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Blockade of endogenous Angiotensin II type I receptor agonistic autoantibody activity improves mitochondria reactive oxygen species and hypertension in a rat model of Preeclampsia.

Vaka VR, Cunningham MW Jr, Deer E, Franks M, Ibrahim T, Amaral LM, Usry N, Cornelius DC, Dechend R, Wallukat G, LaMarca BD.

Am J Physiol Regul Integr Comp Physiol. 2019 Nov 13. doi: 10.1152/ajpregu.00179.2019. [Epub ahead of print]


Autoantibodies Activating the β2-Adrenergic Receptor Characterize Patients With Primary and Secondary Glaucoma.

Hohberger B, Kunze R, Wallukat G, Kara K, Mardin CY, Lämmer R, Schlötzer-Schrehardt U, Hosari S, Horn F, Munoz L, Herrmann M.

Front Immunol. 2019 Oct 1;10:2112. doi: 10.3389/fimmu.2019.02112. eCollection 2019.


Doberman pinschers present autoimmunity associated with functional autoantibodies: A model to study the autoimmune background of human dilated cardiomyopathy.

Wess G, Wallukat G, Fritscher A, Becker NP, Wenzel K, Müller J, Schimke I.

PLoS One. 2019 Jul 5;14(7):e0214263. doi: 10.1371/journal.pone.0214263. eCollection 2019.


Lethal immunoglobulins: Autoantibodies and sudden cardiac death, Autoimmun Rev. 2019 Feb 14. pii: S1568-9972(19)30037-0. doi: 10.1016/j.autrev.2018.12.005. [Epub ahead of print] of Ryabkova VA et al.

Wallukat G, Schimke I.

Autoimmun Rev. 2019 Jul;18(7):749-750. doi: 10.1016/j.autrev.2019.05.009. Epub 2019 May 4. No abstract available.


Analytics of Functional Autoantibodies in Patients with Chagas Disease.

Wallukat G, Wenzel K, Schimke I.

Methods Mol Biol. 2019;1955:247-261. doi: 10.1007/978-1-4939-9148-8_19.


Renal natural killer cell activation and mitochondrial oxidative stress; new mechanisms in AT1-AA mediated hypertensive pregnancy.

Cunningham MW Jr, Vaka VR, McMaster K, Ibrahim T, Cornelius DC, Amaral L, Campbell N, Wallukat G, McDuffy S, Usry N, Dechend R, LaMarca B.

Pregnancy Hypertens. 2019 Jan;15:72-77. doi: 10.1016/j.preghy.2018.11.004. Epub 2018 Nov 30.


Interleukin-4 supplementation improves the pathophysiology of hypertension in response to placental ischemia in RUPP rats.

Cottrell JN, Amaral LM, Harmon A, Cornelius DC, Cunningham MW Jr, Vaka VR, Ibrahim T, Herse F, Wallukat G, Dechend R, LaMarca B.

Am J Physiol Regul Integr Comp Physiol. 2019 Feb 1;316(2):R165-R171. doi: 10.1152/ajpregu.00167.2018. Epub 2019 Jan 9.


Functional autoantibodies against Endothelin-1 receptor type A and Angiotensin II receptor type 1 in patients with preeclampsia.

Buttrup Larsen S, Wallukat G, Schimke I, Sandager A, Tvilum Christensen T, Uldbjerg N, Tørring N.

Pregnancy Hypertens. 2018 Oct;14:189-194. doi: 10.1016/j.preghy.2018.10.002. Epub 2018 Oct 13.


Functional autoantibody diseases: Basics and treatment related to cardiomyopathies.

Becker NP, Goettel P, Mueller J, Wallukat G, Schimke I.

Front Biosci (Landmark Ed). 2019 Jan 1;24:48-95. Review.


Correction: Functional autoantibodies in patients with different forms of dementia.

Wallukat G, Prüss H, Müller J, Schimke I.

PLoS One. 2018 Aug 27;13(8):e0203253. doi: 10.1371/journal.pone.0203253. eCollection 2018.


