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A Mechanism to Minimize Errors during Non-homologous End Joining.

Stinson BM, Moreno AT, Walter JC, Loparo JJ.

Mol Cell. 2019 Dec 12. pii: S1097-2765(19)30866-4. doi: 10.1016/j.molcel.2019.11.018. [Epub ahead of print]


Mitotic CDK Promotes Replisome Disassembly, Fork Breakage, and Complex DNA Rearrangements.

Deng L, Wu RA, Sonneville R, Kochenova OV, Labib K, Pellman D, Walter JC.

Mol Cell. 2019 Mar 7;73(5):915-929.e6. doi: 10.1016/j.molcel.2018.12.021.


TRAIP is a master regulator of DNA interstrand crosslink repair.

Wu RA, Semlow DR, Kamimae-Lanning AN, Kochenova OV, Chistol G, Hodskinson MR, Amunugama R, Sparks JL, Wang M, Deng L, Mimoso CA, Low E, Patel KJ, Walter JC.

Nature. 2019 Mar;567(7747):267-272. doi: 10.1038/s41586-019-1002-0. Epub 2019 Mar 6.


The CMG Helicase Bypasses DNA-Protein Cross-Links to Facilitate Their Repair.

Sparks JL, Chistol G, Gao AO, Räschle M, Larsen NB, Mann M, Duxin JP, Walter JC.

Cell. 2019 Jan 10;176(1-2):167-181.e21. doi: 10.1016/j.cell.2018.10.053. Epub 2018 Dec 27.


Replication-Coupled DNA-Protein Crosslink Repair by SPRTN and the Proteasome in Xenopus Egg Extracts.

Larsen NB, Gao AO, Sparks JL, Gallina I, Wu RA, Mann M, Räschle M, Walter JC, Duxin JP.

Mol Cell. 2019 Feb 7;73(3):574-588.e7. doi: 10.1016/j.molcel.2018.11.024. Epub 2018 Dec 27.


A conserved mechanism drives partition complex assembly on bacterial chromosomes and plasmids.

Debaugny RE, Sanchez A, Rech J, Labourdette D, Dorignac J, Geniet F, Palmeri J, Parmeggiani A, Boudsocq F, Anton Leberre V, Walter JC, Bouet JY.

Mol Syst Biol. 2018 Nov 16;14(11):e8516. doi: 10.15252/msb.20188516.


A single XLF dimer bridges DNA ends during nonhomologous end joining.

Graham TGW, Carney SM, Walter JC, Loparo JJ.

Nat Struct Mol Biol. 2018 Sep;25(9):877-884. doi: 10.1038/s41594-018-0120-y. Epub 2018 Sep 3.


Allogenic Fc Domain-Facilitated Uptake of IgG in Nasal Lamina Propria: Friend or Foe for Intranasal CNS Delivery?

Ladel S, Flamm J, Zadeh AS, Filzwieser D, Walter JC, Schlossbauer P, Kinscherf R, Lischka K, Luksch H, Schindowski K.

Pharmaceutics. 2018 Jul 26;10(3). pii: E107. doi: 10.3390/pharmaceutics10030107.


Replication Fork Reversal during DNA Interstrand Crosslink Repair Requires CMG Unloading.

Amunugama R, Willcox S, Wu RA, Abdullah UB, El-Sagheer AH, Brown T, McHugh PJ, Griffith JD, Walter JC.

Cell Rep. 2018 Jun 19;23(12):3419-3428. doi: 10.1016/j.celrep.2018.05.061.


Extracts for Analysis of DNA Replication in a Nucleus-Free System.

Sparks J, Walter JC.

Cold Spring Harb Protoc. 2019 Mar 1;2019(3). doi: 10.1101/pdb.prot097154.


Surfing on Protein Waves: Proteophoresis as a Mechanism for Bacterial Genome Partitioning.

Walter JC, Dorignac J, Lorman V, Rech J, Bouet JY, Nollmann M, Palmeri J, Parmeggiani A, Geniet F.

