Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 642

1.

Propofol: Milk of Amnesia.

Walsh CT.

Cell. 2018 Sep 20;175(1):10-13. doi: 10.1016/j.cell.2018.08.031. Epub 2018 Sep 11.

PMID:
30217361
2.

Enzymatic Cascade Reactions in Biosynthesis.

Walsh CT, Moore BS.

Angew Chem Int Ed Engl. 2018 Aug 28. doi: 10.1002/anie.201807844. [Epub ahead of print]

PMID:
30156048
3.

Nature Builds Macrocycles and Heterocycles into Its Antimicrobial Frameworks: Deciphering Biosynthetic Strategy.

Walsh CT.

ACS Infect Dis. 2018 Sep 14;4(9):1283-1299. doi: 10.1021/acsinfecdis.8b00101. Epub 2018 Jul 23.

PMID:
29993235
4.

Correction to: Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Walsh CT, Tu BP, Tang Y.

Chem Rev. 2018 May 23;118(10):5261-5263. doi: 10.1021/acs.chemrev.8b00181. Epub 2018 Apr 5. No abstract available.

PMID:
29620360
5.

Eight Kinetically Stable but Thermodynamically Activated Molecules that Power Cell Metabolism.

Walsh CT, Tu BP, Tang Y.

Chem Rev. 2018 Feb 28;118(4):1460-1494. doi: 10.1021/acs.chemrev.7b00510. Epub 2017 Dec 22. Erratum in: Chem Rev. 2018 May 23;118(10 ):5261-5263.

6.

Recent Advances in Enzymatic Complexity Generation: Cyclization Reactions.

Walsh CT, Tang Y.

Biochemistry. 2018 Jun 5;57(22):3087-3104. doi: 10.1021/acs.biochem.7b01161. Epub 2017 Dec 20. Review.

PMID:
29236467
7.

Are highly morphed peptide frameworks lurking silently in microbial genomes valuable as next generation antibiotic scaffolds?

Walsh CT.

Nat Prod Rep. 2017 Jul 1;34(7):687-693. doi: 10.1039/c7np00011a. Epub 2017 May 17. Review.

PMID:
28513710
8.

Structure-Activity Relationship and Molecular Mechanics Reveal the Importance of Ring Entropy in the Biosynthesis and Activity of a Natural Product.

Tran HL, Lexa KW, Julien O, Young TS, Walsh CT, Jacobson MP, Wells JA.

J Am Chem Soc. 2017 Feb 22;139(7):2541-2544. doi: 10.1021/jacs.6b10792. Epub 2017 Feb 13.

9.

At the Intersection of Chemistry, Biology, and Medicine.

Walsh CT.

Annu Rev Biochem. 2017 Jun 20;86:1-19. doi: 10.1146/annurev-biochem-110716-121241. Epub 2017 Jan 11. Review.

PMID:
28125288
10.

Oxidative Cyclization in Natural Product Biosynthesis.

Tang MC, Zou Y, Watanabe K, Walsh CT, Tang Y.

Chem Rev. 2017 Apr 26;117(8):5226-5333. doi: 10.1021/acs.chemrev.6b00478. Epub 2016 Dec 12. Review.

11.

Structural elements of an NRPS cyclization domain and its intermodule docking domain.

Dowling DP, Kung Y, Croft AK, Taghizadeh K, Kelly WL, Walsh CT, Drennan CL.

Proc Natl Acad Sci U S A. 2016 Nov 1;113(44):12432-12437. Epub 2016 Oct 17.

12.

Levels of Evidence for Foot and Ankle Questions on the Orthopaedic In-Training Examination: 15-Year Trends.

Walsh CT, Grandizio LC, Klena JC, Parenti JM, Cush GJ.

J Surg Educ. 2016 Nov - Dec;73(6):999-1003. doi: 10.1016/j.jsurg.2016.05.019. Epub 2016 Aug 25.

PMID:
27569751
13.

Pectin impacts cellulose fibre architecture and hydrogel mechanics in the absence of calcium.

Lopez-Sanchez P, Martinez-Sanz M, Bonilla MR, Wang D, Walsh CT, Gilbert EP, Stokes JR, Gidley MJ.

