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Items: 42

1.

Inflammation and Hypoxia: HIF and PHD Isoform Selectivity.

Watts ER, Walmsley SR.

Trends Mol Med. 2019 Jan;25(1):33-46. doi: 10.1016/j.molmed.2018.10.006. Epub 2018 Nov 12. Review.

PMID:
30442494
2.

The role of neutrophils in cancer.

Grecian R, Whyte MKB, Walmsley SR.

Br Med Bull. 2018 Dec 1;128(1):5-14. doi: 10.1093/bmb/ldy029.

3.

Getting DAMP(s) Wets the Whistle for Neutrophil Recruitment.

Watts ER, Walmsley SR.

Immunity. 2018 May 15;48(5):846-848. doi: 10.1016/j.immuni.2018.04.027.

PMID:
29768171
4.

Opsonic Phagocytosis in Chronic Obstructive Pulmonary Disease Is Enhanced by Nrf2 Agonists.

Bewley MA, Budd RC, Ryan E, Cole J, Collini P, Marshall J, Kolsum U, Beech G, Emes RD, Tcherniaeva I, Berbers GAM, Walmsley SR, Donaldson G, Wedzicha JA, Kilty I, Rumsey W, Sanchez Y, Brightling CE, Donnelly LE, Barnes PJ, Singh D, Whyte MKB, Dockrell DH; COPDMAP.

Am J Respir Crit Care Med. 2018 Sep 15;198(6):739-750. doi: 10.1164/rccm.201705-0903OC.

5.

Pseudomonas expression of an oxygen sensing prolyl hydroxylase homologue regulates neutrophil host responses in vitro and in vivo.

Dickinson RS, Murphy F, Doherty C, Williams S, Mirchandani A, Willson J, Scotti JS, Preston G, Schofield CJ, Whyte MKB, Walmsley SR.

Wellcome Open Res. 2017 Oct 26;2:104. doi: 10.12688/wellcomeopenres.12871.1. eCollection 2017.

6.

Prolyl hydroxylase 2 inactivation enhances glycogen storage and promotes excessive neutrophilic responses.

Sadiku P, Willson JA, Dickinson RS, Murphy F, Harris AJ, Lewis A, Sammut D, Mirchandani AS, Ryan E, Watts ER, Thompson AAR, Marriott HM, Dockrell DH, Taylor CT, Schneider M, Maxwell PH, Chilvers ER, Mazzone M, Moral V, Pugh CW, Ratcliffe PJ, Schofield CJ, Ghesquiere B, Carmeliet P, Whyte MK, Walmsley SR.

J Clin Invest. 2017 Sep 1;127(9):3407-3420. doi: 10.1172/JCI90848. Epub 2017 Aug 14.

7.

Hypoxia determines survival outcomes of bacterial infection through HIF-1alpha dependent re-programming of leukocyte metabolism.

Thompson AA, Dickinson RS, Murphy F, Thomson JP, Marriott HM, Tavares A, Willson J, Williams L, Lewis A, Mirchandani A, Dos Santos Coelho P, Doherty C, Ryan E, Watts E, Morton NM, Forbes S, Stimson RH, Hameed AG, Arnold N, Preston JA, Lawrie A, Finisguerra V, Mazzone M, Sadiku P, Goveia J, Taverna F, Carmeliet P, Foster SJ, Chilvers ER, Cowburn AS, Dockrell DH, Johnson RS, Meehan RR, Whyte MK, Walmsley SR.

Sci Immunol. 2017 Feb 10;2(8). pii: eaal2861. doi: 10.1126/sciimmunol.aal2861.

8.

Hypoxia and host pathogen responses.

Walmsley SR, Rupp J.

Microbes Infect. 2017 Mar;19(3):143. doi: 10.1016/j.micinf.2017.01.006. Epub 2017 Jan 20. No abstract available.

PMID:
28115212
9.

Mutations in succinate dehydrogenase B (SDHB) enhance neutrophil survival independent of HIF-1α expression.

Jones R, McDonald KE, Willson JA, Ghesquière B, Sammut D, Daniel E, Harris AJ, Lewis A, Thompson AA, Dickinson RS, Plant T, Murphy F, Sadiku P, Keevil BG, Carmeliet P, Whyte MK, Newell-Price J, Walmsley SR.

