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Items: 38

1.

Engineered CRISPR-Cas12a variants with increased activities and improved targeting ranges for gene, epigenetic and base editing.

Kleinstiver BP, Sousa AA, Walton RT, Tak YE, Hsu JY, Clement K, Welch MM, Horng JE, Malagon-Lopez J, Scarfò I, Maus MV, Pinello L, Aryee MJ, Joung JK.

Nat Biotechnol. 2019 Mar;37(3):276-282. doi: 10.1038/s41587-018-0011-0. Epub 2019 Feb 11.

2.

Creating a Theoretically Grounded, Gamified Health App: Lessons From Developing the Cigbreak Smoking Cessation Mobile Phone Game.

Edwards EA, Caton H, Lumsden J, Rivas C, Steed L, Pirunsarn Y, Jumbe S, Newby C, Shenvi A, Mazumdar S, Smith JQ, Greenhill D, Griffiths CJ, Walton RT.

JMIR Serious Games. 2018 Nov 29;6(4):e10252. doi: 10.2196/10252.

3.

Discovery of widespread type I and type V CRISPR-Cas inhibitors.

Marino ND, Zhang JY, Borges AL, Sousa AA, Leon LM, Rauch BJ, Walton RT, Berry JD, Joung JK, Kleinstiver BP, Bondy-Denomy J.

Science. 2018 Oct 12;362(6411):240-242. doi: 10.1126/science.aau5174. Epub 2018 Sep 6.

4.

Vitamin D receptor genotype influences risk of upper respiratory infection.

Jolliffe DA, Greiller CL, Mein CA, Hoti M, Bakhsoliani E, Telcian AG, Simpson A, Barnes NC, Curtin JA, Custovic A, Johnston SL, Griffiths CJ, Walton RT, Martineau AR.

Br J Nutr. 2018 Oct;120(8):891-900. doi: 10.1017/S000711451800209X. Epub 2018 Aug 22.

5.

Prevalence, determinants and clinical correlates of vitamin D deficiency in patients with Chronic Obstructive Pulmonary Disease in London, UK.

Jolliffe DA, James WY, Hooper RL, Barnes NC, Greiller CL, Islam K, Bhowmik A, Timms PM, Rajakulasingam RK, Choudhury AB, Simcock DE, Hyppönen E, Walton RT, Corrigan CJ, Griffiths CJ, Martineau AR.

J Steroid Biochem Mol Biol. 2018 Jan;175:138-145. doi: 10.1016/j.jsbmb.2017.01.019. Epub 2017 Feb 1.

6.

Prevalence, determinants and clinical correlates of vitamin D deficiency in adults with inhaled corticosteroid-treated asthma in London, UK.

Jolliffe DA, Kilpin K, MacLaughlin BD, Greiller CL, Hooper RL, Barnes NC, Timms PM, Rajakulasingam RK, Bhowmik A, Choudhury AB, Simcock DE, Hyppönen E, Corrigan CJ, Walton RT, Griffiths CJ, Martineau AR.

J Steroid Biochem Mol Biol. 2018 Jan;175:88-96. doi: 10.1016/j.jsbmb.2016.11.004. Epub 2016 Nov 5.

PMID:
27825992
7.

Air pollution, ethnicity and telomere length in east London schoolchildren: An observational study.

Walton RT, Mudway IS, Dundas I, Marlin N, Koh LC, Aitlhadj L, Vulliamy T, Jamaludin JB, Wood HE, Barratt BM, Beevers S, Dajnak D, Sheikh A, Kelly FJ, Griffiths CJ, Grigg J.

Environ Int. 2016 Nov;96:41-47. doi: 10.1016/j.envint.2016.08.021. Epub 2016 Sep 1.

8.

Gamification for health promotion: systematic review of behaviour change techniques in smartphone apps.

Edwards EA, Lumsden J, Rivas C, Steed L, Edwards LA, Thiyagarajan A, Sohanpal R, Caton H, Griffiths CJ, Munafò MR, Taylor S, Walton RT.

BMJ Open. 2016 Oct 4;6(10):e012447. doi: 10.1136/bmjopen-2016-012447. Review.

9.

Environmental and genetic determinants of vitamin D status among older adults in London, UK.

Jolliffe DA, Hanifa Y, Witt KD, Venton TR, Rowe M, Timms PM, Hyppönen E, Walton RT, Griffiths CJ, Martineau AR.

J Steroid Biochem Mol Biol. 2016 Nov;164:30-35. doi: 10.1016/j.jsbmb.2016.01.005. Epub 2016 Jan 14.