Carbohydr Polym. 2016 Nov 20;153:236-245. doi: 10.1016/j.carbpol.2016.07.113. Epub 2016 Jul 28.

PMID:
27561492
14.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

15.

A chemocentric view of the natural product inventory.

Walsh CT.

Nat Chem Biol. 2015 Sep;11(9):620-4. doi: 10.1038/nchembio.1894. No abstract available.

PMID:
26284660
16.
17.

Insights into the chemical logic and enzymatic machinery of NRPS assembly lines.

Walsh CT.

Nat Prod Rep. 2016 Feb;33(2):127-35. doi: 10.1039/c5np00035a. Review.

PMID:
26175103
18.

Crystal structure of O-methyltransferase CalO6 from the calicheamicin biosynthetic pathway: a case of challenging structure determination at low resolution.

Tsodikov OV, Hou C, Walsh CT, Garneau-Tsodikova S.

BMC Struct Biol. 2015 Jul 15;15:13. doi: 10.1186/s12900-015-0040-6.

19.

The Pseudomonas aeruginosa antimetabolite L -2-amino-4-methoxy-trans-3-butenoic acid (AMB) is made from glutamate and two alanine residues via a thiotemplate-linked tripeptide precursor.

Rojas Murcia N, Lee X, Waridel P, Maspoli A, Imker HJ, Chai T, Walsh CT, Reimmann C.

Front Microbiol. 2015 Mar 12;6:170. doi: 10.3389/fmicb.2015.00170. eCollection 2015.

20.

Correction: Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics.

Li B, Wever WJ, Walsh CT, Bowers AA.

Nat Prod Rep. 2015 Feb;32(2):348-9. doi: 10.1039/c4np90047b. No abstract available.

PMID:
25598489
21.

Biological matching of chemical reactivity: pairing indole nucleophilicity with electrophilic isoprenoids.

Walsh CT.

ACS Chem Biol. 2014 Dec 19;9(12):2718-28. doi: 10.1021/cb500695k. Epub 2014 Oct 29. Review.

PMID:
25303280
22.

Crystallographic evidence of drastic conformational changes in the active site of a flavin-dependent N-hydroxylase.

Setser JW, Heemstra JR Jr, Walsh CT, Drennan CL.

Biochemistry. 2014 Sep 30;53(38):6063-77. doi: 10.1021/bi500655q. Epub 2014 Sep 16.

23.

Enzymatic glycosylation of vancomycin aglycon: completion of a total synthesis of vancomycin and N- and C-terminus substituent effects of the aglycon substrate.

Nakayama A, Okano A, Feng Y, Collins JC, Collins KC, Walsh CT, Boger DL.

Org Lett. 2014 Jul 3;16(13):3572-5. doi: 10.1021/ol501568t. Epub 2014 Jun 23.

24.

Blurring the lines between ribosomal and nonribosomal peptide scaffolds.

Walsh CT.

ACS Chem Biol. 2014 Aug 15;9(8):1653-61. doi: 10.1021/cb5003587. Epub 2014 Jun 9. Review.

PMID:
24883916
25.

Dithiolopyrrolones: biosynthesis, synthesis, and activity of a unique class of disulfide-containing antibiotics.

Li B, Wever WJ, Walsh CT, Bowers AA.

Nat Prod Rep. 2014 Jul;31(7):905-23. doi: 10.1039/c3np70106a. Review. Erratum in: Nat Prod Rep. 2015 Feb;32(2):348-9.

26.

Assembly line polyketide synthases: mechanistic insights and unsolved problems.

Khosla C, Herschlag D, Cane DE, Walsh CT.

Biochemistry. 2014 May 13;53(18):2875-83. doi: 10.1021/bi500290t. Epub 2014 May 1. Review.

27.

Shock, stress or signal? Implications of freshwater flows for a top-level estuarine predator.

Taylor MD, van der Meulen DE, Ives MC, Walsh CT, Reinfelds IV, Gray CA.

PLoS One. 2014 Apr 21;9(4):e95680. doi: 10.1371/journal.pone.0095680. eCollection 2014.

