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Pyrin dephosphorylation is sufficient to trigger inflammasome activation in familial Mediterranean fever patients.

Magnotti F, Lefeuvre L, Benezech S, Malsot T, Waeckel L, Martin A, Kerever S, Chirita D, Desjonqueres M, Duquesne A, Gerfaud-Valentin M, Laurent A, Sève P, Popoff MR, Walzer T, Belot A, Jamilloux Y, Henry T.

EMBO Mol Med. 2019 Nov 7;11(11):e10547. doi: 10.15252/emmm.201910547. Epub 2019 Oct 7.


Monogenic lupus: Dissecting heterogeneity.

Omarjee O, Picard C, Frachette C, Moreews M, Rieux-Laucat F, Soulas-Sprauel P, Viel S, Lega JC, Bader-Meunier B, Walzer T, Mathieu AL, Cimaz R, Belot A.

Autoimmun Rev. 2019 Oct;18(10):102361. doi: 10.1016/j.autrev.2019.102361. Epub 2019 Aug 8. Review.


Styk1 is specifically expressed in NK1.1+ lymphocytes including NK, γδ T, and iNKT cells in mice, but is dispensable for their ontogeny and function.

Wilharm A, Sandrock I, Marotel M, Demera A, Naumann R, Walzer T, Prinz I.

Eur J Immunol. 2019 May;49(5):686-693. doi: 10.1002/eji.201848033. Epub 2019 Feb 18.


Styk1 expression is a hallmark of murine NK cells and other NK1.1+ subsets but is dispensable for NK-cell development and effector functions.

Fauteux S, Faure F, Marotel M, Geary C, Daussy C, Sun JC, Walzer T.

Eur J Immunol. 2019 May;49(5):677-685. doi: 10.1002/eji.201847721. Epub 2019 Feb 15.


The role of Eomes in human CD4 T cell differentiation: A question of context.

Dejean AS, Joulia E, Walzer T.

Eur J Immunol. 2019 Jan;49(1):38-41. doi: 10.1002/eji.201848000.


Comparison of RT-qPCR and Nanostring in the measurement of blood interferon response for the diagnosis of type I interferonopathies.

Pescarmona R, Belot A, Villard M, Besson L, Lopez J, Mosnier I, Mathieu AL, Lombard C, Garnier L, Frachette C, Walzer T, Viel S.

Cytokine. 2019 Jan;113:446-452. doi: 10.1016/j.cyto.2018.10.023. Epub 2018 Nov 7.


A point mutation in the Ncr1 signal peptide impairs the development of innate lymphoid cell subsets.

Almeida FF, Tognarelli S, Marçais A, Kueh AJ, Friede ME, Liao Y, Willis SN, Luong K, Faure F, Mercier FE, Galluso J, Firth M, Narni-Mancinelli E, Rais B, Scadden DT, Spallotta F, Weil S, Giannattasio A, Kalensee F, Zöller T, Huntington ND, Schleicher U, Chiocchetti AG, Ugolini S, Herold MJ, Shi W, Koch J, Steinle A, Vivier E, Walzer T, Belz GT, Ullrich E.

Oncoimmunology. 2018 Aug 15;7(10):e1475875. doi: 10.1080/2162402X.2018.1475875. eCollection 2018.


Hepatitis B Virus Blocks the CRE/CREB Complex and Prevents TLR9 Transcription and Function in Human B Cells.

Tout I, Gomes M, Ainouze M, Marotel M, Pecoul T, Durantel D, Vaccarella S, Dubois B, Loustaud-Ratti V, Walzer T, Alain S, Chemin I, Hasan U.

J Immunol. 2018 Oct 15;201(8):2331-2344. doi: 10.4049/jimmunol.1701726. Epub 2018 Sep 5.


Identification of Primary Natural Killer Cell Modulators by Chemical Library Screening with a Luciferase-Based Functional Assay.

Hayek S, Bekaddour N, Besson L, Alves de Sousa R, Pietrancosta N, Viel S, Smith N, Jacob Y, Nisole S, Mandal R, Wishart DS, Walzer T, Herbeuval JP, Vidalain PO.

SLAS Discov. 2019 Jan;24(1):25-37. doi: 10.1177/2472555218797078. Epub 2018 Sep 5.


Human papillomavirus type 16 antagonizes IRF6 regulation of IL-1β.