PMID:
26776442
10.

Single nucleotide polymorphisms in the vitamin D pathway associating with circulating concentrations of vitamin D metabolites and non-skeletal health outcomes: Review of genetic association studies.

Jolliffe DA, Walton RT, Griffiths CJ, Martineau AR.

J Steroid Biochem Mol Biol. 2016 Nov;164:18-29. doi: 10.1016/j.jsbmb.2015.12.007. Epub 2015 Dec 11. Review.

PMID:
26686945
11.

Maternal genotype and severe preeclampsia: a HuGE review.

Fong FM, Sahemey MK, Hamedi G, Eyitayo R, Yates D, Kuan V, Thangaratinam S, Walton RT.

Am J Epidemiol. 2014 Aug 15;180(4):335-45. doi: 10.1093/aje/kwu151. Epub 2014 Jul 15. Review.

PMID:
25028703
12.

Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution.

Janha RE, Worwui A, Linton KJ, Shaheen SO, Sisay-Joof F, Walton RT.

BMC Evol Biol. 2014 Apr 1;14:71. doi: 10.1186/1471-2148-14-71.

13.

Computerized advice on drug dosage to improve prescribing practice.

Gillaizeau F, Chan E, Trinquart L, Colombet I, Walton RT, Rège-Walther M, Burnand B, Durieux P.

Cochrane Database Syst Rev. 2013 Nov 12;(11):CD002894. doi: 10.1002/14651858.CD002894.pub3. Review.

PMID:
24218045
14.

The role of zebrafish (Danio rerio) in dissecting the genetics and neural circuits of executive function.

Parker MO, Brock AJ, Walton RT, Brennan CH.

Front Neural Circuits. 2013 Apr 8;7:63. doi: 10.3389/fncir.2013.00063. eCollection 2013. Review.

15.

Treatment for tobacco dependence: a potential application for stratified medicine?

Brock AJ, Takeda A, Brennan C, Walton RT.

Per Med. 2011 Sep;8(5):571-579. doi: 10.2217/pme.11.60.

PMID:
29793253
16.

Effects of genetic variation at the CYP2C19/CYP2C9 locus on pharmacokinetics of chlorcycloguanil in adult Gambians.

Janha RE, Sisay-Joof F, Hamid-Adiamoh M, Worwui A, Chapman HL, Opara H, Dunyo S, Milligan P, Rockett K, Winstanley P, Pirmohamed M, Miller AK, Conway DJ, Walton RT.

Pharmacogenomics. 2009 Sep;10(9):1423-31. doi: 10.2217/pgs.09.72.

17.

Computerized advice on drug dosage to improve prescribing practice.

Durieux P, Trinquart L, Colombet I, Niès J, Walton R, Rajeswaran A, Rège Walther M, Harvey E, Burnand B.

Cochrane Database Syst Rev. 2008 Jul 16;(3):CD002894. doi: 10.1002/14651858.CD002894.pub2. Review. Update in: Cochrane Database Syst Rev. 2013;11:CD002894.

PMID:
18646085
18.

HIV and chemokine binding to red blood cells--DARC matters.

Walton RT, Rowland-Jones SL.

Cell Host Microbe. 2008 Jul 17;4(1):3-5. doi: 10.1016/j.chom.2008.06.006. Review.

19.

Effects of Acute Nicotine Abstinence on Cue-elicited Ventral Striatum/Nucleus Accumbens Activation in Female Cigarette Smokers: A Functional Magnetic Resonance Imaging Study.

David SP, Munafò MR, Johansen-Berg H, Mackillop J, Sweet LH, Cohen RA, Niaura R, Rogers RD, Matthews PM, Walton RT.

Brain Imaging Behav. 2007 Dec;1(3-4):43-57.

20.

Association of COMT Val108/158Met genotype with smoking cessation in a nicotine replacement therapy randomized trial.

Johnstone EC, Elliot KM, David SP, Murphy MF, Walton RT, Munafò MR.

Cancer Epidemiol Biomarkers Prev. 2007 Jun;16(6):1065-9.

21.

Genetic variation in the dopamine D4 receptor (DRD4) gene and smoking cessation: follow-up of a randomised clinical trial of transdermal nicotine patch.

David SP, Munafò MR, Murphy MF, Proctor M, Walton RT, Johnstone EC.

Pharmacogenomics J. 2008 Apr;8(2):122-8. Epub 2007 Mar 27.

22.

The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial.

