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Modeling of Photoreceptor Donor-Host Interaction Following Transplantation Reveals a Role for Crx, Müller Glia, and Rho/ROCK Signaling in Neurite Outgrowth.

Tsai ELS, Ortin-Martinez A, Gurdita A, Comanita L, Yan N, Smiley S, Delplace V, Shoichet MS, Nickerson PEB, Wallace VA.

Stem Cells. 2019 Apr;37(4):529-541. doi: 10.1002/stem.2985. Epub 2019 Feb 14.


Induction of rod versus cone photoreceptor-specific progenitors from retinal precursor cells.

Khalili S, Ballios BG, Belair-Hickey J, Donaldson L, Liu J, Coles BLK, Grisé KN, Baakdhah T, Bader GD, Wallace VA, Bernier G, Shoichet MS, van der Kooy D.

Stem Cell Res. 2018 Dec;33:215-227. doi: 10.1016/j.scr.2018.11.005. Epub 2018 Nov 13.


Material Exchange in Photoreceptor Transplantation: Updating Our Understanding of Donor/Host Communication and the Future of Cell Engraftment Science.

Nickerson PEB, Ortin-Martinez A, Wallace VA.

Front Neural Circuits. 2018 Mar 6;12:17. doi: 10.3389/fncir.2018.00017. eCollection 2018. Review.


Exosomes Mediate Mobilization of Autocrine Wnt10b to Promote Axonal Regeneration in the Injured CNS.

Tassew NG, Charish J, Shabanzadeh AP, Luga V, Harada H, Farhani N, D'Onofrio P, Choi B, Ellabban A, Nickerson PEB, Wallace VA, Koeberle PD, Wrana JL, Monnier PP.

Cell Rep. 2017 Jul 5;20(1):99-111. doi: 10.1016/j.celrep.2017.06.009.


Retinal interneuron survival requires non-cell-autonomous Atrx activity.

Lagali PS, Medina CF, Zhao BY, Yan K, Baker AN, Coupland SG, Tsilfidis C, Wallace VA, Picketts DJ.

Hum Mol Genet. 2016 Nov 1;25(21):4787-4803. doi: 10.1093/hmg/ddw306.


A Reinterpretation of Cell Transplantation: GFP Transfer From Donor to Host Photoreceptors.

Ortin-Martinez A, Tsai EL, Nickerson PE, Bergeret M, Lu Y, Smiley S, Comanita L, Wallace VA.

Stem Cells. 2017 Apr;35(4):932-939. doi: 10.1002/stem.2552. Epub 2017 Jan 19.


Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation.

Bassett EA, Tokarew N, Allemano EA, Mazerolle C, Morin K, Mears AJ, McNeill B, Ringuette R, Campbell C, Smiley S, Pokrajac NT, Dubuc AM, Ramaswamy V, Northcott PA, Remke M, Monnier PP, Potter D, Paes K, Kirkpatrick LL, Coker KJ, Rice DS, Perez-Iratxeta C, Taylor MD, Wallace VA.

Elife. 2016 Nov 8;5. pii: e16764. doi: 10.7554/eLife.16764.


Sortilin regulates sorting and secretion of Sonic hedgehog.

Campbell C, Beug S, Nickerson PE, Peng J, Mazerolle C, Bassett EA, Ringuette R, Jama FA, Morales C, Christ A, Wallace VA.

J Cell Sci. 2016 Oct 15;129(20):3832-3844. Epub 2016 Sep 15.


Corrigendum: Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.

Smiley S, Nickerson PE, Comanita L, Daftarian N, El-Sehemy A, Tsai EL, Matan-Lithwick S, Yan K, Thurig S, Touahri Y, Dixit R, Aavani T, De Repentigny Y, Baker A, Tsilfidis C, Biernaskie J, Sauvé Y, Schuurmans C, Kothary R, Mears AJ, Wallace VA.

Sci Rep. 2016 Apr 22;6:24012. doi: 10.1038/srep24012. No abstract available.


Establishment of a cone photoreceptor transplantation platform based on a novel cone-GFP reporter mouse line.

Smiley S, Nickerson PE, Comanita L, Daftarian N, El-Sehemy A, Tsai EL, Matan-Lithwick S, Yan K, Thurig S, Touahri Y, Dixit R, Aavani T, De Repentingy Y, Baker A, Tsilfidis C, Biernaskie J, Sauvé Y, Schuurmans C, Kothary R, Mears AJ, Wallace VA.