Phys Rev Lett. 2017 Jul 14;119(2):028101. doi: 10.1103/PhysRevLett.119.028101. Epub 2017 Jul 13.


Ensemble and Single-Molecule Analysis of Non-Homologous End Joining in Frog Egg Extracts.

Graham TGW, Walter JC, Loparo JJ.

Methods Enzymol. 2017;591:233-270. doi: 10.1016/bs.mie.2017.03.020. Epub 2017 May 15.


Mechanisms of DNA replication termination.

Dewar JM, Walter JC.

Nat Rev Mol Cell Biol. 2017 Aug;18(8):507-516. doi: 10.1038/nrm.2017.42. Epub 2017 May 24. Review.


Non-Markovian dynamics of reaction coordinate in polymer folding.

Sakaue T, Walter JC, Carlon E, Vanderzande C.

Soft Matter. 2017 May 3;13(17):3174-3181. doi: 10.1039/c7sm00395a.


CRL2Lrr1 promotes unloading of the vertebrate replisome from chromatin during replication termination.

Dewar JM, Low E, Mann M, Räschle M, Walter JC.

Genes Dev. 2017 Feb 1;31(3):275-290. doi: 10.1101/gad.291799.116. Epub 2017 Feb 24.


Replication-Dependent Unhooking of DNA Interstrand Cross-Links by the NEIL3 Glycosylase.

Semlow DR, Zhang J, Budzowska M, Drohat AC, Walter JC.

Cell. 2016 Oct 6;167(2):498-511.e14. doi: 10.1016/j.cell.2016.09.008. Epub 2016 Sep 29.


Assays to Study Mitotic Centrosome and Spindle Pole Assembly and Regulation.

Joukov V, Walter JC, De Nicolo A.

Methods Mol Biol. 2016;1413:207-35. doi: 10.1007/978-1-4939-3542-0_14.


Stochastic Self-Assembly of ParB Proteins Builds the Bacterial DNA Segregation Apparatus.

Sanchez A, Cattoni DI, Walter JC, Rech J, Parmeggiani A, Nollmann M, Bouet JY.

Cell Syst. 2015 Aug 26;1(2):163-73. doi: 10.1016/j.cels.2015.07.013. Epub 2015 Aug 26.


Two-Stage Synapsis of DNA Ends during Non-homologous End Joining.

Graham TG, Walter JC, Loparo JJ.

Mol Cell. 2016 Mar 17;61(6):850-8. doi: 10.1016/j.molcel.2016.02.010.


Parathyroid Imaging with Simultaneous Acquisition of 99mTc-Sestamibi and 123I: The Relative Merits of Pinhole Collimation and SPECT/CT.

Bhatt PR, Klingensmith WC 3rd, Bagrosky BM, Walter JC, McFann KK, McIntyre RC Jr, Raeburn CD, Koo PJ.

J Nucl Med Technol. 2015 Dec;43(4):275-81. doi: 10.2967/jnmt.115.164939. Epub 2015 Nov 19.


What is the DNA repair defect underlying Fanconi anemia?

Duxin JP, Walter JC.

Curr Opin Cell Biol. 2015 Dec;37:49-60. doi: 10.1016/ Epub 2015 Nov 11. Review.


The mechanism of DNA replication termination in vertebrates.

Dewar JM, Budzowska M, Walter JC.

Nature. 2015 Sep 17;525(7569):345-50. doi: 10.1038/nature14887. Epub 2015 Aug 31.


Regulation of the Rev1-pol ζ complex during bypass of a DNA interstrand cross-link.

Budzowska M, Graham TG, Sobeck A, Waga S, Walter JC.

EMBO J. 2015 Jul 14;34(14):1971-85. doi: 10.15252/embj.201490878. Epub 2015 Jun 12.


DNA repair. Proteomics reveals dynamic assembly of repair complexes during bypass of DNA cross-links.