Letter to the Editor regarding the article "The heart failure burden of type 2 diabetes mellitus-a review of pathophysiology and interventions".

Dandel M, Wallukat G, Hetzer R.

Heart Fail Rev. 2018 Sep;23(5):817-818. doi: 10.1007/s10741-018-9725-9. Review. No abstract available.


Antigen-free control wells in an ELISA set-up for the determination of autoantibodies against G protein-coupled receptors-a requisite for correct data evaluation.

Haberland A, Müller J, Wallukat G, Wenzel K.

Anal Bioanal Chem. 2018 Aug;410(21):5101-5105. doi: 10.1007/s00216-018-1172-x. Epub 2018 Jun 11.


Auto-antibodies against the angiotensin II type I receptor in women with uteroplacental acute atherosis and preeclampsia at delivery and several years postpartum.

Rieber-Mohn AB, Sugulle M, Wallukat G, Alnæs-Katjavivi P, Leite Størvold G, Bolstad N, Redman CW, Dechend R, Staff AC.

J Reprod Immunol. 2018 Aug;128:23-29. doi: 10.1016/j.jri.2018.05.008. Epub 2018 May 22.


Functional autoantibodies in patients with different forms of dementia.

Wallukat G, Prüss H, Müller J, Schimke I.

PLoS One. 2018 Mar 14;13(3):e0192778. doi: 10.1371/journal.pone.0192778. eCollection 2018. Erratum in: PLoS One. 2018 Aug 27;13(8):e0203253.


Agonistic Autoantibodies to the β2-Adrenergic Receptor Involved in the Pathogenesis of Open-Angle Glaucoma.

Jünemann A, Hohberger B, Rech J, Sheriff A, Fu Q, Schlötzer-Schrehardt U, Voll RE, Bartel S, Kalbacher H, Hoebeke J, Rejdak R, Horn F, Wallukat G, Kunze R, Herrmann M.

Front Immunol. 2018 Feb 12;9:145. doi: 10.3389/fimmu.2018.00145. eCollection 2018.


Difference between beta1-adrenoceptor autoantibodies of human and animal origin-Limitations detecting beta1-adrenoceptor autoantibodies using peptide based ELISA technology.

Wenzel K, Schulze-Rothe S, Müller J, Wallukat G, Haberland A.

PLoS One. 2018 Feb 9;13(2):e0192615. doi: 10.1371/journal.pone.0192615. eCollection 2018.


β1-adrenergic receptor O-glycosylation regulates N-terminal cleavage and signaling responses in cardiomyocytes.

Park M, Reddy GR, Wallukat G, Xiang YK, Steinberg SF.

Sci Rep. 2017 Aug 11;7(1):7890. doi: 10.1038/s41598-017-06607-z.


Performance and in-house validation of a bioassay for the determination of beta1-autoantibodies found in patients with cardiomyopathy.

Wenzel K, Schulze-Rothe S, Haberland A, Müller J, Wallukat G, Davideit H.

Heliyon. 2017 Jul 31;3(7):e00362. doi: 10.1016/j.heliyon.2017.e00362. eCollection 2017 Jul.


Autoantibodies Directed Against the β1-Adrenergic Receptor in Patients With Dilated Cardiomyopathy.

Müller J, Wallukat G, Schimke I.

J Am Coll Cardiol. 2017 Aug 8;70(6):808-809. doi: 10.1016/j.jacc.2017.04.068. No abstract available.


Angiotensin II responsiveness after preeclampsia: translational data from an experimental rat model and early-onset human preeclampsia.

van der Graaf AM, Toering TJ, van der Wiel MWK, Frenay AS, Wallukat G, Dechend R, Navis G, Groen H, Lely AT, Faas MM.

J Hypertens. 2017 Dec;35(12):2468-2478. doi: 10.1097/HJH.0000000000001474.


Proliferation of endogenous regulatory T cells improve the pathophysiology associated with placental ischaemia of pregnancy.

Ibrahim T, Przybyl L, Harmon AC, Amaral LM, Faulkner JL, Cornelius DC, Cunningham MW, Hünig T, Herse F, Wallukat G, Dechend R, LaMarca B.