David SP, Munafò MR, Murphy MF, Walton RT, Johnstone EC.

Nicotine Tob Res. 2007 Feb;9(2):225-31.

23.

Association of the mu-opioid receptor gene with smoking cessation.

Munafò MR, Elliot KM, Murphy MF, Walton RT, Johnstone EC.

Pharmacogenomics J. 2007 Oct;7(5):353-61. Epub 2007 Jan 16.

PMID:
17224915
24.

Ventral striatum/nucleus accumbens activation to smoking-related pictorial cues in smokers and nonsmokers: a functional magnetic resonance imaging study.

David SP, Munafò MR, Johansen-Berg H, Smith SM, Rogers RD, Matthews PM, Walton RT.

Biol Psychiatry. 2005 Sep 15;58(6):488-94. Epub 2005 Jul 14.

25.

A functional genetic variation of the serotonin (5-HT) transporter affects 5-HT1A receptor binding in humans.

David SP, Murthy NV, Rabiner EA, Munafó MR, Johnstone EC, Jacob R, Walton RT, Grasby PM.

J Neurosci. 2005 Mar 9;25(10):2586-90.

26.

Association between the serotonin transporter gene and alcohol consumption in social drinkers.

Munafò MR, Lingford-Hughes AR, Johnstone EC, Walton RT.

Am J Med Genet B Neuropsychiatr Genet. 2005 May 5;135B(1):10-4.

PMID:
15729746
27.

Association between the DRD2 gene Taq1A (C32806T) polymorphism and alcohol consumption in social drinkers.

Munafò MR, Johnstone EC, Welsh KI, Walton RT.

Pharmacogenomics J. 2005;5(2):96-101.

PMID:
15668731
28.

Identification of CYP2B6 sequence variants by use of multiplex PCR with allele-specific genotyping.

Jacob RM, Johnstone EC, Neville MJ, Walton RT.

Clin Chem. 2004 Aug;50(8):1372-7. Epub 2004 Jun 3.

29.
30.

Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch.

Johnstone EC, Yudkin PL, Hey K, Roberts SJ, Welch SJ, Murphy MF, Griffiths SE, Walton RT.

Pharmacogenetics. 2004 Feb;14(2):83-90.

PMID:
15077009
31.

Does the DRD2-Taq1 A polymorphism influence treatment response to bupropion hydrochloride for reduction of the nicotine withdrawal syndrome?

David SP, Niaura R, Papandonatos GD, Shadel WG, Burkholder GJ, Britt DM, Day A, Stumpff J, Hutchison K, Murphy M, Johnstone E, Griffiths SE, Walton RT.

Nicotine Tob Res. 2003 Dec;5(6):935-42.

PMID:
14668077
32.

Polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers: seeking confirmation of the association in a follow-up study.

Johnstone EC, Clark TG, Griffiths SE, Murphy MF, Walton RT.

Pharmacogenetics. 2002 Oct;12(7):585-7. No abstract available.

PMID:
12360111
33.

Genetic testing: the future of smoking cessation therapy?

Johnstone EC, York EE, Walton RT.

Expert Rev Mol Diagn. 2002 Jan;2(1):60-8. Review.

PMID:
11963809
34.

Computerised advice on drug dosage to improve prescribing practice.

Walton RT, Harvey E, Dovey S, Freemantle N.

Cochrane Database Syst Rev. 2001;(1):CD002894. Review. Update in: Cochrane Database Syst Rev. 2008;(3):CD002894.

PMID:
11279772
35.

Association between polymorphisms in dopamine metabolic enzymes and tobacco consumption in smokers.

McKinney EF, Walton RT, Yudkin P, Fuller A, Haldar NA, Mant D, Murphy M, Welsh KI, Marshall SE.

Pharmacogenetics. 2000 Aug;10(6):483-91.

PMID:
10975602
36.

Evaluation of computer support for prescribing (CAPSULE) using simulated cases.

Walton RT, Gierl C, Yudkin P, Mistry H, Vessey MP, Fox J.

BMJ. 1997 Sep 27;315(7111):791-5.

37.

Treatment of plantar ulcers in leprosy patients in the community with adhesive zinc tape.

Walton RT, Fritschi EP, Umapathy VA.

Lepr Rev. 1986 Mar;57(1):53-6. No abstract available.

PMID:
3517537
38.

QT prolongation after ileojejunal bypass.

Chambers JB, Walton RT, Coupe MO, Ward DE.

Lancet. 1985 Dec 7;2(8467):1308. No abstract available.

PMID:
2866373

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