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Ambidextrous helical nanotubes from self-assembly of designed helical hairpin motifs.

Hughes SA, Wang F, Wang S, Kreutzberger MAB, Osinski T, Orlova A, Wall JS, Zuo X, Egelman EH, Conticello VP.

Proc Natl Acad Sci U S A. 2019 Jul 16;116(29):14456-14464. doi: 10.1073/pnas.1903910116. Epub 2019 Jul 1.


An extensively glycosylated archaeal pilus survives extreme conditions.

Wang F, Cvirkaite-Krupovic V, Kreutzberger MAB, Su Z, de Oliveira GAP, Osinski T, Sherman N, DiMaio F, Wall JS, Prangishvili D, Krupovic M, Egelman EH.

Nat Microbiol. 2019 May 20. doi: 10.1038/s41564-019-0458-x. [Epub ahead of print]


Mechanistic insights into the pH-dependent membrane peptide ATRAM.

Nguyen VP, Palanikumar L, Kennel SJ, Alves DS, Ye Y, Wall JS, Magzoub M, Barrera FN.

J Control Release. 2019 Mar 28;298:142-153. doi: 10.1016/j.jconrel.2019.02.010. Epub 2019 Feb 11.


Anticytomegalovirus Peptides Point to New Insights for CMV Entry Mechanisms and the Limitations of In Vitro Screenings.

Jackson JW, Hancock TJ, Dogra P, Patel R, Arav-Boger R, Williams AD, Kennel SJ, Wall JS, Sparer TE.

mSphere. 2019 Feb 13;4(1). pii: e00586-18. doi: 10.1128/mSphere.00586-18.


Macrophage-Mediated Phagocytosis and Dissolution of Amyloid-Like Fibrils in Mice, Monitored by Optical Imaging.

Richey T, Foster JS, Williams AD, Williams AB, Stroh A, Macy S, Wooliver C, Heidel RE, Varanasi SK, Ergen EN, Trent DJ, Kania SA, Kennel SJ, Martin EB, Wall JS.

Am J Pathol. 2019 May;189(5):989-998. doi: 10.1016/j.ajpath.2019.01.011. Epub 2019 Feb 6.


Bifunctional amyloid-reactive peptide promotes binding of antibody 11-1F4 to diverse amyloid types and enhances therapeutic efficacy.

Wall JS, Williams AD, Foster JS, Richey T, Stuckey A, Macy S, Wooliver C, Campagna SR, Tague ED, Farmer AT, Lands RH, Martin EB, Heidel RE, Kennel SJ.

Proc Natl Acad Sci U S A. 2018 Nov 13;115(46):E10839-E10848. doi: 10.1073/pnas.1805515115. Epub 2018 Oct 30.


Relative skeletal distribution of proliferating marrow in the adult dog determined using 3'-deoxy-3'-[18 F]fluorothymidine.

Rowe JA, Morandi F, Osborne DR, Wall JS, Kennel SJ, Reed RB, LeBlanc AK.

Anat Histol Embryol. 2019 Jan;48(1):46-52. doi: 10.1111/ahe.12410. Epub 2018 Oct 23.


Comparison of the 3D structures of mouse and human α-synuclein fibrils by solid-state NMR and STEM.

Hwang S, Fricke P, Zinke M, Giller K, Wall JS, Riedel D, Becker S, Lange A.

J Struct Biol. 2019 Apr 1;206(1):43-48. doi: 10.1016/j.jsb.2018.04.003. Epub 2018 Apr 17.


A functional assay to identify amyloidogenic light chains.

Martin EB, Williams AD, Heidel RE, Foster JS, Lands RH, Kennel SJ, Wall JS.

Amyloid. 2018 Jun;25(2):93-100. doi: 10.1080/13506129.2018.1456425. Epub 2018 Mar 23.


Evaluation of the effect of D-amino acid incorporation into amyloid-reactive peptides.

Martin EB, Williams A, Richey T, Wooliver C, Stuckey A, Foster JS, Kennel SJ, Wall JS.

J Transl Med. 2017 Dec 11;15(1):247. doi: 10.1186/s12967-017-1351-0.


Mesenchymal stromal cells protect human cardiomyocytes from amyloid fibril damage.

Lin Y, Marin-Argany M, Dick CJ, Redhage KR, Blancas-Mejia LM, Bulur P, Butler GW, Deeds MC, Madden BJ, Williams A, Wall JS, Dietz A, Ramirez-Alvarado M.

Cytotherapy. 2017 Dec;19(12):1426-1437. doi: 10.1016/j.jcyt.2017.08.021. Epub 2017 Oct 14.


A Peptide-Fc Opsonin with Pan-Amyloid Reactivity.

Foster JS, Williams AD, Macy S, Richey T, Stuckey A, Wooliver DC, Koul-Tiwari R, Martin EB, Kennel SJ, Wall JS.

Front Immunol. 2017 Sep 4;8:1082. doi: 10.3389/fimmu.2017.01082. eCollection 2017.


Kinetic stability and sequence/structure studies of urine-derived Bence-Jones proteins from multiple myeloma and light chain amyloidosis patients.

Blancas-Mejía LM, Martin EB, Williams A, Wall JS, Ramirez-Alvarado M.

Biophys Chem. 2017 Nov;230:89-98. doi: 10.1016/j.bpc.2017.08.011. Epub 2017 Sep 1.


Pretargeting immunotherapy: a novel treatment approach for systemic amyloidosis.

Wall JS, Foster JS, Martin EB, Kennel SJ.

Pharm Pat Anal. 2017 Sep;6(5):215-223. doi: 10.4155/ppa-2017-0022. Epub 2017 Aug 21.


