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Items: 1 to 50 of 235

1.

Inference of cell type content from human brain transcriptomic datasets illuminates the effects of age, manner of death, dissection, and psychiatric diagnosis.

Hagenauer MH, Schulmann A, Li JZ, Vawter MP, Walsh DM, Thompson RC, Turner CA, Bunney WE, Myers RM, Barchas JD, Schatzberg AF, Watson SJ, Akil H.

PLoS One. 2018 Jul 17;13(7):e0200003. doi: 10.1371/journal.pone.0200003. eCollection 2018.

2.

An in vitro paradigm to assess potential anti-Aβ antibodies for Alzheimer's disease.

Jin M, O'Nuallain B, Hong W, Boyd J, Lagomarsino VN, O'Malley TT, Liu W, Vanderburg CR, Frosch MP, Young-Pearse T, Selkoe DJ, Walsh DM.

Nat Commun. 2018 Jul 11;9(1):2676. doi: 10.1038/s41467-018-05068-w.

3.

MicroRNA-132 provides neuroprotection for tauopathies via multiple signaling pathways.

El Fatimy R, Li S, Chen Z, Mushannen T, Gongala S, Wei Z, Balu DT, Rabinovsky R, Cantlon A, Elkhal A, Selkoe DJ, Sonntag KC, Walsh DM, Krichevsky AM.

Acta Neuropathol. 2018 Jul 7. doi: 10.1007/s00401-018-1880-5. [Epub ahead of print]

PMID:
29982852
4.

Extracellular Forms of Aβ and Tau from iPSC Models of Alzheimer's Disease Disrupt Synaptic Plasticity.

Hu NW, Corbett GT, Moore S, Klyubin I, O'Malley TT, Walsh DM, Livesey FJ, Rowan MJ.

Cell Rep. 2018 May 15;23(7):1932-1938. doi: 10.1016/j.celrep.2018.04.040.

5.

Production and Use of Recombinant Aβ for Aggregation Studies.

O'Malley TT, Linse S, Walsh DM.

Methods Mol Biol. 2018;1777:307-320. doi: 10.1007/978-1-4939-7811-3_19.

PMID:
29744844
6.

Electronic Health Physical Activity Behavior Change Intervention to Self-Manage Cardiovascular Disease: Qualitative Exploration of Patient and Health Professional Requirements.

Walsh DM, Moran K, Cornelissen V, Buys R, Cornelis N, Woods C.

J Med Internet Res. 2018 May 8;20(5):e163. doi: 10.2196/jmir.9181.

7.

Measuring a new facet of post traumatic growth: Development of a scale of physical post traumatic growth in men with prostate cancer.

Walsh DMJ, Groarke AM, Morrison TG, Durkan G, Rogers E, Sullivan FJ.

PLoS One. 2018 Apr 27;13(4):e0195992. doi: 10.1371/journal.pone.0195992. eCollection 2018.

8.

What predicts emotional response in men awaiting prostate biopsy?

Groarke A, Curtis R, Walsh DMJ, Sullivan FJ.

BMC Urol. 2018 Apr 24;18(1):27. doi: 10.1186/s12894-018-0340-9.

9.

Diffusible, highly bioactive oligomers represent a critical minority of soluble Aβ in Alzheimer's disease brain.

Hong W, Wang Z, Liu W, O'Malley TT, Jin M, Willem M, Haass C, Frosch MP, Walsh DM.

Acta Neuropathol. 2018 Jul;136(1):19-40. doi: 10.1007/s00401-018-1846-7. Epub 2018 Apr 23.

PMID:
29687257
10.

The development and codesign of the PATHway intervention: a theory-driven eHealth platform for the self-management of cardiovascular disease.

Walsh DMJ, Moran K, Cornelissen V, Buys R, Claes J, Zampognaro P, Melillo F, Maglaveras N, Chouvarda I, Triantafyllidis A, Filos D, Woods CB.