Sci Rep. 2016 Mar 11;6:22867. doi: 10.1038/srep22867. Erratum in: Sci Rep. 2016 Apr 22;6:24012. De Repentigny, Yves [corrected to De Repentingy, Yves].


A Notch-Gli2 axis sustains Hedgehog responsiveness of neural progenitors and Müller glia.

Ringuette R, Atkins M, Lagali PS, Bassett EA, Campbell C, Mazerolle C, Mears AJ, Picketts DJ, Wallace VA.

Dev Biol. 2016 Mar 1;411(1):85-100. doi: 10.1016/j.ydbio.2016.01.006. Epub 2016 Feb 2.


LRP2 Acts as SHH Clearance Receptor to Protect the Retinal Margin from Mitogenic Stimuli.

Christ A, Christa A, Klippert J, Eule JC, Bachmann S, Wallace VA, Hammes A, Willnow TE.

Dev Cell. 2015 Oct 12;35(1):36-48. doi: 10.1016/j.devcel.2015.09.001. Epub 2015 Oct 1.


ϒ-secretase and LARG mediate distinct RGMa activities to control appropriate layer targeting within the optic tectum.

Banerjee P, Harada H, Tassew NG, Charish J, Goldschneider D, Wallace VA, Sugita S, Mehlen P, Monnier PP.

Cell Death Differ. 2016 Mar;23(3):442-53. doi: 10.1038/cdd.2015.111. Epub 2015 Aug 21.


Autologous fibrin glue as an encapsulating scaffold for delivery of retinal progenitor cells.

Ahmed TA, Ringuette R, Wallace VA, Griffith M.

Front Bioeng Biotechnol. 2015 Feb 3;2:85. doi: 10.3389/fbioe.2014.00085. eCollection 2014.


Snf2h-mediated chromatin organization and histone H1 dynamics govern cerebellar morphogenesis and neural maturation.

Alvarez-Saavedra M, De Repentigny Y, Lagali PS, Raghu Ram EV, Yan K, Hashem E, Ivanochko D, Huh MS, Yang D, Mears AJ, Todd MA, Corcoran CP, Bassett EA, Tokarew NJ, Kokavec J, Majumder R, Ioshikhes I, Wallace VA, Kothary R, Meshorer E, Stopka T, Skoultchi AI, Picketts DJ.

Nat Commun. 2014 Jun 20;5:4181. doi: 10.1038/ncomms5181.


Combinatorial hedgehog and mitogen signaling promotes the in vitro expansion but not retinal differentiation potential of retinal progenitor cells.

Ringuette R, Wang Y, Atkins M, Mears AJ, Yan K, Wallace VA.

Invest Ophthalmol Vis Sci. 2014 Jan 2;55(1):43-54. doi: 10.1167/iovs.13-12592.


Hedgehog signaling regulates MyoD expression and activity.

Voronova A, Coyne E, Al Madhoun A, Fair JV, Bosiljcic N, St-Louis C, Li G, Thurig S, Wallace VA, Wiper-Bergeron N, Skerjanc IS.

J Biol Chem. 2013 Feb 8;288(6):4389-404. doi: 10.1074/jbc.M112.400184. Epub 2012 Dec 24.


Hedgehog regulates Norrie disease protein to drive neural progenitor self-renewal.

McNeill B, Mazerolle C, Bassett EA, Mears AJ, Ringuette R, Lagali P, Picketts DJ, Paes K, Rice D, Wallace VA.

Hum Mol Genet. 2013 Mar 1;22(5):1005-16. doi: 10.1093/hmg/dds505. Epub 2012 Nov 30.


Gene networks: dissecting pathways in retinal development and disease.

Gregory-Evans CY, Wallace VA, Gregory-Evans K.

Prog Retin Eye Res. 2013 Mar;33:40-66. doi: 10.1016/j.preteyeres.2012.10.003. Epub 2012 Nov 2. Review.


Cell fate determination in the vertebrate retina.

Bassett EA, Wallace VA.

Trends Neurosci. 2012 Sep;35(9):565-73. doi: 10.1016/j.tins.2012.05.004. Epub 2012 Jun 15. Review.


Identification of Wnt/β-catenin modulated genes in the developing retina.

