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Refining AML outcome prediction.

Hourigan CS, Gale RP, Walter RB.

Leukemia. 2018 Dec 14. doi: 10.1038/s41375-018-0317-4. [Epub ahead of print] No abstract available.


Genetic determinants of risk in pulmonary arterial hypertension: international genome-wide association studies and meta-analysis.

Rhodes CJ, Batai K, Bleda M, Haimel M, Southgate L, Germain M, Pauciulo MW, Hadinnapola C, Aman J, Girerd B, Arora A, Knight J, Hanscombe KB, Karnes JH, Kaakinen M, Gall H, Ulrich A, Harbaum L, Cebola I, Ferrer J, Lutz K, Swietlik EM, Ahmad F, Amouyel P, Archer SL, Argula R, Austin ED, Badesch D, Bakshi S, Barnett C, Benza R, Bhatt N, Bogaard HJ, Burger CD, Chakinala M, Church C, Coghlan JG, Condliffe R, Corris PA, Danesino C, Debette S, Elliott CG, Elwing J, Eyries M, Fortin T, Franke A, Frantz RP, Frost A, Garcia JGN, Ghio S, Ghofrani HA, Gibbs JSR, Harley J, He H, Hill NS, Hirsch R, Houweling AC, Howard LS, Ivy D, Kiely DG, Klinger J, Kovacs G, Lahm T, Laudes M, Machado RD, Ross RVM, Marsolo K, Martin LJ, Moledina S, Montani D, Nathan SD, Newnham M, Olschewski A, Olschewski H, Oudiz RJ, Ouwehand WH, Peacock AJ, Pepke-Zaba J, Rehman Z, Robbins I, Roden DM, Rosenzweig EB, Saydain G, Scelsi L, Schilz R, Seeger W, Shaffer CM, Simms RW, Simon M, Sitbon O, Suntharalingam J, Tang H, Tchourbanov AY, Thenappan T, Torres F, Toshner MR, Treacy CM, Noordegraaf AV, Waisfisz Q, Walsworth AK, Walter RE, Wharton J, White RJ, Wilt J, Wort SJ, Yung D, Lawrie A, Humbert M, Soubrier F, Trégouët DA, Prokopenko I, Kittles R, Gräf S, Nichols WC, Trembath RC, Desai AA, Morrell NW, Wilkins MR; UK NIHR BioResource Rare Diseases Consortium; UK PAH Cohort Study Consortium; US PAH Biobank Consortium.

Lancet Respir Med. 2018 Dec 5. pii: S2213-2600(18)30409-0. doi: 10.1016/S2213-2600(18)30409-0. [Epub ahead of print]


Long-term experimental hybridisation results in the evolution of a new sex chromosome in swordtail fish.

Franchini P, Jones JC, Xiong P, Kneitz S, Gompert Z, Warren WC, Walter RB, Meyer A, Schartl M.

Nat Commun. 2018 Dec 3;9(1):5136. doi: 10.1038/s41467-018-07648-2.


Split-Night Polysomnography Overestimates Apnea-Hypopnea Index in High-Risk Professions.

Rouse JK, Shirley SR, Holley AB, Mysliwiec V, Walter RJ.

Mil Med. 2018 Nov 21. doi: 10.1093/milmed/usy317. [Epub ahead of print]


Exendin-4 overcomes cytokine-induced decreases in gap junction coupling via protein kinase A and Epac2 in mouse and human islets.

Farnsworth NL, Walter R, Piscopio RA, Schleicher WE, Benninger RKP.

J Physiol. 2018 Nov 9. doi: 10.1113/JP276106. [Epub ahead of print]


Phase 1/2 trial of cladribine, high-dose cytarabine, mitoxantrone, and G-CSF with dose-escalated mitoxantrone for relapsed/refractory acute myeloid leukemia or other high-grade myeloid neoplasms.