Transl Behav Med. 2018 Mar 15. doi: 10.1093/tbm/iby017. [Epub ahead of print]

PMID:
29554380
11.

Distinguishing cell shoving mechanisms.

Nan P, Walsh DM, Landman KA, Hughes BD.

PLoS One. 2018 Mar 12;13(3):e0193975. doi: 10.1371/journal.pone.0193975. eCollection 2018.

12.

A Model to Predict Psychological- and Health-Related Adjustment in Men with Prostate Cancer: The Role of Post Traumatic Growth, Physical Post Traumatic Growth, Resilience and Mindfulness.

Walsh DMJ, Morrison TG, Conway RJ, Rogers E, Sullivan FJ, Groarke A.

Front Psychol. 2018 Feb 15;9:136. doi: 10.3389/fpsyg.2018.00136. eCollection 2018.

13.

Detection of Aggregation-Competent Tau in Neuron-Derived Extracellular Vesicles.

Guix FX, Corbett GT, Cha DJ, Mustapic M, Liu W, Mengel D, Chen Z, Aikawa E, Young-Pearse T, Kapogiannis D, Selkoe DJ, Walsh DM.

Int J Mol Sci. 2018 Feb 27;19(3). pii: E663. doi: 10.3390/ijms19030663.

14.

The oral glucose test predicts laminitis risk in ponies fed a diet high in nonstructural carbohydrates.

Meier AD, de Laat MA, Reiche DB, Pollitt CC, Walsh DM, McGree JM, Sillence MN.

Domest Anim Endocrinol. 2018 Apr;63:1-9. doi: 10.1016/j.domaniend.2017.10.008. Epub 2017 Nov 16.

PMID:
29172109
15.

Soluble Aβ aggregates can inhibit prion propagation.

Sarell CJ, Quarterman E, Yip DC, Terry C, Nicoll AJ, Wadsworth JDF, Farrow MA, Walsh DM, Collinge J.

Open Biol. 2017 Nov;7(11). pii: 170158. doi: 10.1098/rsob.170158.

16.

Human Brain-Derived Aβ Oligomers Bind to Synapses and Disrupt Synaptic Activity in a Manner That Requires APP.

Wang Z, Jackson RJ, Hong W, Taylor WM, Corbett GT, Moreno A, Liu W, Li S, Frosch MP, Slutsky I, Young-Pearse TL, Spires-Jones TL, Walsh DM.

J Neurosci. 2017 Dec 6;37(49):11947-11966. doi: 10.1523/JNEUROSCI.2009-17.2017. Epub 2017 Nov 3.

17.

What is the optimal distribution of myelin along a single axon?

Walsh DM, Landman KA, Hughes BD.

Neurosci Lett. 2017 Sep 29;658:97-101. doi: 10.1016/j.neulet.2017.08.037. Epub 2017 Aug 31.

PMID:
28838809
18.

Behavior Change Techniques in Physical Activity eHealth Interventions for People With Cardiovascular Disease: Systematic Review.

Duff OM, Walsh DM, Furlong BA, O'Connor NE, Moran KA, Woods CB.

J Med Internet Res. 2017 Aug 2;19(8):e281. doi: 10.2196/jmir.7782. Review.

19.

Post-mortem molecular profiling of three psychiatric disorders.

Ramaker RC, Bowling KM, Lasseigne BN, Hagenauer MH, Hardigan AA, Davis NS, Gertz J, Cartagena PM, Walsh DM, Vawter MP, Jones EG, Schatzberg AF, Barchas JD, Watson SJ, Bunney BG, Akil H, Bunney WE, Li JZ, Cooper SJ, Myers RM.

Genome Med. 2017 Jul 28;9(1):72. doi: 10.1186/s13073-017-0458-5.

20.
21.

Alterations in airway microbiota in patients with PaO2/FiO2 ratio ≤ 300 after burn and inhalation injury.

Walsh DM, McCullough SD, Yourstone S, Jones SW, Cairns BA, Jones CD, Jaspers I, Diaz-Sanchez D.