Am J Reprod Immunol. 2017 Nov;78(5). doi: 10.1111/aji.12724. Epub 2017 Jul 6.


Cardiomyopathy - An approach to the autoimmune background.

Becker NP, Müller J, Göttel P, Wallukat G, Schimke I.

Autoimmun Rev. 2017 Mar;16(3):269-286. doi: 10.1016/j.autrev.2017.01.012. Epub 2017 Feb 2. Review.


Autoantibodies Directed Against the Endothelin A Receptor in Patients With Benign Prostatic Hyperplasia.

Wallukat G, Jandrig B, Kunze R, Wendler JJ, Müller J, Schostak M, Schimke I.

Prostate. 2017 Apr;77(5):458-465. doi: 10.1002/pros.23284. Epub 2016 Nov 24.


Reduced uterine perfusion pressure T-helper 17 cells cause pathophysiology associated with preeclampsia during pregnancy.

Cornelius DC, Amaral LM, Wallace K, Campbell N, Thomas AJ, Scott J, Herse F, Wallukat G, Dechend R, LaMarca B.

Am J Physiol Regul Integr Comp Physiol. 2016 Dec 1;311(6):R1192-R1199. doi: 10.1152/ajpregu.00117.2016. Epub 2016 Oct 26.


Agonistic Autoantibodies to the Angiotensin II Type 1 Receptor Enhance Angiotensin II-Induced Renal Vascular Sensitivity and Reduce Renal Function During Pregnancy.

Cunningham MW Jr, Williams JM, Amaral L, Usry N, Wallukat G, Dechend R, LaMarca B.

Hypertension. 2016 Nov;68(5):1308-1313. Epub 2016 Oct 3.


Aptamer BC 007 - A broad spectrum neutralizer of pathogenic autoantibodies against G-protein-coupled receptors.

Haberland A, Holtzhauer M, Schlichtiger A, Bartel S, Schimke I, Müller J, Dandel M, Luppa PB, Wallukat G.

Eur J Pharmacol. 2016 Oct 15;789:37-45. doi: 10.1016/j.ejphar.2016.06.061. Epub 2016 Jul 1.


High throughput bioassay for beta1-adrenoceptor autoantibody detection.

Joshi-Barr S, Haberland A, Bartel S, Müller J, Choi T, Wallukat G.

Int J Cardiol. 2016 Sep 15;219:98-104. doi: 10.1016/j.ijcard.2016.06.002. Epub 2016 Jun 8.


Vitamin D supplementation improves pathophysiology in a rat model of preeclampsia.

Faulkner JL, Cornelius DC, Amaral LM, Harmon AC, Cunningham MW Jr, Darby MM, Ibrahim T, Thomas DS, Herse F, Wallukat G, Dechend R, LaMarca B.

Am J Physiol Regul Integr Comp Physiol. 2016 Feb 15;310(4):R346-54. doi: 10.1152/ajpregu.00388.2015. Epub 2015 Dec 16.


Aptamer BC007 for neutralization of pathogenic autoantibodies directed against G-protein coupled receptors: A vision of future treatment of patients with cardiomyopathies and positivity for those autoantibodies.

Wallukat G, Müller J, Haberland A, Berg S, Schulz A, Freyse EJ, Vetter R, Salzsieder E, Kreutz R, Schimke I.

Atherosclerosis. 2016 Jan;244:44-7. doi: 10.1016/j.atherosclerosis.2015.11.001. Epub 2015 Nov 10.


Detection of DCM-associated β1-adrenergic receptor autoantibodies requires functional readouts or native human β1-receptors as targets.

Bornholz B, Hanzen B, Reinke Y, Felix SB, Jahns R, Schimke I, Wallukat G, Boege F.

Int J Cardiol. 2016 Jan 1;202:728-30. doi: 10.1016/j.ijcard.2015.10.068. Epub 2015 Oct 9. No abstract available.


Blockade of CD40 ligand for intercellular communication reduces hypertension, placental oxidative stress, and AT1-AA in response to adoptive transfer of CD4+ T lymphocytes from RUPP rats.

