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Items: 1 to 50 of 240

1.

An ensemble of flexible conformations underlies mechanotransduction by the cadherin-catenin adhesion complex.

Bush M, Alhanshali BM, Qian S, Stanley CB, Heller WT, Matsui T, Weiss TM, Nicholl ID, Walz T, Callaway DJE, Bu Z.

Proc Natl Acad Sci U S A. 2019 Oct 7. pii: 201911489. doi: 10.1073/pnas.1911489116. [Epub ahead of print]

2.

The Molecular Architecture of Native BBSome Obtained by an Integrated Structural Approach.

Chou HT, Apelt L, Farrell DP, White SR, Woodsmith J, Svetlov V, Goldstein JS, Nager AR, Li Z, Muller J, Dollfus H, Nudler E, Stelzl U, DiMaio F, Nachury MV, Walz T.

Structure. 2019 Sep 3;27(9):1384-1394.e4. doi: 10.1016/j.str.2019.06.006. Epub 2019 Jul 11.

PMID:
31303482
3.

ATG2 transports lipids to promote autophagosome biogenesis.

Valverde DP, Yu S, Boggavarapu V, Kumar N, Lees JA, Walz T, Reinisch KM, Melia TJ.

J Cell Biol. 2019 Jun 3;218(6):1787-1798. doi: 10.1083/jcb.201811139. Epub 2019 Apr 5.

PMID:
30952800
4.

Structural Insights into Mdn1, an Essential AAA Protein Required for Ribosome Biogenesis.

Chen Z, Suzuki H, Kobayashi Y, Wang AC, DiMaio F, Kawashima SA, Walz T, Kapoor TM.

Cell. 2018 Oct 18;175(3):822-834.e18. doi: 10.1016/j.cell.2018.09.015. Epub 2018 Oct 11.

5.

Cryo-EM structure of the insect olfactory receptor Orco.

Butterwick JA, Del Mármol J, Kim KH, Kahlson MA, Rogow JA, Walz T, Ruta V.

Nature. 2018 Aug;560(7719):447-452. doi: 10.1038/s41586-018-0420-8. Epub 2018 Aug 15.

6.

Structure of the Cdc48 ATPase with its ubiquitin-binding cofactor Ufd1-Npl4.

Bodnar NO, Kim KH, Ji Z, Wales TE, Svetlov V, Nudler E, Engen JR, Walz T, Rapoport TA.

Nat Struct Mol Biol. 2018 Jul;25(7):616-622. doi: 10.1038/s41594-018-0085-x. Epub 2018 Jul 2.

7.

Structural and kinetic basis for the selectivity of aducanumab for aggregated forms of amyloid-β.

Arndt JW, Qian F, Smith BA, Quan C, Kilambi KP, Bush MW, Walz T, Pepinsky RB, Bussière T, Hamann S, Cameron TO, Weinreb PH.

Sci Rep. 2018 Apr 23;8(1):6412. doi: 10.1038/s41598-018-24501-0.

8.

Visualization of ligand-induced transmembrane signaling in the full-length human insulin receptor.

Gutmann T, Kim KH, Grzybek M, Walz T, Coskun Ü.

J Cell Biol. 2018 May 7;217(5):1643-1649. doi: 10.1083/jcb.201711047. Epub 2018 Feb 16.

9.

Architecture of the human PI4KIIIα lipid kinase complex.

Lees JA, Zhang Y, Oh MS, Schauder CM, Yu X, Baskin JM, Dobbs K, Notarangelo LD, De Camilli P, Walz T, Reinisch KM.

Proc Natl Acad Sci U S A. 2017 Dec 26;114(52):13720-13725. doi: 10.1073/pnas.1718471115. Epub 2017 Dec 11.

10.

Molecular basis for the recognition of the human AAUAAA polyadenylation signal.

Sun Y, Zhang Y, Hamilton K, Manley JL, Shi Y, Walz T, Tong L.

