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Items: 34


Tailored first-line and second-line CDK4-targeting treatment combinations in mouse models of pancreatic cancer.

Chou A, Froio D, Nagrial AM, Parkin A, Murphy KJ, Chin VT, Wohl D, Steinmann A, Stark R, Drury A, Walters SN, Vennin C, Burgess A, Pinese M, Chantrill LA, Cowley MJ, Molloy TJ; Australian Pancreatic Cancer Genome Initiative (APGI), Waddell N, Johns A, Grimmond SM, Chang DK, Biankin AV, Sansom OJ, Morton JP, Grey ST, Cox TR, Turchini J, Samra J, Clarke SJ, Timpson P, Gill AJ, Pajic M.

Gut. 2018 Dec;67(12):2142-2155. doi: 10.1136/gutjnl-2017-315144. Epub 2017 Oct 28.


A RhoA-FRET Biosensor Mouse for Intravital Imaging in Normal Tissue Homeostasis and Disease Contexts.

Nobis M, Herrmann D, Warren SC, Kadir S, Leung W, Killen M, Magenau A, Stevenson D, Lucas MC, Reischmann N, Vennin C, Conway JRW, Boulghourjian A, Zaratzian A, Law AM, Gallego-Ortega D, Ormandy CJ, Walters SN, Grey ST, Bailey J, Chtanova T, Quinn JMW, Baldock PA, Croucher PI, Schwarz JP, Mrowinska A, Zhang L, Herzog H, Masedunskas A, Hardeman EC, Gunning PW, Del Monte-Nieto G, Harvey RP, Samuel MS, Pajic M, McGhee EJ, Johnsson AE, Sansom OJ, Welch HCE, Morton JP, Strathdee D, Anderson KI, Timpson P.

Cell Rep. 2017 Oct 3;21(1):274-288. doi: 10.1016/j.celrep.2017.09.022.


Transient tissue priming via ROCK inhibition uncouples pancreatic cancer progression, sensitivity to chemotherapy, and metastasis.

Vennin C, Chin VT, Warren SC, Lucas MC, Herrmann D, Magenau A, Melenec P, Walters SN, Del Monte-Nieto G, Conway JR, Nobis M, Allam AH, McCloy RA, Currey N, Pinese M, Boulghourjian A, Zaratzian A, Adam AA, Heu C, Nagrial AM, Chou A, Steinmann A, Drury A, Froio D, Giry-Laterriere M, Harris NL, Phan T, Jain R, Weninger W, McGhee EJ, Whan R, Johns AL, Samra JS, Chantrill L, Gill AJ, Kohonen-Corish M, Harvey RP, Biankin AV; Australian Pancreatic Cancer Genome Initiative (APGI), Evans TR, Anderson KI, Grey ST, Ormandy CJ, Gallego-Ortega D, Wang Y, Samuel MS, Sansom OJ, Burgess A, Cox TR, Morton JP, Pajic M, Timpson P.

Sci Transl Med. 2017 Apr 5;9(384). pii: eaai8504. doi: 10.1126/scitranslmed.aai8504.


Targeted deletion of Traf2 allows immunosuppression-free islet allograft survival in mice.

Villanueva JE, Walters SN, Saito M, Malle EK, Zammit NW, Watson KA, Brink R, La Gruta NL, Alexander SI, Grey ST.

Diabetologia. 2017 Apr;60(4):679-689. doi: 10.1007/s00125-016-4198-7. Epub 2017 Jan 6.


Intravital FRAP Imaging using an E-cadherin-GFP Mouse Reveals Disease- and Drug-Dependent Dynamic Regulation of Cell-Cell Junctions in Live Tissue.

Erami Z, Herrmann D, Warren SC, Nobis M, McGhee EJ, Lucas MC, Leung W, Reischmann N, Mrowinska A, Schwarz JP, Kadir S, Conway JRW, Vennin C, Karim SA, Campbell AD, Gallego-Ortega D, Magenau A, Murphy KJ, Ridgway RA, Law AM, Walters SN, Grey ST, Croucher DR, Zhang L, Herzog H, Hardeman EC, Gunning PW, Ormandy CJ, Evans TRJ, Strathdee D, Sansom OJ, Morton JP, Anderson KI, Timpson P.

Cell Rep. 2016 Jan 5;14(1):152-167. doi: 10.1016/j.celrep.2015.12.020. Epub 2015 Dec 24.


Nuclear factor κB-inducing kinase activation as a mechanism of pancreatic β cell failure in obesity.

Malle EK, Zammit NW, Walters SN, Koay YC, Wu J, Tan BM, Villanueva JE, Brink R, Loudovaris T, Cantley J, McAlpine SR, Hesselson D, Grey ST.