Blood. 2016 May 26;127(21):2641-4. doi: 10.1182/blood-2016-02-696922. Epub 2016 Mar 22. No abstract available.

10.

Exploring the HIFs, buts and maybes of hypoxia signalling in disease: lessons from zebrafish models.

Elks PM, Renshaw SA, Meijer AH, Walmsley SR, van Eeden FJ.

Dis Model Mech. 2015 Nov;8(11):1349-60. doi: 10.1242/dmm.021865. Review.

11.

The regulation of pulmonary inflammation by the hypoxia-inducible factor-hydroxylase oxygen-sensing pathway.

Whyte MK, Walmsley SR.

Ann Am Thorac Soc. 2014 Dec;11 Suppl 5:S271-6. doi: 10.1513/AnnalsATS.201403-108AW. Review.

12.

A local circadian clock calls time on lung inflammation.

Thompson AA, Walmsley SR, Whyte MK.

Nat Med. 2014 Aug;20(8):809-11. doi: 10.1038/nm.3649.

PMID:
25100521
13.

HIF-mediated innate immune responses: cell signaling and therapeutic implications.

Harris AJ, Thompson AR, Whyte MK, Walmsley SR.

Hypoxia (Auckl). 2014 May 24;2:47-58. eCollection 2014. Review.

14.

Neutrophil energetics and oxygen sensing.

Walmsley SR, Whyte MK.

Blood. 2014 May 1;123(18):2753-4. doi: 10.1182/blood-2014-03-560409.

15.

A zebrafish compound screen reveals modulation of neutrophil reverse migration as an anti-inflammatory mechanism.

Robertson AL, Holmes GR, Bojarczuk AN, Burgon J, Loynes CA, Chimen M, Sawtell AK, Hamza B, Willson J, Walmsley SR, Anderson SR, Coles MC, Farrow SN, Solari R, Jones S, Prince LR, Irimia D, Rainger GE, Kadirkamanathan V, Whyte MK, Renshaw SA.

Sci Transl Med. 2014 Feb 26;6(225):225ra29. doi: 10.1126/scitranslmed.3007672.

16.

Hypoxia inducible factor signaling modulates susceptibility to mycobacterial infection via a nitric oxide dependent mechanism.

Elks PM, Brizee S, van der Vaart M, Walmsley SR, van Eeden FJ, Renshaw SA, Meijer AH.

PLoS Pathog. 2013;9(12):e1003789. doi: 10.1371/journal.ppat.1003789. Epub 2013 Dec 19.

17.

Hypoxia-inducible factor 2α regulates key neutrophil functions in humans, mice, and zebrafish.

Thompson AA, Elks PM, Marriott HM, Eamsamarng S, Higgins KR, Lewis A, Williams L, Parmar S, Shaw G, McGrath EE, Formenti F, Van Eeden FJ, Kinnula VL, Pugh CW, Sabroe I, Dockrell DH, Chilvers ER, Robbins PA, Percy MJ, Simon MC, Johnson RS, Renshaw SA, Whyte MK, Walmsley SR.

Blood. 2014 Jan 16;123(3):366-76. doi: 10.1182/blood-2013-05-500207. Epub 2013 Nov 6.

18.

Cezanne regulates inflammatory responses to hypoxia in endothelial cells by targeting TRAF6 for deubiquitination.

Luong le A, Fragiadaki M, Smith J, Boyle J, Lutz J, Dean JL, Harten S, Ashcroft M, Walmsley SR, Haskard DO, Maxwell PH, Walczak H, Pusey C, Evans PC.

Circ Res. 2013 Jun 7;112(12):1583-91. doi: 10.1161/CIRCRESAHA.111.300119. Epub 2013 Apr 5.

PMID:
23564640
19.

Hypoxia, the HIF pathway and neutrophilic inflammatory responses.

Thompson AA, Binham J, Plant T, Whyte MK, Walmsley SR.

Biol Chem. 2013 Apr;394(4):471-7. doi: 10.1515/hsz-2012-0335. Review.

PMID:
23324383
20.

Functional redundancy of class I phosphoinositide 3-kinase (PI3K) isoforms in signaling growth factor-mediated human neutrophil survival.

Juss JK, Hayhoe RP, Owen CE, Bruce I, Walmsley SR, Cowburn AS, Kulkarni S, Boyle KB, Stephens L, Hawkins PT, Chilvers ER, Condliffe AM.

