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Items: 1 to 50 of 189

1.

Single-Molecule Mechanistic Study of Enzyme Hysteresis.

Jiang Y, Li X, Morrow BR, Pothukuchy A, Gollihar J, Novak R, Reilly CB, Ellington AD, Walt DR.

ACS Cent Sci. 2019 Oct 23;5(10):1691-1698. doi: 10.1021/acscentsci.9b00718. Epub 2019 Sep 24.

2.

A rapid triage test for active pulmonary tuberculosis in adult patients with persistent cough.

Ahmad R, Xie L, Pyle M, Suarez MF, Broger T, Steinberg D, Ame SM, Lucero MG, Szucs MJ, MacMullan M, Berven FS, Dutta A, Sanvictores DM, Tallo VL, Bencher R, Eisinger DP, Dhingra U, Deb S, Ali SM, Mehta S, Fawzi WW, Riley ID, Sazawal S, Premji Z, Black R, Murray CJL, Rodriguez B, Carr SA, Walt DR, Gillette MA.

Sci Transl Med. 2019 Oct 23;11(515). pii: eaaw8287. doi: 10.1126/scitranslmed.aaw8287. Erratum in: Sci Transl Med. 2019 Oct 30;11(516):.

PMID:
31645455
3.

Single-Molecule Arrays for Ultrasensitive Detection of Blood-Based Biomarkers for Immunotherapy.

Cohen L, Keegan A, Walt DR.

Methods Mol Biol. 2020;2055:399-412. doi: 10.1007/978-1-4939-9773-2_18.

PMID:
31502162
4.

Clinical testing should be individualized, not based on populations.

Walt DR.

J Clin Invest. 2019 Sep 3;129(9):3472-3473. doi: 10.1172/JCI130903. No abstract available.

5.

Protein Detection by Counting Molecules.

Duffy DC, Walt DR.

Clin Chem. 2019 Jun;65(6):809-810. doi: 10.1373/clinchem.2018.298653. Epub 2019 Jan 28. Review. No abstract available.

PMID:
30692115
6.

Impact of clinical sample handling and processing on ultra-low level measurements of plasma cytokines.

Cohen L, Keegan A, Melanson SEF, Walt DR.

Clin Biochem. 2019 Mar;65:38-44. doi: 10.1016/j.clinbiochem.2019.01.001. Epub 2019 Jan 8.

PMID:
30633878
7.

Competitive Immunoassays for the Detection of Small Molecules Using Single Molecule Arrays.

Wang X, Cohen L, Wang J, Walt DR.

J Am Chem Soc. 2018 Dec 26;140(51):18132-18139. doi: 10.1021/jacs.8b11185. Epub 2018 Dec 11.

PMID:
30495929
8.

Evaluation of Antibody Biotinylation Approaches for Enhanced Sensitivity of Single Molecule Array (Simoa) Immunoassays.

Cohen L, Walt DR.

Bioconjug Chem. 2018 Oct 17;29(10):3452-3458. doi: 10.1021/acs.bioconjchem.8b00601. Epub 2018 Oct 1.

PMID:
30272951
9.

Detection of amyloid β oligomers toward early diagnosis of Alzheimer's disease.

Hwang SS, Chan H, Sorci M, Van Deventer J, Wittrup D, Belfort G, Walt D.

Anal Biochem. 2019 Feb 1;566:40-45. doi: 10.1016/j.ab.2018.09.011. Epub 2018 Sep 26.

PMID:
30267709
10.

Highly Sensitive and Multiplexed Protein Measurements.

Cohen L, Walt DR.

Chem Rev. 2019 Jan 9;119(1):293-321. doi: 10.1021/acs.chemrev.8b00257. Epub 2018 Aug 28.

PMID:
30152694
11.

Finding useful biomarkers for Parkinson's disease.

Chen-Plotkin AS, Albin R, Alcalay R, Babcock D, Bajaj V, Bowman D, Buko A, Cedarbaum J, Chelsky D, Cookson MR, Dawson TM, Dewey R, Foroud T, Frasier M, German D, Gwinn K, Huang X, Kopil C, Kremer T, Lasch S, Marek K, Marto JA, Merchant K, Mollenhauer B, Naito A, Potashkin J, Reimer A, Rosenthal LS, Saunders-Pullman R, Scherzer CR, Sherer T, Singleton A, Sutherland M, Thiele I, van der Brug M, Van Keuren-Jensen K, Vaillancourt D, Walt D, West A, Zhang J.

Sci Transl Med. 2018 Aug 15;10(454). pii: eaam6003. doi: 10.1126/scitranslmed.aam6003. Review.

12.

Bottom-up single-molecule strategy for understanding subunit function of tetrameric β-galactosidase.

Li X, Jiang Y, Chong S, Walt DR.

