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Items: 39


Kappa Opioid Receptors Drive a Tonic Aversive Component of Chronic Pain.

Liu SS, Pickens S, Burma NE, Ibarra-Lecue I, Yang H, Xue L, Cook C, Hakimian JK, Severino AL, Lueptow L, Komarek K, Taylor AMW, Olmstead MC, Carroll FI, Bass CE, Andrews AM, Walwyn W, Trang T, Evans CJ, Leslie F, Cahill CM.

J Neurosci. 2019 Mar 12. pii: 0274-19. doi: 10.1523/JNEUROSCI.0274-19.2019. [Epub ahead of print]


Pain Therapy Guided by Purpose and Perspective in Light of the Opioid Epidemic.

Severino AL, Shadfar A, Hakimian JK, Crane O, Singh G, Heinzerling K, Walwyn WM.

Front Psychiatry. 2018 Apr 23;9:119. doi: 10.3389/fpsyt.2018.00119. eCollection 2018. Review.


Mu-opioid receptors in nociceptive afferents produce a sustained suppression of hyperalgesia in chronic pain.

Severino A, Chen W, Hakimian JK, Kieffer BL, Gaveriaux-Ruff C, Walwyn W, Marvizón JCG.

Pain. 2018 Aug;159(8):1607-1620. doi: 10.1097/j.pain.0000000000001247.


CerebraLux: a low-cost, open-source, wireless probe for optogenetic stimulation.

Dagnew R, Lin YY, Agatep J, Cheng M, Jann A, Quach V, Monroe M, Singh G, Minasyan A, Hakimian J, Kee T, Cushman J, Walwyn W.

Neurophotonics. 2017 Oct;4(4):045001. doi: 10.1117/1.NPh.4.4.045001. Epub 2017 Oct 11.


Beta-arrestin 1 regulation of reward-motivated behaviors and glutamatergic function.

Mittal N, Minasyan A, Romaneschi N, Hakimian JK, Gonzalez-Fernandez G, Albert R, Desai N, Mendez IA, Schallert T, Ostlund SB, Walwyn W.

PLoS One. 2017 Oct 3;12(10):e0185796. doi: 10.1371/journal.pone.0185796. eCollection 2017.


Morphine activation of mu opioid receptors causes disinhibition of neurons in the ventral tegmental area mediated by β-arrestin2 and c-Src.

Bull FA, Baptista-Hon DT, Lambert JJ, Walwyn W, Hales TG.

Sci Rep. 2017 Aug 30;7(1):9969. doi: 10.1038/s41598-017-10360-8.


Src Kinase Inhibition Attenuates Morphine Tolerance without Affecting Reinforcement or Psychomotor Stimulation.

Bull FA, Baptista-Hon DT, Sneddon C, Wright L, Walwyn W, Hales TG.

Anesthesiology. 2017 Nov;127(5):878-889. doi: 10.1097/ALN.0000000000001834.


Specific behavioral and cellular adaptations induced by chronic morphine are reduced by dietary omega-3 polyunsaturated fatty acids.

Hakimian J, Minasyan A, Zhe-Ying L, Loureiro M, Beltrand A, Johnston C, Vorperian A, Romaneschi N, Atallah W, Gomez-Pinilla F, Walwyn W.

PLoS One. 2017 Apr 5;12(4):e0175090. doi: 10.1371/journal.pone.0175090. eCollection 2017.


Allostatic Mechanisms of Opioid Tolerance Beyond Desensitization and Downregulation.

Cahill CM, Walwyn W, Taylor AMW, Pradhan AAA, Evans CJ.

Trends Pharmacol Sci. 2016 Nov;37(11):963-976. doi: 10.1016/ Epub 2016 Sep 23. Review.


Frontostriatal Circuit Dynamics Correlate with Cocaine Cue-Evoked Behavioral Arousal during Early Abstinence.

Smith WC, Rosenberg MH, Claar LD, Chang V, Shah SN, Walwyn WM, Evans CJ, Masmanidis SC.

eNeuro. 2016 Jun 23;3(3). pii: ENEURO.0105-16.2016. doi: 10.1523/ENEURO.0105-16.2016. eCollection 2016 May-Jun.


Agonist-Specific Recruitment of Arrestin Isoforms Differentially Modify Delta Opioid Receptor Function.

Pradhan AA, Perroy J, Walwyn WM, Smith ML, Vicente-Sanchez A, Segura L, Bana A, Kieffer BL, Evans CJ.

J Neurosci. 2016 Mar 23;36(12):3541-51. doi: 10.1523/JNEUROSCI.4124-15.2016.


Nicotine Modifies Corticostriatal Plasticity and Amphetamine Rewarding Behaviors in Mice(1,2,3).