Ha A, Perez-Iratxeta C, Liu H, Mears AJ, Wallace VA.

Mol Vis. 2012;18:645-56. Epub 2012 Mar 16.


Overlapping expression patterns and redundant roles for AP-2 transcription factors in the developing mammalian retina.

Bassett EA, Korol A, Deschamps PA, Buettner R, Wallace VA, Williams T, West-Mays JA.

Dev Dyn. 2012 Apr;241(4):814-29. doi: 10.1002/dvdy.23762.


Comparative genomics identification of a novel set of temporally regulated hedgehog target genes in the retina.

McNeill B, Perez-Iratxeta C, Mazerolle C, Furimsky M, Mishina Y, Andrade-Navarro MA, Wallace VA.

Mol Cell Neurosci. 2012 Mar;49(3):333-40. doi: 10.1016/j.mcn.2011.12.008. Epub 2012 Jan 16.


Suppressor of fused is required to maintain the multipotency of neural progenitor cells in the retina.

Cwinn MA, Mazerolle C, McNeill B, Ringuette R, Thurig S, Hui CC, Wallace VA.

J Neurosci. 2011 Mar 30;31(13):5169-80. doi: 10.1523/JNEUROSCI.5495-10.2011.


Concise review: making a retina--from the building blocks to clinical applications.

Wallace VA.

Stem Cells. 2011 Mar;29(3):412-7. doi: 10.1002/stem.602. Review.


Processing-dependent trafficking of Sonic hedgehog to the regulated secretory pathway in neurons.

Beug ST, Parks RJ, McBride HM, Wallace VA.

Mol Cell Neurosci. 2011 Mar;46(3):583-96. doi: 10.1016/j.mcn.2010.12.009. Epub 2010 Dec 21.


Loss of LMO4 in the retina leads to reduction of GABAergic amacrine cells and functional deficits.

Duquette PM, Zhou X, Yap NL, MacLaren EJ, Lu JJ, Wallace VA, Chen HH.

PLoS One. 2010 Oct 7;5(10):e13232. doi: 10.1371/journal.pone.0013232.


Hedgehog to Hes1: the heist of a Notch target.

Wall DS, Wallace VA.

Cell Cycle. 2009 May 1;8(9):1301-2. Epub 2009 May 3. No abstract available.


E2F4 is required for early eye patterning.

Ruzhynsky VA, Furimsky M, Park DS, Wallace VA, Slack RS.

Dev Neurosci. 2009;31(3):238-46. doi: 10.1159/000210186. Epub 2009 Mar 27.


Progenitor cell proliferation in the retina is dependent on Notch-independent Sonic hedgehog/Hes1 activity.

Wall DS, Mears AJ, McNeill B, Mazerolle C, Thurig S, Wang Y, Kageyama R, Wallace VA.

J Cell Biol. 2009 Jan 12;184(1):101-12. doi: 10.1083/jcb.200805155. Epub 2009 Jan 5.


Altered visual function and interneuron survival in Atrx knockout mice: inference for the human syndrome.

Medina CF, Mazerolle C, Wang Y, Bérubé NG, Coupland S, Gibbons RJ, Wallace VA, Picketts DJ.

Hum Mol Genet. 2009 Mar 1;18(5):966-77. doi: 10.1093/hmg/ddn424. Epub 2008 Dec 16.


Control of glial precursor cell development in the mouse optic nerve by sonic hedgehog from retinal ganglion cells.

Dakubo GD, Beug ST, Mazerolle CJ, Thurig S, Wang Y, Wallace VA.

Brain Res. 2008 Sep 4;1228:27-42. doi: 10.1016/j.brainres.2008.06.058. Epub 2008 Jun 24.


Indian hedgehog signaling from endothelial cells is required for sclera and retinal pigment epithelium development in the mouse eye.

Dakubo GD, Mazerolle C, Furimsky M, Yu C, St-Jacques B, McMahon AP, Wallace VA.

Dev Biol. 2008 Aug 1;320(1):242-55. doi: 10.1016/j.ydbio.2008.05.528. Epub 2008 May 20.


beta-catenin/TCF/Lef controls a differentiation-associated transcriptional program in renal epithelial progenitors.