Proc Natl Acad Sci U S A. 2018 Aug 14;115(33):8346-8351. doi: 10.1073/pnas.1805690115. Epub 2018 Jul 30.

13.

How many human proteoforms are there?

Aebersold R, Agar JN, Amster IJ, Baker MS, Bertozzi CR, Boja ES, Costello CE, Cravatt BF, Fenselau C, Garcia BA, Ge Y, Gunawardena J, Hendrickson RC, Hergenrother PJ, Huber CG, Ivanov AR, Jensen ON, Jewett MC, Kelleher NL, Kiessling LL, Krogan NJ, Larsen MR, Loo JA, Ogorzalek Loo RR, Lundberg E, MacCoss MJ, Mallick P, Mootha VK, Mrksich M, Muir TW, Patrie SM, Pesavento JJ, Pitteri SJ, Rodriguez H, Saghatelian A, Sandoval W, Schlüter H, Sechi S, Slavoff SA, Smith LM, Snyder MP, Thomas PM, Uhlén M, Van Eyk JE, Vidal M, Walt DR, White FM, Williams ER, Wohlschlager T, Wysocki VH, Yates NA, Young NL, Zhang B.

Nat Chem Biol. 2018 Feb 14;14(3):206-214. doi: 10.1038/nchembio.2576.

14.

Ultrasensitive Single-Molecule Enzyme Detection and Analysis Using a Polymer Microarray.

Duan BK, Cavanagh PE, Li X, Walt DR.

Anal Chem. 2018 Mar 6;90(5):3091-3098. doi: 10.1021/acs.analchem.7b03980. Epub 2018 Feb 21.

PMID:
29425025
15.

Development of a Rapid Salivary Proteomic Platform for Oral Feeding Readiness in the Preterm Newborn.

Khanna P, Maron JL, Walt DR.

Front Pediatr. 2017 Dec 12;5:268. doi: 10.3389/fped.2017.00268. eCollection 2017.

16.

Single Molecule Arrays for ultra-sensitive detection of rat cytokines in serum.

Cohen L, Xie L, Xylas ME, Walt DR.

J Immunol Methods. 2018 Jan;452:20-25. doi: 10.1016/j.jim.2017.10.002. Epub 2017 Oct 14.

PMID:
29037955
17.

Long-Term Measurements of Human Inflammatory Cytokines Reveal Complex Baseline Variations between Individuals.

Wu D, Dinh TL, Bausk BP, Walt DR.

Am J Pathol. 2017 Dec;187(12):2620-2626. doi: 10.1016/j.ajpath.2017.08.007. Epub 2017 Sep 15.

PMID:
28919109
18.

Parkinson's disease biomarkers: perspective from the NINDS Parkinson's Disease Biomarkers Program.

Gwinn K, David KK, Swanson-Fischer C, Albin R, Hillaire-Clarke CS, Sieber BA, Lungu C, Bowman FD, Alcalay RN, Babcock D, Dawson TM, Dewey RB Jr, Foroud T, German D, Huang X, Petyuk V, Potashkin JA, Saunders-Pullman R, Sutherland M, Walt DR, West AB, Zhang J, Chen-Plotkin A, Scherzer CR, Vaillancourt DE, Rosenthal LS.

Biomark Med. 2017 May;11(6):451-473. doi: 10.2217/bmm-2016-0370. Epub 2017 Jun 23.

19.

Digital direct detection of microRNAs using single molecule arrays.

Cohen L, Hartman MR, Amardey-Wellington A, Walt DR.

Nucleic Acids Res. 2017 Aug 21;45(14):e137. doi: 10.1093/nar/gkx542.

20.

Using Next-Generation Sequencing to Explore Genetics and Race in the High School Classroom.

Yang X, Hartman MR, Harrington KT, Etson CM, Fierman MB, Slonim DK, Walt DR.

CBE Life Sci Educ. 2017 Summer;16(2). pii: ar22. doi: 10.1187/cbe.16-09-0281.

21.

Highly localized divergence within supergenes in Atlantic cod (Gadus morhua) within the Gulf of Maine.

Barney BT, Munkholm C, Walt DR, Palumbi SR.

BMC Genomics. 2017 Mar 31;18(1):271. doi: 10.1186/s12864-017-3660-3.

22.

Single-Molecule Arrays for Protein and Nucleic Acid Analysis.

Cohen L, Walt DR.

Annu Rev Anal Chem (Palo Alto Calif). 2017 Jun 12;10(1):345-363. doi: 10.1146/annurev-anchem-061516-045340. Epub 2017 Mar 15. Review.

PMID:
28301748
23.

Personal microbiomes and next-generation sequencing for laboratory-based education.

Hartman MR, Harrington KT, Etson CM, Fierman MB, Slonim DK, Walt DR.

