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Aldosterone Regulates Pendrin and Epithelial Sodium Channel Activity through Intercalated Cell Mineralocorticoid Receptor-Dependent and -Independent Mechanisms over a Wide Range in Serum Potassium.

Pham TD, Verlander JW, Wang Y, Romero CA, Yue Q, Chen C, Thumova M, Eaton DC, Lazo-Fernandez Y, Wall SM.

J Am Soc Nephrol. 2020 Feb 13. pii: ASN.2019050551. doi: 10.1681/ASN.2019050551. [Epub ahead of print]


Low-Dose Interleukin-2 Ameliorates Colitis in a Preclinical Humanized Mouse Model.

Goettel JA, Kotlarz D, Emani R, Canavan JB, Konnikova L, Illig D, Frei SM, Field M, Kowalik M, Peng K, Gringauz J, Mitsialis V, Wall SM, Tsou A, Griffith AE, Huang Y, Friedman JR, Towne JE, Plevy SE, O'Hara Hall A, Snapper SB.

Cell Mol Gastroenterol Hepatol. 2019;8(2):193-195. doi: 10.1016/j.jcmgh.2019.05.001. Epub 2019 May 9. No abstract available.


Blood collection in unstressed, conscious, and freely moving mice through implantation of catheters in the jugular vein: a new simplified protocol.

Park AY, Plotsky PM, Pham TD, Pacak K, Wynne BM, Wall SM, Lazo-Fernandez Y.

Physiol Rep. 2018 Nov;6(21):e13904. doi: 10.14814/phy2.13904.


The Role of Intercalated Cell Nedd4-2 in BP Regulation, Ion Transport, and Transporter Expression.

Nanami M, Pham TD, Kim YH, Yang B, Sutliff RL, Staub O, Klein JD, Lopez-Cayuqueo KI, Chambrey R, Park AY, Wang X, Pech V, Verlander JW, Wall SM.

J Am Soc Nephrol. 2018 Jun;29(6):1706-1719. doi: 10.1681/ASN.2017080826. Epub 2018 May 17.


Human TGF-β1 deficiency causes severe inflammatory bowel disease and encephalopathy.

Kotlarz D, Marquardt B, Barøy T, Lee WS, Konnikova L, Hollizeck S, Magg T, Lehle AS, Walz C, Borggraefe I, Hauck F, Bufler P, Conca R, Wall SM, Schumacher EM, Misceo D, Frengen E, Bentsen BS, Uhlig HH, Hopfner KP, Muise AM, Snapper SB, Strømme P, Klein C.

Nat Genet. 2018 Mar;50(3):344-348. doi: 10.1038/s41588-018-0063-6. Epub 2018 Feb 26.


α-Ketoglutarate stimulates pendrin-dependent Cl- absorption in the mouse CCD through protein kinase C.

Lazo-Fernandez Y, Welling PA, Wall SM.

Am J Physiol Renal Physiol. 2018 Jul 1;315(1):F7-F15. doi: 10.1152/ajprenal.00576.2017. Epub 2018 Feb 7.


Reply to Edemir: Physiological regulation and single-cell RNA sequencing.

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA.

Proc Natl Acad Sci U S A. 2018 Jan 16;115(3):E351-E352. doi: 10.1073/pnas.1720333115. Epub 2018 Jan 8. No abstract available.


Renal intercalated cells and blood pressure regulation.

Wall SM.

Kidney Res Clin Pract. 2017 Dec;36(4):305-317. doi: 10.23876/j.krcp.2017.36.4.305. Epub 2017 Dec 31. Review.


Transcriptomes of major renal collecting duct cell types in mouse identified by single-cell RNA-seq.

Chen L, Lee JW, Chou CL, Nair AV, Battistone MA, Păunescu TG, Merkulova M, Breton S, Verlander JW, Wall SM, Brown D, Burg MB, Knepper MA.

Proc Natl Acad Sci U S A. 2017 Nov 14;114(46):E9989-E9998. doi: 10.1073/pnas.1710964114. Epub 2017 Oct 31.


Enhanced TH17 Responses in Patients with IL10 Receptor Deficiency and Infantile-onset IBD.

Shouval DS, Konnikova L, Griffith AE, Wall SM, Biswas A, Werner L, Nunberg M, Kammermeier J, Goettel JA, Anand R, Chen H, Weiss B, Li J, Loizides A, Yerushalmi B, Yanagi T, Beier R, Conklin LS, Ebens CL, Santos FGMS, Sherlock M, Goldsmith JD, Kotlarz D, Glover SC, Shah N, Bousvaros A, Uhlig HH, Muise AM, Klein C, Snapper SB.

Inflamm Bowel Dis. 2017 Nov;23(11):1950-1961. doi: 10.1097/MIB.0000000000001270.


