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Items: 1 to 50 of 81

1.

Author Correction: Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system.

Selvaraju K, Mofers A, Pellegrini P, Salomonsson J, Ahlner A, Morad V, Hillert EK, Espinosa B, Arnér ESJ, Jensen L, Malmström J, Turkina MV, D'Arcy P, Walters MA, Sunnerhagen M, Linder S.

Sci Rep. 2019 Nov 20;9(1):17501. doi: 10.1038/s41598-019-53667-4.

2.

Management Strategies in the Intensive Care Unit to Improve Psychosocial Outcomes.

Parsons LC, Walters MA.

Crit Care Nurs Clin North Am. 2019 Dec;31(4):537-545. doi: 10.1016/j.cnc.2019.07.009. Epub 2019 Sep 21. Review.

PMID:
31685120
3.

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death.

Bosnakovski D, da Silva MT, Sunny ST, Ener ET, Toso EA, Yuan C, Cui Z, Walters MA, Jadhav A, Kyba M.

Sci Adv. 2019 Sep 11;5(9):eaaw7781. doi: 10.1126/sciadv.aaw7781. eCollection 2019 Sep.

4.

Cytotoxic unsaturated electrophilic compounds commonly target the ubiquitin proteasome system.

Selvaraju K, Mofers A, Pellegrini P, Salomonsson J, Ahlner A, Morad V, Hillert EK, Espinosa B, Arnér ESJ, Jensen L, Malmström J, Turkina MV, D'Arcy P, Walters MA, Sunnerhagen M, Linder S.

Sci Rep. 2019 Jul 8;9(1):9841. doi: 10.1038/s41598-019-46168-x. Erratum in: Sci Rep. 2019 Nov 20;9(1):17501.

5.

Discovery of Benzoylsulfonohydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A.

Leaver DJ, Cleary B, Nguyen N, Priebbenow DL, Lagiakos HR, Sanchez J, Xue L, Huang F, Sun Y, Mujumdar P, Mudududdla R, Varghese S, Teguh S, Charman SA, White KL, Katneni K, Cuellar M, Strasser JM, Dahlin JL, Walters MA, Street IP, Monahan BJ, Jarman KE, Sabroux HJ, Falk H, Chung MC, Hermans SJ, Parker MW, Thomas T, Baell JB.

J Med Chem. 2019 Aug 8;62(15):7146-7159. doi: 10.1021/acs.jmedchem.9b00665. Epub 2019 Jul 17.

PMID:
31256587
6.

Assessment of the Silver Penetration and Distribution in Carious Lesions of Deciduous Teeth Treated with Silver Diamine Fluoride.

Li Y, Liu Y, Psoter WJ, Nguyen OM, Bromage TG, Walters MA, Hu B, Rabieh S, Kumararaja FC.

Caries Res. 2019;53(4):431-440. doi: 10.1159/000496210. Epub 2019 Feb 26.

PMID:
30808824
7.

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.

Xue L, Shi DH, Harjani JR, Huang F, Beveridge JG, Dingjan T, Ban K, Diab S, Duffy S, Lucantoni L, Fletcher S, Chiu FCK, Blundell S, Ellis K, Ralph SA, Wirjanata G, Teguh S, Noviyanti R, Chavchich M, Creek D, Price RN, Marfurt J, Charman SA, Cuellar ME, Strasser JM, Dahlin JL, Walters MA, Edstein MD, Avery VM, Baell JB.

J Med Chem. 2019 Mar 14;62(5):2485-2498. doi: 10.1021/acs.jmedchem.8b01799. Epub 2019 Mar 5.

PMID:
30715882
8.

The Short and Longer Term Impacts of Hate Crimes Experienced Directly, Indirectly, and Through the Media.

Paterson JL, Brown R, Walters MA.

Pers Soc Psychol Bull. 2019 Jul;45(7):994-1010. doi: 10.1177/0146167218802835. Epub 2018 Nov 7.

PMID:
30400746
9.

Risk Management in Early Discovery Medicinal Chemistry.

