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Mevalonate Pathway Provides Ubiquinone to Maintain Pyrimidine Synthesis and Survival in p53-Deficient Cancer Cells Exposed to Metabolic Stress.

Kaymak I, Maier CR, Schmitz W, Campbell AD, Dankworth B, Ade CP, Walz S, Paauwe M, Kalogirou C, Marouf H, Rosenfeldt MT, Gay DM, McGregor GH, Sansom OJ, Schulze A.

Cancer Res. 2020 Jan 15;80(2):189-203. doi: 10.1158/0008-5472.CAN-19-0650. Epub 2019 Nov 19.


A MYC-GCN2-eIF2α negative feedback loop limits protein synthesis to prevent MYC-dependent apoptosis in colorectal cancer.

Schmidt S, Gay D, Uthe FW, Denk S, Paauwe M, Matthes N, Diefenbacher ME, Bryson S, Warrander FC, Erhard F, Ade CP, Baluapuri A, Walz S, Jackstadt R, Ford C, Vlachogiannis G, Valeri N, Otto C, Schülein-Völk C, Maurus K, Schmitz W, Knight JRP, Wolf E, Strathdee D, Schulze A, Germer CT, Rosenwald A, Sansom OJ, Eilers M, Wiegering A.

Nat Cell Biol. 2019 Nov;21(11):1413-1424. doi: 10.1038/s41556-019-0408-0. Epub 2019 Nov 4.


Maternal risk factors and neonatal outcomes in placental abruption among patients with equal access to health care.

Eubanks AA, Walz S, Thiel LM.

J Matern Fetal Neonatal Med. 2019 Sep 1:1-6. doi: 10.1080/14767058.2019.1657088. [Epub ahead of print]


The Myb-MuvB Complex Is Required for YAP-Dependent Transcription of Mitotic Genes.

Pattschull G, Walz S, Gründl M, Schwab M, Rühl E, Baluapuri A, Cindric-Vranesic A, Kneitz S, Wolf E, Ade CP, Rosenwald A, von Eyss B, Gaubatz S.

Cell Rep. 2019 Jun 18;27(12):3533-3546.e7. doi: 10.1016/j.celrep.2019.05.071.


Novel Smartphone Game Improves Physical Activity Behavior in Type 2 Diabetes.

Höchsmann C, Müller O, Ambühl M, Klenk C, Königstein K, Infanger D, Walz SP, Schmidt-Trucksäss A.

Am J Prev Med. 2019 Jul;57(1):41-50. doi: 10.1016/j.amepre.2019.02.017. Epub 2019 May 22.


Bone Health Issues in Patients with Prostate Cancer: An Evidence-Based Review.

Walz S, Maas M, Stenzl A, Todenhöfer T.

World J Mens Health. 2019 May 2. doi: 10.5534/wjmh.190044. [Epub ahead of print] Review.


MYC Recruits SPT5 to RNA Polymerase II to Promote Processive Transcription Elongation.

Baluapuri A, Hofstetter J, Dudvarski Stankovic N, Endres T, Bhandare P, Vos SM, Adhikari B, Schwarz JD, Narain A, Vogt M, Wang SY, Düster R, Jung LA, Vanselow JT, Wiegering A, Geyer M, Maric HM, Gallant P, Walz S, Schlosser A, Cramer P, Eilers M, Wolf E.

Mol Cell. 2019 May 16;74(4):674-687.e11. doi: 10.1016/j.molcel.2019.02.031. Epub 2019 Mar 27.


Recruitment of BRCA1 limits MYCN-driven accumulation of stalled RNA polymerase.

Herold S, Kalb J, Büchel G, Ade CP, Baluapuri A, Xu J, Koster J, Solvie D, Carstensen A, Klotz C, Rodewald S, Schülein-Völk C, Dobbelstein M, Wolf E, Molenaar J, Versteeg R, Walz S, Eilers M.

Nature. 2019 Mar;567(7749):545-549. doi: 10.1038/s41586-019-1030-9. Epub 2019 Mar 20.