PLoS One. 2017 Mar 30;12(3):e0173848. doi: 10.1371/journal.pone.0173848. eCollection 2017.

22.

Large Soluble Oligomers of Amyloid β-Protein from Alzheimer Brain Are Far Less Neuroactive Than the Smaller Oligomers to Which They Dissociate.

Yang T, Li S, Xu H, Walsh DM, Selkoe DJ.

J Neurosci. 2017 Jan 4;37(1):152-163. doi: 10.1523/JNEUROSCI.1698-16.2016.

23.

Evidence for Cooperative Selection of Axons for Myelination by Adjacent Oligodendrocytes in the Optic Nerve.

Walsh DM, Merson TD, Landman KA, Hughes BD.

PLoS One. 2016 Nov 9;11(11):e0165673. doi: 10.1371/journal.pone.0165673. eCollection 2016.

24.

The Aggregation Paths and Products of Aβ42 Dimers Are Distinct from Those of the Aβ42 Monomer.

O'Malley TT, Witbold WM 3rd, Linse S, Walsh DM.

Biochemistry. 2016 Nov 8;55(44):6150-6161. Epub 2016 Oct 26.

25.
26.

Is cell migration or proliferation dominant in the formation of linear arrays of oligodendrocytes?

Walsh DM, Röth PT, Holmes WR, Landman KA, Merson TD, Hughes BD.

J Theor Biol. 2016 Oct 7;406:17-30. doi: 10.1016/j.jtbi.2016.06.028. Epub 2016 Jun 21.

PMID:
27343034
27.

Non-Fibrillar Oligomeric Amyloid-β within Synapses.

Pickett EK, Koffie RM, Wegmann S, Henstridge CM, Herrmann AG, Colom-Cadena M, Lleo A, Kay KR, Vaught M, Soberman R, Walsh DM, Hyman BT, Spires-Jones TL.

J Alzheimers Dis. 2016 May 30;53(3):787-800. doi: 10.3233/JAD-160007.

PMID:
27258414
28.

A critical appraisal of the pathogenic protein spread hypothesis of neurodegeneration.

Walsh DM, Selkoe DJ.

Nat Rev Neurosci. 2016 Apr;17(4):251-60. doi: 10.1038/nrn.2016.13. Review.

PMID:
26988744
29.

N-Terminal Extensions Retard Aβ42 Fibril Formation but Allow Cross-Seeding and Coaggregation with Aβ42.

Szczepankiewicz O, Linse B, Meisl G, Thulin E, Frohm B, Sala Frigerio C, Colvin MT, Jacavone AC, Griffin RG, Knowles T, Walsh DM, Linse S.

J Am Chem Soc. 2015 Nov 25;137(46):14673-85. doi: 10.1021/jacs.5b07849. Epub 2015 Nov 17.

30.

Soluble Aβ oligomers impair hippocampal LTP by disrupting glutamatergic/GABAergic balance.

Lei M, Xu H, Li Z, Wang Z, O'Malley TT, Zhang D, Walsh DM, Xu P, Selkoe DJ, Li S.

Neurobiol Dis. 2016 Jan;85:111-121. doi: 10.1016/j.nbd.2015.10.019. Epub 2015 Oct 22.

31.

Autoregulated paracellular clearance of amyloid-β across the blood-brain barrier.

Keaney J, Walsh DM, O'Malley T, Hudson N, Crosbie DE, Loftus T, Sheehan F, McDaid J, Humphries MM, Callanan JJ, Brett FM, Farrell MA, Humphries P, Campbell M.

Sci Adv. 2015 Sep 4;1(8):e1500472.

32.

Lessons from a Rare Familial Dementia: Amyloid and Beyond.

Cantlon A, Frigerio CS, Walsh DM.

J Parkinsons Dis Alzheimers Dis. 2015 Aug;2(1). pii: 12.

33.

IgG Conformer's Binding to Amyloidogenic Aggregates.