Singh G, Dahlin JL, Walters MA.

Methods Enzymol. 2018;610:1-25. doi: 10.1016/bs.mie.2018.09.012. Epub 2018 Oct 19.

PMID:
30390795
10.

Feeling for and as a group member: Understanding LGBT victimization via group-based empathy and intergroup emotions.

Paterson JL, Brown R, Walters MA.

Br J Soc Psychol. 2019 Jan;58(1):211-224. doi: 10.1111/bjso.12269. Epub 2018 Jul 24.

PMID:
30040132
11.

ALARM NMR for HTS triage and chemical probe validation.

Dahlin JL, Cuellar M, Singh G, Nelson KM, Strasser J, Rappe T, Xia Y, Veglia G, Walters MA.

Curr Protoc Chem Biol. 2018 Mar;10(1):91-117. doi: 10.1002/cpch.35. Epub 2018 Apr 9.

12.

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model.

Pérez Ortiz JM, Mollema N, Toker N, Adamski CJ, O'Callaghan B, Duvick L, Friedrich J, Walters MA, Strasser J, Hawkinson JE, Zoghbi HY, Henzler C, Orr HT, Lagalwar S.

Neurobiol Dis. 2018 Aug;116:93-105. doi: 10.1016/j.nbd.2018.05.002. Epub 2018 May 11.

13.

Hate Crimes Against Trans People: Assessing Emotions, Behaviors, and Attitudes Toward Criminal Justice Agencies.

Walters MA, Paterson J, Brown R, McDonnell L.

J Interpers Violence. 2017 Jun 1:886260517715026. doi: 10.1177/0886260517715026. [Epub ahead of print]

PMID:
29294810
14.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity.

Menon D, Innes A, Oakley AJ, Dahlstrom JE, Jensen LM, Brüstle A, Tummala P, Rooke M, Casarotto MG, Baell JB, Nguyen N, Xie Y, Cuellar M, Strasser J, Dahlin JL, Walters MA, Burgio G, O'Neill LAJ, Board PG.

Sci Rep. 2017 Dec 19;7(1):17832. doi: 10.1038/s41598-017-17861-6.

15.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors.

Dahlin JL, Nelson KM, Strasser JM, Barsyte-Lovejoy D, Szewczyk MM, Organ S, Cuellar M, Singh G, Shrimp JH, Nguyen N, Meier JL, Arrowsmith CH, Brown PJ, Baell JB, Walters MA.

Nat Commun. 2017 Nov 15;8(1):1527. doi: 10.1038/s41467-017-01657-3.

16.

Management of Chronic Stable Angina.

Walters MA.

Crit Care Nurs Clin North Am. 2017 Dec;29(4):487-493. doi: 10.1016/j.cnc.2017.08.008. Epub 2017 Sep 29. Review.

PMID:
29107310
17.

Curcumin May (Not) Defy Science.

Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA.

ACS Med Chem Lett. 2017 May 11;8(5):467-470. doi: 10.1021/acsmedchemlett.7b00139. eCollection 2017 May 11. No abstract available.

18.

The Essential Medicinal Chemistry of Curcumin.

Nelson KM, Dahlin JL, Bisson J, Graham J, Pauli GF, Walters MA.

J Med Chem. 2017 Mar 9;60(5):1620-1637. doi: 10.1021/acs.jmedchem.6b00975. Epub 2017 Jan 11. Review.

19.

Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen.

Choi SH, Bosnakovski D, Strasser JM, Toso EA, Walters MA, Kyba M.

J Biomol Screen. 2016 Aug;21(7):680-8. doi: 10.1177/1087057116651868. Epub 2016 May 31.

20.

Allosteric Indole Amide Inhibitors of p97: Identification of a Novel Probe of the Ubiquitin Pathway.

Alverez C, Bulfer SL, Chakrasali R, Chimenti MS, Deshaies RJ, Green N, Kelly M, LaPorte MG, Lewis TS, Liang M, Moore WJ, Neitz RJ, Peshkov VA, Walters MA, Zhang F, Arkin MR, Wipf P, Huryn DM.