Effectiveness of a Behavior Change Technique-Based Smartphone Game to Improve Intrinsic Motivation and Physical Activity Adherence in Patients With Type 2 Diabetes: Randomized Controlled Trial.

Höchsmann C, Infanger D, Klenk C, Königstein K, Walz SP, Schmidt-Trucksäss A.

JMIR Serious Games. 2019 Feb 13;7(1):e11444. doi: 10.2196/11444.


Molecular markers in disease detection and follow-up of patients with non-muscle invasive bladder cancer.

Maas M, Walz S, Stühler V, Aufderklamm S, Rausch S, Bedke J, Stenzl A, Todenhöfer T.

Expert Rev Mol Diagn. 2018 May;18(5):443-455. doi: 10.1080/14737159.2018.1469979. Review.


Performance of Urinary Markers for Detection of Upper Tract Urothelial Carcinoma: Is Upper Tract Urine More Accurate than Urine from the Bladder?

Bier S, Hennenlotter J, Esser M, Mohrhardt S, Rausch S, Schwentner C, Maas M, Deininger S, Walz S, Bedke J, Stenzl A, Todenhöfer T.

Dis Markers. 2018 Jan 30;2018:5823870. doi: 10.1155/2018/5823870. eCollection 2018.


Expression of tumour progression-associated genes in circulating tumour cells of patients at different stages of prostate cancer.

Russo GI, Bier S, Hennenlotter J, Beger G, Pavlenco L, van de Flierdt J, Hauch S, Maas M, Walz S, Rausch S, Bedke J, Morgia G, Stenzl A, Todenhöfer T.

BJU Int. 2018 Jul;122(1):152-159. doi: 10.1111/bju.14200. Epub 2018 Apr 10.


Interventions to Improve Follow-Up of Laboratory Test Results Pending at Discharge: A Systematic Review.

Whitehead NS, Williams L, Meleth S, Kennedy S, Epner P, Singh H, Wooldridge K, Dalal AK, Walz SE, Lorey T, Graber ML.

J Hosp Med. 2018 Feb 28. doi: 10.12788/jhm.2944. [Epub ahead of print]


Current concepts and trends in the treatment of bone metastases in patients with advanced prostate cancer.

Hegemann M, Maas M, Rausch S, Walz S, Bedke J, Stenzl A, Todenhöfer T.

Asian J Androl. 2017 Dec 29. doi: 10.4103/aja.aja_59_17. [Epub ahead of print] Review.


Association with Aurora-A Controls N-MYC-Dependent Promoter Escape and Pause Release of RNA Polymerase II during the Cell Cycle.

Büchel G, Carstensen A, Mak KY, Roeschert I, Leen E, Sumara O, Hofstetter J, Herold S, Kalb J, Baluapuri A, Poon E, Kwok C, Chesler L, Maric HM, Rickman DS, Wolf E, Bayliss R, Walz S, Eilers M.

Cell Rep. 2017 Dec 19;21(12):3483-3497. doi: 10.1016/j.celrep.2017.11.090.


The MYC mRNA 3'-UTR couples RNA polymerase II function to glutamine and ribonucleotide levels.

Dejure FR, Royla N, Herold S, Kalb J, Walz S, Ade CP, Mastrobuoni G, Vanselow JT, Schlosser A, Wolf E, Kempa S, Eilers M.

EMBO J. 2017 Jul 3;36(13):1854-1868. doi: 10.15252/embj.201796662. Epub 2017 Apr 13.


Mobile Exergaming for Health-Effects of a serious game application for smartphones on physical activity and exercise adherence in type 2 diabetes mellitus-study protocol for a randomized controlled trial.

Höchsmann C, Walz SP, Schäfer J, Holopainen J, Hanssen H, Schmidt-Trucksäss A.

Trials. 2017 Mar 6;18(1):103. doi: 10.1186/s13063-017-1853-3.


A meta-analysis of HLA peptidome composition in different hematological entities: entity-specific dividing lines and "pan-leukemia" antigens.

Backert L, Kowalewski DJ, Walz S, Schuster H, Berlin C, Neidert MC, Schemionek M, Brümmendorf TH, Vucinic V, Niederwieser D, Kanz L, Salih HR, Kohlbacher O, Weisel K, Rammensee HG, Stevanovic S, Walz JS.