Cornelius DC, Castillo J, Porter J, Amaral LM, Campbell N, Paige A, Thomas AJ, Harmon A, Cunningham MW Jr, Wallace K, Herse F, Wallukat G, Dechend R, LaMarca B.

Am J Physiol Regul Integr Comp Physiol. 2015 Nov 15;309(10):R1243-50. doi: 10.1152/ajpregu.00273.2015. Epub 2015 Aug 26.


An increased population of regulatory T cells improves the pathophysiology of placental ischemia in a rat model of preeclampsia.

Cornelius DC, Amaral LM, Harmon A, Wallace K, Thomas AJ, Campbell N, Scott J, Herse F, Haase N, Moseley J, Wallukat G, Dechend R, LaMarca B.

Am J Physiol Regul Integr Comp Physiol. 2015 Oct 15;309(8):R884-91. doi: 10.1152/ajpregu.00154.2015. Epub 2015 Aug 19.


Identification of a Novel Agonist-Like Autoantibody in Preeclamptic Patients.

Velloso EP, Pimentel RL, Braga JF, Cabral AC, Reis ZS, Bader M, Santos RA, Wallukat G.

Am J Hypertens. 2016 Mar;29(3):405-12. doi: 10.1093/ajh/hpv099. Epub 2015 Jul 8.


Complex regional pain syndrome and dysautonomia in a 14-year-old girl responsive to therapeutic plasma exchange.

Hendrickson JE, Hendrickson ET, Gehrie EA, Sidhu D, Wallukat G, Schimke I, Tormey CA.

J Clin Apher. 2016 Aug;31(4):368-74. doi: 10.1002/jca.21407. Epub 2015 May 23.


IL-10 supplementation increases Tregs and decreases hypertension in the RUPP rat model of preeclampsia.

Harmon A, Cornelius D, Amaral L, Paige A, Herse F, Ibrahim T, Wallukat G, Faulkner J, Moseley J, Dechend R, LaMarca B.

Hypertens Pregnancy. 2015;34(3):291-306. doi: 10.3109/10641955.2015.1032054. Epub 2015 May 21.


Immunoadsorption can improve cardiac function in transplant candidates with non-ischemic dilated cardiomyopathy associated with diabetes mellitus.

Dandel M, Englert A, Wallukat G, Riese A, Knosalla C, Stein J, Hetzer R.

Atheroscler Suppl. 2015 May;18:124-33. doi: 10.1016/j.atherosclerosissup.2015.02.023.


Regulatory T cells ameliorate intrauterine growth retardation in a transgenic rat model for preeclampsia.

Przybyl L, Ibrahim T, Haase N, Golic M, Rugor J, Luft FC, Bendix I, Serdar M, Wallukat G, Staff AC, Müller DN, Hünig T, Felderhoff-Müser U, Herse F, LaMarca B, Dechend R.

Hypertension. 2015 Jun;65(6):1298-306. doi: 10.1161/HYPERTENSIONAHA.114.04892. Epub 2015 Apr 6.


Agonistic autoantibodies directed against G-protein-coupled receptors and their relationship to cardiovascular diseases.

Wallukat G, Schimke I.

Semin Immunopathol. 2014 May;36(3):351-63. doi: 10.1007/s00281-014-0425-9. Epub 2014 Apr 29. Review.


Neutralization of pathogenic beta1-receptor autoantibodies by aptamers in vivo: the first successful proof of principle in spontaneously hypertensive rats.

Haberland A, Wallukat G, Berg S, Schulz AM, Freyse EJ, Vetter R, Salzsieder E, Müller J, Kreutz R, Schimke I.

Mol Cell Biochem. 2014 Aug;393(1-2):177-80. doi: 10.1007/s11010-014-2057-8. Epub 2014 Apr 18.


Progesterone supplementation attenuates hypertension and the autoantibody to the angiotensin II type I receptor in response to elevated interleukin-6 during pregnancy.

Amaral LM, Kiprono L, Cornelius DC, Shoemaker C, Wallace K, Moseley J, Wallukat G, Martin JN Jr, Dechend R, LaMarca B.

