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Items: 1 to 50 of 259


Computational modelling for decision-making: where, why, what, who and how.

Calder M, Craig C, Culley D, de Cani R, Donnelly CA, Douglas R, Edmonds B, Gascoigne J, Gilbert N, Hargrove C, Hinds D, Lane DC, Mitchell D, Pavey G, Robertson D, Rosewell B, Sherwin S, Walport M, Wilson A.

R Soc Open Sci. 2018 Jun 20;5(6):172096. doi: 10.1098/rsos.172096. eCollection 2018 Jun. Review.


Four principles to make evidence synthesis more useful for policy.

Donnelly CA, Boyd I, Campbell P, Craig C, Vallance P, Walport M, Whitty CJM, Woods E, Wormald C.

Nature. 2018 Jun;558(7710):361-364. doi: 10.1038/d41586-018-05414-4. No abstract available.


Harveian Oration 2015: Medicine, science and values - with hindsight and foresight.

Walport M.

Clin Med (Lond). 2016 Apr;16(2):164-70. doi: 10.7861/clinmedicine.16-2-164. No abstract available.


Providing incentives to share data early in health emergencies: the role of journal editors.

Whitty CJ, Mundel T, Farrar J, Heymann DL, Davies SC, Walport MJ.

Lancet. 2015 Nov 7;386(10006):1797-8. doi: 10.1016/S0140-6736(15)00758-8. No abstract available.


A database on global health research in Africa.

Collins F, Beaudet A, Draghia-Akli R, Gruss P, Savill J, Syrota A, Dautry A, Ulfendahl M, Walport M, Onken J, Glass RI.

Lancet Glob Health. 2013 Aug;1(2):e64-e65. doi: 10.1016/S2214-109X(13)70012-3. Epub 2013 Jul 5. No abstract available.


Newsmaker interview: Mark Walport. U.K. science adviser faces emotionally charged issues and uncertain science.

Walport M.

Science. 2013 Oct 25;342(6157):412. doi: 10.1126/science.342.6157.412. No abstract available.


Mark Walport: government's Wellcome new source of advice. Interviewed by Tony Delamothe.

Walport M.

BMJ. 2013 May 3;346:f2821. doi: 10.1136/bmj.f2821. No abstract available.


Accelerating the development of a safe and effective HIV vaccine: HIV vaccine case study for the Decade of Vaccines.

Koff WC, Russell ND, Walport M, Feinberg MB, Shiver JW, Karim SA, Walker BD, McGlynn MG, Nweneka CV, Nabel GJ.

Vaccine. 2013 Apr 18;31 Suppl 2:B204-8. doi: 10.1016/j.vaccine.2012.10.115. Review.


New models for large prospective studies: is there a better way?

Manolio TA, Weis BK, Cowie CC, Hoover RN, Hudson K, Kramer BS, Berg C, Collins R, Ewart W, Gaziano JM, Hirschfeld S, Marcus PM, Masys D, McCarty CA, McLaughlin J, Patel AV, Peakman T, Pedersen NL, Schaefer C, Scott JA, Sprosen T, Walport M, Collins FS.

Am J Epidemiol. 2012 May 1;175(9):859-66. doi: 10.1093/aje/kwr453. Epub 2012 Mar 12.


Medical research: No catch to UK charity funding.

Walport M, Foulkes I, Weissberg P, Morgan D, Nebhrajani S.

Nature. 2012 Feb 15;482(7385):308. doi: 10.1038/482308a. No abstract available.


Grand challenges in global mental health.

Collins PY, Patel V, Joestl SS, March D, Insel TR, Daar AS; Scientific Advisory Board and the Executive Committee of the Grand Challenges on Global Mental Health, Anderson W, Dhansay MA, Phillips A, Shurin S, Walport M, Ewart W, Savill SJ, Bordin IA, Costello EJ, Durkin M, Fairburn C, Glass RI, Hall W, Huang Y, Hyman SE, Jamison K, Kaaya S, Kapur S, Kleinman A, Ogunniyi A, Otero-Ojeda A, Poo MM, Ravindranath V, Sahakian BJ, Saxena S, Singer PA, Stein DJ.

Nature. 2011 Jul 6;475(7354):27-30. doi: 10.1038/475027a. No abstract available.


Science as a public enterprise: the case for open data.

Boulton G, Rawlins M, Vallance P, Walport M.

Lancet. 2011 May 14;377(9778):1633-5. doi: 10.1016/S0140-6736(11)60647-8. No abstract available.


Sharing research data to improve public health.

Walport M, Brest P.

