jun;28(6):1084-9. doi: 10.1161/ATVBAHA.107.155796. Epub 2008 Feb 28.


Atherosclerosis-prone hemodynamics differentially regulates endothelial and smooth muscle cell phenotypes and promotes pro-inflammatory priming.

Hastings NE, Simmers MB, McDonald OG, Wamhoff BR, Blackman BR.

Am J Physiol Cell Physiol. 2007 Dec;293(6):C1824-33. Epub 2007 Oct 3.


RNA interference targeting alpha8 integrin attenuates smooth muscle cell growth.

Zargham R, Wamhoff BR, Thibault G.

FEBS Lett. 2007 Mar 6;581(5):939-43. Epub 2007 Feb 6.


Conditional mouse models to study developmental and pathophysiological gene function in muscle.

Wamhoff BR, Sinha S, Owens GK.

Handb Exp Pharmacol. 2007;(178):441-68. Review.


Origin of neointimal smooth muscle: we've come full circle.

Hoofnagle MH, Thomas JA, Wamhoff BR, Owens GK.

Arterioscler Thromb Vasc Biol. 2006 Dec;26(12):2579-81. No abstract available.


Upregulation of intermediate-conductance Ca2+-activated K+ channel (IKCa1) mediates phenotypic modulation of coronary smooth muscle.

Tharp DL, Wamhoff BR, Turk JR, Bowles DK.

Am J Physiol Heart Circ Physiol. 2006 Nov;291(5):H2493-503. Epub 2006 Jun 23.


Exercise training prevents Ca2+ dysregulation in coronary smooth muscle from diabetic dyslipidemic yucatan swine.

Witczak CA, Wamhoff BR, Sturek M.

J Appl Physiol (1985). 2006 Sep;101(3):752-62. Epub 2006 Jun 8.


Excitation-transcription coupling in arterial smooth muscle.

Wamhoff BR, Bowles DK, Owens GK.

Circ Res. 2006 Apr 14;98(7):868-78. Review.


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