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Plasmodium Condensin Core Subunits SMC2/SMC4 Mediate Atypical Mitosis and Are Essential for Parasite Proliferation and Transmission.

Pandey R, Abel S, Boucher M, Wall RJ, Zeeshan M, Rea E, Freville A, Lu XM, Brady D, Daniel E, Stanway RR, Wheatley S, Batugedara G, Hollin T, Bottrill AR, Gupta D, Holder AA, Le Roch KG, Tewari R.

Cell Rep. 2020 Feb 11;30(6):1883-1897.e6. doi: 10.1016/j.celrep.2020.01.033.


The Qi Site of Cytochrome b is a Promiscuous Drug Target in Trypanosoma cruzi and Leishmania donovani.

Wall RJ, Carvalho S, Milne R, Bueren-Calabuig JA, Moniz S, Cantizani-Perez J, MacLean L, Kessler A, Cotillo I, Sastry L, Manthri S, Patterson S, Zuccotto F, Thompson S, Martin J, Marco M, Miles TJ, De Rycker M, Thomas MG, Fairlamb AH, Gilbert IH, Wyllie S.

ACS Infect Dis. 2020 Mar 13;6(3):515-528. doi: 10.1021/acsinfecdis.9b00426. Epub 2020 Jan 30.


Systematic analysis of Plasmodium myosins reveals differential expression, localisation, and function in invasive and proliferative parasite stages.

Wall RJ, Zeeshan M, Katris NJ, Limenitakis R, Rea E, Stock J, Brady D, Waller RF, Holder AA, Tewari R.

Cell Microbiol. 2019 Oct;21(10):e13082. doi: 10.1111/cmi.13082. Epub 2019 Jul 23.


Preclinical candidate for the treatment of visceral leishmaniasis that acts through proteasome inhibition.

Wyllie S, Brand S, Thomas M, De Rycker M, Chung CW, Pena I, Bingham RP, Bueren-Calabuig JA, Cantizani J, Cebrian D, Craggs PD, Ferguson L, Goswami P, Hobrath J, Howe J, Jeacock L, Ko EJ, Korczynska J, MacLean L, Manthri S, Martinez MS, Mata-Cantero L, Moniz S, Nühs A, Osuna-Cabello M, Pinto E, Riley J, Robinson S, Rowland P, Simeons FRC, Shishikura Y, Spinks D, Stojanovski L, Thomas J, Thompson S, Viayna Gaza E, Wall RJ, Zuccotto F, Horn D, Ferguson MAJ, Fairlamb AH, Fiandor JM, Martin J, Gray DW, Miles TJ, Gilbert IH, Read KD, Marco M, Wyatt PG.

Proc Natl Acad Sci U S A. 2019 May 7;116(19):9318-9323. doi: 10.1073/pnas.1820175116. Epub 2019 Apr 8.


Pharmacological Validation of N-Myristoyltransferase as a Drug Target in Leishmania donovani.

Corpas-Lopez V, Moniz S, Thomas M, Wall RJ, Torrie LS, Zander-Dinse D, Tinti M, Brand S, Stojanovski L, Manthri S, Hallyburton I, Zuccotto F, Wyatt PG, De Rycker M, Horn D, Ferguson MAJ, Clos J, Read KD, Fairlamb AH, Gilbert IH, Wyllie S.

ACS Infect Dis. 2019 Jan 11;5(1):111-122. doi: 10.1021/acsinfecdis.8b00226. Epub 2018 Nov 12.


Clinical and veterinary trypanocidal benzoxaboroles target CPSF3.

Wall RJ, Rico E, Lukac I, Zuccotto F, Elg S, Gilbert IH, Freund Y, Alley MRK, Field MC, Wyllie S, Horn D.

Proc Natl Acad Sci U S A. 2018 Sep 18;115(38):9616-9621. doi: 10.1073/pnas.1807915115. Epub 2018 Sep 5.


Author Correction: Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.

Wall RJ, Ferguson DJP, Freville A, Franke-Fayard B, Brady D, Zeeshan M, Bottrill AR, Wheatley S, Fry AM, Janse CJ, Yamano H, Holder AA, Guttery DS, Tewari R.

Sci Rep. 2018 Aug 21;8(1):12814. doi: 10.1038/s41598-018-30924-6.


Antitrypanosomal 8-Hydroxy-Naphthyridines Are Chelators of Divalent Transition Metals.

Wall RJ, Moniz S, Thomas MG, Norval S, Ko EJ, Marco M, Miles TJ, Gilbert IH, Horn D, Fairlamb AH, Wyllie S.

