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Items: 1 to 50 of 96

1.

Un-phased: Lipid Droplets Modulate the Bioavailability of Antibiotics.

Walther TC, Farese RV Jr.

Dev Cell. 2019 Sep 9;50(5):530-532. doi: 10.1016/j.devcel.2019.08.009.

PMID:
31505174
2.

Genome wide analysis of 3' UTR sequence elements and proteins regulating mRNA stability during maternal-to-zygotic transition in zebrafish.

Vejnar CE, Abdel Messih M, Takacs CM, Yartseva V, Oikonomou P, Christiano R, Stoeckius M, Lau S, Lee MT, Beaudoin JD, Musaev D, Darwich-Codore H, Walther TC, Tavazoie S, Cifuentes D, Giraldez AJ.

Genome Res. 2019 Jul;29(7):1100-1114. doi: 10.1101/gr.245159.118. Epub 2019 Jun 21.

PMID:
31227602
3.

Lowe syndrome-linked endocytic adaptors direct membrane cycling kinetics with OCRL in Dictyostelium discoideum.

Luscher A, Fröhlich F, Barisch C, Littlewood C, Metcalfe J, Leuba F, Palma A, Pirruccello M, Cesareni G, Stagi M, Walther TC, Soldati T, De Camilli P, Swan LE.

Mol Biol Cell. 2019 Aug 1;30(17):2268-2282. doi: 10.1091/mbc.E18-08-0510. Epub 2019 Jun 19.

4.

Hepatocyte Deletion of Triglyceride-Synthesis Enzyme Acyl CoA: Diacylglycerol Acyltransferase 2 Reduces Steatosis Without Increasing Inflammation or Fibrosis in Mice.

Gluchowski NL, Gabriel KR, Chitraju C, Bronson RT, Mejhert N, Boland S, Wang K, Lai ZW, Farese RV Jr, Walther TC.

Hepatology. 2019 May 13. doi: 10.1002/hep.30765. [Epub ahead of print]

PMID:
31081165
5.

The triglyceride synthesis enzymes DGAT1 and DGAT2 have distinct and overlapping functions in adipocytes.

Chitraju C, Walther TC, Farese RV Jr.

J Lipid Res. 2019 Jun;60(6):1112-1120. doi: 10.1194/jlr.M093112. Epub 2019 Apr 1.

6.

Probing the Global Cellular Responses to Lipotoxicity Caused by Saturated Fatty Acids.

Piccolis M, Bond LM, Kampmann M, Pulimeno P, Chitraju C, Jayson CBK, Vaites LP, Boland S, Lai ZW, Gabriel KR, Elliott SD, Paulo JA, Harper JW, Weissman JS, Walther TC, Farese RV Jr.

Mol Cell. 2019 Apr 4;74(1):32-44.e8. doi: 10.1016/j.molcel.2019.01.036. Epub 2019 Mar 4.

PMID:
30846318
7.

The unfolded protein response and endoplasmic reticulum protein targeting machineries converge on the stress sensor IRE1.

Acosta-Alvear D, Karagöz GE, Fröhlich F, Li H, Walther TC, Walter P.

Elife. 2018 Dec 24;7. pii: e43036. doi: 10.7554/eLife.43036.

8.

Lipidomic Analysis of α-Synuclein Neurotoxicity Identifies Stearoyl CoA Desaturase as a Target for Parkinson Treatment.

Fanning S, Haque A, Imberdis T, Baru V, Barrasa MI, Nuber S, Termine D, Ramalingam N, Ho GPH, Noble T, Sandoe J, Lou Y, Landgraf D, Freyzon Y, Newby G, Soldner F, Terry-Kantor E, Kim TE, Hofbauer HF, Becuwe M, Jaenisch R, Pincus D, Clish CB, Walther TC, Farese RV Jr, Srinivasan S, Welte MA, Kohlwein SD, Dettmer U, Lindquist S, Selkoe D.

Mol Cell. 2019 Mar 7;73(5):1001-1014.e8. doi: 10.1016/j.molcel.2018.11.028. Epub 2018 Dec 4.

PMID:
30527540
9.