Ainouze M, Rochefort P, Parroche P, Roblot G, Tout I, Briat F, Zannetti C, Marotel M, Goutagny N, Auron P, Traverse-Glehen A, Lunel-Potencier A, Golfier F, Masson M, Robitaille A, Tommasino M, Carreira C, Walzer T, Henry T, Zanier K, Trave G, Hasan UA.

PLoS Pathog. 2018 Aug 8;14(8):e1007158. doi: 10.1371/journal.ppat.1007158. eCollection 2018 Aug.


Plasmacytoid dendritic cells control dengue and Chikungunya virus infections via IRF7-regulated interferon responses.

Webster B, Werneke SW, Zafirova B, This S, Coléon S, Décembre E, Paidassi H, Bouvier I, Joubert PE, Duffy D, Walzer T, Albert ML, Dreux M.

Elife. 2018 Jun 19;7. pii: e34273. doi: 10.7554/eLife.34273.


One-Year Follow-Up of Natural Killer Cell Activity in Multiple Myeloma Patients Treated With Adjuvant Lenalidomide Therapy.

Besson L, Charrier E, Karlin L, Allatif O, Marçais A, Rouzaire P, Belmont L, Attal M, Lombard C, Salles G, Walzer T, Viel S.

Front Immunol. 2018 Apr 13;9:704. doi: 10.3389/fimmu.2018.00704. eCollection 2018.


Deletion of Inflammasome Components Is Not Sufficient To Prevent Fatal Inflammation in Models of Familial Hemophagocytic Lymphohistiocytosis.

Fauteux-Daniel S, Viel S, Besson L, Zhang J, Marotel M, Mathieu AL, Pescarmona R, Charrier E, Henry T, Belot A, Walzer T.

J Immunol. 2018 Jun 1;200(11):3769-3776. doi: 10.4049/jimmunol.1701628. Epub 2018 Apr 25.


Large deletion in 6q associated to A20 haploinsufficiency and thoracoabdominal heterotaxy.

Viel S, Cheyssac E, Pescarmona R, Besson L, Till M, Viremouneix L, Touitou I, Sarrabay G, Walzer T, Belot A.

Ann Rheum Dis. 2018 Nov;77(11):1697-1698. doi: 10.1136/annrheumdis-2018-213300. Epub 2018 Apr 20. No abstract available.


Antigen-Induced but Not Innate Memory CD8 T Cells Express NKG2D and Are Recruited to the Lung Parenchyma upon Viral Infection.

Grau M, Valsesia S, Mafille J, Djebali S, Tomkowiak M, Mathieu AL, Laubreton D, de Bernard S, Jouve PE, Ventre E, Buffat L, Walzer T, Leverrier Y, Marvel J.

J Immunol. 2018 May 15;200(10):3635-3646. doi: 10.4049/jimmunol.1701698. Epub 2018 Apr 9.


An immunosuppressive pathway for tumor progression.

Marçais A, Walzer T.

Nat Med. 2018 Mar 6;24(3):260-261. doi: 10.1038/nm.4508. No abstract available.


A Case of Type 2 Hypersensitivity to Rasburicase Diagnosed with a Natural Killer Cell Activation Assay.

Viel S, Pescarmona R, Belot A, Nosbaum A, Lombard C, Walzer T, Bérard F.

Front Immunol. 2018 Jan 29;9:110. doi: 10.3389/fimmu.2018.00110. eCollection 2018.


T-bet and Eomes govern differentiation and function of mouse and human NK cells and ILC1.

Zhang J, Marotel M, Fauteux-Daniel S, Mathieu AL, Viel S, Marçais A, Walzer T.

Eur J Immunol. 2018 May;48(5):738-750. doi: 10.1002/eji.201747299. Epub 2018 Feb 28. Review.


S1PR5 is essential for human natural killer cell migration toward sphingosine-1 phosphate.

Drouillard A, Mathieu AL, Marçais A, Belot A, Viel S, Mingueneau M, Guckian K, Walzer T.

J Allergy Clin Immunol. 2018 Jun;141(6):2265-2268.e1. doi: 10.1016/j.jaci.2017.11.022. Epub 2017 Dec 14. No abstract available.


Human Naive and Memory T Cells Display Opposite Migratory Responses to Sphingosine-1 Phosphate.

Drouillard A, Neyra A, Mathieu AL, Marçais A, Wencker M, Marvel J, Belot A, Walzer T.

J Immunol. 2018 Jan 15;200(2):551-557. doi: 10.4049/jimmunol.1701278. Epub 2017 Dec 13.


Late-onset hemophagocytic lymphohistiocytosis with neurological presentation.