J Exp Med. 2015 Jul 27;212(8):1239-54. doi: 10.1084/jem.20150218. Epub 2015 Jun 29.


TRAF2 regulates peripheral CD8(+) T-cell and NKT-cell homeostasis by modulating sensitivity to IL-15.

Villanueva JE, Malle EK, Gardam S, Silveira PA, Zammit NW, Walters SN, Brink R, Grey ST.

Eur J Immunol. 2015 Jun;45(6):1820-31. doi: 10.1002/eji.201445416. Epub 2015 May 26.


Reduction of ARNT in myeloid cells causes immune suppression and delayed wound healing.

Scott C, Bonner J, Min D, Boughton P, Stokes R, Cha KM, Walters SN, Maslowski K, Sierro F, Grey ST, Twigg S, McLennan S, Gunton JE.

Am J Physiol Cell Physiol. 2014 Aug 15;307(4):C349-57. doi: 10.1152/ajpcell.00306.2013. Epub 2014 Jul 2.


A role for intrathymic B cells in the generation of natural regulatory T cells.

Walters SN, Webster KE, Daley S, Grey ST.

J Immunol. 2014 Jul 1;193(1):170-6. doi: 10.4049/jimmunol.1302519. Epub 2014 May 28.


BAFF regulates activation of self-reactive T cells through B-cell dependent mechanisms and mediates protection in NOD mice.

Mariño E, Walters SN, Villanueva JE, Richards JL, Mackay CR, Grey ST.

Eur J Immunol. 2014 Apr;44(4):983-93. doi: 10.1002/eji.201344186. Epub 2014 Feb 16.


Influence of chronic hyperglycemia on the loss of the unfolded protein response in transplanted islets.

Walters SN, Luzuriaga J, Chan JY, Grey ST, Laybutt DR.

J Mol Endocrinol. 2013 Sep 6;51(2):225-32. doi: 10.1530/JME-13-0016. Print 2013 Oct.


Baculoviral inhibitors of apoptosis repeat containing (BIRC) proteins fine-tune TNF-induced nuclear factor κB and c-Jun N-terminal kinase signalling in mouse pancreatic beta cells.

Tan BM, Zammit NW, Yam AO, Slattery R, Walters SN, Malle E, Grey ST.

Diabetologia. 2013 Mar;56(3):520-32. doi: 10.1007/s00125-012-2784-x. Epub 2012 Dec 20.


Low-dose rapamycin unmasks the protective potential of targeting intragraft NF-κB for islet transplants.

Zammit NW, Tan BM, Walters SN, Liuwantara D, Villanueva JE, Malle EK, Grey ST.

Cell Transplant. 2013;22(12):2355-66. doi: 10.3727/096368912X658737. Epub 2012 Oct 31.


A preexistent hypoxic gene signature predicts impaired islet graft function and glucose homeostasis.

Cantley J, Walters SN, Jung MH, Weinberg A, Cowley MJ, Whitworth TP, Kaplan W, Hawthorne WJ, O'Connell PJ, Weir G, Grey ST.

Cell Transplant. 2013;22(11):2147-59. doi: 10.3727/096368912X658728. Epub 2012 Oct 31.


Human islets express a marked proinflammatory molecular signature prior to transplantation.

Cowley MJ, Weinberg A, Zammit NW, Walters SN, Hawthorne WJ, Loudovaris T, Thomas H, Kay T, Gunton JE, Alexander SI, Kaplan W, Chapman J, O'Connell PJ, Grey ST.

Cell Transplant. 2012;21(9):2063-78. doi: 10.3727/096368911X627372. Epub 2012 Mar 8.


BAFF and MyD88 signals promote a lupuslike disease independent of T cells.

Groom JR, Fletcher CA, Walters SN, Grey ST, Watt SV, Sweet MJ, Smyth MJ, Mackay CR, Mackay F.

J Exp Med. 2007 Aug 6;204(8):1959-71. Epub 2007 Jul 30.


Association between islet xenograft rejection mediated by activated macrophages and upregulated chemokines.

Chandra AP, Ou-Yang L, Wong JK, Ha H, Walters SN, Patel AT, Hawthorne WJ, Yi SN.

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2007 Feb;32(1):26-35.


Chemokine and toll-like receptor signaling in macrophage mediated islet xenograft rejection.

Chandra AP, Ouyang L, Yi S, Wong JK, Ha H, Walters SN, Patel AT, Stokes R, Jardine M, Hawthorne WJ, O'Connell PJ.

Xenotransplantation. 2007 Jan;14(1):48-59.


Nuclear factor-kappaB regulates beta-cell death: a critical role for A20 in beta-cell protection.

Liuwantara D, Elliot M, Smith MW, Yam AO, Walters SN, Marino E, McShea A, Grey ST.

Diabetes. 2006 Sep;55(9):2491-501.


