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Nicotinamide N-Methyltransferase and Its Precursor Substrate Methionine Directly and Indirectly Control Malignant Metabolism During Progression of Renal Cell Carcinoma.

Holstein S, Venz S, Junker H, Walther R, Stope MB, Zimmermann U.

Anticancer Res. 2019 Oct;39(10):5427-5436. doi: 10.21873/anticanres.13736.


Cdc42 defines apical identity and regulates epithelial morphogenesis by promoting apical recruitment of Par6-aPKC and Crumbs.

Nunes de Almeida F, Walther RF, Pressé MT, Vlassaks E, Pichaud F.

Development. 2019 Aug 12;146(15). pii: dev175497. doi: 10.1242/dev.175497.


Extended scaffold glucuronides: en route to the universal synthesis of O-aryl glucuronide prodrugs.

Walther R, Jarlstad Olesen MT, Zelikin AN.

Org Biomol Chem. 2019 Jul 24;17(29):6970-6974. doi: 10.1039/c9ob01384a.


Regulation of Cdc42 and its effectors in epithelial morphogenesis.

Pichaud F, Walther RF, Nunes de Almeida F.

J Cell Sci. 2019 May 21;132(10). pii: jcs217869. doi: 10.1242/jcs.217869. Review.


Cabazitaxel inhibits prostate cancer cell growth by inhibition of androgen receptor and heat shock protein expression.

Rottach AM, Ahrend H, Martin B, Walther R, Zimmermann U, Burchardt M, Stope MB.

World J Urol. 2019 Oct;37(10):2137-2145. doi: 10.1007/s00345-018-2615-x. Epub 2019 Jan 2.


Non-covalent hitchhiking on endogenous carriers as a protraction mechanism for antiviral macromolecular prodrugs.

Frich CK, Krüger F, Walther R, Domar C, Andersen AHF, Tvilum A, Dagnæs-Hansen F, Denton PW, Tolstrup M, Paludan SR, Münch J, Zelikin AN.

J Control Release. 2019 Jan 28;294:298-310. doi: 10.1016/j.jconrel.2018.12.016. Epub 2018 Dec 12.


Innate glycosidic activity in metallic implants for localized synthesis of antibacterial drugs.

Ter Meer M, Dillion R, Nielsen SM, Walther R, Meyer RL, Daamen WF, van den Heuvel LP, van der Vliet JA, Lomme RMLM, Hoogeveen YL, Schultze Kool LJ, Schaffer JE, Zelikin AN.

Chem Commun (Camb). 2019 Jan 3;55(4):443-446. doi: 10.1039/c8cc08737g.


Identification and Directed Development of Non-Organic Catalysts with Apparent Pan-Enzymatic Mimicry into Nanozymes for Efficient Prodrug Conversion.

Walther R, Winther AK, Fruergaard AS, van den Akker W, Sørensen L, Nielsen SM, Jarlstad Olesen MT, Dai Y, Jeppesen HS, Lamagni P, Savateev A, Pedersen SL, Frich CK, Vigier-Carrière C, Lock N, Singh M, Bansal V, Meyer RL, Zelikin AN.

Angew Chem Int Ed Engl. 2019 Jan 2;58(1):278-282. doi: 10.1002/anie.201812668. Epub 2018 Nov 28.


Combatting implant-associated biofilms through localized drug synthesis.

Walther R, Nielsen SM, Christiansen R, Meyer RL, Zelikin AN.

J Control Release. 2018 Oct 10;287:94-102. doi: 10.1016/j.jconrel.2018.08.025. Epub 2018 Aug 20.


Reduced Purposeful Head Movements During Community Ambulation Following Unilateral Vestibular Loss.

Paul SS, Dibble LE, Walther RG, Shelton C, Gurgel RK, Lester ME.

Neurorehabil Neural Repair. 2018 Apr-May;32(4-5):309-316. doi: 10.1177/1545968318770271. Epub 2018 Apr 20.


Rap1, Canoe and Mbt cooperate with Bazooka to promote zonula adherens assembly in the fly photoreceptor.

Walther RF, Burki M, Pinal N, Rogerson C, Pichaud F.

J Cell Sci. 2018 Mar 26;131(6). pii: jcs207779. doi: 10.1242/jcs.207779.


