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Items: 1 to 50 of 94

1.

Bioavailable flavonoids: cytochrome P450-mediated metabolism of methoxyflavones.

Walle UK, Walle T.

Drug Metab Dispos. 2007 Nov;35(11):1985-9. Epub 2007 Aug 20.

PMID:
17709371
2.

Novel methoxylated flavone inhibitors of cytochrome P450 1B1 in SCC-9 human oral cancer cells.

Walle T, Walle UK.

J Pharm Pharmacol. 2007 Jun;59(6):857-62.

PMID:
17637178
3.

Improving metabolic stability of cancer chemoprotective polyphenols.

Walle T, Wen X, Walle UK.

Expert Opin Drug Metab Toxicol. 2007 Jun;3(3):379-88. Review.

PMID:
17539745
4.

Cancer chemopreventive properties of orally bioavailable flavonoids--methylated versus unmethylated flavones.

Walle T, Ta N, Kawamori T, Wen X, Tsuji PA, Walle UK.

Biochem Pharmacol. 2007 May 1;73(9):1288-96. Epub 2006 Dec 28.

5.

Benzo[A]pyrene-induced oral carcinogenesis and chemoprevention: studies in bioengineered human tissue.

Walle T, Walle UK, Sedmera D, Klausner M.

Drug Metab Dispos. 2006 Mar;34(3):346-50. Epub 2005 Dec 28.

PMID:
16381670
6.

Flavonoid glycosides inhibit oral cancer cell proliferation--role of cellular uptake and hydrolysis to the aglycones.

Browning AM, Walle UK, Walle T.

J Pharm Pharmacol. 2005 Aug;57(8):1037-42.

PMID:
16102260
7.

S-adenosyl-L-methionine: transcellular transport and uptake by Caco-2 cells and hepatocytes.

McMillan JM, Walle UK, Walle T.

J Pharm Pharmacol. 2005 May;57(5):599-605.

PMID:
15901349
8.

Covalent binding of the flavonoid quercetin to human serum albumin.

Kaldas MI, Walle UK, van der Woude H, McMillan JM, Walle T.

J Agric Food Chem. 2005 May 18;53(10):4194-7.

PMID:
15884859
9.

5,7-Dimethoxyflavone downregulates CYP1A1 expression and benzo[a]pyrene-induced DNA binding in Hep G2 cells.

Wen X, Walle UK, Walle T.

Carcinogenesis. 2005 Apr;26(4):803-9. Epub 2005 Jan 20.

PMID:
15661813
10.

Flavonoid glucosides are hydrolyzed and thus activated in the oral cavity in humans.

Walle T, Browning AM, Steed LL, Reed SG, Walle UK.

J Nutr. 2005 Jan;135(1):48-52.

PMID:
15623831
11.

High absorption but very low bioavailability of oral resveratrol in humans.

Walle T, Hsieh F, DeLegge MH, Oatis JE Jr, Walle UK.

Drug Metab Dispos. 2004 Dec;32(12):1377-82. Epub 2004 Aug 27.

PMID:
15333514
13.

Evidence of covalent binding of the dietary flavonoid quercetin to DNA and protein in human intestinal and hepatic cells.

Walle T, Vincent TS, Walle UK.

Biochem Pharmacol. 2003 May 15;65(10):1603-10.

PMID:
12754096
14.

Resveratrol transport and metabolism by human intestinal Caco-2 cells.

Kaldas MI, Walle UK, Walle T.

J Pharm Pharmacol. 2003 Mar;55(3):307-12.

PMID:
12724035
15.

Induction of human UDP-glucuronosyltransferase UGT1A1 by flavonoids-structural requirements.

Walle UK, Walle T.

Drug Metab Dispos. 2002 May;30(5):564-9.

PMID:
11950788
16.

Carbon dioxide is the major metabolite of quercetin in humans.

Walle T, Walle UK, Halushka PV.