Halpern AB, Othus M, Huebner EM, Scott BL, Hendrie PC, Percival MM, Becker PS, Smith HA, Oehler VG, Orozco JJ, Cassaday RD, Gardner KM, Chen TL, Buckley SA, Orlowski KF, Anwar A, Estey EH, Walter RB.

Haematologica. 2018 Nov 8. pii: haematol.2018.204792. doi: 10.3324/haematol.2018.204792. [Epub ahead of print]


Prognostic and therapeutic role of CLEC12A in acute myeloid leukemia.

Morsink LM, Walter RB, Ossenkoppele GJ.

Blood Rev. 2018 Nov 1. pii: S0268-960X(18)30072-9. doi: 10.1016/j.blre.2018.10.003. [Epub ahead of print] Review.


Workshop report: Cryopreservation of aquatic biomedical models.

Hagedorn M, Varga Z, Walter RB, Tiersch TR.

Cryobiology. 2018 Oct 31. pii: S0011-2240(18)30269-4. doi: 10.1016/j.cryobiol.2018.10.264. [Epub ahead of print]


C3HeB/FeJ Mice mimic many aspects of gene expression and pathobiological features of human hepatocellular carcinoma.

Zavadil JA, Herzig MCS, Hildreth K, Foroushani A, Boswell W, Walter R, Reddick R, White H, Zare H, Walter CA.

Mol Carcinog. 2018 Oct 26. doi: 10.1002/mc.22929. [Epub ahead of print]


Second cycle remission achievement with 7+3 and survival in adults with newly diagnosed acute myeloid leukemia: analysis of recent SWOG trials.

Othus M, Estey EH, Garcia-Manero G, Wood BL, Stirewalt DL, Godwin JE, Weick JK, Anderson JE, Appelbaum FR, Erba HP, Walter RB.

Leukemia. 2018 Oct 12. doi: 10.1038/s41375-018-0274-y. [Epub ahead of print] No abstract available.


Engineering resistance to CD33-targeted immunotherapy in normal hematopoiesis by CRISPR/Cas9-deletion of CD33 exon 2.

Humbert O, Laszlo GS, Sichel S, Ironside C, Haworth KG, Bates OM, Beddoe ME, Carrillo RR, Kiem HP, Walter RB.

Leukemia. 2018 Oct 5. doi: 10.1038/s41375-018-0277-8. [Epub ahead of print] No abstract available.


A comparison of patients with acute myeloid leukemia and high-risk myelodysplastic syndrome treated on versus off study.

Buckley SA, Percival ME, Othus M, Halpern AB, Huebner EM, Becker PS, Shaw C, Shadman M, Walter RB, Estey EH.

Leuk Lymphoma. 2018 Oct 2:1-7. doi: 10.1080/10428194.2018.1516036. [Epub ahead of print]


Salvage extracorporeal membrane oxygenation in induction-associated acute respiratory distress syndrome in acute leukemia patients: A case series.

Huprikar NA, Peterson MR, DellaVolpe JD, Sams VG, Lantry JH, Walter RJ, Osswald MB, Chung KK, Mason PE.

Int J Artif Organs. 2018 Sep 17:391398818799160. doi: 10.1177/0391398818799160. [Epub ahead of print]


COVA4231, a potent CD3/CD33 bispecific FynomAb with IgG-like pharmacokinetics for the treatment of acute myeloid leukemia.

Klupsch K, Baeriswyl V, Scholz R, Dannenberg J, Santimaria R, Senn D, Kage E, Zumsteg A, Attinger-Toller I, von der Bey U, König-Friedrich S, Dupuy F, Lembke W, Albani C, Wendelspiess S, Dinkel L, Saro D, Hepler RW, Laszlo GS, Gudgeon CJ, Bertschinger J, Brack S, Walter RB.

Leukemia. 2018 Sep 11. doi: 10.1038/s41375-018-0249-z. [Epub ahead of print] No abstract available.


Percutaneous screw fixation for painful non-union of lateral malleolus ankle fractures.

Batten TJ, Scott-Davies C, Butler M, Parsons SW, Walter RP.