ACS Med Chem Lett. 2015 Dec 22;7(2):182-7. doi: 10.1021/acsmedchemlett.5b00396. eCollection 2016 Feb 11.

21.

Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A.

Kim J, Li G, Walters MA, Taylor SS, Veglia G.

Structure. 2016 Mar 1;24(3):353-63. doi: 10.1016/j.str.2015.11.016. Epub 2016 Jan 28.

22.

Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast.

Zhang Y, Tian D, Matsuyama H, Hamazaki T, Shiratsuchi T, Terada N, Hook DJ, Walters MA, Georg GI, Hawkinson JE.

J Biomol Screen. 2016 Apr;21(4):381-90. doi: 10.1177/1087057115624637. Epub 2016 Jan 8.

23.

Assay Interference by Chemical Reactivity.

Dahlin JL, Baell J, Walters MA.

In: Sittampalam GS, Grossman A, Brimacombe K, Arkin M, Auld D, Austin CP, Baell J, Bejcek B, Caaveiro JMM, Chung TDY, Coussens NP, Dahlin JL, Devanaryan V, Foley TL, Glicksman M, Hall MD, Haas JV, Hoare SRJ, Inglese J, Iversen PW, Kahl SD, Kales SC, Kirshner S, Lal-Nag M, Li Z, McGee J, McManus O, Riss T, Saradjian P, Trask OJ Jr., Weidner JR, Wildey MJ, Xia M, Xu X, editors. Assay Guidance Manual [Internet]. Bethesda (MD): Eli Lilly & Company and the National Center for Advancing Translational Sciences; 2004-.
2015 Sep 18.

24.

How to Triage PAINS-Full Research.

Dahlin JL, Walters MA.

Assay Drug Dev Technol. 2016 Apr;14(3):168-74. doi: 10.1089/adt.2015.674. Epub 2015 Oct 23.

25.

Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.

Kurbanov EK, Chiu TL, Solberg J, Francis S, Maize KM, Fernandez J, Johnson RL, Hawkinson JE, Walters MA, Finzel BC, Amin EA.

J Med Chem. 2015 Nov 12;58(21):8723-33. doi: 10.1021/acs.jmedchem.5b01446. Epub 2015 Oct 29.

PMID:
26492514
26.

Corrigendum: The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Ross R, Roth B, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Nov;11(11):887. doi: 10.1038/nchembio1115-887c. No abstract available.

PMID:
26485080
27.

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

Dahlin JL, Nissink JWM, Francis S, Strasser JM, John K, Zhang Z, Walters MA.

Bioorg Med Chem Lett. 2015 Nov 1;25(21):4740-4752. doi: 10.1016/j.bmcl.2015.08.020. Epub 2015 Aug 10.

28.

The promise and peril of chemical probes.

Arrowsmith CH, Audia JE, Austin C, Baell J, Bennett J, Blagg J, Bountra C, Brennan PE, Brown PJ, Bunnage ME, Buser-Doepner C, Campbell RM, Carter AJ, Cohen P, Copeland RA, Cravatt B, Dahlin JL, Dhanak D, Edwards AM, Frederiksen M, Frye SV, Gray N, Grimshaw CE, Hepworth D, Howe T, Huber KV, Jin J, Knapp S, Kotz JD, Kruger RG, Lowe D, Mader MM, Marsden B, Mueller-Fahrnow A, Müller S, O'Hagan RC, Overington JP, Owen DR, Rosenberg SH, Roth B, Ross R, Schapira M, Schreiber SL, Shoichet B, Sundström M, Superti-Furga G, Taunton J, Toledo-Sherman L, Walpole C, Walters MA, Willson TM, Workman P, Young RN, Zuercher WJ.

Nat Chem Biol. 2015 Aug;11(8):536-41. doi: 10.1038/nchembio.1867. No abstract available. Erratum in: Nat Chem Biol. 2015 Aug;11(8):541. Roth, Brian [Corrected to Roth, Bryan] and Frederiksen, Mathias [Added]. Nat Chem Biol. 2015 Nov;11(11):887.

