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Items: 1 to 50 of 225


Providing incentives to share data early in health emergencies: the role of journal editors.

Whitty CJ, Mundel T, Farrar J, Heymann DL, Davies SC, Walport MJ.

Lancet. 2015 Nov 7;386(10006):1797-8. doi: 10.1016/S0140-6736(15)00758-8. No abstract available.


Identification and characterization of a lupus suppressor 129 locus on chromosome 3.

Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT, Botto M.

J Immunol. 2010 Jun 1;184(11):6256-65. doi: 10.4049/jimmunol.0901463. Epub 2010 Apr 30.


SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience.

Mehta P, Norsworthy PJ, Hall AE, Kelly SJ, Walport MJ, Botto M, Pickering MC.

Rheumatology (Oxford). 2010 Apr;49(4):823-4. doi: 10.1093/rheumatology/kep387. Epub 2009 Dec 4. No abstract available.


A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.

Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT, Botto M.

Genes Immun. 2009 Jan;10(1):47-55. doi: 10.1038/gene.2008.78. Epub 2008 Oct 9.


Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walport MJ, Botto M.

Arthritis Rheum. 2008 Jul;58(7):2131-41. doi: 10.1002/art.23553.


Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

Rose KL, Paixao-Cavalcante D, Fish J, Manderson AP, Malik TH, Bygrave AE, Lin T, Sacks SH, Walport MJ, Cook HT, Botto M, Pickering MC.

J Clin Invest. 2008 Feb;118(2):608-18. doi: 10.1172/JCI32525.


C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT, Botto M.

Mol Immunol. 2008 Feb;45(3):787-95. Epub 2007 Aug 1.


Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.

Pickering MC, de Jorge EG, Martinez-Barricarte R, Recalde S, Garcia-Layana A, Rose KL, Moss J, Walport MJ, Cook HT, de Córdoba SR, Botto M.

J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21.


Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.

Ferry H, Potter PK, Crockford TL, Nijnik A, Ehrenstein MR, Walport MJ, Botto M, Cornall RJ.

J Immunol. 2007 Mar 1;178(5):2916-22.


Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice.

Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT, Botto M.

J Immunol. 2007 Feb 15;178(4):2352-60.


A novel mechanism for complement activation at the surface of B cells following antigen binding.

Manderson AP, Quah B, Botto M, Goodnow CC, Walport MJ, Parish CR.

J Immunol. 2006 Oct 15;177(8):5155-62.


Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus.

Heidari Y, Bygrave AE, Rigby RJ, Rose KL, Walport MJ, Cook HT, Vyse TJ, Botto M.

Genes Immun. 2006 Oct;7(7):592-9. Epub 2006 Aug 31.


Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.

Pickering MC, Warren J, Rose KL, Carlucci F, Wang Y, Walport MJ, Cook HT, Botto M.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9649-54. Epub 2006 Jun 12.


The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.

Manderson AP, Carlucci F, Lachmann PJ, Lazarus RA, Festenstein RJ, Cook HT, Walport MJ, Botto M.

Arthritis Res Ther. 2006;8(3):R68. Epub 2006 Apr 10.


Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes.

Haywood ME, Rose SJ, Horswell S, Lees MJ, Fu G, Walport MJ, Morley BJ.

Genes Immun. 2006 Apr;7(3):250-63.


Research funding, partnership and strategy - a UK perspective.

Walport MJ, Lynn DW.

Nat Rev Mol Cell Biol. 2005 Apr;6(4):341-4. doi: 10.1038/nrm1617. Review.


Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice.

Cortes-Hernandez J, Fossati-Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT, Botto M.

Eur J Immunol. 2004 Dec;34(12):3713-22.


Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.

Haywood ME, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ, Morley BJ.

J Immunol. 2004 Oct 1;173(7):4277-85.


CD59a deficiency exacerbates ischemia-reperfusion injury in mice.

Turnberg D, Botto M, Lewis M, Zhou W, Sacks SH, Morgan BP, Walport MJ, Cook HT.

Am J Pathol. 2004 Sep;165(3):825-32.


Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.

Bygrave AE, Rose KL, Cortes-Hernandez J, Warren J, Rigby RJ, Cook HT, Walport MJ, Vyse TJ, Botto M.

PLoS Biol. 2004 Aug;2(8):E243. Epub 2004 Aug 17.


Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice.

Trendelenburg M, Manderson AP, Fossati-Jimack L, Walport MJ, Botto M.

Immunology. 2004 Sep;113(1):80-8.


The role of complement in the development of systemic lupus erythematosus.

Manderson AP, Botto M, Walport MJ.

Annu Rev Immunol. 2004;22:431-56. Review.


Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.

Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ, Botto M.

J Immunol. 2004 Mar 15;172(6):3406-14.


Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

Russell AI, Cunninghame Graham DS, Shepherd C, Roberton CA, Whittaker J, Meeks J, Powell RJ, Isenberg DA, Walport MJ, Vyse TJ.

Hum Mol Genet. 2004 Jan 1;13(1):137-47. Epub 2003 Nov 25.


CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice.

Turnberg D, Botto M, Warren J, Morgan BP, Walport MJ, Cook HT.