Oncotarget. 2017 Jul 4;8(27):43915-43924. doi: 10.18632/oncotarget.14918.


6-Phosphofructo-2-kinase/fructose-2,6-biphosphatase 4 is essential for p53-null cancer cells.

Ros S, Flöter J, Kaymak I, Da Costa C, Houddane A, Dubuis S, Griffiths B, Mitter R, Walz S, Blake S, Behrens A, Brindle KM, Zamboni N, Rider MH, Schulze A.

Oncogene. 2017 Jun 8;36(23):3287-3299. doi: 10.1038/onc.2016.477. Epub 2017 Jan 16.


OmoMYC blunts promoter invasion by oncogenic MYC to inhibit gene expression characteristic of MYC-dependent tumors.

Jung LA, Gebhardt A, Koelmel W, Ade CP, Walz S, Kuper J, von Eyss B, Letschert S, Redel C, d'Artista L, Biankin A, Zender L, Sauer M, Wolf E, Evan G, Kisker C, Eilers M.

Oncogene. 2017 Apr 6;36(14):1911-1924. doi: 10.1038/onc.2016.354. Epub 2016 Oct 17.


Different promoter affinities account for specificity in MYC-dependent gene regulation.

Lorenzin F, Benary U, Baluapuri A, Walz S, Jung LA, von Eyss B, Kisker C, Wolf J, Eilers M, Wolf E.

Elife. 2016 Jul 27;5. pii: e15161. doi: 10.7554/eLife.15161.


Carfilzomib alters the HLA-presented peptidome of myeloma cells and impairs presentation of peptides with aromatic C-termini.

Kowalewski DJ, Walz S, Backert L, Schuster H, Kohlbacher O, Weisel K, Rittig SM, Kanz L, Salih HR, Rammensee HG, Stevanović S, Stickel JS.

Blood Cancer J. 2016 Apr 8;6:e411. doi: 10.1038/bcj.2016.14.


Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy.

Berlin C, Kowalewski DJ, Schuster H, Mirza N, Walz S, Handel M, Schmid-Horch B, Salih HR, Kanz L, Rammensee HG, Stevanović S, Stickel JS.

Leukemia. 2016 Apr;30(4):1003-4. doi: 10.1038/leu.2016.1. No abstract available.


MYC regulates the antitumor immune response through CD47 and PD-L1.

Casey SC, Tong L, Li Y, Do R, Walz S, Fitzgerald KN, Gouw AM, Baylot V, Gütgemann I, Eilers M, Felsher DW.

Science. 2016 Apr 8;352(6282):227-31. doi: 10.1126/science.aac9935. Epub 2016 Mar 10. Erratum in: Science. 2016 Apr 8;352(6282). pii: aaf7984. doi: 10.1126/science.aaf7984.


Comprehensive study on critical micellar concentrations of SDS in acetonitrile-water solvents.

Šteflová J, Štefl M, Walz S, Knop M, Trapp O.

Electrophoresis. 2016 May;37(10):1287-95. doi: 10.1002/elps.201500553. Epub 2016 Mar 14.


The Interaction of Myc with Miz1 Defines Medulloblastoma Subgroup Identity.

Vo BT, Wolf E, Kawauchi D, Gebhardt A, Rehg JE, Finkelstein D, Walz S, Murphy BL, Youn YH, Han YG, Eilers M, Roussel MF.

Cancer Cell. 2016 Jan 11;29(1):5-16. doi: 10.1016/j.ccell.2015.12.003.


The antigenic landscape of multiple myeloma: mass spectrometry (re)defines targets for T-cell-based immunotherapy.

Walz S, Stickel JS, Kowalewski DJ, Schuster H, Weisel K, Backert L, Kahn S, Nelde A, Stroh T, Handel M, Kohlbacher O, Kanz L, Salih HR, Rammensee HG, Stevanović S.

Blood. 2015 Sep 3;126(10):1203-13. doi: 10.1182/blood-2015-04-640532. Epub 2015 Jul 2. Erratum in: Blood. 2015 Oct 22;126(17):2072-3.