29.

Mitigating risk in academic preclinical drug discovery.

Dahlin JL, Inglese J, Walters MA.

Nat Rev Drug Discov. 2015 Apr;14(4):279-94. doi: 10.1038/nrd4578. Review.

30.

PAINS in the assay: chemical mechanisms of assay interference and promiscuous enzymatic inhibition observed during a sulfhydryl-scavenging HTS.

Dahlin JL, Nissink JW, Strasser JM, Francis S, Higgins L, Zhou H, Zhang Z, Walters MA.

J Med Chem. 2015 Mar 12;58(5):2091-113. doi: 10.1021/jm5019093. Epub 2015 Feb 21.

31.

Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.

Maize KM, Kurbanov EK, De La Mora-Rey T, Geders TW, Hwang DJ, Walters MA, Johnson RL, Amin EA, Finzel BC.

Acta Crystallogr D Biol Crystallogr. 2014 Nov;70(Pt 11):2813-22. doi: 10.1107/S1399004714018161. Epub 2014 Oct 16.

32.

Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases.

Dahlin JL, Chen X, Walters MA, Zhang Z.

Crit Rev Biochem Mol Biol. 2015 Jan-Feb;50(1):31-53. doi: 10.3109/10409238.2014.978975. Epub 2014 Nov 3. Review.

33.

Lower incidence of post-dural puncture headache with spinal catheterization after accidental dural puncture in obstetric patients.

Verstraete S, Walters MA, Devroe S, Roofthooft E, Van de Velde M.

Acta Anaesthesiol Scand. 2014 Nov;58(10):1233-9. doi: 10.1111/aas.12394.

PMID:
25307708
34.

Chemistry: Chemical con artists foil drug discovery.

Baell J, Walters MA.

Nature. 2014 Sep 25;513(7519):481-3. doi: 10.1038/513481a. No abstract available.

PMID:
25254460
35.

The essential roles of chemistry in high-throughput screening triage.

Dahlin JL, Walters MA.

Future Med Chem. 2014 Jul;6(11):1265-90. doi: 10.4155/fmc.14.60. Review.

36.

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Chou TF, Bulfer SL, Weihl CC, Li K, Lis LG, Walters MA, Schoenen FJ, Lin HJ, Deshaies RJ, Arkin MR.

J Mol Biol. 2014 Jul 29;426(15):2886-99. doi: 10.1016/j.jmb.2014.05.022. Epub 2014 May 27.

37.

Ultra-High-Throughput Screening of Natural Product Extracts to Identify Proapoptotic Inhibitors of Bcl-2 Family Proteins.

Hassig CA, Zeng FY, Kung P, Kiankarimi M, Kim S, Diaz PW, Zhai D, Welsh K, Morshedian S, Su Y, O'Keefe B, Newman DJ, Rusman Y, Kaur H, Salomon CE, Brown SG, Baire B, Michel AR, Hoye TR, Francis S, Georg GI, Walters MA, Divlianska DB, Roth GP, Wright AE, Reed JC.

J Biomol Screen. 2014 Sep;19(8):1201-11. doi: 10.1177/1087057114536227. Epub 2014 May 27.

38.

Pneumocystis jirovecii Rtt109, a novel drug target for Pneumocystis pneumonia in immunosuppressed humans.

Dahlin JL, Kottom T, Han J, Zhou H, Walters MA, Zhang Z, Limper AH.

Antimicrob Agents Chemother. 2014 Jul;58(7):3650-9. doi: 10.1128/AAC.02637-14. Epub 2014 Apr 14.

39.

Identification of tetrapeptides from a mixture based positional scanning library that can restore nM full agonist function of the L106P, I69T, I102S, A219V, C271Y, and C271R human melanocortin-4 polymorphic receptors (hMC4Rs).