Detection and characterization of molecular-level collagen damage in overstretched cerebral arteries.

Converse MI, Walther RG, Ingram JT, Li Y, Yu SM, Monson KL.

Acta Biomater. 2018 Feb;67:307-318. doi: 10.1016/j.actbio.2017.11.052. Epub 2017 Dec 8.


Characterization of Head-Trunk Coordination Deficits After Unilateral Vestibular Hypofunction Using Wearable Sensors.

Paul SS, Dibble LE, Walther RG, Shelton C, Gurgel RK, Lester ME.

JAMA Otolaryngol Head Neck Surg. 2017 Oct 1;143(10):1008-1014. doi: 10.1001/jamaoto.2017.1443.


Feasibility and Validity of Discriminating Yaw Plane Head-on-Trunk Motion Using Inertial Wearable Sensors.

Paul SS, Walther RG, Beseris EA, Dibble LE, Lester ME.

IEEE Trans Neural Syst Rehabil Eng. 2017 Dec;25(12):2347-2354. doi: 10.1109/TNSRE.2017.2740945. Epub 2017 Aug 17.


Prodrugs in medicinal chemistry and enzyme prodrug therapies.

Walther R, Rautio J, Zelikin AN.

Adv Drug Deliv Rev. 2017 Sep 1;118:65-77. doi: 10.1016/j.addr.2017.06.013. Epub 2017 Jul 1. Review.


Tumor protein D52 (isoform 3) contributes to prostate cancer cell growth via targeting nuclear factor-κB transactivation in LNCaP cells.

Dasari C, Yaghnam DP, Walther R, Ummanni R.

Tumour Biol. 2017 May;39(5):1010428317698382. doi: 10.1177/1010428317698382.


Seromucinous borderline tumor of the testis-A case report.

Scholz B, Beckert M, Mordstein V, Hohmann N, Walther R, Papadopoulos T.

Hum Pathol. 2017 Feb;60:188-191. doi: 10.1016/j.humpath.2016.06.023. Epub 2016 Sep 3.


Pak4 Is Required during Epithelial Polarity Remodeling through Regulating AJ Stability and Bazooka Retention at the ZA.

Walther RF, Nunes de Almeida F, Vlassaks E, Burden JJ, Pichaud F.

Cell Rep. 2016 Apr 5;15(1):45-53. doi: 10.1016/j.celrep.2016.03.014. Epub 2016 Mar 24.


Cytochrome P450 17A1 Inhibitor Abiraterone Acetate Counteracts the Heat Shock Protein 27's Cell Survival Properties in Prostate Cancer Cells.

Weiss M, Ahrend H, Grossebrummel H, Ziegler P, Brandenburg LO, Walther R, Zimmermann U, Burchardt M, Stope MB.

Urol Int. 2016;97(1):112-7. doi: 10.1159/000445251. Epub 2016 Mar 24.


Anti-migratory activity of marine alkaloid monanchocidin A - proteomics-based discovery and confirmation.

Dyshlovoy SA, Venz S, Hauschild J, Tabakmakher KM, Otte K, Madanchi R, Walther R, Guzii AG, Makarieva TN, Shubina LK, Fedorov SN, Stonik VA, Bokemeyer C, Balabanov S, Honecker F, V Amsberg G.

Proteomics. 2016 May;16(10):1590-603. doi: 10.1002/pmic.201500334. Epub 2016 Apr 27.


Prostate Cancer Associated Lipid Signatures in Serum Studied by ESI-Tandem Mass Spectrometryas Potential New Biomarkers.

Duscharla D, Bhumireddy SR, Lakshetti S, Pospisil H, Murthy PV, Walther R, Sripadi P, Ummanni R.

PLoS One. 2016 Mar 9;11(3):e0150253. doi: 10.1371/journal.pone.0150253. eCollection 2016.


Isoform 1 of TPD52 (PC-1) promotes neuroendocrine transdifferentiation in prostate cancer cells.

Moritz T, Venz S, Junker H, Kreuz S, Walther R, Zimmermann U.

Tumour Biol. 2016 Aug;37(8):10435-46. doi: 10.1007/s13277-016-4925-1. Epub 2016 Feb 5.