Organellar Proteomics and Phospho-Proteomics Reveal Subcellular Reorganization in Diet-Induced Hepatic Steatosis.

Krahmer N, Najafi B, Schueder F, Quagliarini F, Steger M, Seitz S, Kasper R, Salinas F, Cox J, Uhlenhaut NH, Walther TC, Jungmann R, Zeigerer A, Borner GHH, Mann M.

Dev Cell. 2018 Oct 22;47(2):205-221.e7. doi: 10.1016/j.devcel.2018.09.017.

PMID:
30352176
10.

Cryo-electron microscopy structure of the lipid droplet-formation protein seipin.

Sui X, Arlt H, Brock KP, Lai ZW, DiMaio F, Marks DS, Liao M, Farese RV Jr, Walther TC.

J Cell Biol. 2018 Dec 3;217(12):4080-4091. doi: 10.1083/jcb.201809067. Epub 2018 Oct 16.

11.

Progranulin in the hematopoietic compartment protects mice from atherosclerosis.

Nguyen AD, Nguyen TA, Singh RK, Eberlé D, Zhang J, Abate JP, Robles A, Koliwad S, Huang EJ, Maxfield FR, Walther TC, Farese RV Jr.

Atherosclerosis. 2018 Oct;277:145-154. doi: 10.1016/j.atherosclerosis.2018.08.042. Epub 2018 Aug 30.

12.

Fine needle aspirates of kidneys: a promising tool for RNA sequencing in native and transplanted kidneys.

Eikrem Ø, Walther TC, Flatberg A, Beisvag V, Strauss P, Farstad M, Beisland C, Koch E, Mueller TF, Marti HP.

BMC Nephrol. 2018 Sep 5;19(1):221. doi: 10.1186/s12882-018-1012-4.

13.

Deciphering the Role of Lipid Droplets in Cardiovascular Disease: A Report From the 2017 National Heart, Lung, and Blood Institute Workshop.

Goldberg IJ, Reue K, Abumrad NA, Bickel PE, Cohen S, Fisher EA, Galis ZS, Granneman JG, Lewandowski ED, Murphy R, Olive M, Schaffer JE, Schwartz-Longacre L, Shulman GI, Walther TC, Chen J.

Circulation. 2018 Jul 17;138(3):305-315. doi: 10.1161/CIRCULATIONAHA.118.033704. Review.

14.

Rab18 is not necessary for lipid droplet biogenesis or turnover in human mammary carcinoma cells.

Jayson CBK, Arlt H, Fischer AW, Lai ZW, Farese RV Jr, Walther TC.

Mol Biol Cell. 2018 Aug 15;29(17):2045-2054. doi: 10.1091/mbc.E18-05-0282. Epub 2018 Jun 27.

15.

Murine knockin model for progranulin-deficient frontotemporal dementia with nonsense-mediated mRNA decay.

Nguyen AD, Nguyen TA, Zhang J, Devireddy S, Zhou P, Karydas AM, Xu X, Miller BL, Rigo F, Ferguson SM, Huang EJ, Walther TC, Farese RV Jr.

Proc Natl Acad Sci U S A. 2018 Mar 20;115(12):E2849-E2858. doi: 10.1073/pnas.1722344115. Epub 2018 Mar 6.

16.

Global Analyses of Selective Insulin Resistance in Hepatocytes Caused by Palmitate Lipotoxicity.

Li Z, Lai ZW, Christiano R, Gazos-Lopes F, Walther TC, Farese RV Jr.

Mol Cell Proteomics. 2018 May;17(5):836-849. doi: 10.1074/mcp.RA117.000560. Epub 2018 Feb 5.

17.

Mechanism and Determinants of Amphipathic Helix-Containing Protein Targeting to Lipid Droplets.

Prévost C, Sharp ME, Kory N, Lin Q, Voth GA, Farese RV Jr, Walther TC.

Dev Cell. 2018 Jan 8;44(1):73-86.e4. doi: 10.1016/j.devcel.2017.12.011. Epub 2018 Jan 8.

18.

Functional Contribution of the Spastic Paraplegia-Related Triglyceride Hydrolase DDHD2 to the Formation and Content of Lipid Droplets.