Proc Natl Acad Sci U S A. 2018 Feb 13;115(7):E1419-E1428. doi: 10.1073/pnas.1718723115. Epub 2017 Dec 5.

11.

Discovery and characterization of stable and toxic Tau/phospholipid oligomeric complexes.

Ait-Bouziad N, Lv G, Mahul-Mellier AL, Xiao S, Zorludemir G, Eliezer D, Walz T, Lashuel HA.

Nat Commun. 2017 Nov 22;8(1):1678. doi: 10.1038/s41467-017-01575-4.

12.

6S RNA Mimics B-Form DNA to Regulate Escherichia coli RNA Polymerase.

Chen J, Wassarman KM, Feng S, Leon K, Feklistov A, Winkelman JT, Li Z, Walz T, Campbell EA, Darst SA.

Mol Cell. 2017 Oct 19;68(2):388-397.e6. doi: 10.1016/j.molcel.2017.09.006. Epub 2017 Oct 5.

13.

Rac1 GTPase activates the WAVE regulatory complex through two distinct binding sites.

Chen B, Chou HT, Brautigam CA, Xing W, Yang S, Henry L, Doolittle LK, Walz T, Rosen MK.

Elife. 2017 Sep 26;6. pii: e29795. doi: 10.7554/eLife.29795.

14.

Macromolecular Assemblies of the Mammalian Circadian Clock.

Aryal RP, Kwak PB, Tamayo AG, Gebert M, Chiu PL, Walz T, Weitz CJ.

Mol Cell. 2017 Sep 7;67(5):770-782.e6. doi: 10.1016/j.molcel.2017.07.017.

15.

Structural basis of MsbA-mediated lipopolysaccharide transport.

Mi W, Li Y, Yoon SH, Ernst RK, Walz T, Liao M.

Nature. 2017 Sep 14;549(7671):233-237. doi: 10.1038/nature23649. Epub 2017 Sep 6.

16.

A Prodomain Fragment from the Proteolytic Activation of Growth Differentiation Factor 11 Remains Associated with the Mature Growth Factor and Keeps It Soluble.

Pepinsky B, Gong BJ, Gao Y, Lehmann A, Ferrant J, Amatucci J, Sun Y, Bush M, Walz T, Pederson N, Cameron T, Wen D.

Biochemistry. 2017 Aug 22;56(33):4405-4418. doi: 10.1021/acs.biochem.7b00302. Epub 2017 Aug 3.

PMID:
28715204
17.

Electron crystallography reveals that substrate release from the PTS IIC glucose transporter is coupled to a subtle conformational change.

Kalbermatter D, Chiu PL, Jeckelmann JM, Ucurum Z, Walz T, Fotiadis D.

J Struct Biol. 2017 Jul;199(1):39-45. doi: 10.1016/j.jsb.2017.05.005. Epub 2017 May 15.

PMID:
28522226
18.

The structural basis for the functional comparability of factor VIII and the long-acting variant recombinant factor VIII Fc fusion protein.

Leksa NC, Chiu PL, Bou-Assaf GM, Quan C, Liu Z, Goodman AB, Chambers MG, Tsutakawa SE, Hammel M, Peters RT, Walz T, Kulman JD.

J Thromb Haemost. 2017 Jun;15(6):1167-1179. doi: 10.1111/jth.13700. Epub 2017 May 3.

19.

Role of Pore-Lining Residues in Defining the Rate of Water Conduction by Aquaporin-0.

Saboe PO, Rapisarda C, Kaptan S, Hsiao YS, Summers SR, De Zorzi R, Dukovski D, Yu J, de Groot BL, Kumar M, Walz T.

Biophys J. 2017 Mar 14;112(5):953-965. doi: 10.1016/j.bpj.2017.01.026.

20.

Towards standardised definitions of shoulder arthroplasty complications: a systematic review of terms and definitions.

