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Items: 21

1.

Protein Chemistry Looking Ahead: 8th Chemical Protein Synthesis Meeting 16-19 June 2019, Berlin, Germany.

Bello C, Hartrampf N, Walport LJ, Conibear AC.

Cell Chem Biol. 2019 Oct 17;26(10):1349-1354. doi: 10.1016/j.chembiol.2019.09.011.

PMID:
31626782
2.

Mechanistic and structural studies of KDM-catalysed demethylation of histone 1 isotype 4 at lysine 26.

Walport LJ, Hopkinson RJ, Chowdhury R, Zhang Y, Bonnici J, Schiller R, Kawamura A, Schofield CJ.

FEBS Lett. 2018 Oct;592(19):3264-3273. doi: 10.1002/1873-3468.13231. Epub 2018 Sep 14.

3.

Adventures in Defining Roles of Oxygenases in the Regulation of Protein Biosynthesis.

Walport LJ, Schofield CJ.

Chem Rec. 2018 Dec;18(12):1760-1781. doi: 10.1002/tcr.201800056. Epub 2018 Aug 27. Review.

PMID:
30151867
4.

Human histone demethylase KDM6B can catalyse sequential oxidations.

Hopkinson RJ, Langley GW, Belle R, Walport LJ, Dunne K, Münzel M, Salah E, Kawamura A, Claridge TDW, Schofield CJ.

Chem Commun (Camb). 2018 Jul 12;54(57):7975-7978. doi: 10.1039/c8cc04057e.

5.

Strategies for transitioning macrocyclic peptides to cell-permeable drug leads.

Walport LJ, Obexer R, Suga H.

Curr Opin Biotechnol. 2017 Dec;48:242-250. doi: 10.1016/j.copbio.2017.07.007. Epub 2017 Aug 5. Review.

PMID:
28783603
6.

Highly selective inhibition of histone demethylases by de novo macrocyclic peptides.

Kawamura A, Münzel M, Kojima T, Yapp C, Bhushan B, Goto Y, Tumber A, Katoh T, King ON, Passioura T, Walport LJ, Hatch SB, Madden S, Müller S, Brennan PE, Chowdhury R, Hopkinson RJ, Suga H, Schofield CJ.

Nat Commun. 2017 Apr 6;8:14773. doi: 10.1038/ncomms14773.

7.

Exploring sequence space: harnessing chemical and biological diversity towards new peptide leads.

Obexer R, Walport LJ, Suga H.

Curr Opin Chem Biol. 2017 Jun;38:52-61. doi: 10.1016/j.cbpa.2017.02.020. Epub 2017 Mar 17. Review.

PMID:
28319812
8.

Arginine demethylation is catalysed by a subset of JmjC histone lysine demethylases.

Walport LJ, Hopkinson RJ, Chowdhury R, Schiller R, Ge W, Kawamura A, Schofield CJ.

Nat Commun. 2016 Jun 23;7:11974. doi: 10.1038/ncomms11974.

9.

Analysis of JmjC Demethylase-Catalyzed Demethylation Using Geometrically-Constrained Lysine Analogues.

Langley GW, Brinkø A, Münzel M, Walport LJ, Schofield CJ, Hopkinson RJ.

ACS Chem Biol. 2016 Mar 18;11(3):755-62. doi: 10.1021/acschembio.5b00738. Epub 2015 Nov 25.

PMID:
26555343
10.

Betti reaction enables efficient synthesis of 8-hydroxyquinoline inhibitors of 2-oxoglutarate oxygenases.

Thinnes CC, Tumber A, Yapp C, Scozzafava G, Yeh T, Chan MC, Tran TA, Hsu K, Tarhonskaya H, Walport LJ, Wilkins SE, Martinez ED, Müller S, Pugh CW, Ratcliffe PJ, Brennan PE, Kawamura A, Schofield CJ.

Chem Commun (Camb). 2015 Oct 28;51(84):15458-61. doi: 10.1039/c5cc06095h.

PMID:
26345662
11.

Epigenetic regulation by histone demethylases in hypoxia.

Hancock RL, Dunne K, Walport LJ, Flashman E, Kawamura A.

Epigenomics. 2015 Aug;7(5):791-811. doi: 10.2217/epi.15.24. Epub 2015 Apr 2. Review.

12.

Studies on the catalytic domains of multiple JmjC oxygenases using peptide substrates.

Williams ST, Walport LJ, Hopkinson RJ, Madden SK, Chowdhury R, Schofield CJ, Kawamura A.

Epigenetics. 2014 Dec;9(12):1596-603. doi: 10.4161/15592294.2014.983381.

13.