Schmidt-Ott KM, Masckauchan TN, Chen X, Hirsh BJ, Sarkar A, Yang J, Paragas N, Wallace VA, Dufort D, Pavlidis P, Jagla B, Kitajewski J, Barasch J.

Development. 2007 Sep;134(17):3177-90.


Proliferative and cell fate effects of Hedgehog signaling in the vertebrate retina.

Wallace VA.

Brain Res. 2008 Feb 4;1192:61-75. Epub 2007 Jun 16. Review.


Ciliary margin transdifferentiation from neural retina is controlled by canonical Wnt signaling.

Liu H, Xu S, Wang Y, Mazerolle C, Thurig S, Coles BL, Ren JC, Taketo MM, van der Kooy D, Wallace VA.

Dev Biol. 2007 Aug 1;308(1):54-67. Epub 2007 May 16.


Cell cycle regulator E2F4 is essential for the development of the ventral telencephalon.

Ruzhynsky VA, McClellan KA, Vanderluit JL, Jeong Y, Furimsky M, Park DS, Epstein DJ, Wallace VA, Slack RS.

J Neurosci. 2007 May 30;27(22):5926-35.


Stem cells: a source for neuron repair in retinal disease.

Wallace VA.

Can J Ophthalmol. 2007 Jun;42(3):442-6. Review.


Cancer biology: second step to retinal tumours.

Wallace VA.

Nature. 2006 Nov 2;444(7115):45-6. No abstract available.


Mapping canonical Wnt signaling in the developing and adult retina.

Liu H, Thurig S, Mohamed O, Dufort D, Wallace VA.

Invest Ophthalmol Vis Sci. 2006 Nov;47(11):5088-97.


Oct-3/4 dose dependently regulates specification of embryonic stem cells toward a cardiac lineage and early heart development.

Zeineddine D, Papadimou E, Chebli K, Gineste M, Liu J, Grey C, Thurig S, Behfar A, Wallace VA, Skerjanc IS, Pucéat M.

Dev Cell. 2006 Oct;11(4):535-46.


Disruption of MEF2 activity in cardiomyoblasts inhibits cardiomyogenesis.

Karamboulas C, Dakubo GD, Liu J, De Repentigny Y, Yutzey K, Wallace VA, Kothary R, Skerjanc IS.

J Cell Sci. 2006 Oct 15;119(Pt 20):4315-21. Epub 2006 Sep 26. Erratum in: J Cell Sci. 2006 Oct 15;119(Pt 20):4367. J Cell Sci. 2007 Jan 1;120(Pt 1):200.


Direct and indirect effects of hedgehog pathway activation in the mammalian retina.

Yu C, Mazerolle CJ, Thurig S, Wang Y, Pacal M, Bremner R, Wallace VA.

Mol Cell Neurosci. 2006 Jul;32(3):274-82.


Expression of Notch and Wnt pathway components and activation of Notch signaling in medulloblastomas from heterozygous patched mice.

Dakubo GD, Mazerolle CJ, Wallace VA.

J Neurooncol. 2006 Sep;79(3):221-7. Epub 2006 Apr 6.


Complementary Gli activity mediates early patterning of the mouse visual system.

Furimsky M, Wallace VA.

Dev Dyn. 2006 Mar;235(3):594-605.


Retinal ganglion cell-derived sonic hedgehog locally controls proliferation and the timing of RGC development in the embryonic mouse retina.

Wang Y, Dakubo GD, Thurig S, Mazerolle CJ, Wallace VA.

Development. 2005 Nov;132(22):5103-13. Epub 2005 Oct 19.


Hedgehogs and retinal ganglion cells: organizers of the mammalian retina.

Dakubo GD, Wallace VA.

Neuroreport. 2004 Mar 1;15(3):479-82. Review.


Abnormalities of the vitreoretinal interface caused by dysregulated Hedgehog signaling during retinal development.

Black GC, Mazerolle CJ, Wang Y, Campsall KD, Petrin D, Leonard BC, Damji KF, Evans DG, McLeod D, Wallace VA.

Hum Mol Genet. 2003 Dec 15;12(24):3269-76. Epub 2003 Oct 21.


Retinal ganglion cell-derived sonic hedgehog signaling is required for optic disc and stalk neuroepithelial cell development.

Dakubo GD, Wang YP, Mazerolle C, Campsall K, McMahon AP, Wallace VA.

Development. 2003 Jul;130(13):2967-80.

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