Jacxsens M, Walz T, Durchholz H, Müller AM, Flury M, Schwyzer HK, Audigé L.

Arch Orthop Trauma Surg. 2017 Mar;137(3):347-355. doi: 10.1007/s00402-017-2635-9. Epub 2017 Feb 6. Review.

PMID:
28168641
21.

Erratum: A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation.

Wei J, Zhang Y, Yu TY, Sadre-Bazzaz K, Rudolph MJ, Amodeo GA, Symington LS, Walz T, Tong L.

Cell Discov. 2017 Jan 17;3:16055. doi: 10.1038/celldisc.2016.55. eCollection 2017.

22.

A unified molecular mechanism for the regulation of acetyl-CoA carboxylase by phosphorylation.

Wei J, Zhang Y, Yu TY, Sadre-Bazzaz K, Rudolph MJ, Amodeo GA, Symington LS, Walz T, Tong L.

Cell Discov. 2016 Nov 29;2:16044. eCollection 2016. Erratum in: Cell Discov. 2017 Jan 17;3:16055.

23.

Covalently circularized nanodiscs for studying membrane proteins and viral entry.

Nasr ML, Baptista D, Strauss M, Sun ZJ, Grigoriu S, Huser S, Plückthun A, Hagn F, Walz T, Hogle JM, Wagner G.

Nat Methods. 2017 Jan;14(1):49-52. doi: 10.1038/nmeth.4079. Epub 2016 Nov 21.

24.

CATCHR, HOPS and CORVET tethering complexes share a similar architecture.

Chou HT, Dukovski D, Chambers MG, Reinisch KM, Walz T.

Nat Struct Mol Biol. 2016 Aug;23(8):761-3. doi: 10.1038/nsmb.3264. Epub 2016 Jul 18.

25.

Molecular architecture of the complete COG tethering complex.

Ha JY, Chou HT, Ungar D, Yip CK, Walz T, Hughson FM.

Nat Struct Mol Biol. 2016 Aug;23(8):758-60. doi: 10.1038/nsmb.3263. Epub 2016 Jul 18.

26.

UtpA and UtpB chaperone nascent pre-ribosomal RNA and U3 snoRNA to initiate eukaryotic ribosome assembly.

Hunziker M, Barandun J, Petfalski E, Tan D, Delan-Forino C, Molloy KR, Kim KH, Dunn-Davies H, Shi Y, Chaker-Margot M, Chait BT, Walz T, Tollervey D, Klinge S.

Nat Commun. 2016 Jun 29;7:12090. doi: 10.1038/ncomms12090.

27.

Relating conformation to function in integrin α5β1.

Su Y, Xia W, Li J, Walz T, Humphries MJ, Vestweber D, Cabañas C, Lu C, Springer TA.

Proc Natl Acad Sci U S A. 2016 Jul 5;113(27):E3872-81. doi: 10.1073/pnas.1605074113. Epub 2016 Jun 17.

28.

A mechanism of viral immune evasion revealed by cryo-EM analysis of the TAP transporter.

Oldham ML, Hite RK, Steffen AM, Damko E, Li Z, Walz T, Chen J.

Nature. 2016 Jan 28;529(7587):537-40. doi: 10.1038/nature16506. Epub 2016 Jan 20.

29.

Magnetically Directed Two-Dimensional Crystallization of OmpF Membrane Proteins in Block Copolymers.

Klara SS, Saboe PO, Sines IT, Babaei M, Chiu PL, DeZorzi R, Dayal K, Walz T, Kumar M, Mauter MS.

J Am Chem Soc. 2016 Jan 13;138(1):28-31. doi: 10.1021/jacs.5b03320. Epub 2015 Dec 24.

PMID:
26677866
30.

The Special Issue of Microscopy on single-particle cryo-electron microscopy.

Cheng Y, Walz T.