Journal changes and initiatives.

Walther RE, Weisel RD.

J Thorac Cardiovasc Surg. 2016 Feb;151(2):328-9. doi: 10.1016/j.jtcvs.2015.12.026. No abstract available.


The marine triterpene glycoside frondoside A exhibits activity in vitro and in vivo in prostate cancer.

Dyshlovoy SA, Menchinskaya ES, Venz S, Rast S, Amann K, Hauschild J, Otte K, Kalinin VI, Silchenko AS, Avilov SA, Alsdorf W, Madanchi R, Bokemeyer C, Schumacher U, Walther R, Aminin DL, Fedorov SN, Shubina LK, Stonik VA, Balabanov S, Honecker F, von Amsberg G.

Int J Cancer. 2016 May 15;138(10):2450-65. doi: 10.1002/ijc.29977. Epub 2016 Jan 23.


Cytochrome P450 17A1 inhibitor abiraterone attenuates cellular growth of prostate cancer cells independently from androgen receptor signaling by modulation of oncogenic and apoptotic pathways.

Grossebrummel H, Peter T, Mandelkow R, Weiss M, Muzzio D, Zimmermann U, Walther R, Jensen F, Knabbe C, Zygmunt M, Burchardt M, Stope MB.

Int J Oncol. 2016 Feb;48(2):793-800. doi: 10.3892/ijo.2015.3274. Epub 2015 Nov 27.


Exosomal particles secreted by prostate cancer cells are potent mRNA and protein vehicles for the interference of tumor and tumor environment.

Rauschenberger L, Staar D, Thom K, Scharf C, Venz S, Homuth G, Schlüter R, Brandenburg LO, Ziegler P, Zimmermann U, Weitschies W, Völker U, Lendeckel U, Walther R, Burchardt M, Stope MB.

Prostate. 2016 Mar;76(4):409-24. doi: 10.1002/pros.23132. Epub 2015 Dec 8.


Cold Atmospheric Plasma Treatment Induces Anti-Proliferative Effects in Prostate Cancer Cells by Redox and Apoptotic Signaling Pathways.

Weiss M, Gümbel D, Hanschmann EM, Mandelkow R, Gelbrich N, Zimmermann U, Walther R, Ekkernkamp A, Sckell A, Kramer A, Burchardt M, Lillig CH, Stope MB.

PLoS One. 2015 Jul 1;10(7):e0130350. doi: 10.1371/journal.pone.0130350. eCollection 2015.


Novel Cell-Penetrating Peptide-Based Vaccine Induces Robust CD4+ and CD8+ T Cell-Mediated Antitumor Immunity.

Derouazi M, Di Berardino-Besson W, Belnoue E, Hoepner S, Walther R, Benkhoucha M, Teta P, Dufour Y, Yacoub Maroun C, Salazar AM, Martinvalet D, Dietrich PY, Walker PR.

Cancer Res. 2015 Aug 1;75(15):3020-31. doi: 10.1158/0008-5472.CAN-14-3017. Epub 2015 Jun 26.


Marine alkaloid Monanchocidin a overcomes drug resistance by induction of autophagy and lysosomal membrane permeabilization.

Dyshlovoy SA, Hauschild J, Amann K, Tabakmakher KM, Venz S, Walther R, Guzii AG, Makarieva TN, Shubina LK, Fedorov SN, Stonik VA, Bokemeyer C, Balabanov S, Honecker F, von Amsberg G.

Oncotarget. 2015 Jul 10;6(19):17328-41.


Prostate cancer-associated autoantibodies in serum against tumor-associated antigens as potential new biomarkers.

Ummanni R, Duscharla D, Barett C, Venz S, Schlomm T, Heinzer H, Walther R, Bokemeyer C, Brümmendorf TH, Murthy PV, Balabanov S.

J Proteomics. 2015 Apr 24;119:218-29. doi: 10.1016/j.jprot.2015.02.005. Epub 2015 Feb 24.


Management of obstructive sleep apnea in a developmentally delayed pediatric patient with aggressive behavior and Pierre Robin sequence.

Skinner HJ, Walther RB, Dolwick MF, Berry RB, Wagner MH.

J Clin Sleep Med. 2015 Jan 15;11(2):181-3. doi: 10.5664/jcsm.4470.