Injury. 2018 Oct;49(10):1936-1941. doi: 10.1016/j.injury.2018.08.010. Epub 2018 Aug 16.


Analysis of the putative tumor suppressor gene cdkn2ab in pigment cells and melanoma of Xiphophorus and medaka.

Regneri J, Klotz B, Wilde B, Kottler VA, Hausmann M, Kneitz S, Regensburger M, Maurus K, Götz R, Lu Y, Walter RB, Herpin A, Schartl M.

Pigment Cell Melanoma Res. 2018 Aug 16. doi: 10.1111/pcmr.12729. [Epub ahead of print]


Relationship between CD33 expression, splicing polymorphism, and in vitro cytotoxicity of gemtuzumab ozogamicin and the CD33/CD3 BiTErAMG 330.

Laszlo GS, Beddoe ME, Godwin CD, Bates OM, Gudgeon CJ, Harrington KH, Walter RB.

Haematologica. 2018 Aug 16. pii: haematol.2018.202069. doi: 10.3324/haematol.2018.202069. [Epub ahead of print] No abstract available.


Inhibition of MDM2 via Nutlin-3A: A Potential Therapeutic Approach for Pleural Mesotheliomas with MDM2-Induced Inactivation of Wild-Type P53.

Walter RFH, Werner R, Wessolly M, Mairinger E, Borchert S, Schmeller J, Kollmeier J, Mairinger T, Hager T, Bankfalvi A, Christoph DC, Eberhardt WEE, Plönes T, Aigner C, Schmid KW, Wohlschlaeger J, Mairinger FD.

J Oncol. 2018 Jul 17;2018:1986982. doi: 10.1155/2018/1986982. eCollection 2018.


Comparative proteomics reveals a diagnostic signature for pulmonary head-and-neck cancer metastasis.

Bohnenberger H, Kaderali L, Ströbel P, Yepes D, Plessmann U, Dharia NV, Yao S, Heydt C, Merkelbach-Bruse S, Emmert A, Hoffmann J, Bodemeyer J, Reuter-Jessen K, Lois AM, Dröge LH, Baumeister P, Walz C, Biggemann L, Walter R, Häupl B, Comoglio F, Pan KT, Scheich S, Lenz C, Küffer S, Bremmer F, Kitz J, Sitte M, Beißbarth T, Hinterthaner M, Sebastian M, Lotz J, Schildhaus HU, Wolff H, Danner BC, Brandts C, Büttner R, Canis M, Stegmaier K, Serve H, Urlaub H, Oellerich T.

EMBO Mol Med. 2018 Sep;10(9). pii: e8428. doi: 10.15252/emmm.201708428.


A phase 1 trial of vadastuximab talirine combined with hypomethylating agents in patients with CD33-positive AML.

Fathi AT, Erba HP, Lancet JE, Stein EM, Ravandi F, Faderl S, Walter RB, Advani AS, DeAngelo DJ, Kovacsovics TJ, Jillella A, Bixby D, Levy MY, O'Meara MM, Ho PA, Voellinger J, Stein AS.

Blood. 2018 Sep 13;132(11):1125-1133. doi: 10.1182/blood-2018-03-841171. Epub 2018 Jul 25.


Impact of region of diagnosis, ethnicity, age, and gender on survival in acute myeloid leukemia (AML).

Acharya UH, Halpern AB, Wu QV, Voutsinas JM, Walter RB, Yun S, Kanaan M, Estey EH.

J Drug Assess. 2018 Jul 10;7(1):51-53. doi: 10.1080/21556660.2018.1492925. eCollection 2018.


Gallium Hydrides and O/N-Donors as Tunable Systems in C-F Bond Activation.

Jaeger AD, Walter R, Ehm C, Lentz D.

Chem Asian J. 2018 Oct 4;13(19):2908-2915. doi: 10.1002/asia.201801030. Epub 2018 Aug 31.


Subsistence practices, past biodiversity, and anthropogenic impacts revealed by New Zealand-wide ancient DNA survey.