J Am Soc Nephrol. 2003 Sep;14(9):2271-9.


Antibody-mediated glomerulonephritis in mice: the role of endotoxin, complement and genetic background.

Robson MG, Cook HT, Pusey CD, Walport MJ, Davies KA.

Clin Exp Immunol. 2003 Sep;133(3):326-33.


Both Fcgamma receptor I and Fcgamma receptor III mediate disease in accelerated nephrotoxic nephritis.

Tarzi RM, Davies KA, Claassens JW, Verbeek JS, Walport MJ, Cook HT.

Am J Pathol. 2003 May;162(5):1677-83.


Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells.

Potter PK, Cortes-Hernandez J, Quartier P, Botto M, Walport MJ.

J Immunol. 2003 Mar 15;170(6):3223-32.


The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.

Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto M.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16969-74. Epub 2002 Dec 11.


Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms.

Cortes-Hernandez J, Fossati-Jimack L, Carugati A, Potter PK, Walport MJ, Cook HT, Botto M.

Clin Exp Immunol. 2002 Dec;130(3):459-66.


Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells.

Tarzi RM, Davies KA, Robson MG, Fossati-Jimack L, Saito T, Walport MJ, Cook HT.

Kidney Int. 2002 Dec;62(6):2087-96.


C1q, autoimmunity and apoptosis.

Botto M, Walport MJ.

Immunobiology. 2002 Sep;205(4-5):395-406. Review.


Role of surfactant proteins A, D, and C1q in the clearance of apoptotic cells in vivo and in vitro: calreticulin and CD91 as a common collectin receptor complex.

Vandivier RW, Ogden CA, Fadok VA, Hoffmann PR, Brown KK, Botto M, Walport MJ, Fisher JH, Henson PM, Greene KE.

J Immunol. 2002 Oct 1;169(7):3978-86.


The follicular dendritic cell restricted epitope, FDC-M2, is complement C4; localization of immune complexes in mouse tissues.

Taylor PR, Pickering MC, Kosco-Vilbois MH, Walport MJ, Botto M, Gordon S, Martinez-Pomares L.

Eur J Immunol. 2002 Jul;32(7):1888-96.


Complement and systemic lupus erythematosus.

Walport MJ.

Arthritis Res. 2002;4 Suppl 3:S279-93. Epub 2002 May 9. Review.


Uncontrolled C3 activation causes membranoproliferative glomerulonephritis in mice deficient in complement factor H.

Pickering MC, Cook HT, Warren J, Bygrave AE, Moss J, Walport MJ, Botto M.

Nat Genet. 2002 Aug;31(4):424-8. Epub 2002 Jul 1.


Defective Fc-dependent processing of immune complexes in patients with systemic lupus erythematosus.

Davies KA, Robson MG, Peters AM, Norsworthy P, Nash JT, Walport MJ.

Arthritis Rheum. 2002 Apr;46(4):1028-38.


Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody.

Azeredo da Silveira S, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M, Izui S.

J Exp Med. 2002 Mar 18;195(6):665-72.


C1q deficiency and autoimmunity: the effects of genetic background on disease expression.

Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M, Walport MJ.

J Immunol. 2002 Mar 1;168(5):2538-43.


Increased susceptibility of C1q-deficient mice to Salmonella enterica serovar Typhimurium infection.

Warren J, Mastroeni P, Dougan G, Noursadeghi M, Cohen J, Walport MJ, Botto M.

Infect Immun. 2002 Feb;70(2):551-7.


Reconstitution of the complement function in C1q-deficient (C1qa-/-) mice with wild-type bone marrow cells.

Petry F, Botto M, Holtappels R, Walport MJ, Loos M.

J Immunol. 2001 Oct 1;167(7):4033-7.


Continual low-level activation of the classical complement pathway.

Manderson AP, Pickering MC, Botto M, Walport MJ, Parish CR.

J Exp Med. 2001 Sep 17;194(6):747-56.


Intact B cell tolerance in the absence of the first component of the classical complement pathway.

Cutler AJ, Cornall RJ, Ferry H, Manderson AP, Botto M, Walport MJ.

Eur J Immunol. 2001 Jul;31(7):2087-93.


Ultraviolet-radiation-induced keratinocyte apoptosis in C1q-deficient mice.

Pickering MC, Fischer S, Lewis MR, Walport MJ, Botto M, Cook HT.

J Invest Dermatol. 2001 Jul;117(1):52-8.


Targeted deletion of the CD59 gene causes spontaneous intravascular hemolysis and hemoglobinuria.

Holt DS, Botto M, Bygrave AE, Hanna SM, Walport MJ, Morgan BP.

Blood. 2001 Jul 15;98(2):442-9.


Pathogenesis of systemic lupus erythematosus (SLE).

Robson MG, Walport MJ.

Clin Exp Allergy. 2001 May;31(5):678-85. Review. No abstract available.


Accelerated nephrotoxic nephritis is exacerbated in C1q-deficient mice.

Robson MG, Cook HT, Botto M, Taylor PR, Busso N, Salvi R, Pusey CD, Walport MJ, Davies KA.

J Immunol. 2001 Jun 1;166(11):6820-8.

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