Microscopy (Oxf). 2016 Feb;65(1):1-2. doi: 10.1093/jmicro/dfv359. Epub 2015 Nov 18. No abstract available.

PMID:
26586604
31.

Structures of the double-ring AAA ATPase Pex1-Pex6 involved in peroxisome biogenesis.

Tan D, Blok NB, Rapoport TA, Walz T.

FEBS J. 2016 Mar;283(6):986-92. doi: 10.1111/febs.13569. Epub 2015 Nov 12. Review.

32.

Single-particle electron microscopy in the study of membrane protein structure.

De Zorzi R, Mi W, Liao M, Walz T.

Microscopy (Oxf). 2016 Feb;65(1):81-96. doi: 10.1093/jmicro/dfv058. Epub 2015 Oct 15.

33.

Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel.

Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R.

Nature. 2015 Nov 12;527(7577):198-203. doi: 10.1038/nature14958. Epub 2015 Oct 5.

34.

Evaluation of super-resolution performance of the K2 electron-counting camera using 2D crystals of aquaporin-0.

Chiu PL, Li X, Li Z, Beckett B, Brilot AF, Grigorieff N, Agard DA, Cheng Y, Walz T.

J Struct Biol. 2015 Nov;192(2):163-73. doi: 10.1016/j.jsb.2015.08.015. Epub 2015 Aug 28.

35.

Transcriptional Profiling of Breast Cancer Metastases Identifies Liver Metastasis-Selective Genes Associated with Adverse Outcome in Luminal A Primary Breast Cancer.

Kimbung S, Johansson I, Danielsson A, Veerla S, Egyhazi Brage S, Frostvik Stolt M, Skoog L, Carlsson L, Einbeigi Z, Lidbrink E, Linderholm B, Loman N, Malmström PO, Söderberg M, Walz TM, Fernö M, Hatschek T, Hedenfalk I; TEX study group.

Clin Cancer Res. 2016 Jan 1;22(1):146-57. doi: 10.1158/1078-0432.CCR-15-0487. Epub 2015 Aug 14.

36.

2D and 3D crystallization of the wild-type IIC domain of the glucose PTS transporter from Escherichia coli.

Kalbermatter D, Jeckelmann JM, Chiu PL, Ucurum Z, Walz T, Fotiadis D.

J Struct Biol. 2015 Sep;191(3):376-80. doi: 10.1016/j.jsb.2015.08.003. Epub 2015 Aug 8.

PMID:
26260226
37.

Highly permeable artificial water channels that can self-assemble into two-dimensional arrays.

Shen YX, Si W, Erbakan M, Decker K, De Zorzi R, Saboe PO, Kang YJ, Majd S, Butler PJ, Walz T, Aksimentiev A, Hou JL, Kumar M.

Proc Natl Acad Sci U S A. 2015 Aug 11;112(32):9810-5. doi: 10.1073/pnas.1508575112. Epub 2015 Jul 27.

38.

Unique double-ring structure of the peroxisomal Pex1/Pex6 ATPase complex revealed by cryo-electron microscopy.

Blok NB, Tan D, Wang RY, Penczek PA, Baker D, DiMaio F, Rapoport TA, Walz T.

Proc Natl Acad Sci U S A. 2015 Jul 28;112(30):E4017-25. doi: 10.1073/pnas.1500257112. Epub 2015 Jul 13.

39.

Mapping the interaction between factor VIII and von Willebrand factor by electron microscopy and mass spectrometry.

Chiu PL, Bou-Assaf GM, Chhabra ES, Chambers MG, Peters RT, Kulman JD, Walz T.

Blood. 2015 Aug 20;126(8):935-8. doi: 10.1182/blood-2015-04-641688. Epub 2015 Jun 11.

40.

Structural analyses of the chromatin remodelling enzymes INO80-C and SWR-C.

Watanabe S, Tan D, Lakshminarasimhan M, Washburn MP, Hong EJ, Walz T, Peterson CL.