Benezech S, Walzer T, Charrier E, Heidelberg D, De Saint-Basile G, Bertrand Y, Belot A.

Clin Case Rep. 2017 Sep 12;5(11):1743-1749. doi: 10.1002/ccr3.1135. eCollection 2017 Nov.


Familial Mediterranean fever mutations are hypermorphic mutations that specifically decrease the activation threshold of the Pyrin inflammasome.

Jamilloux Y, Lefeuvre L, Magnotti F, Martin A, Benezech S, Allatif O, Penel-Page M, Hentgen V, Sève P, Gerfaud-Valentin M, Duquesne A, Desjonquères M, Laurent A, Rémy-Piccolo V, Cimaz R, Cantarini L, Bourdonnay E, Walzer T, Py BF, Belot A, Henry T.

Rheumatology (Oxford). 2018 Jan 1;57(1):100-111. doi: 10.1093/rheumatology/kex373.


Regulation of mTOR, Metabolic Fitness, and Effector Functions by Cytokines in Natural Killer Cells.

Viel S, Besson L, Marotel M, Walzer T, Marçais A.

Cancers (Basel). 2017 Sep 28;9(10). pii: E132. doi: 10.3390/cancers9100132. Review.


High mTOR activity is a hallmark of reactive natural killer cells and amplifies early signaling through activating receptors.

Marçais A, Marotel M, Degouve S, Koenig A, Fauteux-Daniel S, Drouillard A, Schlums H, Viel S, Besson L, Allatif O, Bléry M, Vivier E, Bryceson Y, Thaunat O, Walzer T.

Elife. 2017 Sep 6;6. pii: e26423. doi: 10.7554/eLife.26423.


Geoepidemiology and Immunologic Features of Autoinflammatory Diseases: a Comprehensive Review.

Jamilloux Y, Belot A, Magnotti F, Benezech S, Gerfaud-Valentin M, Bourdonnay E, Walzer T, Sève P, Henry T.

Clin Rev Allergy Immunol. 2018 Jun;54(3):454-479. doi: 10.1007/s12016-017-8613-8. Review.


Eomes expression reports the progressive differentiation of IFN-γ-producing Th1-like γδ T cells.

Lino CNR, Barros-Martins J, Oberdörfer L, Walzer T, Prinz I.

Eur J Immunol. 2017 Jun;47(6):970-981. doi: 10.1002/eji.201646753. Epub 2017 Apr 24.


Sphingosine 1-phosphate signaling through its receptor S1P5 promotes chromosome segregation and mitotic progression.

Andrieu G, Ledoux A, Branka S, Bocquet M, Gilhodes J, Walzer T, Kasahara K, Inagaki M, Sabbadini RA, Cuvillier O, Hatzoglou A.

Sci Signal. 2017 Mar 28;10(472). pii: eaah4007. doi: 10.1126/scisignal.aah4007.


Immune signatures of protective spleen memory CD8 T cells.

Brinza L, Djebali S, Tomkowiak M, Mafille J, Loiseau C, Jouve PE, de Bernard S, Buffat L, Lina B, Ottmann M, Rosa-Calatrava M, Schicklin S, Bonnefoy N, Lauvau G, Grau M, Wencker M, Arpin C, Walzer T, Leverrier Y, Marvel J.

Sci Rep. 2016 Nov 24;6:37651. doi: 10.1038/srep37651.


Back to the drawing board: Understanding the complexity of hepatic innate lymphoid cells.

Marotel M, Hasan U, Viel S, Marçais A, Walzer T.

Eur J Immunol. 2016 Sep;46(9):2095-8. doi: 10.1002/eji.201646584.


Efficacy of the Janus kinase 1/2 inhibitor ruxolitinib in the treatment of vasculopathy associated with TMEM173-activating mutations in 3 children.

Frémond ML, Rodero MP, Jeremiah N, Belot A, Jeziorski E, Duffy D, Bessis D, Cros G, Rice GI, Charbit B, Hulin A, Khoudour N, Caballero CM, Bodemer C, Fabre M, Berteloot L, Le Bourgeois M, Reix P, Walzer T, Moshous D, Blanche S, Fischer A, Bader-Meunier B, Rieux-Laucat F, Crow YJ, Neven B.

J Allergy Clin Immunol. 2016 Dec;138(6):1752-1755. doi: 10.1016/j.jaci.2016.07.015. Epub 2016 Aug 20. No abstract available.