Haslach EM, Huang H, Dirain M, Debevec G, Geer P, Santos RG, Giulianotti MA, Pinilla C, Appel JR, Doering SR, Walters MA, Houghten RA, Haskell-Luevano C.

J Med Chem. 2014 Jun 12;57(11):4615-28. doi: 10.1021/jm500064t. Epub 2014 May 14.

40.

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity.

Bosnakovski D, Choi SH, Strasser JM, Toso EA, Walters MA, Kyba M.

Skelet Muscle. 2014 Feb 1;4(1):4. doi: 10.1186/2044-5040-4-4.

41.

From HTS to Phase I: the Institute for Therapeutics Discovery and Development at the University of Minnesota.

Dosa PI, Georg GI, Gurvich VJ, Hawkinson JE, Walters MA, Wong HL.

Comb Chem High Throughput Screen. 2014 Mar;17(3):231-40.

PMID:
24409956
42.

A cell-free fluorometric high-throughput screen for inhibitors of Rtt109-catalyzed histone acetylation.

Dahlin JL, Sinville R, Solberg J, Zhou H, Han J, Francis S, Strasser JM, John K, Hook DJ, Walters MA, Zhang Z.

PLoS One. 2013 Nov 18;8(11):e78877. doi: 10.1371/journal.pone.0078877. eCollection 2013.

43.

Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.

Dosa PI, Ward T, Walters MA, Kim SW.

ACS Med Chem Lett. 2013 Feb 14;4(2):254-258.

44.

Allowable levels of take for the trade in Nearctic songbirds.

Johnson FA, Walters MA, Boomer GS.

Ecol Appl. 2012 Jun;22(4):1114-30.

PMID:
22827122
45.

Acute intrathecal haematoma following neuraxial anaesthesia: diagnostic delay after apparently normal radiological imaging.

Walters MA, Van de Velde M, Wilms G.

Int J Obstet Anesth. 2012 Apr;21(2):181-5. doi: 10.1016/j.ijoa.2011.12.006. Epub 2012 Feb 14.

PMID:
22341785
46.

Assessing synthetic accessibility of chemical compounds using machine learning methods.

Podolyan Y, Walters MA, Karypis G.

J Chem Inf Model. 2010 Jun 28;50(6):979-91. doi: 10.1021/ci900301v.

PMID:
20536191
47.

Identification of novel non-hydroxamate anthrax toxin lethal factor inhibitors by topomeric searching, docking and scoring, and in vitro screening.

Chiu TL, Solberg J, Patil S, Geders TW, Zhang X, Rangarajan S, Francis R, Finzel BC, Walters MA, Hook DJ, Amin EA.

J Chem Inf Model. 2009 Dec;49(12):2726-34. doi: 10.1021/ci900186w.

48.

Lanthanide complexes on Ag nanoparticles: designing contrast agents for magnetic resonance imaging.

Siddiqui TS, Jani A, Williams F, Muller RN, Vander Elst L, Laurent S, Yao F, Wadghiri YZ, Walters MA.

J Colloid Interface Sci. 2009 Sep 1;337(1):88-96. doi: 10.1016/j.jcis.2009.04.096. Epub 2009 May 18.

PMID:
19527906
49.

Synthesis of A83586C analogs with potent anticancer and beta-catenin/ TCF4/osteopontin inhibitory effects and insights into how A83586C modulates E2Fs and pRb.

Hale KJ, Manaviazar S, Lazarides L, George J, Walters MA, Cai J, Delisser VM, Bhatia GS, Peak SA, Dalby SM, Lefranc A, Chen YN, Wood AW, Crowe P, Erwin P, El-Tanani M.

Org Lett. 2009 Feb 5;11(3):737-40. doi: 10.1021/ol802818f.

PMID:
19175352
50.

Total synthesis of (+)-azinothricin and (+)-kettapeptin.

Hale KJ, Manaviazar S, George JH, Walters MA, Dalby SM.

Org Lett. 2009 Feb 5;11(3):733-6. doi: 10.1021/ol802817t.

PMID:
19175351

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