Storey GP, Gonzalez-Fernandez G, Bamford IJ, Hur M, McKinley JW, Heimbigner L, Minasyan A, Walwyn WM, Bamford NS.

eNeuro. 2016 Feb 2;3(1). pii: ENEURO.0095-15.2015. doi: 10.1523/ENEURO.0095-15.2015. eCollection 2016 Jan-Feb.


Sustained Suppression of Hyperalgesia during Latent Sensitization by μ-, δ-, and κ-opioid receptors and α2A Adrenergic Receptors: Role of Constitutive Activity.

Walwyn WM, Chen W, Kim H, Minasyan A, Ennes HS, McRoberts JA, Marvizón JC.

J Neurosci. 2016 Jan 6;36(1):204-21. doi: 10.1523/JNEUROSCI.1751-15.2016.


Latent sensitization: a model for stress-sensitive chronic pain.

Marvizon JC, Walwyn W, Minasyan A, Chen W, Taylor BK.

Curr Protoc Neurosci. 2015 Apr 1;71:9.50.1-14. doi: 10.1002/0471142301.ns0950s71.


Anti-nociception mediated by a κ opioid receptor agonist is blocked by a δ receptor agonist.

Taylor AM, Roberts KW, Pradhan AA, Akbari HA, Walwyn W, Lutfy K, Carroll FI, Cahill CM, Evans CJ.

Br J Pharmacol. 2015 Jan;172(2):691-703. doi: 10.1111/bph.12810. Epub 2014 Sep 5.


Recent advances on the δ opioid receptor: from trafficking to function.

Gendron L, Mittal N, Beaudry H, Walwyn W.

Br J Pharmacol. 2015 Jan;172(2):403-19. doi: 10.1111/bph.12706. Epub 2014 Jul 1. Review.


BDNF released during neuropathic pain potentiates NMDA receptors in primary afferent terminals.

Chen W, Walwyn W, Ennes HS, Kim H, McRoberts JA, Marvizón JC.

Eur J Neurosci. 2014 May;39(9):1439-54. doi: 10.1111/ejn.12516. Epub 2014 Mar 11.


Targeted expression of μ-opioid receptors in a subset of striatal direct-pathway neurons restores opiate reward.

Cui Y, Ostlund SB, James AS, Park CS, Ge W, Roberts KW, Mittal N, Murphy NP, Cepeda C, Kieffer BL, Levine MS, Jentsch JD, Walwyn WM, Sun YE, Evans CJ, Maidment NT, Yang XW.

Nat Neurosci. 2014 Feb;17(2):254-61. doi: 10.1038/nn.3622. Epub 2014 Jan 12.


Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway.

Mittal N, Roberts K, Pal K, Bentolila LA, Fultz E, Minasyan A, Cahill C, Pradhan A, Conner D, DeFea K, Evans C, Walwyn W.

Cell Rep. 2013 Nov 27;5(4):1010-21. doi: 10.1016/j.celrep.2013.10.015. Epub 2013 Nov 14.


Opioid self-administration results in cell-type specific adaptations of striatal medium spiny neurons.

James AS, Chen JY, Cepeda C, Mittal N, Jentsch JD, Levine MS, Evans CJ, Walwyn W.

Behav Brain Res. 2013 Nov 1;256:279-83. doi: 10.1016/j.bbr.2013.08.009. Epub 2013 Aug 19.


Chronic inflammatory injury results in increased coupling of delta opioid receptors to voltage-gated Ca2+ channels.

Pradhan A, Smith M, McGuire B, Evans C, Walwyn W.

Mol Pain. 2013 Mar 4;9:8. doi: 10.1186/1744-8069-9-8.


Evidence that behavioral phenotypes of morphine in β-arr2-/- mice are due to the unmasking of JNK signaling.

Mittal N, Tan M, Egbuta O, Desai N, Crawford C, Xie CW, Evans C, Walwyn W.

Neuropsychopharmacology. 2012 Jul;37(8):1953-62. doi: 10.1038/npp.2012.42. Epub 2012 Apr 11.


Elevated tonic extracellular dopamine concentration and altered dopamine modulation of synaptic activity precede dopamine loss in the striatum of mice overexpressing human α-synuclein.

Lam HA, Wu N, Cely I, Kelly RL, Hean S, Richter F, Magen I, Cepeda C, Ackerson LC, Walwyn W, Masliah E, Chesselet MF, Levine MS, Maidment NT.

J Neurosci Res. 2011 Jul;89(7):1091-102. doi: 10.1002/jnr.22611. Epub 2011 Apr 12.


Analgesic tone conferred by constitutively active mu opioid receptors in mice lacking β-arrestin 2.

Lam H, Maga M, Pradhan A, Evans CJ, Maidment NT, Hales TG, Walwyn W.