Nat Commun. 2015 May 12;6:7108. doi: 10.1038/ncomms8108.

41.

A primer to single-particle cryo-electron microscopy.

Cheng Y, Grigorieff N, Penczek PA, Walz T.

Cell. 2015 Apr 23;161(3):438-449. doi: 10.1016/j.cell.2015.03.050. Review.

42.

Structure of bone morphogenetic protein 9 procomplex.

Mi LZ, Brown CT, Gao Y, Tian Y, Le VQ, Walz T, Springer TA.

Proc Natl Acad Sci U S A. 2015 Mar 24;112(12):3710-5. doi: 10.1073/pnas.1501303112. Epub 2015 Mar 6.

43.

Characterization of putative multidrug resistance transporters of the major facilitator-superfamily expressed in Salmonella Typhi.

Shaheen A, Ismat F, Iqbal M, Haque A, De Zorzi R, Mirza O, Walz T, Rahman M.

J Infect Chemother. 2015 May;21(5):357-62. doi: 10.1016/j.jiac.2015.01.002. Epub 2015 Jan 9.

PMID:
25724589
44.

Effect of lipid head groups on double-layered two-dimensional crystals formed by aquaporin-0.

Hite RK, Chiu PL, Schuller JM, Walz T.

PLoS One. 2015 Jan 30;10(1):e0117371. doi: 10.1371/journal.pone.0117371. eCollection 2015.

45.

Molecular architecture of the αβ T cell receptor-CD3 complex.

Birnbaum ME, Berry R, Hsiao YS, Chen Z, Shingu-Vazquez MA, Yu X, Waghray D, Fischer S, McCluskey J, Rossjohn J, Walz T, Garcia KC.

Proc Natl Acad Sci U S A. 2014 Dec 9;111(49):17576-81. doi: 10.1073/pnas.1420936111. Epub 2014 Nov 24.

46.

Structure and function of a single-chain, multi-domain long-chain acyl-CoA carboxylase.

Tran TH, Hsiao YS, Jo J, Chou CY, Dietrich LE, Walz T, Tong L.

Nature. 2015 Feb 5;518(7537):120-4. doi: 10.1038/nature13912. Epub 2014 Nov 10.

47.

Molecular subtype and tumor characteristics of breast cancer metastases as assessed by gene expression significantly influence patient post-relapse survival.

Tobin NP, Harrell JC, Lövrot J, Egyhazi Brage S, Frostvik Stolt M, Carlsson L, Einbeigi Z, Linderholm B, Loman N, Malmberg M, Walz T, Fernö M, Perou CM, Bergh J, Hatschek T, Lindström LS; TEX Trialists Group.

Ann Oncol. 2015 Jan;26(1):81-8. doi: 10.1093/annonc/mdu498. Epub 2014 Oct 31.

48.

Structural study of the RIPoptosome core reveals a helical assembly for kinase recruitment.

Jang TH, Zheng C, Li J, Richards C, Hsiao YS, Walz T, Wu H, Park HH.

Biochemistry. 2014 Aug 26;53(33):5424-31. doi: 10.1021/bi500585u. Epub 2014 Aug 13.

49.

Structure and dynamics of AMPA receptor GluA2 in resting, pre-open, and desensitized states.

Dürr KL, Chen L, Stein RA, De Zorzi R, Folea IM, Walz T, Mchaourab HS, Gouaux E.

Cell. 2014 Aug 14;158(4):778-792. doi: 10.1016/j.cell.2014.07.023. Epub 2014 Aug 7.

50.

Molecular imprinting as a signal-activation mechanism of the viral RNA sensor RIG-I.

Wu B, Peisley A, Tetrault D, Li Z, Egelman EH, Magor KE, Walz T, Penczek PA, Hur S.

Mol Cell. 2014 Aug 21;55(4):511-23. doi: 10.1016/j.molcel.2014.06.010. Epub 2014 Jul 10.

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