Am J Obstet Gynecol. 2014 Aug;211(2):158.e1-6. doi: 10.1016/j.ajog.2014.02.018. Epub 2014 Feb 15.


A vision of future treatment in chagas heart disease.

Wallukat G, Haberland A, Schimke I.

J Am Coll Cardiol. 2014 Mar 18;63(10):1027. doi: 10.1016/j.jacc.2013.08.1660. Epub 2013 Dec 15. No abstract available.


The patent situation concerning the treatment of diseases associated with autoantibodies directed against G-protein-coupled receptors.

Haberland A, Wallukat G, Schimke I.

Pharm Pat Anal. 2013 Mar;2(2):231-48. doi: 10.4155/ppa.12.88. Review.


Administration of interleukin-17 soluble receptor C suppresses TH17 cells, oxidative stress, and hypertension in response to placental ischemia during pregnancy.

Cornelius DC, Hogg JP, Scott J, Wallace K, Herse F, Moseley J, Wallukat G, Dechend R, LaMarca B.

Hypertension. 2013 Dec;62(6):1068-73. doi: 10.1161/HYPERTENSIONAHA.113.01514. Epub 2013 Sep 23.


Endothelin-1, oxidative stress, and endogenous angiotensin II: mechanisms of angiotensin II type I receptor autoantibody-enhanced renal and blood pressure response during pregnancy.

Brewer J, Liu R, Lu Y, Scott J, Wallace K, Wallukat G, Moseley J, Herse F, Dechend R, Martin JN Jr, Lamarca B.

Hypertension. 2013 Nov;62(5):886-92. doi: 10.1161/HYPERTENSIONAHA.113.01648. Epub 2013 Sep 16.


Amyloid-β peptides activate α1-adrenergic cardiovascular receptors.

Haase N, Herse F, Spallek B, Haase H, Morano I, Qadri F, Szijártó IA, Rohm I, Yilmaz A, Warrington JP, Ryan MJ, Gollasch M, Müller DN, Dechend R, Wallukat G.

Hypertension. 2013 Nov;62(5):966-72. doi: 10.1161/HYPERTENSIONAHA.113.01348. Epub 2013 Sep 3.


Activation of angiotensin-converting enzyme 2/angiotensin-(1-7)/Mas axis attenuates the cardiac reactivity to acute emotional stress.

Martins Lima A, Xavier CH, Ferreira AJ, Raizada MK, Wallukat G, Velloso EP, dos Santos RA, Fontes MA.

Am J Physiol Heart Circ Physiol. 2013 Oct 1;305(7):H1057-67. doi: 10.1152/ajpheart.00433.2013. Epub 2013 Jul 19.


Combined measurement of N-terminal pro-B-type natriuretic peptide and highly sensitive cardiac troponin T for diagnosis and monitoring of heart injury in chronic Chagas' disease.

Munoz Saravia SG, Haberland A, Bartel S, Araujo R, Valda G, Reynaga DD, Ramirez ID, Borges AC, Wallukat G, Ziebig R, Schimke I.

Clin Biochem. 2013 Oct;46(15):1615-8. doi: 10.1016/j.clinbiochem.2013.06.011. Epub 2013 Jun 27.


Interfering with Gal-1-mediated angiogenesis contributes to the pathogenesis of preeclampsia.

Freitag N, Tirado-González I, Barrientos G, Herse F, Thijssen VL, Weedon-Fekjær SM, Schulz H, Wallukat G, Klapp BF, Nevers T, Sharma S, Staff AC, Dechend R, Blois SM.

Proc Natl Acad Sci U S A. 2013 Jul 9;110(28):11451-6. doi: 10.1073/pnas.1303707110. Epub 2013 Jun 24.


CD4+ T Cells Play a Critical Role in Mediating Hypertension in Response to Placental Ischemia.

Novotny S, Wallace K, Herse F, Moseley J, Darby M, Heath J, Gill J, Wallukat G, Martin JN, Dechend R, LaMarca B.

J Hypertens (Los Angel). 2013 Jun 17;2. pii: 14873.

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