Räschle M, Smeenk G, Hansen RK, Temu T, Oka Y, Hein MY, Nagaraj N, Long DT, Walter JC, Hofmann K, Storchova Z, Cox J, Bekker-Jensen S, Mailand N, Mann M.

Science. 2015 May 1;348(6234):1253671. doi: 10.1126/science.1253671. Epub 2015 Apr 30.


Single-Molecule Visualization of MCM2-7 DNA Loading: Seeing Is Believing.

Chistol G, Walter JC.

Cell. 2015 Apr 23;161(3):429-430. doi: 10.1016/j.cell.2015.04.006.


DNA interstrand cross-link repair requires replication-fork convergence.

Zhang J, Dewar JM, Budzowska M, Motnenko A, Cohn MA, Walter JC.

Nat Struct Mol Biol. 2015 Mar;22(3):242-7. doi: 10.1038/nsmb.2956. Epub 2015 Feb 2.


Repair of a DNA-protein crosslink by replication-coupled proteolysis.

Duxin JP, Dewar JM, Yardimci H, Walter JC.

Cell. 2014 Oct 9;159(2):346-57. doi: 10.1016/j.cell.2014.09.024.


BRCA1 promotes unloading of the CMG helicase from a stalled DNA replication fork.

Long DT, Joukov V, Budzowska M, Walter JC.

Mol Cell. 2014 Oct 2;56(1):174-85. doi: 10.1016/j.molcel.2014.08.012. Epub 2014 Sep 11.


Motor protein traffic regulation by supply-demand balance of resources.

Ciandrini L, Neri I, Walter JC, Dauloudet O, Parmeggiani A.

Phys Biol. 2014 Sep 10;11(5):056006. doi: 10.1088/1478-3975/11/5/056006.


The Cep192-organized aurora A-Plk1 cascade is essential for centrosome cycle and bipolar spindle assembly.

Joukov V, Walter JC, De Nicolo A.

Mol Cell. 2014 Aug 21;55(4):578-91. doi: 10.1016/j.molcel.2014.06.016. Epub 2014 Jul 17.


Thymine DNA glycosylase is a CRL4Cdt2 substrate.

Slenn TJ, Morris B, Havens CG, Freeman RM Jr, Takahashi TS, Walter JC.

J Biol Chem. 2014 Aug 15;289(33):23043-55. doi: 10.1074/jbc.M114.574194. Epub 2014 Jun 19.


Mechanism and regulation of incisions during DNA interstrand cross-link repair.

Zhang J, Walter JC.

DNA Repair (Amst). 2014 Jul;19:135-42. doi: 10.1016/j.dnarep.2014.03.018. Epub 2014 Apr 24. Review.


XPF-ERCC1 acts in Unhooking DNA interstrand crosslinks in cooperation with FANCD2 and FANCP/SLX4.

Klein Douwel D, Boonen RA, Long DT, Szypowska AA, Räschle M, Walter JC, Knipscheer P.

Mol Cell. 2014 May 8;54(3):460-71. doi: 10.1016/j.molcel.2014.03.015. Epub 2014 Apr 10.


Prereplication-complex formation: a molecular double take?

Yardimci H, Walter JC.

Nat Struct Mol Biol. 2014 Jan;21(1):20-5. doi: 10.1038/nsmb.2738.


Chromosome biology: conflict management for replication and transcription.

Dewar JM, Walter JC.

Curr Biol. 2013 Mar 4;23(5):R200-2. doi: 10.1016/j.cub.2013.01.054.


Unwinding relaxation dynamics of polymers.

Walter JC, Baiesi M, Barkema GT, Carlon E.

Phys Rev Lett. 2013 Feb 8;110(6):068301. Epub 2013 Feb 4.


The MCM8-MCM9 complex promotes RAD51 recruitment at DNA damage sites to facilitate homologous recombination.

Park J, Long DT, Lee KY, Abbas T, Shibata E, Negishi M, Luo Y, Schimenti JC, Gambus A, Walter JC, Dutta A.

Mol Cell Biol. 2013 Apr;33(8):1632-44. doi: 10.1128/MCB.01503-12. Epub 2013 Feb 11.