Inloes JM, Kiosses WB, Wang H, Walther TC, Farese RV Jr, Cravatt BF.

Biochemistry. 2018 Feb 6;57(5):827-838. doi: 10.1021/acs.biochem.7b01028. Epub 2017 Dec 26.

19.

Lipid Droplet Biogenesis.

Walther TC, Chung J, Farese RV Jr.

Annu Rev Cell Dev Biol. 2017 Oct 6;33:491-510. doi: 10.1146/annurev-cellbio-100616-060608. Epub 2017 Aug 9. Review.

PMID:
28793795
20.

Triglyceride Synthesis by DGAT1 Protects Adipocytes from Lipid-Induced ER Stress during Lipolysis.

Chitraju C, Mejhert N, Haas JT, Diaz-Ramirez LG, Grueter CA, Imbriglio JE, Pinto S, Koliwad SK, Walther TC, Farese RV Jr.

Cell Metab. 2017 Aug 1;26(2):407-418.e3. doi: 10.1016/j.cmet.2017.07.012.

21.

The proteome and transcriptome of the infectious metacyclic form of Trypanosoma brucei define quiescent cells primed for mammalian invasion.

Christiano R, Kolev NG, Shi H, Ullu E, Walther TC, Tschudi C.

Mol Microbiol. 2017 Oct;106(1):74-92. doi: 10.1111/mmi.13754. Epub 2017 Aug 4.

22.

Lipid droplets and liver disease: from basic biology to clinical implications.

Gluchowski NL, Becuwe M, Walther TC, Farese RV Jr.

Nat Rev Gastroenterol Hepatol. 2017 Jun;14(6):343-355. doi: 10.1038/nrgastro.2017.32. Epub 2017 Apr 21. Review.

23.

Identification and characterization of a novel DGAT1 missense mutation associated with congenital diarrhea.

Gluchowski NL, Chitraju C, Picoraro JA, Mejhert N, Pinto S, Xin W, Kamin DS, Winter HS, Chung WK, Walther TC, Farese RV Jr.

J Lipid Res. 2017 Jun;58(6):1230-1237. doi: 10.1194/jlr.P075119. Epub 2017 Apr 3.

24.

Mice lacking lipid droplet-associated hydrolase, a gene linked to human prostate cancer, have normal cholesterol ester metabolism.

Kory N, Grond S, Kamat SS, Li Z, Krahmer N, Chitraju C, Zhou P, Fröhlich F, Semova I, Ejsing C, Zechner R, Cravatt BF, Farese RV Jr, Walther TC.

J Lipid Res. 2017 Jan;58(1):226-235. doi: 10.1194/jlr.M072538. Epub 2016 Nov 11.

25.

Proteomic and phosphoproteomic analyses of yeast reveal the global cellular response to sphingolipid depletion.

Fröhlich F, Olson DK, Christiano R, Farese RV Jr, Walther TC.

Proteomics. 2016 Nov;16(21):2759-2763. doi: 10.1002/pmic.201600269.

26.

Seipin is required for converting nascent to mature lipid droplets.

Wang H, Becuwe M, Housden BE, Chitraju C, Porras AJ, Graham MM, Liu XN, Thiam AR, Savage DB, Agarwal AK, Garg A, Olarte MJ, Lin Q, Fröhlich F, Hannibal-Bach HK, Upadhyayula S, Perrimon N, Kirchhausen T, Ejsing CS, Walther TC, Farese RV.

Elife. 2016 Aug 26;5. pii: e16582. doi: 10.7554/eLife.16582.

27.

Targeting Fat: Mechanisms of Protein Localization to Lipid Droplets.

Kory N, Farese RV Jr, Walther TC.

Trends Cell Biol. 2016 Jul;26(7):535-546. doi: 10.1016/j.tcb.2016.02.007. Epub 2016 Mar 16. Review.

28.

Taming the sphinx: Mechanisms of cellular sphingolipid homeostasis.

Olson DK, Fröhlich F, Farese RV Jr, Walther TC.