Seersholm FV, Cole TL, Grealy A, Rawlence NJ, Greig K, Knapp M, Stat M, Hansen AJ, Easton LJ, Shepherd L, Tennyson AJD, Scofield RP, Walter R, Bunce M.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7771-7776. doi: 10.1073/pnas.1803573115. Epub 2018 Jul 9.


Complex history of dog (Canis familiaris) origins and translocations in the Pacific revealed by ancient mitogenomes.

Greig K, Gosling A, Collins CJ, Boocock J, McDonald K, Addison DJ, Allen MS, David B, Gibbs M, Higham CFW, Liu F, McNiven IJ, O'Connor S, Tsang CH, Walter R, Matisoo-Smith E.

Sci Rep. 2018 Jun 14;8(1):9130. doi: 10.1038/s41598-018-27363-8.


Evaluating measurable residual disease in acute myeloid leukemia.

Ravandi F, Walter RB, Freeman SD.

Blood Adv. 2018 Jun 12;2(11):1356-1366. doi: 10.1182/bloodadvances.2018016378. Review.


Immunohistochemically detectable metallothionein expression in malignant pleural mesotheliomas is strongly associated with early failure to platin-based chemotherapy.

Mairinger FD, Schmeller J, Borchert S, Wessolly M, Mairinger E, Kollmeier J, Hager T, Mairinger T, Christoph DC, Walter RFH, Eberhardt WEE, Plönes T, Wohlschlaeger J, Jasani B, Schmid KW, Bankfalvi A.

Oncotarget. 2018 Apr 27;9(32):22254-22268. doi: 10.18632/oncotarget.24962. eCollection 2018 Apr 27.


Methylation of L1RE1, RARB, and RASSF1 function as possible biomarkers for the differential diagnosis of lung cancer.

Walter RFH, Rozynek P, Casjens S, Werner R, Mairinger FD, Speel EJM, Zur Hausen A, Meier S, Wohlschlaeger J, Theegarten D, Behrens T, Schmid KW, Brüning T, Johnen G.

PLoS One. 2018 May 31;13(5):e0195716. doi: 10.1371/journal.pone.0195716. eCollection 2018.


Next-generation sequencing for measuring minimal residual disease in AML.

Walter RB, Appelbaum FR.

Nat Rev Clin Oncol. 2018 Aug;15(8):473-474. doi: 10.1038/s41571-018-0040-0. No abstract available.


Waveband specific transcriptional control of select genetic pathways in vertebrate skin (Xiphophorus maculatus).

Walter RB, Boswell M, Chang J, Boswell WT, Lu Y, Navarro K, Walter SM, Walter DJ, Salinas R, Savage M.

BMC Genomics. 2018 May 10;19(1):355. doi: 10.1186/s12864-018-4735-5.


Does a Low Arousal Threshold Equal Low PAP Adherence?

Holley AB, Walter RJ.

J Clin Sleep Med. 2018 May 15;14(5):713-714. doi: 10.5664/jcsm.7088. No abstract available.


Phase 1/2 trial of GCLAM with dose-escalated mitoxantrone for newly diagnosed AML or other high-grade myeloid neoplasms.

Halpern AB, Othus M, Huebner EM, Scott BL, Becker PS, Percival MM, Hendrie PC, Gardner KM, Chen TL, Buckley SA, Orlowski KF, Anwar A, Appelbaum FR, Erba HP, Estey EH, Walter RB.

Leukemia. 2018 Apr 17. doi: 10.1038/s41375-018-0135-8. [Epub ahead of print]


Advancements in the management of medically less-fit and older adults with newly diagnosed acute myeloid leukemia.

Michaelis LC, Klepin HD, Walter RB.

Expert Opin Pharmacother. 2018 Jun;19(8):865-882. doi: 10.1080/14656566.2018.1465562. Epub 2018 Apr 26. Review.


Deep NPM1 Sequencing Following Allogeneic Hematopoietic Cell Transplantation Improves Risk Assessment in Adults with NPM1-Mutated AML.