Lancet. 2011 Feb 12;377(9765):537-9. doi: 10.1016/S0140-6736(10)62234-9. Epub 2011 Jan 7. No abstract available.


Do summary care records have the potential to do more harm than good? No.

Walport M.

BMJ. 2010 Jun 16;340:c3022. doi: 10.1136/bmj.c3022. No abstract available.


Identification and characterization of a lupus suppressor 129 locus on chromosome 3.

Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT, Botto M.

J Immunol. 2010 Jun 1;184(11):6256-65. doi: 10.4049/jimmunol.0901463. Epub 2010 Apr 30.


Funding scientific discovery: an interview with Sir Mark Walport. Interviewed by Kristin H. Kain.

Walport M.

Dis Model Mech. 2010 May-Jun;3(5-6):265-7. doi: 10.1242/dmm.005710.


SLE with C1q deficiency treated with fresh frozen plasma: a 10-year experience.

Mehta P, Norsworthy PJ, Hall AE, Kelly SJ, Walport MJ, Botto M, Pickering MC.

Rheumatology (Oxford). 2010 Apr;49(4):823-4. doi: 10.1093/rheumatology/kep387. Epub 2009 Dec 4. No abstract available.


Looking for landmarks: the role of expert review and bibliometric analysis in evaluating scientific publication outputs.

Allen L, Jones C, Dolby K, Lynn D, Walport M.

PLoS One. 2009 Jun 18;4(6):e5910. doi: 10.1371/journal.pone.0005910.


Strengthening capacity for health research in Africa.

Whitworth JA, Kokwaro G, Kinyanjui S, Snewin VA, Tanner M, Walport M, Sewankambo N.

Lancet. 2008 Nov 1;372(9649):1590-3. doi: 10.1016/S0140-6736(08)61660-8. No abstract available.


A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice.

Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT, Botto M.

Genes Immun. 2009 Jan;10(1):47-55. doi: 10.1038/gene.2008.78. Epub 2008 Oct 9.


Ready for avian flu?

Yamada T, Dautry A, Walport M.

Nature. 2008 Jul 10;454(7201):162. doi: 10.1038/454162a. No abstract available.


Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice.

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walport MJ, Botto M.

Arthritis Rheum. 2008 Jul;58(7):2131-41. doi: 10.1002/art.23553.


Factor I is required for the development of membranoproliferative glomerulonephritis in factor H-deficient mice.

Rose KL, Paixao-Cavalcante D, Fish J, Manderson AP, Malik TH, Bygrave AE, Lin T, Sacks SH, Walport MJ, Cook HT, Botto M, Pickering MC.

J Clin Invest. 2008 Feb;118(2):608-18. doi: 10.1172/JCI32525.


C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice.

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT, Botto M.

Mol Immunol. 2008 Feb;45(3):787-95. Epub 2007 Aug 1.


Spontaneous hemolytic uremic syndrome triggered by complement factor H lacking surface recognition domains.

Pickering MC, de Jorge EG, Martinez-Barricarte R, Recalde S, Garcia-Layana A, Rose KL, Moss J, Walport MJ, Cook HT, de Córdoba SR, Botto M.

J Exp Med. 2007 Jun 11;204(6):1249-56. Epub 2007 May 21.


Increased positive selection of B1 cells and reduced B cell tolerance to intracellular antigens in c1q-deficient mice.

Ferry H, Potter PK, Crockford TL, Nijnik A, Ehrenstein MR, Walport MJ, Botto M, Cornall RJ.

J Immunol. 2007 Mar 1;178(5):2916-22.


Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice.

Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT, Botto M.

J Immunol. 2007 Feb 15;178(4):2352-60.


A novel mechanism for complement activation at the surface of B cells following antigen binding.

Manderson AP, Quah B, Botto M, Goodnow CC, Walport MJ, Parish CR.

J Immunol. 2006 Oct 15;177(8):5155-62.


Open access, UK PubMed Central and the Wellcome Trust.

Walport M, Kiley R.

J R Soc Med. 2006 Sep;99(9):438-9. No abstract available.


Identification of chromosome intervals from 129 and C57BL/6 mouse strains linked to the development of systemic lupus erythematosus.

Heidari Y, Bygrave AE, Rigby RJ, Rose KL, Walport MJ, Cook HT, Vyse TJ, Botto M.

Genes Immun. 2006 Oct;7(7):592-9. Epub 2006 Aug 31.


Prevention of C5 activation ameliorates spontaneous and experimental glomerulonephritis in factor H-deficient mice.