Targeting Translation Initiation Bypasses Signaling Crosstalk Mechanisms That Maintain High MYC Levels in Colorectal Cancer.

Wiegering A, Uthe FW, Jamieson T, Ruoss Y, Hüttenrauch M, Küspert M, Pfann C, Nixon C, Herold S, Walz S, Taranets L, Germer CT, Rosenwald A, Sansom OJ, Eilers M.

Cancer Discov. 2015 Jul;5(7):768-781. doi: 10.1158/2159-8290.CD-14-1040. Epub 2015 May 1.


Investigation of the enantiomerization barriers of the phthalimidone derivatives EM12 and lenalidomide by dynamic electrokinetic chromatography.

Walz S, Weis S, Franz M, Rominger F, Trapp O.

Electrophoresis. 2015 Mar;36(5):796-804. doi: 10.1002/elps.201400499. Epub 2015 Feb 4.


Tumor cell-specific inhibition of MYC function using small molecule inhibitors of the HUWE1 ubiquitin ligase.

Peter S, Bultinck J, Myant K, Jaenicke LA, Walz S, Müller J, Gmachl M, Treu M, Boehmelt G, Ade CP, Schmitz W, Wiegering A, Otto C, Popov N, Sansom O, Kraut N, Eilers M.

EMBO Mol Med. 2014 Dec;6(12):1525-41. doi: 10.15252/emmm.201403927.


Mapping the HLA ligandome landscape of acute myeloid leukemia: a targeted approach toward peptide-based immunotherapy.

Berlin C, Kowalewski DJ, Schuster H, Mirza N, Walz S, Handel M, Schmid-Horch B, Salih HR, Kanz L, Rammensee HG, Stevanović S, Stickel JS.

Leukemia. 2015 Mar;29(3):647-59. doi: 10.1038/leu.2014.233. Epub 2014 Aug 5. Erratum in: Leukemia. 2016 Apr;30(4):1003-4.


Activation and repression by oncogenic MYC shape tumour-specific gene expression profiles.

Walz S, Lorenzin F, Morton J, Wiese KE, von Eyss B, Herold S, Rycak L, Dumay-Odelot H, Karim S, Bartkuhn M, Roels F, Wüstefeld T, Fischer M, Teichmann M, Zender L, Wei CL, Sansom O, Wolf E, Eilers M.

Nature. 2014 Jul 24;511(7510):483-7. doi: 10.1038/nature13473. Epub 2014 Jul 9. Erratum in: Nature. 2014 Dec 18;516(7531):440.


Maximum heat loss potential is lower in football linemen during an NCAA summer training camp because of lower self-generated air flow.

Deren TM, Coris EE, Casa DJ, DeMartini JK, Bain AR, Walz SM, Jay O.

J Strength Cond Res. 2014 Jun;28(6):1656-63. doi: 10.1519/JSC.0000000000000427.


The role of MIZ-1 in MYC-dependent tumorigenesis.

Wiese KE, Walz S, von Eyss B, Wolf E, Athineos D, Sansom O, Eilers M.

Cold Spring Harb Perspect Med. 2013 Dec 1;3(12):a014290. doi: 10.1101/cshperspect.a014290. Review.


New stent surface materials: the impact of polymer-dependent interactions of human endothelial cells, smooth muscle cells, and platelets.

Busch R, Strohbach A, Rethfeldt S, Walz S, Busch M, Petersen S, Felix S, Sternberg K.

Acta Biomater. 2014 Feb;10(2):688-700. doi: 10.1016/j.actbio.2013.10.015. Epub 2013 Oct 19.


Miz1 is required to maintain autophagic flux.

Wolf E, Gebhardt A, Kawauchi D, Walz S, von Eyss B, Wagner N, Renninger C, Krohne G, Asan E, Roussel MF, Eilers M.

Nat Commun. 2013;4:2535. doi: 10.1038/ncomms3535.


Cystathionase mediates senescence evasion in melanocytes and melanoma cells.

Leikam C, Hufnagel A, Walz S, Kneitz S, Fekete A, Müller MJ, Eilers M, Schartl M, Meierjohann S.