Zhou Y, Othus M, Walter RB, Estey EH, Wu D, Wood BL.

Biol Blood Marrow Transplant. 2018 Aug;24(8):1615-1620. doi: 10.1016/j.bbmt.2018.04.017. Epub 2018 Apr 21.


Eighteen-month Clinical Study of Universal Adhesives in Noncarious Cervical Lesions.

Ruschel VC, Shibata S, Stolf SC, Chung Y, Baratieri LN, Heymann HO, Walter R.

Oper Dent. 2018 May/Jun;43(3):241-249. doi: 10.2341/16-320-C.


Parallel evolutionary forces influence the evolution of male and female songs in a tropical songbird.

Graham BA, Heath DD, Walter RP, Mark MM, Mennill DJ.

J Evol Biol. 2018 Jul;31(7):979-994. doi: 10.1111/jeb.13279. Epub 2018 May 7.


Minimal Residual Disease Testing After Induction Chemotherapy for Acute Myeloid Leukemia: Moving Beyond Prognostication?

Walter RB.

J Clin Oncol. 2018 May 20;36(15):1463-1465. doi: 10.1200/JCO.2018.78.3266. Epub 2018 Apr 6. No abstract available.


Ambulatory Surgery Has Minimal Impact on Sleep Parameters: A Prospective Observational Trial.

Hudson AJ, Walter RJ, Flynn J, Szpisjak DF, Olsen C, Rodgers M, Capaldi VF 2nd, McDuffie B, Lettieri CJ.

J Clin Sleep Med. 2018 Apr 15;14(4):593-602. doi: 10.5664/jcsm.7052.


Simultaneous multiple interaction T-cell engaging (SMITE) bispecific antibodies overcome bispecific T-cell engager (BiTE) resistance via CD28 co-stimulation.

Correnti CE, Laszlo GS, de van der Schueren WJ, Godwin CD, Bandaranayake A, Busch MA, Gudgeon CJ, Bates OM, Olson JM, Mehlin C, Walter RB.

Leukemia. 2018 May;32(5):1239-1243. doi: 10.1038/s41375-018-0014-3. Epub 2018 Jan 31. No abstract available.


Investigational CD33-targeted therapeutics for acute myeloid leukemia.

Walter RB.

Expert Opin Investig Drugs. 2018 Apr;27(4):339-348. doi: 10.1080/13543784.2018.1452911. Epub 2018 Mar 15. Review.


Effect of Phosphorylated Chitosan on Dentin Erosion: An in vitro Study.

Beltrame APCA, Suchyta D, Abd Alraheam I, Mohammed A, Schoenfisch M, Walter R, Almeida ICS, Souza LC, Miguez PA.

Caries Res. 2018;52(5):378-386. doi: 10.1159/000486521. Epub 2018 Mar 6.


Clonal polymorphism and high heterozygosity in the celibate genome of the Amazon molly.

Warren WC, García-Pérez R, Xu S, Lampert KP, Chalopin D, Stöck M, Loewe L, Lu Y, Kuderna L, Minx P, Montague MJ, Tomlinson C, Hillier LW, Murphy DN, Wang J, Wang Z, Garcia CM, Thomas GCW, Volff JN, Farias F, Aken B, Walter RB, Pruitt KD, Marques-Bonet T, Hahn MW, Kneitz S, Lynch M, Schartl M.

Nat Ecol Evol. 2018 Apr;2(4):669-679. doi: 10.1038/s41559-018-0473-y. Epub 2018 Feb 12.


Arthroscopic subtalar arthrodesis through the sinus tarsi portal approach: A series of 77 cases.

Walter RP, Walker RW, Butler M, Parsons S.

Foot Ankle Surg. 2018 Oct;24(5):417-422. doi: 10.1016/j.fas.2017.04.006. Epub 2017 Apr 23.


Minimal/measurable residual disease in AML: a consensus document from the European LeukemiaNet MRD Working Party.