Adipose-Resident Group 1 Innate Lymphoid Cells Promote Obesity-Associated Insulin Resistance.

O'Sullivan TE, Rapp M, Fan X, Weizman OE, Bhardwaj P, Adams NM, Walzer T, Dannenberg AJ, Sun JC.

Immunity. 2016 Aug 16;45(2):428-41. doi: 10.1016/j.immuni.2016.06.016. Epub 2016 Aug 2.


Characterization of the Inflammasome in Human Kupffer Cells in Response to Synthetic Agonists and Pathogens.

Zannetti C, Roblot G, Charrier E, Ainouze M, Tout I, Briat F, Isorce N, Faure-Dupuy S, Michelet M, Marotel M, Kati S, Schulz TF, Rivoire M, Traverse-Glehen A, Luangsay S, Alatiff O, Henry T, Walzer T, Durantel D, Hasan U.

J Immunol. 2016 Jul 1;197(1):356-67. doi: 10.4049/jimmunol.1502301. Epub 2016 May 25.


NKp46-mediated Dicer1 inactivation results in defective NK-cell differentiation and effector functions in mice.

Degouve S, Tavares A, Viel S, Walzer T, Marçais A.

Eur J Immunol. 2016 Aug;46(8):1902-11. doi: 10.1002/eji.201546163. Epub 2016 Jun 8.


Transforming growth factor-β and Notch ligands act as opposing environmental cues in regulating the plasticity of type 3 innate lymphoid cells.

Viant C, Rankin LC, Girard-Madoux MJ, Seillet C, Shi W, Smyth MJ, Bartholin L, Walzer T, Huntington ND, Vivier E, Belz GT.

Sci Signal. 2016 May 3;9(426):ra46. doi: 10.1126/scisignal.aaf2176.


[Memory NK cells discovered in non-human primates].

Walzer T, Marçais A.

Med Sci (Paris). 2016 Mar;32(3):246-8. doi: 10.1051/medsci/20163203007. Epub 2016 Mar 23. French. No abstract available.


Murine peripheral NK-cell populations originate from site-specific immature NK cells more than from BM-derived NK cells.

Pinhas N, Sternberg-Simon M, Chiossone L, Shahaf G, Walzer T, Vivier E, Mehr R.

Eur J Immunol. 2016 May;46(5):1258-70. doi: 10.1002/eji.201545847. Epub 2016 Mar 31.


TGF-β inhibits the activation and functions of NK cells by repressing the mTOR pathway.

Viel S, Marçais A, Guimaraes FS, Loftus R, Rabilloud J, Grau M, Degouve S, Djebali S, Sanlaville A, Charrier E, Bienvenu J, Marie JC, Caux C, Marvel J, Town L, Huntington ND, Bartholin L, Finlay D, Smyth MJ, Walzer T.

Sci Signal. 2016 Feb 16;9(415):ra19. doi: 10.1126/scisignal.aad1884.


Alteration of Natural Killer cell phenotype and function in obese individuals.

Viel S, Besson L, Charrier E, Marçais A, Disse E, Bienvenu J, Walzer T, Dumontet C.

Clin Immunol. 2017 Apr;177:12-17. doi: 10.1016/j.clim.2016.01.007. Epub 2016 Jan 18.


NKp46+ Innate Lymphoid Cells Dampen Vaginal CD8 T Cell Responses following Local Immunization with a Cholera Toxin-Based Vaccine.

Luci C, Bekri S, Bihl F, Pini J, Bourdely P, Nouhen K, Malgogne A, Walzer T, Braud VM, Anjuère F.

PLoS One. 2015 Dec 2;10(12):e0143224. doi: 10.1371/journal.pone.0143224. eCollection 2015.


Terminal NK cell maturation is controlled by concerted actions of T-bet and Zeb2 and is essential for melanoma rejection.

van Helden MJ, Goossens S, Daussy C, Mathieu AL, Faure F, Marçais A, Vandamme N, Farla N, Mayol K, Viel S, Degouve S, Debien E, Seuntjens E, Conidi A, Chaix J, Mangeot P, de Bernard S, Buffat L, Haigh JJ, Huylebroeck D, Lambrecht BN, Berx G, Walzer T.

J Exp Med. 2015 Nov 16;212(12):2015-25. doi: 10.1084/jem.20150809. Epub 2015 Oct 26.


Inherited anomalies of innate immune receptors in pediatric-onset inflammatory diseases.