Biochim Biophys Acta. 2016 Aug;1861(8 Pt B):784-792. doi: 10.1016/j.bbalip.2015.12.021. Epub 2015 Dec 30. Review.

29.

Lipid droplets go nuclear.

Farese RV Jr, Walther TC.

J Cell Biol. 2016 Jan 4;212(1):7-8. doi: 10.1083/jcb.201512056.

30.

The leukodystrophy protein FAM126A (hyccin) regulates PtdIns(4)P synthesis at the plasma membrane.

Baskin JM, Wu X, Christiano R, Oh MS, Schauder CM, Gazzerro E, Messa M, Baldassari S, Assereto S, Biancheri R, Zara F, Minetti C, Raimondi A, Simons M, Walther TC, Reinisch KM, De Camilli P.

Nat Cell Biol. 2016 Jan;18(1):132-8. doi: 10.1038/ncb3271. Epub 2015 Nov 16.

31.

The GARP complex is required for cellular sphingolipid homeostasis.

Fröhlich F, Petit C, Kory N, Christiano R, Hannibal-Bach HK, Graham M, Liu X, Ejsing CS, Farese RV, Walther TC.

Elife. 2015 Sep 10;4. doi: 10.7554/eLife.08712.

32.

Stromal cell-derived factor 2 is critical for Hsp90-dependent eNOS activation.

Siragusa M, Fröhlich F, Park EJ, Schleicher M, Walther TC, Sessa WC.

Sci Signal. 2015 Aug 18;8(390):ra81. doi: 10.1126/scisignal.aaa2819.

33.

Protein Crowding Is a Determinant of Lipid Droplet Protein Composition.

Kory N, Thiam AR, Farese RV Jr, Walther TC.

Dev Cell. 2015 Aug 10;34(3):351-63. doi: 10.1016/j.devcel.2015.06.007. Epub 2015 Jul 23.

34.

The Erv41-Erv46 complex serves as a retrograde receptor to retrieve escaped ER proteins.

Shibuya A, Margulis N, Christiano R, Walther TC, Barlowe C.

J Cell Biol. 2015 Jan 19;208(2):197-209. doi: 10.1083/jcb.201408024. Epub 2015 Jan 12.

35.

Rom2-dependent phosphorylation of Elo2 controls the abundance of very long-chain fatty acids.

Olson DK, Fröhlich F, Christiano R, Hannibal-Bach HK, Ejsing CS, Walther TC.

J Biol Chem. 2015 Feb 13;290(7):4238-47. doi: 10.1074/jbc.M114.629279. Epub 2014 Dec 17.

36.

Global proteome turnover analyses of the Yeasts S. cerevisiae and S. pombe.

Christiano R, Nagaraj N, Fröhlich F, Walther TC.

Cell Rep. 2014 Dec 11;9(5):1959-1965. doi: 10.1016/j.celrep.2014.10.065. Epub 2014 Nov 26.

37.

A role for eisosomes in maintenance of plasma membrane phosphoinositide levels.

Fröhlich F, Christiano R, Olson DK, Alcazar-Roman A, DeCamilli P, Walther TC.

Mol Biol Cell. 2014 Sep 15;25(18):2797-806. doi: 10.1091/mbc.E13-11-0639. Epub 2014 Jul 23.

38.

Mutations disrupting the Kennedy phosphatidylcholine pathway in humans with congenital lipodystrophy and fatty liver disease.

Payne F, Lim K, Girousse A, Brown RJ, Kory N, Robbins A, Xue Y, Sleigh A, Cochran E, Adams C, Dev Borman A, Russel-Jones D, Gorden P, Semple RK, Saudek V, O'Rahilly S, Walther TC, Barroso I, Savage DB.

Proc Natl Acad Sci U S A. 2014 Jun 17;111(24):8901-6. doi: 10.1073/pnas.1408523111. Epub 2014 Jun 2.

39.

High confidence proteomic analysis of yeast LDs identifies additional droplet proteins and reveals connections to dolichol synthesis and sterol acetylation.

Currie E, Guo X, Christiano R, Chitraju C, Kory N, Harrison K, Haas J, Walther TC, Farese RV Jr.