Oncogene. 2014 Feb 6;33(6):771-82. doi: 10.1038/onc.2012.641. Epub 2013 Jan 28.


Patient safety & post-analytical error.

Walz SE, Darcy TP.

Clin Lab Med. 2013 Mar;33(1):183-94. doi: 10.1016/j.cll.2012.10.001. Epub 2012 Dec 20.


Preparticipation cardiovascular screening among National Collegiate Athletic Association Division I institutions.

Coris EE, Sahebzamani F, Curtis A, Jennings J, Walz SM, Nugent D, Reese E, Zwygart KK, Konin JG, Pescasio M, Drezner JA.

Br J Sports Med. 2013 Feb;47(3):182-4. doi: 10.1136/bjsports-2012-091356. Epub 2012 Sep 13.


Wear behavior of dental Y-TZP ceramic against natural enamel after different finishing procedures.

Mitov G, Heintze SD, Walz S, Woll K, Muecklich F, Pospiech P.

Dent Mater. 2012 Aug;28(8):909-18. doi: 10.1016/ Epub 2012 May 18.


Multiple histone deacetylases are recruited by corepressor Sin3 and contribute to gene repression mediated by Opi1 regulator of phospholipid biosynthesis in the yeast Saccharomyces cerevisiae.

Grigat M, Jäschke Y, Kliewe F, Pfeifer M, Walz S, Schüller HJ.

Mol Genet Genomics. 2012 Jun;287(6):461-72. doi: 10.1007/s00438-012-0692-x. Epub 2012 Apr 28.


Physical demands of National Collegiate Athletic Association Division I football players during preseason training in the heat.

DeMartini JK, Martschinske JL, Casa DJ, Lopez RM, Ganio MS, Walz SM, Coris EE.

J Strength Cond Res. 2011 Nov;25(11):2935-43. doi: 10.1519/JSC.0b013e318231a643.


Provider characteristics, clinical-work processes and their relationship to discharge summary quality for sub-acute care patients.

Kind AJ, Thorpe CT, Sattin JA, Walz SE, Smith MA.

J Gen Intern Med. 2012 Jan;27(1):78-84. doi: 10.1007/s11606-011-1860-0. Epub 2011 Sep 7.


Sweating is greater in NCAA football linemen independently of heat production.

Deren TM, Coris EE, Bain AR, Walz SM, Jay O.

Med Sci Sports Exerc. 2012 Feb;44(2):244-52. doi: 10.1249/MSS.0b013e31822cb4e2.


Pending laboratory tests and the hospital discharge summary in patients discharged to sub-acute care.

Walz SE, Smith M, Cox E, Sattin J, Kind AJ.

J Gen Intern Med. 2011 Apr;26(4):393-8. doi: 10.1007/s11606-010-1583-7. Epub 2010 Nov 30.


Assessment of the duration of protection in Campylobacter jejuni experimental infection in humans.

Tribble DR, Baqar S, Scott DA, Oplinger ML, Trespalacios F, Rollins D, Walker RI, Clements JD, Walz S, Gibbs P, Burg EF 3rd, Moran AP, Applebee L, Bourgeois AL.

Infect Immun. 2010 Apr;78(4):1750-9. doi: 10.1128/IAI.01021-09. Epub 2010 Jan 19.


Gastrointestinal temperature trends in football linemen during physical exertion under heat stress.

Coris EE, Mehra S, Walz SM, Duncanson R, Jennings J, Nugent D, Zwygart K, Pescasio M.

South Med J. 2009 Jun;102(6):569-74. doi: 10.1097/SMJ.0b013e3181a4f389.


Return to activity considerations in a football player predisposed to exertional heat illness: a case study.

Coris EE, Walz S, Konin J, Pescasio M.

J Sport Rehabil. 2007 Aug;16(3):260-70.


Heat illness symptom index (HISI): a novel instrument for the assessment of heat illness in athletes.

Coris EE, Walz SM, Duncanson R, Ramirez AM, Roetzheim RG.

South Med J. 2006 Apr;99(4):340-5.


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