Pickering MC, Warren J, Rose KL, Carlucci F, Wang Y, Walport MJ, Cook HT, Botto M.

Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9649-54. Epub 2006 Jun 12.


The in vivo expression of actin/salt-resistant hyperactive DNase I inhibits the development of anti-ssDNA and anti-histone autoantibodies in a murine model of systemic lupus erythematosus.

Manderson AP, Carlucci F, Lachmann PJ, Lazarus RA, Festenstein RJ, Cook HT, Walport MJ, Botto M.

Arthritis Res Ther. 2006;8(3):R68. Epub 2006 Apr 10.


The future of clinical pharmacology in the UK.

Breckenridge A, Dollery C, Rawlins M, Walport M.

Lancet. 2006 Apr 1;367(9516):1051. doi: 10.1016/S0140-6736(06)68460-2. No abstract available.


Overlapping BXSB congenic intervals, in combination with microarray gene expression, reveal novel lupus candidate genes.

Haywood ME, Rose SJ, Horswell S, Lees MJ, Fu G, Walport MJ, Morley BJ.

Genes Immun. 2006 Apr;7(3):250-63.


Research funding, partnership and strategy - a UK perspective.

Walport MJ, Lynn DW.

Nat Rev Mol Cell Biol. 2005 Apr;6(4):341-4. doi: 10.1038/nrm1617. Review.


"The difficult art of giving".

Walport M.

Trans Med Soc Lond. 2005-2006;122:29-56. No abstract available.


Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice.

Cortes-Hernandez J, Fossati-Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT, Botto M.

Eur J Immunol. 2004 Dec;34(12):3713-22.


Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease.

Haywood ME, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ, Morley BJ.

J Immunol. 2004 Oct 1;173(7):4277-85.


CD59a deficiency exacerbates ischemia-reperfusion injury in mice.

Turnberg D, Botto M, Lewis M, Zhou W, Sacks SH, Morgan BP, Walport MJ, Cook HT.

Am J Pathol. 2004 Sep;165(3):825-32.


Spontaneous autoimmunity in 129 and C57BL/6 mice-implications for autoimmunity described in gene-targeted mice.

Bygrave AE, Rose KL, Cortes-Hernandez J, Warren J, Rigby RJ, Cook HT, Walport MJ, Vyse TJ, Botto M.

PLoS Biol. 2004 Aug;2(8):E243. Epub 2004 Aug 17.


Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice.

Trendelenburg M, Manderson AP, Fossati-Jimack L, Walport MJ, Botto M.

Immunology. 2004 Sep;113(1):80-8.


The role of complement in the development of systemic lupus erythematosus.

Manderson AP, Botto M, Walport MJ.

Annu Rev Immunol. 2004;22:431-56. Review.


Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.

Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ, Botto M.

J Immunol. 2004 Mar 15;172(6):3406-14.


Polymorphism at the C-reactive protein locus influences gene expression and predisposes to systemic lupus erythematosus.

Russell AI, Cunninghame Graham DS, Shepherd C, Roberton CA, Whittaker J, Meeks J, Powell RJ, Isenberg DA, Walport MJ, Vyse TJ.

Hum Mol Genet. 2004 Jan 1;13(1):137-47. Epub 2003 Nov 25.


CD59a deficiency exacerbates accelerated nephrotoxic nephritis in mice.

Turnberg D, Botto M, Warren J, Morgan BP, Walport MJ, Cook HT.

J Am Soc Nephrol. 2003 Sep;14(9):2271-9.


Antibody-mediated glomerulonephritis in mice: the role of endotoxin, complement and genetic background.

Robson MG, Cook HT, Pusey CD, Walport MJ, Davies KA.

Clin Exp Immunol. 2003 Sep;133(3):326-33.


Both Fcgamma receptor I and Fcgamma receptor III mediate disease in accelerated nephrotoxic nephritis.

Tarzi RM, Davies KA, Claassens JW, Verbeek JS, Walport MJ, Cook HT.

Am J Pathol. 2003 May;162(5):1677-83.


Lupus-prone mice have an abnormal response to thioglycolate and an impaired clearance of apoptotic cells.

Potter PK, Cortes-Hernandez J, Quartier P, Botto M, Walport MJ.

J Immunol. 2003 Mar 15;170(6):3223-32.


The classical pathway is the dominant complement pathway required for innate immunity to Streptococcus pneumoniae infection in mice.

Brown JS, Hussell T, Gilliland SM, Holden DW, Paton JC, Ehrenstein MR, Walport MJ, Botto M.

Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16969-74. Epub 2002 Dec 11.

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