Antimicrob Agents Chemother. 2018 Jul 27;62(8). pii: e00235-18. doi: 10.1128/AAC.00235-18. Print 2018 Aug.


Plasmodium APC3 mediates chromosome condensation and cytokinesis during atypical mitosis in male gametogenesis.

Wall RJ, Ferguson DJP, Freville A, Franke-Fayard B, Brady D, Zeeshan M, Bottrill AR, Wheatley S, Fry AM, Janse CJ, Yamano H, Holder AA, Guttery DS, Tewari R.

Sci Rep. 2018 Apr 4;8(1):5610. doi: 10.1038/s41598-018-23871-9. Erratum in: Sci Rep. 2018 Aug 21;8(1):12814.


Compositional and expression analyses of the glideosome during the Plasmodium life cycle reveal an additional myosin light chain required for maximum motility.

Green JL, Wall RJ, Vahokoski J, Yusuf NA, Ridzuan MAM, Stanway RR, Stock J, Knuepfer E, Brady D, Martin SR, Howell SA, Pires IP, Moon RW, Molloy JE, Kursula I, Tewari R, Holder AA.

J Biol Chem. 2017 Oct 27;292(43):17857-17875. doi: 10.1074/jbc.M117.802769. Epub 2017 Sep 11.


The permeability of fractured rocks in pressurised volcanic and geothermal systems.

Lamur A, Kendrick JE, Eggertsson GH, Wall RJ, Ashworth JD, Lavallée Y.

Sci Rep. 2017 Jul 21;7(1):6173. doi: 10.1038/s41598-017-05460-4.


Seismic and experimental insights into eruption precursors at Volcán de Colima.

Lamb OD, De Angelis S, Wall RJ, Lamur A, Varley NR, Reyes-Dávila G, Arámbula-Mendoza R, Hornby AJ, Kendrick JE, Lavallée Y.

Geophys Res Lett. 2017 Jun 28;44(12):6092-6100. doi: 10.1002/2017GL073350.


The Role of Folate Transport in Antifolate Drug Action in Trypanosoma brucei.

Dewar S, Sienkiewicz N, Ong HB, Wall RJ, Horn D, Fairlamb AH.

J Biol Chem. 2016 Nov 18;291(47):24768-24778. Epub 2016 Oct 4.


SAS6-like protein in Plasmodium indicates that conoid-associated apical complex proteins persist in invasive stages within the mosquito vector.

Wall RJ, Roques M, Katris NJ, Koreny L, Stanway RR, Brady D, Waller RF, Tewari R.

Sci Rep. 2016 Jun 24;6:28604. doi: 10.1038/srep28604.


Plasmodium P-Type Cyclin CYC3 Modulates Endomitotic Growth during Oocyst Development in Mosquitoes.

Roques M, Wall RJ, Douglass AP, Ramaprasad A, Ferguson DJ, Kaindama ML, Brusini L, Joshi N, Rchiad Z, Brady D, Guttery DS, Wheatley SP, Yamano H, Holder AA, Pain A, Wickstead B, Tewari R.

PLoS Pathog. 2015 Nov 13;11(11):e1005273. doi: 10.1371/journal.ppat.1005273. eCollection 2015 Nov.


The Plasmodium Class XIV Myosin, MyoB, Has a Distinct Subcellular Location in Invasive and Motile Stages of the Malaria Parasite and an Unusual Light Chain.

Yusuf NA, Green JL, Wall RJ, Knuepfer E, Moon RW, Schulte-Huxel C, Stanway RR, Martin SR, Howell SA, Douse CH, Cota E, Tate EW, Tewari R, Holder AA.

J Biol Chem. 2015 May 8;290(19):12147-64. doi: 10.1074/jbc.M115.637694. Epub 2015 Mar 23.


Characterisation of chlorinated, brominated and mixed halogenated dioxins, furans and biphenyls as potent and as partial agonists of the Aryl hydrocarbon receptor.

Wall RJ, Fernandes A, Rose M, Bell DR, Mellor IR.

Environ Int. 2015 Mar;76:49-56. doi: 10.1016/j.envint.2014.12.002. Epub 2014 Dec 23.


The repeat region of the circumsporozoite protein is critical for sporozoite formation and maturation in Plasmodium.

Ferguson DJ, Balaban AE, Patzewitz EM, Wall RJ, Hopp CS, Poulin B, Mohmmed A, Malhotra P, Coppi A, Sinnis P, Tewari R.

PLoS One. 2014 Dec 1;9(12):e113923. doi: 10.1371/journal.pone.0113923. eCollection 2014.