The role of pendrin in blood pressure regulation.

Wall SM.

Am J Physiol Renal Physiol. 2016 Feb 1;310(3):F193-203. doi: 10.1152/ajprenal.00400.2015. Epub 2015 Nov 4. Review.


The chloride-bicarbonate exchanger pendrin is increased in the kidney of the pregnant rat.

West CA, Verlander JW, Wall SM, Baylis C.

Exp Physiol. 2015 Oct;100(10):1177-86. doi: 10.1113/EP085396. Epub 2015 Sep 2.


Pendrin localizes to the adrenal medulla and modulates catecholamine release.

Lazo-Fernandez Y, Aguilera G, Pham TD, Park AY, Beierwaltes WH, Sutliff RL, Verlander JW, Pacak K, Osunkoya AO, Ellis CL, Kim YH, Shipley GL, Wynne BM, Hoover RS, Sen SK, Plotsky PM, Wall SM.

Am J Physiol Endocrinol Metab. 2015 Sep 15;309(6):E534-45. doi: 10.1152/ajpendo.00035.2015. Epub 2015 Jul 14. Erratum in: Am J Physiol Endocrinol Metab. 2015 Nov 15;309(10):E885.


ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. II. Bafilomycin-sensitive H+ secretion.

Nanami M, Pech V, Lazo-Fernandez Y, Weinstein AM, Wall SM.

Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F259-68. doi: 10.1152/ajprenal.00120.2015. Epub 2015 May 27.


Pendrin gene ablation alters ENaC subcellular distribution and open probability.

Pech V, Wall SM, Nanami M, Bao HF, Kim YH, Lazo-Fernandez Y, Yue Q, Pham TD, Eaton DC, Verlander JW.

Am J Physiol Renal Physiol. 2015 Jul 15;309(2):F154-63. doi: 10.1152/ajprenal.00564.2014. Epub 2015 May 13.


ENaC inhibition stimulates HCl secretion in the mouse cortical collecting duct. I. Stilbene-sensitive Cl- secretion.

Nanami M, Lazo-Fernandez Y, Pech V, Verlander JW, Agazatian D, Weinstein AM, Bao HF, Eaton DC, Wall SM.

Am J Physiol Renal Physiol. 2015 Aug 1;309(3):F251-8. doi: 10.1152/ajprenal.00471.2013. Epub 2015 Apr 29.


Integrated compensatory network is activated in the absence of NCC phosphorylation.

Grimm PR, Lazo-Fernandez Y, Delpire E, Wall SM, Dorsey SG, Weinman EJ, Coleman R, Wade JB, Welling PA.

J Clin Invest. 2015 May;125(5):2136-50. doi: 10.1172/JCI78558. Epub 2015 Apr 20.


The role of pendrin in renal physiology.

Wall SM, Lazo-Fernandez Y.

Annu Rev Physiol. 2015;77:363-78. doi: 10.1146/annurev-physiol-021014-071854. Review.


Contractile force is enhanced in Aortas from pendrin null mice due to stimulation of angiotensin II-dependent signaling.

Sutliff RL, Walp ER, Kim YH, Walker LA, El-Ali AM, Ma J, Bonsall R, Ramosevac S, Eaton DC, Verlander JW, Hansen L, Gleason RL Jr, Pham TD, Hong S, Pech V, Wall SM.

PLoS One. 2014 Aug 22;9(8):e105101. doi: 10.1371/journal.pone.0105101. eCollection 2014.


Epithelial anion transporter pendrin contributes to inflammatory lung pathology in mouse models of Bordetella pertussis infection.

Scanlon KM, Gau Y, Zhu J, Skerry C, Wall SM, Soleimani M, Carbonetti NH.

Infect Immun. 2014 Oct;82(10):4212-21. doi: 10.1128/IAI.02222-14. Epub 2014 Jul 28.


Cortical distal nephron Cl(-) transport in volume homeostasis and blood pressure regulation.

Wall SM, Weinstein AM.

Am J Physiol Renal Physiol. 2013 Aug 15;305(4):F427-38. doi: 10.1152/ajprenal.00022.2013. Epub 2013 May 1. Review.


Nitric oxide reduces Cl⁻ absorption in the mouse cortical collecting duct through an ENaC-dependent mechanism.

Pech V, Thumova M, Dikalov SI, Hummler E, Rossier BC, Harrison DG, Wall SM.

Am J Physiol Renal Physiol. 2013 Jun 1;304(11):F1390-7. doi: 10.1152/ajprenal.00292.2012. Epub 2013 Mar 20.


Pendrin protein abundance in the kidney is regulated by nitric oxide and cAMP.

Thumova M, Pech V, Froehlich O, Agazatian D, Wang X, Verlander JW, Kim YH, Wall SM.