J Lipid Res. 2014 Jul;55(7):1465-77. doi: 10.1194/jlr.M050229. Epub 2014 May 27.

40.

Lipid droplet biogenesis.

Wilfling F, Haas JT, Walther TC, Farese RV Jr.

Curr Opin Cell Biol. 2014 Aug;29:39-45. doi: 10.1016/j.ceb.2014.03.008. Epub 2014 Apr 14. Review.

41.

Identification of small ORFs in vertebrates using ribosome footprinting and evolutionary conservation.

Bazzini AA, Johnstone TG, Christiano R, Mackowiak SD, Obermayer B, Fleming ES, Vejnar CE, Lee MT, Rajewsky N, Walther TC, Giraldez AJ.

EMBO J. 2014 May 2;33(9):981-93. doi: 10.1002/embj.201488411. Epub 2014 Apr 4.

42.

Arf1/COPI machinery acts directly on lipid droplets and enables their connection to the ER for protein targeting.

Wilfling F, Thiam AR, Olarte MJ, Wang J, Beck R, Gould TJ, Allgeyer ES, Pincet F, Bewersdorf J, Farese RV Jr, Walther TC.

Elife. 2014;3:e01607. doi: 10.7554/eLife.01607. Epub 2014 Feb 4.

43.

A mechanism for retromer endosomal coat complex assembly with cargo.

Harrison MS, Hung CS, Liu TT, Christiano R, Walther TC, Burd CG.

Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):267-72. doi: 10.1073/pnas.1316482111. Epub 2013 Dec 16.

44.

The biophysics and cell biology of lipid droplets.

Thiam AR, Farese RV Jr, Walther TC.

Nat Rev Mol Cell Biol. 2013 Dec;14(12):775-86. doi: 10.1038/nrm3699. Epub 2013 Nov 13. Review.

45.

COPI buds 60-nm lipid droplets from reconstituted water-phospholipid-triacylglyceride interfaces, suggesting a tension clamp function.

Thiam AR, Antonny B, Wang J, Delacotte J, Wilfling F, Walther TC, Beck R, Rothman JE, Pincet F.

Proc Natl Acad Sci U S A. 2013 Aug 13;110(33):13244-9. doi: 10.1073/pnas.1307685110. Epub 2013 Jul 30.

46.

Cellular fatty acid metabolism and cancer.

Currie E, Schulze A, Zechner R, Walther TC, Farese RV Jr.

Cell Metab. 2013 Aug 6;18(2):153-61. doi: 10.1016/j.cmet.2013.05.017. Epub 2013 Jun 20. Review.

47.

Balancing the fat: lipid droplets and human disease.

Krahmer N, Farese RV Jr, Walther TC.

EMBO Mol Med. 2013 Jul;5(7):973-83. doi: 10.1002/emmm.201100671. Epub 2013 Jun 6. Review.

48.

Native SILAC: metabolic labeling of proteins in prototroph microorganisms based on lysine synthesis regulation.

Fröhlich F, Christiano R, Walther TC.

Mol Cell Proteomics. 2013 Jul;12(7):1995-2005. doi: 10.1074/mcp.M112.025742. Epub 2013 Apr 16.

49.

Triacylglycerol synthesis enzymes mediate lipid droplet growth by relocalizing from the ER to lipid droplets.

Wilfling F, Wang H, Haas JT, Krahmer N, Gould TJ, Uchida A, Cheng JX, Graham M, Christiano R, Fröhlich F, Liu X, Buhman KK, Coleman RA, Bewersdorf J, Farese RV Jr, Walther TC.

Dev Cell. 2013 Feb 25;24(4):384-99. doi: 10.1016/j.devcel.2013.01.013. Epub 2013 Feb 14.

50.

Secreted progranulin is a homodimer and is not a component of high density lipoproteins (HDL).

Nguyen AD, Nguyen TA, Cenik B, Yu G, Herz J, Walther TC, Davidson WS, Farese RV Jr.

J Biol Chem. 2013 Mar 22;288(12):8627-35. doi: 10.1074/jbc.M112.441949. Epub 2013 Jan 30.

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