Picard C, Mathieu AL, Hasan U, Henry T, Jamilloux Y, Walzer T, Belot A.

Autoimmun Rev. 2015 Dec;14(12):1147-53. doi: 10.1016/j.autrev.2015.08.002. Epub 2015 Aug 9. Review.


PRKDC mutations associated with immunodeficiency, granuloma, and autoimmune regulator-dependent autoimmunity.

Mathieu AL, Verronese E, Rice GI, Fouyssac F, Bertrand Y, Picard C, Chansel M, Walter JE, Notarangelo LD, Butte MJ, Nadeau KC, Csomos K, Chen DJ, Chen K, Delgado A, Rigal C, Bardin C, Schuetz C, Moshous D, Reumaux H, Plenat F, Phan A, Zabot MT, Balme B, Viel S, Bienvenu J, Cochat P, van der Burg M, Caux C, Kemp EH, Rouvet I, Malcus C, Méritet JF, Lim A, Crow YJ, Fabien N, Ménétrier-Caux C, De Villartay JP, Walzer T, Belot A.

J Allergy Clin Immunol. 2015 Jun;135(6):1578-88.e5. doi: 10.1016/j.jaci.2015.01.040. Epub 2015 Apr 2.


Unique Eomes(+) NK Cell Subsets Are Present in Uterus and Decidua During Early Pregnancy.

Montaldo E, Vacca P, Chiossone L, Croxatto D, Loiacono F, Martini S, Ferrero S, Walzer T, Moretta L, Mingari MC.

Front Immunol. 2016 Jan 7;6:646. doi: 10.3389/fimmu.2015.00646. eCollection 2015.


mTOR: a gate to NK cell maturation and activation.

Marçais A, Walzer T.

Cell Cycle. 2014;13(21):3315-6. doi: 10.4161/15384101.2014.972919. No abstract available.


microRNA-mediated regulation of mTOR complex components facilitates discrimination between activation and anergy in CD4 T cells.

Marcais A, Blevins R, Graumann J, Feytout A, Dharmalingam G, Carroll T, Amado IF, Bruno L, Lee K, Walzer T, Mann M, Freitas AA, Boothby M, Fisher AG, Merkenschlager M.

J Exp Med. 2014 Oct 20;211(11):2281-95. doi: 10.1084/jem.20132059. Epub 2014 Oct 13.


Mutations in CECR1 associated with a neutrophil signature in peripheral blood.

Belot A, Wassmer E, Twilt M, Lega JC, Zeef LA, Oojageer A, Kasher PR, Mathieu AL, Malcus C, Demaret J, Fabien N, Collardeau-Frachon S, Mechtouff L, Derex L, Walzer T, Rice GI, Durieu I, Crow YJ.

Pediatr Rheumatol Online J. 2014 Sep 24;12:44. doi: 10.1186/1546-0096-12-44. eCollection 2014.


Human natural killer cells promote cross-presentation of tumor cell-derived antigens by dendritic cells.

Deauvieau F, Ollion V, Doffin AC, Achard C, Fonteneau JF, Verronese E, Durand I, Ghittoni R, Marvel J, Dezutter-Dambuyant C, Walzer T, Vie H, Perrot I, Goutagny N, Caux C, Valladeau-Guilemond J.

Int J Cancer. 2015 Mar 1;136(5):1085-94. doi: 10.1002/ijc.29087. Epub 2014 Aug 6.


The metabolic checkpoint kinase mTOR is essential for IL-15 signaling during the development and activation of NK cells.

Marçais A, Cherfils-Vicini J, Viant C, Degouve S, Viel S, Fenis A, Rabilloud J, Mayol K, Tavares A, Bienvenu J, Gangloff YG, Gilson E, Vivier E, Walzer T.

Nat Immunol. 2014 Aug;15(8):749-757. doi: 10.1038/ni.2936. Epub 2014 Jun 29.


Dok1 and Dok2 proteins regulate natural killer cell development and function.

Celis-Gutierrez J, Boyron M, Walzer T, Pandolfi PP, Jonjić S, Olive D, Dalod M, Vivier E, Nunès JA.

EMBO J. 2014 Sep 1;33(17):1928-40. doi: 10.15252/embj.201387404. Epub 2014 Jun 24.


Rapid Learning of Adverse Medical Event Disclosure and Apology.

Raemer DB, Locke S, Walzer TB, Gardner R, Baer L, Simon R.

J Patient Saf. 2016 Sep;12(3):140-7. doi: 10.1097/PTS.0000000000000080.


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