Am J Physiol Renal Physiol. 2012 Sep 15;303(6):F812-20. doi: 10.1152/ajprenal.00577.2011. Epub 2012 Jul 18.


ENaC inhibition stimulates Cl- secretion in the mouse cortical collecting duct through an NKCC1-dependent mechanism.

Pech V, Thumova M, Kim YH, Agazatian D, Hummler E, Rossier BC, Weinstein AM, Nanami M, Wall SM.

Am J Physiol Renal Physiol. 2012 Jul 1;303(1):F45-55. doi: 10.1152/ajprenal.00030.2012. Epub 2012 Apr 11.


Angiotensin II acts through the angiotensin 1a receptor to upregulate pendrin.

Verlander JW, Hong S, Pech V, Bailey JL, Agazatian D, Matthews SW, Coffman TM, Le T, Inagami T, Whitehill FM, Weiner ID, Farley DB, Kim YH, Wall SM.

Am J Physiol Renal Physiol. 2011 Dec;301(6):F1314-25. doi: 10.1152/ajprenal.00114.2011. Epub 2011 Sep 14.


Pendrin and sodium channels: relevance to hypertension.

Wall SM, Pech V.

J Nephrol. 2010 Nov-Dec;23 Suppl 16:S118-23. Review.


Pendrin modulates ENaC function by changing luminal HCO3-.

Pech V, Pham TD, Hong S, Weinstein AM, Spencer KB, Duke BJ, Walp E, Kim YH, Sutliff RL, Bao HF, Eaton DC, Wall SM.

J Am Soc Nephrol. 2010 Nov;21(11):1928-41. doi: 10.1681/ASN.2009121257. Epub 2010 Oct 21.


The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice.

Leviel F, Hübner CA, Houillier P, Morla L, El Moghrabi S, Brideau G, Hassan H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D.

J Clin Invest. 2010 May;120(5):1627-35. doi: 10.1172/JCI40145. Epub 2010 Apr 12. Erratum in: J Clin Invest. 2011 Apr 1;121(4):1668. Hatim, Hassan [corrected to Hassan, Hatim].


Cftr and ENaC ion channels mediate NaCl absorption in the mouse submandibular gland.

Catalán MA, Nakamoto T, Gonzalez-Begne M, Camden JM, Wall SM, Clarke LL, Melvin JE.

J Physiol. 2010 Feb 15;588(Pt 4):713-24. doi: 10.1113/jphysiol.2009.183541. Epub 2009 Dec 21.


Epac regulates UT-A1 to increase urea transport in inner medullary collecting ducts.

Wang Y, Klein JD, Blount MA, Martin CF, Kent KJ, Pech V, Wall SM, Sands JM.

J Am Soc Nephrol. 2009 Sep;20(9):2018-24. doi: 10.1681/ASN.2008121225. Epub 2009 Aug 6.


Role of pendrin in iodide balance: going with the flow.

Kim YH, Pham TD, Zheng W, Hong S, Baylis C, Pech V, Beierwaltes WH, Farley DB, Braverman LE, Verlander JW, Wall SM.

Am J Physiol Renal Physiol. 2009 Oct;297(4):F1069-79. doi: 10.1152/ajprenal.90581.2008. Epub 2009 Jul 15.


Loss of extracellular superoxide dismutase leads to acute lung damage in the presence of ambient air: a potential mechanism underlying adult respiratory distress syndrome.

Gongora MC, Lob HE, Landmesser U, Guzik TJ, Martin WD, Ozumi K, Wall SM, Wilson DS, Murthy N, Gravanis M, Fukai T, Harrison DG.

Am J Pathol. 2008 Oct;173(4):915-26. doi: 10.2353/ajpath.2008.080119. Epub 2008 Sep 11.


Salt sensitivity of blood pressure in NKCC1-deficient mice.

Kim SM, Eisner C, Faulhaber-Walter R, Mizel D, Wall SM, Briggs JP, Schnermann J.

Am J Physiol Renal Physiol. 2008 Oct;295(4):F1230-8. doi: 10.1152/ajprenal.90392.2008. Epub 2008 Aug 13.


The Slc26a4 transporter functions as an electroneutral Cl-/I-/HCO3- exchanger: role of Slc26a4 and Slc26a6 in I- and HCO3- secretion and in regulation of CFTR in the parotid duct.

Shcheynikov N, Yang D, Wang Y, Zeng W, Karniski LP, So I, Wall SM, Muallem S.

J Physiol. 2008 Aug 15;586(16):3813-24. doi: 10.1113/jphysiol.2008.154468. Epub 2008 Jun 19.


Roles of basolateral solute uptake via NKCC1 and of myosin II in vasopressin-induced cell swelling in inner medullary collecting duct.