Differential expression of the multidrug resistance 1 (MDR1) protein in prostate cancer cells is independent from anticancer drug treatment and Y box binding protein 1 (YB-1) activity.

Saupe M, Rauschenberger L, Preuß M, Oswald S, Fussek S, Zimmermann U, Walther R, Knabbe C, Burchardt M, Stope MB.

World J Urol. 2015 Oct;33(10):1481-6. doi: 10.1007/s00345-014-1469-0. Epub 2014 Dec 28.


On the first application of the Richardson-Lucy algorithm to resolve plasmonic resonances in EELS spectra obtained with a monochromated electron beam.

Walther RM, Gerthsen D.

Microsc Microanal. 2014 Aug;20(4):993-4. doi: 10.1017/S143192761400097X. No abstract available.


Immediate and transient phosphorylation of the heat shock protein 27 initiates chemoresistance in prostate cancer cells.

Stope MB, Weiss M, Preuss M, Streitbörger A, Ritter CA, Zimmermann U, Walther R, Burchardt M.

Oncol Rep. 2014 Dec;32(6):2380-6. doi: 10.3892/or.2014.3492. Epub 2014 Sep 17.


Heat-shock protein HSPB1 attenuates microRNA miR-1 expression thereby restoring oncogenic pathways in prostate cancer cells.

Stope MB, Stender C, Schubert T, Peters S, Weiss M, Ziegler P, Zimmermann U, Walther R, Burchardt M.

Anticancer Res. 2014 Jul;34(7):3475-80.


A novel mouse model for inhibition of DOHH-mediated hypusine modification reveals a crucial function in embryonic development, proliferation and oncogenic transformation.

Sievert H, Pällmann N, Miller KK, Hermans-Borgmeyer I, Venz S, Sendoel A, Preukschas M, Schweizer M, Boettcher S, Janiesch PC, Streichert T, Walther R, Hengartner MO, Manz MG, Brümmendorf TH, Bokemeyer C, Braig M, Hauber J, Duncan KE, Balabanov S.

Dis Model Mech. 2014 Aug;7(8):963-76. doi: 10.1242/dmm.014449. Epub 2014 May 15.


Androgen receptor (AR) inhibitor ErbB3-binding protein-1 (Ebp1) is not targeted by the newly identified AR controlling signaling axis heat-shock protein HSP27 and microRNA miR-1 in prostate cancer cells.

Stope MB, Peters S, Großebrummel H, Zimmermann U, Walther R, Burchardt M.

World J Urol. 2015 Mar;33(3):323-7. doi: 10.1007/s00345-014-1307-4. Epub 2014 May 6.


Browning of white adipose cells by intermediate metabolites: an adaptive mechanism to alleviate redox pressure.

Carrière A, Jeanson Y, Berger-Müller S, André M, Chenouard V, Arnaud E, Barreau C, Walther R, Galinier A, Wdziekonski B, Villageois P, Louche K, Collas P, Moro C, Dani C, Villarroya F, Casteilla L.

Diabetes. 2014 Oct;63(10):3253-65. doi: 10.2337/db13-1885. Epub 2014 May 1.


Long-term culture and functionality of pancreatic islets monitored using microelectrode arrays.

Schönecker S, Kraushaar U, Düfer M, Sahr A, Härdtner C, Guenther E, Walther R, Lendeckel U, Barthlen W, Krippeit-Drews P, Drews G.

Integr Biol (Camb). 2014 May;6(5):540-4. doi: 10.1039/c3ib40261d.


Activity of aaptamine and two derivatives, demethyloxyaaptamine and isoaaptamine, in cisplatin-resistant germ cell cancer.

Dyshlovoy SA, Venz S, Shubina LK, Fedorov SN, Walther R, Jacobsen C, Stonik VA, Bokemeyer C, Balabanov S, Honecker F.

J Proteomics. 2014 Jan 16;96:223-39. doi: 10.1016/j.jprot.2013.11.009. Epub 2013 Nov 21.


Shortened isoforms of the androgen receptor are regulated by the cytoprotective heat-shock protein HSPB1 and the tumor-suppressive microRNA miR-1 in prostate cancer cells.