J Nutr. 2001 Oct;131(10):2648-52.

PMID:
11584085
17.
18.

Disposition and metabolism of the flavonoid chrysin in normal volunteers.

Walle T, Otake Y, Brubaker JA, Walle UK, Halushka PV.

Br J Clin Pharmacol. 2001 Feb;51(2):143-6.

19.

Quercetin and resveratrol potently reduce estrogen sulfotransferase activity in normal human mammary epithelial cells.

Otake Y, Nolan AL, Walle UK, Walle T.

J Steroid Biochem Mol Biol. 2000 Jul-Aug;73(5):265-70.

PMID:
11070355
20.

Quercetin glucosides are completely hydrolyzed in ileostomy patients before absorption.

Walle T, Otake Y, Walle UK, Wilson FA.

J Nutr. 2000 Nov;130(11):2658-61.

PMID:
11053503
21.

Induction of UDP-glucuronosyltransferase UGT1A1 by the flavonoid chrysin in the human hepatoma cell line hep G2.

Walle T, Otake Y, Galijatovic A, Ritter JK, Walle UK.

Drug Metab Dispos. 2000 Sep;28(9):1077-82.

PMID:
10950852
22.

Sulphonation of N-hydroxy-2-acetylaminofluorene by human dehydroepiandrosterone sulphotransferase.

Lewis AJ, Otake Y, Walle UK, Walle T.

Xenobiotica. 2000 Mar;30(3):253-61.

PMID:
10752640
23.

Induction of UDP-glucuronosyltransferase by the flavonoids chrysin and quercetin in Caco-2 cells.

Galijatovic A, Walle UK, Walle T.

Pharm Res. 2000 Jan;17(1):21-6.

PMID:
10714603
24.

Extensive metabolism of the flavonoid chrysin by human Caco-2 and Hep G2 cells.

Galijatovic A, Otake Y, Walle UK, Walle T.

Xenobiotica. 1999 Dec;29(12):1241-56.

PMID:
10647910
26.

Transport of genistein-7-glucoside by human intestinal CACO-2 cells: potential role for MRP2.

Walle UK, French KL, Walgren RA, Walle T.

Res Commun Mol Pathol Pharmacol. 1999 Jan;103(1):45-56.

PMID:
10440570
27.

Phase I and pharmacologic study of a 3-hour infusion of paclitaxel followed by cisplatinum and 5-fluorouracil in patients with advanced solid tumors.

Bhalla KN, Kumar GN, Walle UK, Ibrado AM, Javed T, Stuart RK, Reed C, Arbuck SG, Walle T.

Clin Cancer Res. 1999 Jul;5(7):1723-30.

28.

Transport of the flavonoid chrysin and its conjugated metabolites by the human intestinal cell line Caco-2.

Walle UK, Galijatovic A, Walle T.

Biochem Pharmacol. 1999 Aug 1;58(3):431-8.

PMID:
10424761
29.

Fate of the flavonoid quercetin in human cell lines: chemical instability and metabolism.

Boulton DW, Walle UK, Walle T.

J Pharm Pharmacol. 1999 Mar;51(3):353-9.

PMID:
10344638
30.
31.

Transport of quercetin and its glucosides across human intestinal epithelial Caco-2 cells.

Walgren RA, Walle UK, Walle T.

Biochem Pharmacol. 1998 May 15;55(10):1721-7.

PMID:
9634009
32.

Taxol transport by human intestinal epithelial Caco-2 cells.

Walle UK, Walle T.

Drug Metab Dispos. 1998 Apr;26(4):343-6.

PMID:
9531522
33.

Extensive binding of the bioflavonoid quercetin to human plasma proteins.

Boulton DW, Walle UK, Walle T.

J Pharm Pharmacol. 1998 Feb;50(2):243-9.

PMID:
9530994
34.

Improved bacterial expression of the human P form phenolsulfotransferase. Applications to drug metabolism.

