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Items: 16


The ATR Inhibitor AZD6738 Synergizes with Gemcitabine In Vitro and In Vivo to Induce Pancreatic Ductal Adenocarcinoma Regression.

Wallez Y, Dunlop CR, Johnson TI, Koh SB, Fornari C, Yates JWT, Bernaldo de Quirós Fernández S, Lau A, Richards FM, Jodrell DI.

Mol Cancer Ther. 2018 Aug;17(8):1670-1682. doi: 10.1158/1535-7163.MCT-18-0010. Epub 2018 Jun 11.


Mechanistic Distinctions between CHK1 and WEE1 Inhibition Guide the Scheduling of Triple Therapy with Gemcitabine.

Koh SB, Wallez Y, Dunlop CR, Bernaldo de Quirós Fernández S, Bapiro TE, Richards FM, Jodrell DI.

Cancer Res. 2018 Jun 1;78(11):3054-3066. doi: 10.1158/0008-5472.CAN-17-3932. Epub 2018 May 7.


CLIQ-BID: A method to quantify bacteria-induced damage to eukaryotic cells by automated live-imaging of bright nuclei.

Wallez Y, Bouillot S, Soleilhac E, Huber P, Attrée I, Faudry E.

Sci Rep. 2018 Jan 8;8(1):5. doi: 10.1038/s41598-017-18501-9.


Structure-Guided Strategy for the Development of Potent Bivalent ERK Inhibitors.

Lechtenberg BC, Mace PD, Sessions EH, Williamson R, Stalder R, Wallez Y, Roth GP, Riedl SJ, Pasquale EB.

ACS Med Chem Lett. 2017 Jun 12;8(7):726-731. doi: 10.1021/acsmedchemlett.7b00127. eCollection 2017 Jul 13.


Protein kinase CK2 in breast cancer: the CK2β regulatory subunit takes center stage in epithelial plasticity.

Filhol O, Giacosa S, Wallez Y, Cochet C.

Cell Mol Life Sci. 2015 Sep;72(17):3305-22. doi: 10.1007/s00018-015-1929-8. Epub 2015 May 20. Review.


Association of the breast cancer antiestrogen resistance protein 1 (BCAR1) and BCAR3 scaffolding proteins in cell signaling and antiestrogen resistance.

Wallez Y, Riedl SJ, Pasquale EB.

J Biol Chem. 2014 Apr 11;289(15):10431-44. doi: 10.1074/jbc.M113.541839. Epub 2014 Feb 28.


Structure of ERK2 bound to PEA-15 reveals a mechanism for rapid release of activated MAPK.

Mace PD, Wallez Y, Egger MF, Dobaczewska MK, Robinson H, Pasquale EB, Riedl SJ.

Nat Commun. 2013;4:1681. doi: 10.1038/ncomms2687.


NSP-CAS Protein Complexes: Emerging Signaling Modules in Cancer.

Wallez Y, Mace PD, Pasquale EB, Riedl SJ.

Genes Cancer. 2012 May;3(5-6):382-93. doi: 10.1177/1947601912460050.


NSP-Cas protein structures reveal a promiscuous interaction module in cell signaling.

Mace PD, Wallez Y, Dobaczewska MK, Lee JJ, Robinson H, Pasquale EB, Riedl SJ.

Nat Struct Mol Biol. 2011 Nov 13;18(12):1381-7. doi: 10.1038/nsmb.2152.


SHEP1 partners with CasL to promote marginal zone B-cell maturation.

Browne CD, Hoefer MM, Chintalapati SK, Cato MH, Wallez Y, Ostertag DV, Pasquale EB, Rickert RC.

Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):18944-9. doi: 10.1073/pnas.1007558107. Epub 2010 Oct 18.


The SRC homology 2 domain protein Shep1 plays an important role in the penetration of olfactory sensory axons into the forebrain.

Wang L, Vervoort V, Wallez Y, Coré N, Cremer H, Pasquale EB.

J Neurosci. 2010 Sep 29;30(39):13201-10. doi: 10.1523/JNEUROSCI.3289-10.2010.


The SH2 domain protein Shep1 regulates the in vivo signaling function of the scaffolding protein Cas.

Roselli S, Wallez Y, Wang L, Vervoort V, Pasquale EB.

Cell Signal. 2010 Nov;22(11):1745-52. doi: 10.1016/j.cellsig.2010.06.015. Epub 2010 Jul 24.


Endothelial adherens and tight junctions in vascular homeostasis, inflammation and angiogenesis.

Wallez Y, Huber P.

Biochim Biophys Acta. 2008 Mar;1778(3):794-809. Epub 2007 Sep 15. Review.


Src kinase phosphorylates vascular endothelial-cadherin in response to vascular endothelial growth factor: identification of tyrosine 685 as the unique target site.

Wallez Y, Cand F, Cruzalegui F, Wernstedt C, Souchelnytskyi S, Vilgrain I, Huber P.

Oncogene. 2007 Feb 15;26(7):1067-77. Epub 2006 Aug 14.


Angiogenesis: the VE-cadherin switch.

Wallez Y, Vilgrain I, Huber P.

Trends Cardiovasc Med. 2006 Feb;16(2):55-9. Review.


Vascular endothelial-cadherin tyrosine phosphorylation in angiogenic and quiescent adult tissues.

Lambeng N, Wallez Y, Rampon C, Cand F, Christé G, Gulino-Debrac D, Vilgrain I, Huber P.

Circ Res. 2005 Feb 18;96(3):384-91. Epub 2005 Jan 20.

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