28.
29.

Environmental change drives long-term recruitment and growth variation in an estuarine fish.

Morrongiello JR, Walsh CT, Gray CA, Stocks JR, Crook DA.

Glob Chang Biol. 2014 Jun;20(6):1844-60. doi: 10.1111/gcb.12545. Epub 2014 Apr 12.

PMID:
24510897
30.

Inhibition of endothelial FAK activity prevents tumor metastasis by enhancing barrier function.

Jean C, Chen XL, Nam JO, Tancioni I, Uryu S, Lawson C, Ward KK, Walsh CT, Miller NL, Ghassemian M, Turowski P, Dejana E, Weis S, Cheresh DA, Schlaepfer DD.

J Cell Biol. 2014 Jan 20;204(2):247-63. doi: 10.1083/jcb.201307067.

31.

Cloning and sequencing of the chaetocin biosynthetic gene cluster.

Gerken T, Walsh CT.

Chembiochem. 2013 Nov 25;14(17):2256-8. doi: 10.1002/cbic.201300513. Epub 2013 Oct 2.

PMID:
24123808
32.

An iterative, bimodular nonribosomal peptide synthetase that converts anthranilate and tryptophan into tetracyclic asperlicins.

Gao X, Jiang W, Jiménez-Osés G, Choi MS, Houk KN, Tang Y, Walsh CT.

Chem Biol. 2013 Jul 25;20(7):870-8. doi: 10.1016/j.chembiol.2013.04.019.

33.

Prospects for new antibiotics: a molecule-centered perspective.

Walsh CT, Wencewicz TA.

J Antibiot (Tokyo). 2014 Jan;67(1):7-22. doi: 10.1038/ja.2013.49. Epub 2013 Jun 12. Review.

PMID:
23756684
34.

Nonproteinogenic amino acid building blocks for nonribosomal peptide and hybrid polyketide scaffolds.

Walsh CT, O'Brien RV, Khosla C.

Angew Chem Int Ed Engl. 2013 Jul 8;52(28):7098-124. doi: 10.1002/anie.201208344. Epub 2013 May 31. Review.

35.

Short pathways to complexity generation: fungal peptidyl alkaloid multicyclic scaffolds from anthranilate building blocks.

Walsh CT, Haynes SW, Ames BD, Gao X, Tang Y.

ACS Chem Biol. 2013 Jul 19;8(7):1366-82. doi: 10.1021/cb4001684. Epub 2013 Jun 4. Review.

36.

The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds.

Malcolmson SJ, Young TS, Ruby JG, Skewes-Cox P, Walsh CT.

Proc Natl Acad Sci U S A. 2013 May 21;110(21):8483-8. doi: 10.1073/pnas.1307111110. Epub 2013 May 6.

37.

EcdGHK are three tailoring iron oxygenases for amino acid building blocks of the echinocandin scaffold.

Jiang W, Cacho RA, Chiou G, Garg NK, Tang Y, Walsh CT.

J Am Chem Soc. 2013 Mar 20;135(11):4457-66. doi: 10.1021/ja312572v. Epub 2013 Mar 11.

38.

Complexity generation in fungal peptidyl alkaloid biosynthesis: a two-enzyme pathway to the hexacyclic MDR export pump inhibitor ardeemin.

Haynes SW, Gao X, Tang Y, Walsh CT.

ACS Chem Biol. 2013 Apr 19;8(4):741-8. doi: 10.1021/cb3006787. Epub 2013 Feb 6.

39.

Action and timing of BacC and BacD in the late stages of biosynthesis of the dipeptide antibiotic bacilysin.

Parker JB, Walsh CT.

Biochemistry. 2013 Feb 5;52(5):889-901. doi: 10.1021/bi3016229. Epub 2013 Jan 23.

40.

Codon randomization for rapid exploration of chemical space in thiopeptide antibiotic variants.

Young TS, Dorrestein PC, Walsh CT.

Chem Biol. 2012 Dec 21;19(12):1600-10. doi: 10.1016/j.chembiol.2012.10.013.

41.