Clinical islet transplantation in type 1 diabetes mellitus: results of Australia's first trial.

O'Connell PJ, Hawthorne WJ, Holmes-Walker DJ, Nankivell BJ, Gunton JE, Patel AT, Walters SN, Pleass HC, Allen RD, Chapman JR.

Med J Aust. 2006 Mar 6;184(5):221-5.


Overexpression of glutathione peroxidase with two isoforms of superoxide dismutase protects mouse islets from oxidative injury and improves islet graft function.

Mysore TB, Shinkel TA, Collins J, Salvaris EJ, Fisicaro N, Murray-Segal LJ, Johnson LE, Lepore DA, Walters SN, Stokes R, Chandra AP, O'Connell PJ, d'Apice AJ, Cowan PJ.

Diabetes. 2005 Jul;54(7):2109-16.


Genetic and functional evaluation of the level of inbreeding of the Westran pig: a herd with potential for use in xenotransplantation.

O'Connell PJ, Hawthorne WJ, Simond D, Chapman JR, Chen Y, Patel AT, Walters SN, Burgess J, Weston L, Stokes RA, Moran C, Allen R.

Xenotransplantation. 2005 Jul;12(4):308-15.


Characterization of the swine major histocompatibility complex alleles at eight loci in Westran pigs.

Lee JH, Simond D, Hawthorne WJ, Walters SN, Patel AT, Smith DM, O'Connell PJ, Moran C.

Xenotransplantation. 2005 Jul;12(4):303-7.


Fate of alphaGal +/+ pancreatic islet grafts after transplantation into alphaGal knockout mice.

Chandra AP, Salvaris E, Walters SN, Murray-Segal L, Gock H, Lehnert AM, Wong JK, Cowan PJ, d'Apice AJ, O'Connell PJ.

Xenotransplantation. 2004 Jul;11(4):323-31.


Detailed analysis of allelic variation in the ABCA4 gene in age-related maculopathy.

Schmidt S, Postel EA, Agarwal A, Allen IC Jr, Walters SN, De la Paz MA, Scott WK, Haines JL, Pericak-Vance MA, Gilbert JR.

Invest Ophthalmol Vis Sci. 2003 Jul;44(7):2868-75.


T cell-activated macrophages are capable of both recognition and rejection of pancreatic islet xenografts.

Yi S, Hawthorne WJ, Lehnert AM, Ha H, Wong JK, van Rooijen N, Davey K, Patel AT, Walters SN, Chandra A, O'Connell PJ.

J Immunol. 2003 Mar 1;170(5):2750-8.


CD4+ T cells initiate pancreatic islet xenograft rejection via an interferon-gamma-dependent recruitment of macrophages and natural killer cells.

Yi S, Feng X, Hawthorne WJ, Patel AT, Walters SN, O'Connell PJ.

Transplantation. 2002 Feb 15;73(3):437-46.


Blockade of the CD28 and CD40 pathways result in the acceptance of pig and rat islet xenografts but not rat cardiac grafts in mice.

Lehnert AM, Mottram PL, Han W, Walters SN, Patel AT, Hawthorne WJ, Cowan PJ, d'Apice AJ, O'Connell PJ.

Transpl Immunol. 2001 Oct;9(1):51-6.


Induction of allogeneic islet tolerance in a large-animal model.

Horton PJ, Hawthorne WJ, Walters SN, Patel AT, O'Connell PJ, Chapman JR, Allen RD.

Cell Transplant. 2000 Nov-Dec;9(6):877-87.


A large-animal model to evaluate the clinical potential of fetal pig pancreas fragment transplantation.

Hawthorne WJ, Cachia AR, Walters SN, Patel AT, Clarke JE, O'Connell PJ, Chapman JR, Allen RD.

Cell Transplant. 2000 Nov-Dec;9(6):867-75.


Inducible nitric oxide synthetase is expressed in adult but not fetal pig pancreatic islets.

Feng X, Yi S, Hawthorne WJ, Patel AT, Walters SN, O'Connell PJ.

Xenotransplantation. 2000 Aug;7(3):197-205.


Intracellular location of unoccupied 1,25-dihydroxyvitamin D receptors: a nuclear-cytoplasmic equilibrium.

Walters SN, Reinhardt TA, Dominick MA, Horst RL, Littledike ET.

Arch Biochem Biophys. 1986 Apr;246(1):366-73.


Immobilized enzyme system for the conversion of benzo[a]pyrene to fluorescent metabolites.

Walters SN, D'Silva AP, Fassel VA.

Anal Chem. 1982 Dec;54(14):2571-6. No abstract available.


Effects of altered thyroid states on myelinogenesis.

Walters SN, Morell P.

J Neurochem. 1981 May;36(5):1792-801.


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