Lewis AJ, Kelly MM, Walle UK, Eaton EA, Falany CN, Walle T.

Drug Metab Dispos. 1996 Nov;24(11):1180-5.

PMID:
8937850
35.
36.

Stereoselective sulphate conjugation of salbutamol by human lung and bronchial epithelial cells.

Eaton EA, Walle UK, Wilson HM, Aberg G, Walle T.

Br J Clin Pharmacol. 1996 Mar;41(3):201-6.

37.

Flavonoids, potent inhibitors of the human P-form phenolsulfotransferase. Potential role in drug metabolism and chemoprevention.

Eaton EA, Walle UK, Lewis AJ, Hudson T, Wilson AA, Walle T.

Drug Metab Dispos. 1996 Feb;24(2):232-7.

PMID:
8742236
38.

Stereoselective metabolism of RS-albuterol in humans.

Walle T, Eaton EA, Walle UK, Pesola GR.

Clin Rev Allergy Immunol. 1996 Spring;14(1):101-13. No abstract available.

PMID:
8866175
39.

Dexamethasone induction of taxol metabolism in the rat.

Anderson CD, Wang J, Kumar GN, McMillan JM, Walle UK, Walle T.

Drug Metab Dispos. 1995 Nov;23(11):1286-90.

PMID:
8591732
40.

Quercetin, a potent and specific inhibitor of the human P-form phenosulfotransferase.

Walle T, Eaton EA, Walle UK.

Biochem Pharmacol. 1995 Aug 25;50(5):731-4.

PMID:
7669078
41.

Taxol metabolism and disposition in cancer patients.

Walle T, Walle UK, Kumar GN, Bhalla KN.

Drug Metab Dispos. 1995 Apr;23(4):506-12.

PMID:
7600920
42.

Extensive and saturable accumulation of paclitaxel by the human platelet.

Wild MD, Walle UK, Walle T.

Cancer Chemother Pharmacol. 1995;36(1):41-4.

PMID:
7720174
43.

Human phenol sulfotransferases: chiral substrates and expression in Hep G2 cells.

Walle T, Walle UK, Shwed JA, Thornburg KR, Mathis CE, Pesola GR.

Chem Biol Interact. 1994 Jun;92(1-3):47-55. Review.

PMID:
7913418
44.

Cytochrome P450 3A-mediated human liver microsomal taxol 6 alpha-hydroxylation.

Kumar GN, Walle UK, Walle T.

J Pharmacol Exp Ther. 1994 Mar;268(3):1160-5.

PMID:
7908050
45.

The influence of gender and sex steroid hormones on the plasma binding of propranolol enantiomers.

Walle UK, Fagan TC, Topmiller MJ, Conradi EC, Walle T.

Br J Clin Pharmacol. 1994 Jan;37(1):21-5.

46.

Taxol metabolism in rat hepatocytes.

Walle T, Kumar GN, McMillan JM, Thornburg KR, Walle UK.

Biochem Pharmacol. 1993 Nov 2;46(9):1661-4.

PMID:
7902091
47.

Binding of taxol to human plasma, albumin and alpha 1-acid glycoprotein.

Kumar GN, Walle UK, Bhalla KN, Walle T.

Res Commun Chem Pathol Pharmacol. 1993 Jun;80(3):337-44.

PMID:
8102493
48.
49.

Immunoaffinity isolation of the sulfate conjugate of 4'-hydroxypropranolol from plasma.

Eller TD, Walle UK, Walle T.

J Chromatogr. 1993 Feb 26;612(2):320-5.

PMID:
8468392
50.

Stereoselective sulfation of albuterol in humans. Biosynthesis of the sulfate conjugate by HEP G2 cells.

Walle T, Walle UK, Thornburg KR, Schey KL.

Drug Metab Dispos. 1993 Jan-Feb;21(1):76-80.

PMID:
8095231

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