FEMS Microbiol Lett. 2016 Dec;363(23). pii: fnw266. doi: 10.1093/femsle/fnw266. Epub 2016 Nov 16.

24.

Enzyme Kinetics in Femtoliter Arrays.

Mogalisetti P, Walt DR.

Methods Enzymol. 2016;581:541-560. doi: 10.1016/bs.mie.2016.08.017. Epub 2016 Oct 13.

PMID:
27793293
25.

Using Antigen-antibody Binding Kinetic Parameters to Understand Single-Molecule Array Immunoassay Performance.

Dinh TL, Ngan KC, Shoemaker CB, Walt DR.

Anal Chem. 2016 Dec 6;88(23):11335-11339. Epub 2016 Nov 8.

PMID:
27779850
26.

Incorporation of Slow Off-Rate Modified Aptamers Reagents in Single Molecule Array Assays for Cytokine Detection with Ultrahigh Sensitivity.

Wu D, Katilius E, Olivas E, Dumont Milutinovic M, Walt DR.

Anal Chem. 2016 Sep 6;88(17):8385-9. doi: 10.1021/acs.analchem.6b02451. Epub 2016 Aug 23.

PMID:
27529794
27.

Training the next generation of biomedical investigators in glycosciences.

Agre P, Bertozzi C, Bissell M, Campbell KP, Cummings RD, Desai UR, Estes M, Flotte T, Fogleman G, Gage F, Ginsburg D, Gordon JI, Hart G, Hascall V, Kiessling L, Kornfeld S, Lowe J, Magnani J, Mahal LK, Medzhitov R, Roberts RJ, Sackstein R, Sarkar R, Schnaar R, Schwartz N, Varki A, Walt D, Weissman I.

J Clin Invest. 2016 Feb;126(2):405-8. doi: 10.1172/JCI85905. Epub 2016 Feb 1. Review.

28.

Protein Counting in Single Cancer Cells.

Schubert SM, Walter SR, Manesse M, Walt DR.

Anal Chem. 2016 Mar 1;88(5):2952-7. doi: 10.1021/acs.analchem.6b00146. Epub 2016 Feb 11.

PMID:
26813414
29.

Single molecule array (Simoa) assay with optimal antibody pairs for cytokine detection in human serum samples.

Wu D, Milutinovic MD, Walt DR.

Analyst. 2015 Sep 21;140(18):6277-82. doi: 10.1039/c5an01238d.

PMID:
26270328
30.

Correlations of salivary biomarkers with clinical assessments in patients with cystic fibrosis.

Nie S, Zhang H, Mayer KM, Oppenheim FG, Little FF, Greenberg J, Uluer AZ, Walt DR.

PLoS One. 2015 Aug 10;10(8):e0135237. doi: 10.1371/journal.pone.0135237. eCollection 2015.

31.

The Scope of Analytical Chemistry.

Sweedler JV, Armstrong DW, Baba Y, Desmet G, Dovichi N, Ewing A, Fenselau CC, Kennedy RT, Larive CK, Ligler FS, McCreery RL, Niessner R, Pemberton JE, Tan W, Walt DR, Yates JR 3rd, Zenobi R, Zhang X.

Anal Chem. 2015 Jul 7;87(13):6425. doi: 10.1021/acs.analchem.5b02231. Epub 2015 Jun 18. No abstract available.

PMID:
26086069
32.

Ultra-sensitive protein detection via Single Molecule Arrays towards early stage cancer monitoring.

Schubert SM, Arendt LM, Zhou W, Baig S, Walter SR, Buchsbaum RJ, Kuperwasser C, Walt DR.

Sci Rep. 2015 Jun 8;5:11034. doi: 10.1038/srep11034.

33.

Ultrasensitive Detection of Ricin Toxin in Multiple Sample Matrixes Using Single-Domain Antibodies.

Gaylord ST, Dinh TL, Goldman ER, Anderson GP, Ngan KC, Walt DR.

Anal Chem. 2015 Jul 7;87(13):6570-7. doi: 10.1021/acs.analchem.5b00322. Epub 2015 Jun 9.

PMID:
26001138
34.

Fiber-optic array using molecularly imprinted microspheres for antibiotic analysis.

Carrasco S, Benito-Peña E, Walt DR, Moreno-Bondi MC.

Chem Sci. 2015 May 1;6(5):3139-3147. doi: 10.1039/c5sc00115c. Epub 2015 Mar 25.

35.

Salivary diagnostics using a portable point-of-service platform: a review.

Khanna P, Walt DR.

Clin Ther. 2015 Mar 1;37(3):498-504. doi: 10.1016/j.clinthera.2015.02.004. Epub 2015 Feb 27. Review.

36.

Single-molecule arrays for ultrasensitive detection of host immune response to dengue virus infection.

Gaylord ST, Abdul-Aziz S, Walt DR.