Ribosomally synthesized and post-translationally modified peptide natural products: overview and recommendations for a universal nomenclature.

Arnison PG, Bibb MJ, Bierbaum G, Bowers AA, Bugni TS, Bulaj G, Camarero JA, Campopiano DJ, Challis GL, Clardy J, Cotter PD, Craik DJ, Dawson M, Dittmann E, Donadio S, Dorrestein PC, Entian KD, Fischbach MA, Garavelli JS, Göransson U, Gruber CW, Haft DH, Hemscheidt TK, Hertweck C, Hill C, Horswill AR, Jaspars M, Kelly WL, Klinman JP, Kuipers OP, Link AJ, Liu W, Marahiel MA, Mitchell DA, Moll GN, Moore BS, Müller R, Nair SK, Nes IF, Norris GE, Olivera BM, Onaka H, Patchett ML, Piel J, Reaney MJ, Rebuffat S, Ross RP, Sahl HG, Schmidt EW, Selsted ME, Severinov K, Shen B, Sivonen K, Smith L, Stein T, Süssmuth RD, Tagg JR, Tang GL, Truman AW, Vederas JC, Walsh CT, Walton JD, Wenzel SC, Willey JM, van der Donk WA.

Nat Prod Rep. 2013 Jan;30(1):108-60. doi: 10.1039/c2np20085f. Review.

42.

A backup plan for self-protection: S-methylation of holomycin biosynthetic intermediates in Streptomyces clavuligerus.

Li B, Forseth RR, Bowers AA, Schroeder FC, Walsh CT.

Chembiochem. 2012 Nov 26;13(17):2521-6. doi: 10.1002/cbic.201200536. Epub 2012 Oct 24.

43.

Flavoenzymes: versatile catalysts in biosynthetic pathways.

Walsh CT, Wencewicz TA.

Nat Prod Rep. 2013 Jan;30(1):175-200. doi: 10.1039/c2np20069d. Review.

44.

Assembly of asperlicin peptidyl alkaloids from anthranilate and tryptophan: a two-enzyme pathway generates heptacyclic scaffold complexity in asperlicin E.

Haynes SW, Gao X, Tang Y, Walsh CT.

J Am Chem Soc. 2012 Oct 24;134(42):17444-7. doi: 10.1021/ja308371z. Epub 2012 Oct 9.

45.

Identification and characterization of the echinocandin B biosynthetic gene cluster from Emericella rugulosa NRRL 11440.

Cacho RA, Jiang W, Chooi YH, Walsh CT, Tang Y.

J Am Chem Soc. 2012 Oct 10;134(40):16781-90. doi: 10.1021/ja307220z. Epub 2012 Oct 1.

46.

Pseudomonas syringae self-protection from tabtoxinine-β-lactam by ligase TblF and acetylase Ttr.

Wencewicz TA, Walsh CT.

Biochemistry. 2012 Oct 2;51(39):7712-25. doi: 10.1021/bi3011384. Epub 2012 Sep 19.

PMID:
22994681
47.

Distinct cell wall architectures in seed endosperms in representatives of the Brassicaceae and Solanaceae.

Lee KJ, Dekkers BJ, Steinbrecher T, Walsh CT, Bacic A, Bentsink L, Leubner-Metzger G, Knox JP.

Plant Physiol. 2012 Nov;160(3):1551-66. doi: 10.1104/pp.112.203661. Epub 2012 Sep 6.

48.

Cyclization of fungal nonribosomal peptides by a terminal condensation-like domain.

Gao X, Haynes SW, Ames BD, Wang P, Vien LP, Walsh CT, Tang Y.

Nat Chem Biol. 2012 Oct;8(10):823-30.

49.

An unusual role for a mobile flavin in StaC-like indolocarbazole biosynthetic enzymes.

Goldman PJ, Ryan KS, Hamill MJ, Howard-Jones AR, Walsh CT, Elliott SJ, Drennan CL.

Chem Biol. 2012 Jul 27;19(7):855-65. doi: 10.1016/j.chembiol.2012.05.016.

50.

Supplemental Content

Loading ...
Support Center