PLoS One. 2012;7(9):e45933. doi: 10.1371/journal.pone.0045933. Epub 2012 Sep 24.

21.

Roles of neutrophils in the regulation of the extent of human inflammation through delivery of IL-1 and clearance of chemokines.

Basran A, Jabeen M, Bingle L, Stokes CA, Dockrell DH, Whyte MK, Walmsley SR, Higgins KR, Vogel SN, Wilson HL, Prince LR, Prestwich EC, Sabroe RA, Parker LC, Sabroe I.

J Leukoc Biol. 2013 Jan;93(1):7-19. doi: 10.1189/jlb.0512250. Epub 2012 Aug 17.

22.

Loss of the oxygen sensor PHD3 enhances the innate immune response to abdominal sepsis.

Kiss J, Mollenhauer M, Walmsley SR, Kirchberg J, Radhakrishnan P, Niemietz T, Dudda J, Steinert G, Whyte MK, Carmeliet P, Mazzone M, Weitz J, Schneider M.

J Immunol. 2012 Aug 15;189(4):1955-65. doi: 10.4049/jimmunol.1103471. Epub 2012 Jul 11.

23.

A decoy receptor 3 analogue reduces localised defects in phagocyte function in pneumococcal pneumonia.

Marriott HM, Daigneault M, Thompson AA, Walmsley SR, Gill SK, Witcher DR, Wroblewski VJ, Hellewell PG, Whyte MK, Dockrell DH.

Thorax. 2012 Nov;67(11):985-92. doi: 10.1136/thoraxjnl-2012-201591. Epub 2012 Jun 26.

24.

Deficiency of tumour necrosis factor-related apoptosis-inducing ligand exacerbates lung injury and fibrosis.

McGrath EE, Lawrie A, Marriott HM, Mercer P, Cross SS, Arnold N, Singleton V, Thompson AA, Walmsley SR, Renshaw SA, Sabroe I, Chambers RC, Dockrell DH, Whyte MK.

Thorax. 2012 Sep;67(9):796-803. doi: 10.1136/thoraxjnl-2011-200863. Epub 2012 Apr 11.

25.

Activation of hypoxia-inducible factor-1α (Hif-1α) delays inflammation resolution by reducing neutrophil apoptosis and reverse migration in a zebrafish inflammation model.

Elks PM, van Eeden FJ, Dixon G, Wang X, Reyes-Aldasoro CC, Ingham PW, Whyte MK, Walmsley SR, Renshaw SA.

Blood. 2011 Jul 21;118(3):712-22. doi: 10.1182/blood-2010-12-324186. Epub 2011 May 9.

26.

Prolyl hydroxylase 3 (PHD3) is essential for hypoxic regulation of neutrophilic inflammation in humans and mice.

Walmsley SR, Chilvers ER, Thompson AA, Vaughan K, Marriott HM, Parker LC, Shaw G, Parmar S, Schneider M, Sabroe I, Dockrell DH, Milo M, Taylor CT, Johnson RS, Pugh CW, Ratcliffe PJ, Maxwell PH, Carmeliet P, Whyte MK.

J Clin Invest. 2011 Mar;121(3):1053-63. doi: 10.1172/JCI43273. Epub 2011 Feb 7.

27.

Hypoxia selectively inhibits respiratory burst activity and killing of Staphylococcus aureus in human neutrophils.

McGovern NN, Cowburn AS, Porter L, Walmsley SR, Summers C, Thompson AAR, Anwar S, Willcocks LC, Whyte MKB, Condliffe AM, Chilvers ER.

J Immunol. 2011 Jan 1;186(1):453-463. doi: 10.4049/jimmunol.1002213. Epub 2010 Dec 6.

28.

Distinct cell death programs in monocytes regulate innate responses following challenge with common causes of invasive bacterial disease.

Webster SJ, Daigneault M, Bewley MA, Preston JA, Marriott HM, Walmsley SR, Read RC, Whyte MK, Dockrell DH.

J Immunol. 2010 Sep 1;185(5):2968-79. doi: 10.4049/jimmunol.1000805. Epub 2010 Jul 23.

29.

Hypoxia. Hypoxia, hypoxia inducible factor and myeloid cell function.