Phay M, Welzel AT, Williams AD, McWilliams-Koeppen HP, Blinder V, O'Malley TT, Solomon A, Walsh DM, O'Nuallain B.

PLoS One. 2015 Sep 14;10(9):e0137344. doi: 10.1371/journal.pone.0137344. eCollection 2015.

34.

Targeted Magnetic Nanoparticles for Remote Magnetothermal Disruption of Amyloid-β Aggregates.

Loynachan CN, Romero G, Christiansen MG, Chen R, Ellison R, O'Malley TT, Froriep UP, Walsh DM, Anikeeva P.

Adv Healthc Mater. 2015 Oct;4(14):2100-2109. doi: 10.1002/adhm.201500487. Epub 2015 Aug 19.

PMID:
26288378
35.

C-Terminally Truncated Forms of Tau, But Not Full-Length Tau or Its C-Terminal Fragments, Are Released from Neurons Independently of Cell Death.

Kanmert D, Cantlon A, Muratore CR, Jin M, O'Malley TT, Lee G, Young-Pearse TL, Selkoe DJ, Walsh DM.

J Neurosci. 2015 Jul 29;35(30):10851-65. doi: 10.1523/JNEUROSCI.0387-15.2015.

36.

Anti-Aβ antibodies incapable of reducing cerebral Aβ oligomers fail to attenuate spatial reference memory deficits in J20 mice.

Mably AJ, Liu W, Mc Donald JM, Dodart JC, Bard F, Lemere CA, O'Nuallain B, Walsh DM.

Neurobiol Dis. 2015 Oct;82:372-384. doi: 10.1016/j.nbd.2015.07.008. Epub 2015 Jul 26.

37.

Real-Time Monitoring of Alzheimer's-Related Amyloid Aggregation via Probe Enhancement-Fluorescence Correlation Spectroscopy.

Guan Y, Cao KJ, Cantlon A, Elbel K, Theodorakis EA, Walsh DM, Yang J, Shah JV.

ACS Chem Neurosci. 2015 Sep 16;6(9):1503-8. doi: 10.1021/acschemneuro.5b00176. Epub 2015 Jul 31.

38.

Rapid assessment of cognitive function in down syndrome across intellectual level and dementia status.

Walsh DM, Doran E, Silverman W, Tournay A, Movsesyan N, Lott IT.

J Intellect Disabil Res. 2015 Nov;59(11):1071-9. doi: 10.1111/jir.12200. Epub 2015 May 29.

39.

The Familial British Dementia Mutation Promotes Formation of Neurotoxic Cystine Cross-linked Amyloid Bri (ABri) Oligomers.

Cantlon A, Frigerio CS, Freir DB, Boland B, Jin M, Walsh DM.

J Biol Chem. 2015 Jul 3;290(27):16502-16. doi: 10.1074/jbc.M115.652263. Epub 2015 May 8.

40.

A human monoclonal IgG that binds aβ assemblies and diverse amyloids exhibits anti-amyloid activities in vitro and in vivo.

Levites Y, O'Nuallain B, Puligedda RD, Ondrejcak T, Adekar SP, Chen C, Cruz PE, Rosario AM, Macy S, Mably AJ, Walsh DM, Vidal R, Solomon A, Brown D, Rowan MJ, Golde TE, Dessain SK.

J Neurosci. 2015 Apr 22;35(16):6265-76. doi: 10.1523/JNEUROSCI.5109-14.2015.

41.

The aqueous phase of Alzheimer's disease brain contains assemblies built from ∼4 and ∼7 kDa Aβ species.

Mc Donald JM, O'Malley TT, Liu W, Mably AJ, Brinkmalm G, Portelius E, Wittbold WM 3rd, Frosch MP, Walsh DM.

Alzheimers Dement. 2015 Nov;11(11):1286-305. doi: 10.1016/j.jalz.2015.01.005. Epub 2015 Apr 4.

42.