Stope MB, Bradl J, Peters S, Streitbörger A, Weiss M, Zimmermann U, Walther R, Lillig CH, Burchardt M.

Anticancer Res. 2013 Nov;33(11):4921-6.


High glucose activates the alternative ACE2/Ang-(1-7)/Mas and APN/Ang IV/IRAP RAS axes in pancreatic β-cells.

Härdtner C, Mörke C, Walther R, Wolke C, Lendeckel U.

Int J Mol Med. 2013 Oct;32(4):795-804. doi: 10.3892/ijmm.2013.1469. Epub 2013 Aug 14.


Combination of a proteomics approach and reengineering of meso scale network models for prediction of mode-of-action for tyrosine kinase inhibitors.

Balabanov S, Wilhelm T, Venz S, Keller G, Scharf C, Pospisil H, Braig M, Barett C, Bokemeyer C, Walther R, Brümmendorf TH, Schuppert A.

PLoS One. 2013;8(1):e53668. doi: 10.1371/journal.pone.0053668. Epub 2013 Jan 9.


[Transforming growth factor β in prostate cancer: cellular effects and basic molecular mechanisms].

Stope MB, Rönnau C, Schubert T, Staar D, Bradl J, Ziegler P, Streitbörger A, Kroeger N, Zimmermann U, Walther R, Burchardt M, Börgermann C.

Urologe A. 2013 Mar;52(3):378-83. doi: 10.1007/s00120-012-3049-5. German.


Protein-protein-interaction network organization of the hypusine modification system.

Sievert H, Venz S, Platas-Barradas O, Dhople VM, Schaletzky M, Nagel CH, Braig M, Preukschas M, Pällmann N, Bokemeyer C, Brümmendorf TH, Pörtner R, Walther R, Duncan KE, Hauber J, Balabanov S.

Mol Cell Proteomics. 2012 Nov;11(11):1289-305. doi: 10.1074/mcp.M112.019059. Epub 2012 Aug 10.


Effects of lightweight outdoor clothing on the prevention of hypothermia during low-intensity exercise in the cold.

Burtscher M, Kofler P, Gatterer H, Faulhaber M, Philippe M, Fischer K, Walther R, Herten A.

Clin J Sport Med. 2012 Nov;22(6):505-7. doi: 10.1097/JSM.0b013e318257c9cc.


Composition of molecular cardiolipin species correlates with proliferation of lymphocytes.

Schild L, Lendeckel U, Gardemann A, Wiswedel I, Schmidt CA, Wolke C, Walther R, Grabarczyk P, Busemann C.

Exp Biol Med (Maywood). 2012 Apr;237(4):372-9. doi: 10.1258/ebm.2011.011311. Epub 2012 Apr 4.


Peroxiredoxins 3 and 4 are overexpressed in prostate cancer tissue and affect the proliferation of prostate cancer cells in vitro.

Ummanni R, Barreto F, Venz S, Scharf C, Barett C, Mannsperger HA, Brase JC, Kuner R, Schlomm T, Sauter G, Sültmann H, Korf U, Bokemeyer C, Walther R, Brümmendorf TH, Balabanov S.

J Proteome Res. 2012 Apr 6;11(4):2452-66. doi: 10.1021/pr201172n. Epub 2012 Mar 28.


Proteomic profiling of germ cell cancer cells treated with aaptamine, a marine alkaloid with antiproliferative activity.

Dyshlovoy SA, Naeth I, Venz S, Preukschas M, Sievert H, Jacobsen C, Shubina LK, Gesell Salazar M, Scharf C, Walther R, Krepstakies M, Priyadarshini P, Hauber J, Fedorov SN, Bokemeyer C, Stonik VA, Balabanov S, Honecker F.

J Proteome Res. 2012 Apr 6;11(4):2316-30. doi: 10.1021/pr300170p. Epub 2012 Mar 28.


Effect of the heat shock protein HSP27 on androgen receptor expression and function in prostate cancer cells.

Stope MB, Schubert T, Staar D, Rönnau C, Streitbörger A, Kroeger N, Kubisch C, Zimmermann U, Walther R, Burchardt M.

World J Urol. 2012 Jun;30(3):327-31. doi: 10.1007/s00345-012-0843-z. Epub 2012 Feb 24.


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