Mixed halogenated dioxins/furans (PXDD/Fs) and biphenyls (PXBs) in food: occurrence and toxic equivalent exposure using specific relative potencies.

Fernandes AR, Mortimer D, Wall RJ, Bell DR, Rose M, Carr M, Panton S, Smith F.

Environ Int. 2014 Dec;73:104-10. doi: 10.1016/j.envint.2014.07.007. Epub 2014 Aug 9.


Genome-wide functional analysis of Plasmodium protein phosphatases reveals key regulators of parasite development and differentiation.

Guttery DS, Poulin B, Ramaprasad A, Wall RJ, Ferguson DJ, Brady D, Patzewitz EM, Whipple S, Straschil U, Wright MH, Mohamed AM, Radhakrishnan A, Arold ST, Tate EW, Holder AA, Wickstead B, Pain A, Tewari R.

Cell Host Microbe. 2014 Jul 9;16(1):128-40. doi: 10.1016/j.chom.2014.05.020.


Unique apicomplexan IMC sub-compartment proteins are early markers for apical polarity in the malaria parasite.

Poulin B, Patzewitz EM, Brady D, Silvie O, Wright MH, Ferguson DJ, Wall RJ, Whipple S, Guttery DS, Tate EW, Wickstead B, Holder AA, Tewari R.

Biol Open. 2013 Sep 16;2(11):1160-70. doi: 10.1242/bio.20136163. eCollection 2013.


An ancient protein phosphatase, SHLP1, is critical to microneme development in Plasmodium ookinetes and parasite transmission.

Patzewitz EM, Guttery DS, Poulin B, Ramakrishnan C, Ferguson DJ, Wall RJ, Brady D, Holder AA, Szöőr B, Tewari R.

Cell Rep. 2013 Mar 28;3(3):622-9. doi: 10.1016/j.celrep.2013.01.032. Epub 2013 Feb 21.


Fused mesoionic heterocyclic compounds are a new class of aryl hydrocarbon receptor (AhR) agonist of exceptional potency.

Wall RJ, Bell DR, Bazzi R, Fernandes A, Rose M, Rowlands JC, Mellor IR.

Toxicology. 2012 Dec 16;302(2-3):140-5. doi: 10.1016/j.tox.2012.09.003. Epub 2012 Sep 20.


Novel 2-amino-isoflavones exhibit aryl hydrocarbon receptor agonist or antagonist activity in a species/cell-specific context.

Wall RJ, He G, Denison MS, Congiu C, Onnis V, Fernandes A, Bell DR, Rose M, Rowlands JC, Balboni G, Mellor IR.

Toxicology. 2012 Jul 16;297(1-3):26-33. doi: 10.1016/j.tox.2012.03.011. Epub 2012 Apr 7.


Quality improvement projects targeting health care-associated infections: comparing Virtual Collaborative and Toolkit approaches.

Speroff T, Ely EW, Greevy R, Weinger MB, Talbot TR, Wall RJ, Deshpande JK, France DJ, Nwosu S, Burgess H, Englebright J, Williams MV, Dittus RS.

J Hosp Med. 2011 May;6(5):271-8. doi: 10.1002/jhm.873. Epub 2011 Feb 10.


Organisational culture: variation across hospitals and connection to patient safety climate.

Speroff T, Nwosu S, Greevy R, Weinger MB, Talbot TR, Wall RJ, Deshpande JK, France DJ, Ely EW, Burgess H, Englebright J, Williams MV, Dittus RS.

Qual Saf Health Care. 2010 Dec;19(6):592-6. doi: 10.1136/qshc.2009.039511.


Coordinated patterns of gene expressions for adult muscle build-up in transgenic mice expressing myostatin propeptide.

Zhao B, Li EJ, Wall RJ, Yang J.

BMC Genomics. 2009 Jul 8;10:305. doi: 10.1186/1471-2164-10-305.


Fate of lysostaphin in milk from individual cows through pasteurization and cheesemaking.

Van Hekken DL, Wall RJ, Somkuti GA, Powell MA, Tunick MH, Tomasula PM.

J Dairy Sci. 2009 Feb;92(2):444-57. doi: 10.3168/jds.2008-1019.


Evidence-based algorithms for diagnosing and treating ventilator-associated pneumonia.

Wall RJ, Ely EW, Talbot TR, Weinger MB, Williams MV, Reischel J, Burgess LH, Englebright J, Dittus RS, Speroff T, Deshpande JK.

J Hosp Med. 2008 Sep;3(5):409-22. doi: 10.1002/jhm.317. Review.


Family member satisfaction with end-of-life decision making in the ICU.