Walmsley SR, Chilvers ER, Whyte MK.

Arthritis Res Ther. 2009;11(2):219. doi: 10.1186/ar2632. Epub 2009 Apr 21. Review.

30.

Subversion of a lysosomal pathway regulating neutrophil apoptosis by a major bacterial toxin, pyocyanin.

Prince LR, Bianchi SM, Vaughan KM, Bewley MA, Marriott HM, Walmsley SR, Taylor GW, Buttle DJ, Sabroe I, Dockrell DH, Whyte MK.

J Immunol. 2008 Mar 1;180(5):3502-11.

31.

The HIF/VHL pathway: from oxygen sensing to innate immunity.

Walmsley SR, McGovern NN, Whyte MK, Chilvers ER.

Am J Respir Cell Mol Biol. 2008 Mar;38(3):251-5. Epub 2007 Oct 11. Review.

PMID:
17932373
32.

Neutrophils from patients with heterozygous germline mutations in the von Hippel Lindau protein (pVHL) display delayed apoptosis and enhanced bacterial phagocytosis.

Walmsley SR, Cowburn AS, Clatworthy MR, Morrell NW, Roper EC, Singleton V, Maxwell P, Whyte MK, Chilvers ER.

Blood. 2006 Nov 1;108(9):3176-8. Epub 2006 Jun 29.

33.

The role of HIF-1alpha in myeloid cell inflammation.

Walmsley SR, Cadwallader KA, Chilvers ER.

Trends Immunol. 2005 Aug;26(8):434-9. Review.

PMID:
15979406
34.

Hypoxia-induced neutrophil survival is mediated by HIF-1alpha-dependent NF-kappaB activity.

Walmsley SR, Print C, Farahi N, Peyssonnaux C, Johnson RS, Cramer T, Sobolewski A, Condliffe AM, Cowburn AS, Johnson N, Chilvers ER.

J Exp Med. 2005 Jan 3;201(1):105-15.

35.

z-VAD-fmk augmentation of TNF alpha-stimulated neutrophil apoptosis is compound specific and does not involve the generation of reactive oxygen species.

Cowburn AS, White JF, Deighton J, Walmsley SR, Chilvers ER.

Blood. 2005 Apr 1;105(7):2970-2. Epub 2004 Nov 30.

36.

The survival effect of TNF-alpha in human neutrophils is mediated via NF-kappa B-dependent IL-8 release.

Cowburn AS, Deighton J, Walmsley SR, Chilvers ER.

Eur J Immunol. 2004 Jun;34(6):1733-43.

37.

What can we learn from highly purified neutrophils?

Sabroe I, Prince LR, Dower SK, Walmsley SR, Chilvers ER, Whyte MK.

Biochem Soc Trans. 2004 Jun;32(Pt3):468-9. Review.

PMID:
15157162
38.

Characterization of the survival effect of tumour necrosis factor-alpha in human neutrophils.

Walmsley SR, Cowburn AS, Sobolewski A, Murray J, Farahi N, Sabroe I, Chilvers ER.

Biochem Soc Trans. 2004 Jun;32(Pt3):456-60.

PMID:
15157159
39.

Hypoxic regulation of neutrophil apoptosis role: of reactive oxygen intermediates in constitutive and tumor necrosis factor alpha-induced cell death.

Murray J, Walmsley SR, Mecklenburgh KI, Cowburn AS, White JF, Rossi AG, Chilvers ER.

Ann N Y Acad Sci. 2003 Dec;1010:417-25.

PMID:
15033762
40.

New insights into oxygen sensing at a cellular level.

Walmsley SR, Sheares KK, Sobolewski A, Morrell NW, Chilvers ER.

Thorax. 2004 Feb;59(2):90-2. No abstract available.

41.

Involvement of a ferroprotein sensor in hypoxia-mediated inhibition of neutrophil apoptosis.

Mecklenburgh KI, Walmsley SR, Cowburn AS, Wiesener M, Reed BJ, Upton PD, Deighton J, Greening AP, Chilvers ER.

Blood. 2002 Oct 15;100(8):3008-16.

42.

The majority of suture use today includes swaged-on, monofilament suture.

Walmsley SR, Hauptman J.

Vet Surg. 1999 Jul-Aug;28(4):296. No abstract available.

PMID:
10424711

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