(1)H, (13)C, and (15)N resonance assignments for the tandem PHD finger motifs of human CHD4.

Walport LJ, Morra R, Mancini EJ, Redfield C.

Biomol NMR Assign. 2015 Oct;9(2):239-42. doi: 10.1007/s12104-014-9582-y. Epub 2014 Oct 18.

14.

Human UTY(KDM6C) is a male-specific Nϵ-methyl lysyl demethylase.

Walport LJ, Hopkinson RJ, Vollmar M, Madden SK, Gileadi C, Oppermann U, Schofield CJ, Johansson C.

J Biol Chem. 2014 Jun 27;289(26):18302-13. doi: 10.1074/jbc.M114.555052. Epub 2014 May 5.

15.

Total synthesis of the antitumor antibiotic (±)-streptonigrin: first- and second-generation routes for de novo pyridine formation using ring-closing metathesis.

Donohoe TJ, Jones CR, Kornahrens AF, Barbosa LC, Walport LJ, Tatton MR, O'Hagan M, Rathi AH, Baker DB.

J Org Chem. 2013 Dec 20;78(24):12338-50. doi: 10.1021/jo402388f. Epub 2013 Dec 12.

16.

5-Carboxy-8-hydroxyquinoline is a Broad Spectrum 2-Oxoglutarate Oxygenase Inhibitor which Causes Iron Translocation.

Hopkinson RJ, Tumber A, Yapp C, Chowdhury R, Aik W, Che KH, Li XS, Kristensen JBL, King ONF, Chan MC, Yeoh KK, Choi H, Walport LJ, Thinnes CC, Bush JT, Lejeune C, Rydzik AM, Rose NR, Bagg EA, McDonough MA, Krojer T, Yue WW, Ng SS, Olsen L, Brennan PE, Oppermann U, Muller-Knapp S, Klose RJ, Ratcliffe PJ, Schofield CJ, Kawamura A.

Chem Sci. 2013 Aug 1;4(8):3110-3117. doi: 10.1039/C3SC51122G.

17.

Is JmjC oxygenase catalysis limited to demethylation?

Hopkinson RJ, Walport LJ, Münzel M, Rose NR, Smart TJ, Kawamura A, Claridge TD, Schofield CJ.

Angew Chem Int Ed Engl. 2013 Jul 22;52(30):7709-13. doi: 10.1002/anie.201303282. Epub 2013 Jun 20.

18.

Mechanisms of human histone and nucleic acid demethylases.

Walport LJ, Hopkinson RJ, Schofield CJ.

Curr Opin Chem Biol. 2012 Dec;16(5-6):525-34. doi: 10.1016/j.cbpa.2012.09.015. Epub 2012 Oct 10. Review.

PMID:
23063108
19.

Plant growth regulator daminozide is a selective inhibitor of human KDM2/7 histone demethylases.

Rose NR, Woon EC, Tumber A, Walport LJ, Chowdhury R, Li XS, King ON, Lejeune C, Ng SS, Krojer T, Chan MC, Rydzik AM, Hopkinson RJ, Che KH, Daniel M, Strain-Damerell C, Gileadi C, Kochan G, Leung IK, Dunford J, Yeoh KK, Ratcliffe PJ, Burgess-Brown N, von Delft F, Muller S, Marsden B, Brennan PE, McDonough MA, Oppermann U, Klose RJ, Schofield CJ, Kawamura A.

J Med Chem. 2012 Jul 26;55(14):6639-43. doi: 10.1021/jm300677j. Epub 2012 Jul 11.

20.

Dynamic combinatorial mass spectrometry leads to inhibitors of a 2-oxoglutarate-dependent nucleic acid demethylase.

Woon EC, Demetriades M, Bagg EA, Aik W, Krylova SM, Ma JH, Chan M, Walport LJ, Wegman DW, Dack KN, McDonough MA, Krylov SN, Schofield CJ.

J Med Chem. 2012 Mar 8;55(5):2173-84. doi: 10.1021/jm201417e. Epub 2012 Feb 22.

PMID:
22263962
21.

Linking of 2-oxoglutarate and substrate binding sites enables potent and highly selective inhibition of JmjC histone demethylases.

Woon EC, Tumber A, Kawamura A, Hillringhaus L, Ge W, Rose NR, Ma JH, Chan MC, Walport LJ, Che KH, Ng SS, Marsden BD, Oppermann U, McDonough MA, Schofield CJ.

Angew Chem Int Ed Engl. 2012 Feb 13;51(7):1631-4. doi: 10.1002/anie.201107833. Epub 2012 Jan 12. No abstract available.

PMID:
22241642

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