Gries CJ, Curtis JR, Wall RJ, Engelberg RA.

Chest. 2008 Mar;133(3):704-12. doi: 10.1378/chest.07-1773. Epub 2008 Jan 15.


Are animal models as good as we think?

Wall RJ, Shani M.

Theriogenology. 2008 Jan 1;69(1):2-9. Epub 2007 Nov 7. Review.


Regulation of animal biotechnology: research needs.

Rexroad CE Jr, Green RD, Wall RJ.

Theriogenology. 2007 Sep 1;68 Suppl 1:S3-8. Epub 2007 Jun 15. Review.


Family satisfaction in the ICU: differences between families of survivors and nonsurvivors.

Wall RJ, Curtis JR, Cooke CR, Engelberg RA.

Chest. 2007 Nov;132(5):1425-33. Epub 2007 Jun 15.


Spiritual care of families in the intensive care unit.

Wall RJ, Engelberg RA, Gries CJ, Glavan B, Curtis JR.

Crit Care Med. 2007 Apr;35(4):1084-90.


Refinement, scoring, and validation of the Family Satisfaction in the Intensive Care Unit (FS-ICU) survey.

Wall RJ, Engelberg RA, Downey L, Heyland DK, Curtis JR.

Crit Care Med. 2007 Jan;35(1):271-9.


Radiation pneumonitis.

Wall RJ, Schnapp LM.

Respir Care. 2006 Nov;51(11):1255-60. No abstract available.


Major advances associated with the biosynthesis of milk.

Bauman DE, Mather IH, Wall RJ, Lock AL.

J Dairy Sci. 2006 Apr;89(4):1235-43. Review.


Intensive care unit quality improvement: a "how-to" guide for the interdisciplinary team.

Curtis JR, Cook DJ, Wall RJ, Angus DC, Bion J, Kacmarek R, Kane-Gill SL, Kirchhoff KT, Levy M, Mitchell PH, Moreno R, Pronovost P, Puntillo K.

Crit Care Med. 2006 Jan;34(1):211-8. Review.


Engineering disease resistant cattle.

Donovan DM, Kerr DE, Wall RJ.

Transgenic Res. 2005 Oct;14(5):563-7. Review.


Transgenic expression of myostatin propeptide prevents diet-induced obesity and insulin resistance.

Zhao B, Wall RJ, Yang J.

Biochem Biophys Res Commun. 2005 Nov 11;337(1):248-55.


Using real time process measurements to reduce catheter related bloodstream infections in the intensive care unit.

Wall RJ, Ely EW, Elasy TA, Dittus RS, Foss J, Wilkerson KS, Speroff T.

Qual Saf Health Care. 2005 Aug;14(4):295-302.


Comparison of gene expression in individual preimplantation bovine embryos produced by in vitro fertilisation or somatic cell nuclear transfer.

de A Camargo LS, Powell AM, do Vale Filho VR, Wall RJ.

Reprod Fertil Dev. 2005;17(5):487-96.


Follicular expression of a human beta-cell leukaemia/lymphoma-2 (Bcl-2) transgene does not decrease atresia or increase ovulation rate in swine.

Guthrie HD, Wall RJ, Pursel VG, Foster-Frey JA, Donovan DM, Dawson HD, Welch GR, Garrett WG.

Reprod Fertil Dev. 2005;17(4):457-66.


Genetically enhanced cows resist intramammary Staphylococcus aureus infection.

Wall RJ, Powell AM, Paape MJ, Kerr DE, Bannerman DD, Pursel VG, Wells KD, Talbot N, Hawk HW.

Nat Biotechnol. 2005 Apr;23(4):445-51. Epub 2005 Apr 3. Erratum in: Nat Biotechnol. 2005 Jul;23(7):897.


Growth and tissue accretion rates of swine expressing an insulin-like growth factor I transgene.

Pursel VG, Mitchell AD, Bee G, Elsasser TH, McMurtry JP, Wall RJ, Coleman ME, Schwartz RJ.

Anim Biotechnol. 2004 May;15(1):33-45.


Cell donor influences success of producing cattle by somatic cell nuclear transfer.

Powell AM, Talbot NC, Wells KD, Kerr DE, Pursel VG, Wall RJ.

Biol Reprod. 2004 Jul;71(1):210-6. Epub 2004 Mar 3.


Expression of lysostaphin in milk of transgenic mice affects the growth of neonates.

Mitra A, Hruska KS, Wellnitz O, Kerr DE, Capuco AV, Wall RJ.

Transgenic Res. 2003 Oct;12(5):597-605.


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