Chou CL, Yu MJ, Kassai EM, Morris RG, Hoffert JD, Wall SM, Knepper MA.

Am J Physiol Renal Physiol. 2008 Jul;295(1):F192-201. doi: 10.1152/ajprenal.00011.2008. Epub 2008 Apr 16.


Role of NBCe1 and AE2 in secretory ameloblasts.

Paine ML, Snead ML, Wang HJ, Abuladze N, Pushkin A, Liu W, Kao LY, Wall SM, Kim YH, Kurtz I.

J Dent Res. 2008 Apr;87(4):391-5.


Angiotensin II activates H+-ATPase in type A intercalated cells.

Pech V, Zheng W, Pham TD, Verlander JW, Wall SM.

J Am Soc Nephrol. 2008 Jan;19(1):84-91. doi: 10.1681/ASN.2007030277.


The interaction of pendrin and the epithelial sodium channel in blood pressure regulation.

Wall SM, Pech V.

Curr Opin Nephrol Hypertens. 2008 Jan;17(1):18-24. Review.


Reduced ENaC protein abundance contributes to the lower blood pressure observed in pendrin-null mice.

Kim YH, Pech V, Spencer KB, Beierwaltes WH, Everett LA, Green ED, Shin W, Verlander JW, Sutliff RL, Wall SM.

Am J Physiol Renal Physiol. 2007 Oct;293(4):F1314-24. Epub 2007 Aug 8.


Effect of the Na-K-2Cl cotransporter NKCC1 on systemic blood pressure and smooth muscle tone.

Garg P, Martin CF, Elms SC, Gordon FJ, Wall SM, Garland CJ, Sutliff RL, O'Neill WC.

Am J Physiol Heart Circ Physiol. 2007 May;292(5):H2100-5. Epub 2007 Jan 26.


Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.

Nakaya K, Harbidge DG, Wangemann P, Schultz BD, Green ED, Wall SM, Marcus DC.

Am J Physiol Renal Physiol. 2007 May;292(5):F1314-21. Epub 2007 Jan 2.


Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.

Jabba SV, Oelke A, Singh R, Maganti RJ, Fleming S, Wall SM, Everett LA, Green ED, Wangemann P.

BMC Med. 2006 Dec 22;4:37.


The renal physiology of pendrin (SLC26A4) and its role in hypertension.

Wall SM.

Novartis Found Symp. 2006;273:231-9; discussion 239-43, 261-4.


Angiotensin II increases chloride absorption in the cortical collecting duct in mice through a pendrin-dependent mechanism.

Pech V, Kim YH, Weinstein AM, Everett LA, Pham TD, Wall SM.

Am J Physiol Renal Physiol. 2007 Mar;292(3):F914-20. Epub 2006 Oct 31.


Cellular distribution of the potassium channel KCNQ1 in normal mouse kidney.

Zheng W, Verlander JW, Lynch IJ, Cash M, Shao J, Stow LR, Cain BD, Weiner ID, Wall SM, Wingo CS.

Am J Physiol Renal Physiol. 2007 Jan;292(1):F456-66. Epub 2006 Aug 8.


Dietary Cl(-) restriction upregulates pendrin expression within the apical plasma membrane of type B intercalated cells.

Verlander JW, Kim YH, Shin W, Pham TD, Hassell KA, Beierwaltes WH, Green ED, Everett L, Matthews SW, Wall SM.

Am J Physiol Renal Physiol. 2006 Oct;291(4):F833-9. Epub 2006 May 2.


Hypotension in NKCC1 null mice: role of the kidneys.

Wall SM, Knepper MA, Hassell KA, Fischer MP, Shodeinde A, Shin W, Pham TD, Meyer JW, Lorenz JN, Beierwaltes WH, Dietz JR, Shull GE, Kim YH.

Am J Physiol Renal Physiol. 2006 Feb;290(2):F409-16. Epub 2005 Sep 13.


Intercalated cell H+/OH- transporter expression is reduced in Slc26a4 null mice.

Kim YH, Verlander JW, Matthews SW, Kurtz I, Shin W, Weiner ID, Everett LA, Green ED, Nielsen S, Wall SM.

Am J Physiol Renal Physiol. 2005 Dec;289(6):F1262-72. Epub 2005 Sep 6.


Recent advances in our understanding of intercalated cells.

Wall SM.

Curr Opin Nephrol Hypertens. 2005 Sep;14(5):480-4. Review.


Vasopressin increases urea permeability in the initial IMCD from diabetic rats.

Pech V, Klein JD, Kozlowski SD, Wall SM, Sands JM.

Am J Physiol Renal Physiol. 2005 Sep;289(3):F531-5. Epub 2005 May 10.

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