Mol Pain. 2011 Apr 12;7:24. doi: 10.1186/1744-8069-7-24.


Ligand-directed trafficking of the δ-opioid receptor in vivo: two paths toward analgesic tolerance.

Pradhan AA, Walwyn W, Nozaki C, Filliol D, Erbs E, Matifas A, Evans C, Kieffer BL.

J Neurosci. 2010 Dec 8;30(49):16459-68. doi: 10.1523/JNEUROSCI.3748-10.2010.


Opioid pharmaceuticals and addiction: the issues, and research directions seeking solutions.

Walwyn WM, Miotto KA, Evans CJ.

Drug Alcohol Depend. 2010 May 1;108(3):156-65. doi: 10.1016/j.drugalcdep.2010.01.001. Epub 2010 Feb 25. Review.


Delta receptors are required for full inhibitory coupling of mu-receptors to voltage-dependent Ca(2+) channels in dorsal root ganglion neurons.

Walwyn W, John S, Maga M, Evans CJ, Hales TG.

Mol Pharmacol. 2009 Jul;76(1):134-43. doi: 10.1124/mol.109.055913. Epub 2009 Apr 8.


Distribution and localization of 5-HT(1A) receptors in the rat lumbar spinal cord after transection and deafferentation.

Otoshi CK, Walwyn WM, Tillakaratne NJ, Zhong H, Roy RR, Edgerton VR.

J Neurotrauma. 2009 Apr;26(4):575-84. doi: 10.1089/neu.2008.0640.


p38 MAPK and beta-arrestin 2 mediate functional interactions between endogenous micro-opioid and alpha2A-adrenergic receptors in neurons.

Tan M, Walwyn WM, Evans CJ, Xie CW.

J Biol Chem. 2009 Mar 6;284(10):6270-81. doi: 10.1074/jbc.M806742200. Epub 2009 Jan 6.


Mu opioid receptor-effector coupling and trafficking in dorsal root ganglia neurons.

Walwyn WM, Wei W, Xie CW, Chiu K, Kieffer BL, Evans CJ, Maidment NT.

Neuroscience. 2006 Oct 13;142(2):493-503. Epub 2006 Aug 1.


HSV-1-mediated NGF delivery delays nociceptive deficits in a genetic model of diabetic neuropathy.

Walwyn WM, Matsuka Y, Arai D, Bloom DC, Lam H, Tran C, Spigelman I, Maidment NT.

Exp Neurol. 2006 Mar;198(1):260-70. Epub 2006 Jan 20.


Induction of delta opioid receptor function by up-regulation of membrane receptors in mouse primary afferent neurons.

Walwyn W, Maidment NT, Sanders M, Evans CJ, Kieffer BL, Hales TG.

Mol Pharmacol. 2005 Dec;68(6):1688-98. Epub 2005 Aug 31.


Functional coupling, desensitization and internalization of virally expressed mu opioid receptors in cultured dorsal root ganglion neurons from mu opioid receptor knockout mice.

Walwyn WM, Keith DE Jr, Wei W, Tan AM, Xie CW, Evans CJ, Kieffer BL, Maidment NT.

Neuroscience. 2004;123(1):111-21.


Buprenorphine-induced antinociception is mediated by mu-opioid receptors and compromised by concomitant activation of opioid receptor-like receptors.

Lutfy K, Eitan S, Bryant CD, Yang YC, Saliminejad N, Walwyn W, Kieffer BL, Takeshima H, Carroll FI, Maidment NT, Evans CJ.

J Neurosci. 2003 Nov 12;23(32):10331-7.


Pentobarbital enhances GABAergic neurotransmission to cardiac parasympathetic neurons, which is prevented by expression of GABA(A) epsilon subunit.

Irnaten M, Walwyn WM, Wang J, Venkatesan P, Evans C, Chang KS, Andresen MC, Hales TG, Mendelowitz D.

Anesthesiology. 2002 Sep;97(3):717-24.


Naloxone fails to produce conditioned place aversion in mu-opioid receptor knock-out mice.

Skoubis PD, Matthes HW, Walwyn WM, Kieffer BL, Maidment NT.

Neuroscience. 2001;106(4):757-63.


Extracellular glutamate in the dorsal horn of the lumbar spinal cord in the freely moving rat during hindlimb stepping.

Walwyn WM, Ta-Haung J, Ackerson L, Maidment NT, Edgerton VR.

Pharmacol Biochem Behav. 1999 Aug;63(4):581-8.


Observations on the Action of Quinidine Sulphate on Three Cases of Auricular Fibrillation.

Walwyn WM, Fowler JS.

Edinb Med J. 1922 Aug;29(2):65-73. No abstract available.

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