Bypass of a protein barrier by a replicative DNA helicase.

Yardimci H, Wang X, Loveland AB, Tappin I, Rudner DZ, Hurwitz J, van Oijen AM, Walter JC.

Nature. 2012 Dec 13;492(7428):205-9. doi: 10.1038/nature11730. Epub 2012 Nov 28.


A general approach to break the concentration barrier in single-molecule imaging.

Loveland AB, Habuchi S, Walter JC, van Oijen AM.

Nat Methods. 2012 Oct;9(10):987-92. doi: 10.1038/nmeth.2174. Epub 2012 Sep 9.


Replication-coupled DNA interstrand cross-link repair in Xenopus egg extracts.

Knipscheer P, Räschle M, Schärer OD, Walter JC.

Methods Mol Biol. 2012;920:221-43. doi: 10.1007/978-1-61779-998-3_16.


Construction of plasmids containing site-specific DNA interstrand cross-links for biochemical and cell biological studies.

Enoiu M, Ho TV, Long DT, Walter JC, Schärer OD.

Methods Mol Biol. 2012;920:203-19. doi: 10.1007/978-1-61779-998-3_15.


Probing hybridization parameters from microarray experiments: nearest-neighbor model and beyond.

Hadiwikarta WW, Walter JC, Hooyberghs J, Carlon E.

Nucleic Acids Res. 2012 Oct;40(18):e138. doi: 10.1093/nar/gks475. Epub 2012 May 31.


Fractional Brownian motion and the critical dynamics of zipping polymers.

Walter JC, Ferrantini A, Carlon E, Vanderzande C.

Phys Rev E Stat Nonlin Soft Matter Phys. 2012 Mar;85(3 Pt 1):031120. Epub 2012 Mar 16.


A novel function for BRCA1 in crosslink repair.

Long DT, Walter JC.

Mol Cell. 2012 Apr 27;46(2):111-2. doi: 10.1016/j.molcel.2012.04.010.


Single-molecule analysis of DNA replication in Xenopus egg extracts.

Yardimci H, Loveland AB, van Oijen AM, Walter JC.

Methods. 2012 Jun;57(2):179-86. doi: 10.1016/j.ymeth.2012.03.033. Epub 2012 Apr 6. Review.


Ribonucleotide reductase activity is coupled to DNA synthesis via proliferating cell nuclear antigen.

Salguero I, Guarino E, Shepherd ME, Deegan TD, Havens CG, MacNeill SA, Walter JC, Kearsey SE.

Curr Biol. 2012 Apr 24;22(8):720-6. doi: 10.1016/j.cub.2012.02.070. Epub 2012 Mar 29.


Direct role for proliferating cell nuclear antigen in substrate recognition by the E3 ubiquitin ligase CRL4Cdt2.

Havens CG, Shobnam N, Guarino E, Centore RC, Zou L, Kearsey SE, Walter JC.

J Biol Chem. 2012 Mar 30;287(14):11410-21. doi: 10.1074/jbc.M111.337683. Epub 2012 Feb 2.


A genome-wide screen identifies p97 as an essential regulator of DNA damage-dependent CDT1 destruction.

Raman M, Havens CG, Walter JC, Harper JW.

Mol Cell. 2011 Oct 7;44(1):72-84. doi: 10.1016/j.molcel.2011.06.036.


Selective bypass of a lagging strand roadblock by the eukaryotic replicative DNA helicase.

Fu YV, Yardimci H, Long DT, Ho TV, Guainazzi A, Bermudez VP, Hurwitz J, van Oijen A, Schärer OD, Walter JC.

Cell. 2011 Sep 16;146(6):931-41. doi: 10.1016/j.cell.2011.07.045.


Mechanism of CRL4(Cdt2), a PCNA-dependent E3 ubiquitin ligase.

Havens CG, Walter JC.

Genes Dev. 2011 Aug 1;25(15):1568-82. doi: 10.1101/gad.2068611. Review.

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