A highly sensitive novel immunoassay specifically detects low levels of soluble Aβ oligomers in human cerebrospinal fluid.

Yang T, O'Malley TT, Kanmert D, Jerecic J, Zieske LR, Zetterberg H, Hyman BT, Walsh DM, Selkoe DJ.

Alzheimers Res Ther. 2015 Mar 22;7(1):14. doi: 10.1186/s13195-015-0100-y. eCollection 2015.

43.

Tau immunization: a cautionary tale?

Mably AJ, Kanmert D, Mc Donald JM, Liu W, Caldarone BJ, Lemere CA, O'Nuallain B, Kosik KS, Walsh DM.

Neurobiol Aging. 2015 Mar;36(3):1316-32. doi: 10.1016/j.neurobiolaging.2014.11.022. Epub 2014 Dec 30.

PMID:
25619661
44.

Circadian dysregulation of clock genes: clues to rapid treatments in major depressive disorder.

Bunney BG, Li JZ, Walsh DM, Stein R, Vawter MP, Cartagena P, Barchas JD, Schatzberg AF, Myers RM, Watson SJ, Akil H, Bunney WE.

Mol Psychiatry. 2015 Feb;20(1):48-55. doi: 10.1038/mp.2014.138. Epub 2014 Nov 4. Review.

45.

Germline FH mutations presenting with pheochromocytoma.

Clark GR, Sciacovelli M, Gaude E, Walsh DM, Kirby G, Simpson MA, Trembath RC, Berg JN, Woodward ER, Kinning E, Morrison PJ, Frezza C, Maher ER.

J Clin Endocrinol Metab. 2014 Oct;99(10):E2046-50. doi: 10.1210/jc.2014-1659. Epub 2014 Jul 8.

PMID:
25004247
46.

Secreted amyloid β-proteins in a cell culture model include N-terminally extended peptides that impair synaptic plasticity.

Welzel AT, Maggio JE, Shankar GM, Walker DE, Ostaszewski BL, Li S, Klyubin I, Rowan MJ, Seubert P, Walsh DM, Selkoe DJ.

Biochemistry. 2014 Jun 24;53(24):3908-21.

47.

APP homodimers transduce an amyloid-β-mediated increase in release probability at excitatory synapses.

Fogel H, Frere S, Segev O, Bharill S, Shapira I, Gazit N, O'Malley T, Slomowitz E, Berdichevsky Y, Walsh DM, Isacoff EY, Hirsch JA, Slutsky I.

Cell Rep. 2014 Jun 12;7(5):1560-1576. doi: 10.1016/j.celrep.2014.04.024. Epub 2014 May 15.

48.

Peripheral administration of a humanized anti-PrP antibody blocks Alzheimer's disease Aβ synaptotoxicity.

Klyubin I, Nicoll AJ, Khalili-Shirazi A, Farmer M, Canning S, Mably A, Linehan J, Brown A, Wakeling M, Brandner S, Walsh DM, Rowan MJ, Collinge J.

J Neurosci. 2014 Apr 30;34(18):6140-5. doi: 10.1523/JNEUROSCI.3526-13.2014.

49.

Aβ dimers differ from monomers in structural propensity, aggregation paths and population of synaptotoxic assemblies.

O'Malley TT, Oktaviani NA, Zhang D, Lomakin A, O'Nuallain B, Linse S, Benedek GB, Rowan MJ, Mulder FA, Walsh DM.

Biochem J. 2014 Aug 1;461(3):413-26. doi: 10.1042/BJ20140219.

PMID:
24785004
50.

Simultaneous measurement of a range of particle sizes during Aβ1-42 fibrillogenesis quantified using fluorescence correlation spectroscopy.

Mittag JJ, Milani S, Walsh DM, Rädler JO, McManus JJ.

Biochem Biophys Res Commun. 2014 May 30;448(2):195-9. doi: 10.1016/j.bbrc.2014.04.088. Epub 2014 Apr 24.

PMID:
24769478

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