Schuurhuis GJ, Heuser M, Freeman S, Béné MC, Buccisano F, Cloos J, Grimwade D, Haferlach T, Hills RK, Hourigan CS, Jorgensen JL, Kern W, Lacombe F, Maurillo L, Preudhomme C, van der Reijden BA, Thiede C, Venditti A, Vyas P, Wood BL, Walter RB, Döhner K, Roboz GJ, Ossenkoppele GJ.

Blood. 2018 Mar 22;131(12):1275-1291. doi: 10.1182/blood-2017-09-801498. Epub 2018 Jan 12. Review.


Comparison of Xiphophorus and human melanoma transcriptomes reveals conserved pathway interactions.

Lu Y, Boswell M, Boswell W, Kneitz S, Hausmann M, Klotz B, Regneri J, Savage M, Amores A, Postlethwait J, Warren W, Schartl M, Walter R.

Pigment Cell Melanoma Res. 2018 Jul;31(4):496-508. doi: 10.1111/pcmr.12686. Epub 2018 Jan 29.


A three year study of metal levels in skin biopsies of whales in the Gulf of Mexico after the Deepwater Horizon oil crisis.

Wise JP Jr, Wise JTF, Wise CF, Wise SS, Gianios C Jr, Xie H, Walter R, Boswell M, Zhu C, Zheng T, Perkins C, Wise JP Sr.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Feb;205:15-25. doi: 10.1016/j.cbpc.2017.12.003. Epub 2017 Dec 20.


Unsatisfactory efficacy in randomized study of reduced-dose CPX-351 for medically less fit adults with newly diagnosed acute myeloid leukemia or other high-grade myeloid neoplasm.

Walter RB, Othus M, Orlowski KF, McDaniel EN, Scott BL, Becker PS, Percival MM, Hendrie PC, Medeiros BC, Chiarella MT, Louie AC, Estey EH.

Haematologica. 2018 Mar;103(3):e106-e109. doi: 10.3324/haematol.2017.182642. Epub 2017 Dec 14. No abstract available.


Further Studies on How the Nature of Zeolite Cavities That Are Bounded by Small Pores Influences the Conversion of Methanol to Light Olefins.

Kang JH, Walter R, Xie D, Davis T, Chen CY, Davis ME, Zones SI.

Chemphyschem. 2018 Feb 19;19(4):412-419. doi: 10.1002/cphc.201701197. Epub 2018 Jan 10.


Characterization of basal gene expression trends over a diurnal cycle in Xiphophorus maculatus skin, brain and liver.

Lu Y, Reyes J, Walter S, Gonzalez T, Medrano G, Boswell M, Boswell W, Savage M, Walter R.

Comp Biochem Physiol C Toxicol Pharmacol. 2018 Jun;208:2-11. doi: 10.1016/j.cbpc.2017.11.013. Epub 2017 Dec 5.


A phase 1 trial of vadastuximab talirine as monotherapy in patients with CD33-positive acute myeloid leukemia.

Stein EM, Walter RB, Erba HP, Fathi AT, Advani AS, Lancet JE, Ravandi F, Kovacsovics T, DeAngelo DJ, Bixby D, Faderl S, Jillella AP, Ho PA, O'Meara MM, Zhao B, Biddle-Snead C, Stein AS.

Blood. 2018 Jan 25;131(4):387-396. doi: 10.1182/blood-2017-06-789800. Epub 2017 Dec 1.


Intergroup LEAP trial (S1612): A randomized phase 2/3 platform trial to test novel therapeutics in medically less fit older adults with acute myeloid leukemia.

Walter RB, Michaelis LC, Othus M, Uy GL, Radich JP, Little RF, Hita S, Saini L, Foran JM, Gerds AT, Klepin HD, Hay AE, Assouline S, Lancet JE, Couban S, Litzow MR, Stone RM, Erba HP.

Am J Hematol. 2018 Feb;93(2):E49-E52. doi: 10.1002/ajh.24980. Epub 2017 Dec 4. No abstract available.


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