J Clin Microbiol. 2015 May;53(5):1722-4. doi: 10.1128/JCM.03487-14. Epub 2015 Feb 18.

37.

Stoichiometry of the α-complementation reaction of Escherichia coli β-galactosidase as revealed through single-molecule studies.

Mogalisetti P, Walt DR.

Biochemistry. 2015 Mar 3;54(8):1583-8. doi: 10.1021/bi5015024. Epub 2015 Feb 18.

PMID:
25668156
38.

Catalytic kinetics of single gold nanoparticles observed via optical microwell arrays.

Mayer KM, Shnipes J, Davis D, Walt DR.

Nanotechnology. 2015 Feb 6;26(5):055704. doi: 10.1088/0957-4484/26/5/055704. Epub 2015 Jan 15.

PMID:
25590419
39.

Genome-wide SNP-genotyping array to study the evolution of the human pathogen Vibrio vulnificus biotype 3.

Raz N, Danin-Poleg Y, Hayman RB, Bar-On Y, Linetsky A, Shmoish M, Sanjuán E, Amaro C, Walt DR, Kashi Y.

PLoS One. 2014 Dec 19;9(12):e114576. doi: 10.1371/journal.pone.0114576. eCollection 2014.

40.

Advancing the speed, sensitivity and accuracy of biomolecular detection using multi-length-scale engineering.

Kelley SO, Mirkin CA, Walt DR, Ismagilov RF, Toner M, Sargent EH.

Nat Nanotechnol. 2014 Dec;9(12):969-80. doi: 10.1038/nnano.2014.261. Review.

41.

Disease detection by ultrasensitive quantification of microdosed synthetic urinary biomarkers.

Warren AD, Gaylord ST, Ngan KC, Dumont Milutinovic M, Kwong GA, Bhatia SN, Walt DR.

J Am Chem Soc. 2014 Oct 1;136(39):13709-14. doi: 10.1021/ja505676h. Epub 2014 Sep 23.

42.

Protein measurements in microwells.

Walt DR.

Lab Chip. 2014 Sep 7;14(17):3195-200. doi: 10.1039/c4lc00277f.

PMID:
24825470
43.

Observing single enzyme molecules interconvert between activity states upon heating.

Rojek MJ, Walt DR.

PLoS One. 2014 Jan 21;9(1):e86224. doi: 10.1371/journal.pone.0086224. eCollection 2014.

44.

An automated integrated platform for rapid and sensitive multiplexed protein profiling using human saliva samples.

Nie S, Henley WH, Miller SE, Zhang H, Mayer KM, Dennis PJ, Oblath EA, Alarie JP, Wu Y, Oppenheim FG, Little FF, Uluer AZ, Wang P, Ramsey JM, Walt DR.

Lab Chip. 2014 Mar 21;14(6):1087-98. doi: 10.1039/c3lc51303c.

45.

Salivary inflammatory mediator profiling and correlation to clinical disease markers in asthma.

Little FF, Delgado DM, Wexler PJ, Oppenheim FG, Mitchell P, Feldman JA, Walt DR, Peng RD, Matsui EC.

PLoS One. 2014 Jan 7;9(1):e84449. doi: 10.1371/journal.pone.0084449. eCollection 2014.

46.

Multiplexed fluorescent microarray for human salivary protein analysis using polymer microspheres and fiber-optic bundles.

Nie S, Benito-Peña E, Zhang H, Wu Y, Walt DR.

J Vis Exp. 2013 Oct 10;(80). doi: 10.3791/50726.

47.

Measuring atomic emission from beacons for long-distance chemical signaling.

LaFratta CN, Pelse I, Falla JL, Liu Y, Palacios MA, Manesse M, Whitesides GM, Walt DR.

Anal Chem. 2013 Oct 1;85(19):8933-6. doi: 10.1021/ac402494s. Epub 2013 Sep 9.

PMID:
23987667
48.

Multiplexed salivary protein profiling for patients with respiratory diseases using fiber-optic bundles and fluorescent antibody-based microarrays.

Nie S, Benito-Peña E, Zhang H, Wu Y, Walt DR.

Anal Chem. 2013 Oct 1;85(19):9272-80. doi: 10.1021/ac4019523. Epub 2013 Sep 12.

49.

Assessing the stochastic intermittency of single quantum dot luminescence for robust quantification of biomolecules.

Palacios MA, Lacy MM, Schubert SM, Manesse M, Walt DR.

Anal Chem. 2013 Jul 16;85(14):6639-45. doi: 10.1021/ac4001332. Epub 2013 May 24.

50.

Dynamic microbead arrays for biosensing applications.

Manesse M, Phillips AF, LaFratta CN, Palacios MA, Hayman RB, Walt DR.

Lab Chip. 2013 Jun 7;13(11):2153-60. doi: 10.1039/c3lc00044c.

PMID:
23615790

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