Dual-Energy SPECT and the Development of Peptide p5+14 for Imaging Amyloidosis.

Wall JS, Kennel SJ, Martin EB.

Mol Imaging. 2017 Jan 1;16:1536012117708705. doi: 10.1177/1536012117708705.


Bacteriophage Tail-Tube Assembly Studied by Proton-Detected 4D Solid-State NMR.

Zinke M, Fricke P, Samson C, Hwang S, Wall JS, Lange S, Zinn-Justin S, Lange A.

Angew Chem Int Ed Engl. 2017 Aug 1;56(32):9497-9501. doi: 10.1002/anie.201706060. Epub 2017 Jul 7.


A bifunctional peptide, "peptope", for pre-targeting antibody 7D8 to systemic amyloid deposits.

Wall JS, Williams A, Foster JS, Martin EB, Richey T, Stuckey A, Macy S, Zago W, Kinney GG, Kennel SJ.

Amyloid. 2017 Mar;24(sup1):22-23. doi: 10.1080/13506129.2017.1295372. No abstract available.


Recruitment of human light chain proteins by synthetic fibrils is dependent on disease state and may be used to predict amyloidogenic propensity.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia L, Kennel SJ, Wall JS.

Amyloid. 2017 Mar;24(sup1):24-25. doi: 10.1080/13506129.2017.1295374. No abstract available.


Preliminary characterization of a novel peptide-Fc-fusion construct for targeting amyloid deposits.

Foster JS, Koul-Tiwari R, Williams A, Martin EB, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS.

Amyloid. 2017 Mar;24(sup1):26-27. doi: 10.1080/13506129.2017.1295375. No abstract available.


A novel murine system for validating the specific targeting of peptides to light chain associated (AL) amyloid.

Beierle SP, Foster JS, Richey T, Stuckey A, Macy S, Kennel SJ, Wall JS.

Amyloid. 2017 Mar;24(sup1):74-75. doi: 10.1080/13506129.2017.1295377. No abstract available.


Probing the structural requirements of polybasic peptides for effective and specific amyloid reactivity.

Wall JS, Williams A, Stuckey A, Martin EB, Richey T, Wooliver C, Heidel RE, Cheng X, Kennel SJ.

Amyloid. 2017 Mar;24(sup1):30-31. doi: 10.1080/13506129.2017.1295946. No abstract available.


Serendipitous inhibition of Aβ and rVλ6Wil amyloid fibril growth by bi-functional peptides.

Wall JS, Williams A, Martin EB, Cheng X, Kennel SJ.

Amyloid. 2017 Mar;24(sup1):32-33. doi: 10.1080/13506129.2017.1295947. No abstract available.


Differential recruitment efficacy of patient-derived amyloidogenic and myeloma light chain proteins by synthetic fibrils-A metric for predicting amyloid propensity.

Martin EB, Williams A, Wooliver C, Heidel RE, Adams S, Dunlap J, Ramirez-Alvarado M, Blancas-Mejia LM, Lands RH, Kennel SJ, Wall JS.

PLoS One. 2017 Mar 28;12(3):e0174152. doi: 10.1371/journal.pone.0174152. eCollection 2017.


Secondary structure propensity and chirality of the amyloidophilic peptide p5 and its analogues impacts ligand binding - In vitro characterization.

Wall JS, Williams A, Wooliver C, Martin EB, Cheng X, Heidel RE, Kennel SJ.

Biochem Biophys Rep. 2016 Dec;8:89-99. doi: 10.1016/j.bbrep.2016.08.007. Epub 2016 Aug 11.


Immunoglobulin Light Chains Form an Extensive and Highly Ordered Fibril Involving the N- and C-Termini.

Piehl DW, Blancas-Mejía LM, Wall JS, Kennel SJ, Ramirez-Alvarado M, Rienstra CM.

ACS Omega. 2017 Feb 28;2(2):712-720. doi: 10.1021/acsomega.6b00494. Epub 2017 Feb 27.


Specific Amyloid Binding of Polybasic Peptides In Vivo Is Retained by β-Sheet Conformers but Lost in the Disrupted Coil and All D-Amino Acid Variants.

Wall JS, Williams A, Richey T, Stuckey A, Wooliver C, Christopher Scott J, Donnell R, Martin EB, Kennel SJ.

Mol Imaging Biol. 2017 Oct;19(5):714-722. doi: 10.1007/s11307-017-1063-0.


Self-Assembly of an α-Helical Peptide into a Crystalline Two-Dimensional Nanoporous Framework.

Magnotti EL, Hughes SA, Dillard RS, Wang S, Hough L, Karumbamkandathil A, Lian T, Wall JS, Zuo X, Wright ER, Conticello VP.

J Am Chem Soc. 2016 Dec 21;138(50):16274-16282. doi: 10.1021/jacs.6b06592. Epub 2016 Dec 12.


The D-form of a novel heparan binding peptide decreases cytomegalovirus infection in vivo and in vitro.

Pitt EA, Dogra P, Patel RS, Williams A, Wall JS, Sparer TE.

Antiviral Res. 2016 Nov;135:15-23. doi: 10.1016/j.antiviral.2016.09.012. Epub 2016 Sep 25.


Atomic-resolution structure of a disease-relevant Aβ(1-42) amyloid fibril.

Wälti MA, Ravotti F, Arai H, Glabe CG, Wall JS, Böckmann A, Güntert P, Meier BH, Riek R.

Proc Natl Acad Sci U S A. 2016 Aug 23;113(34):E4976-84. doi: 10.1073/pnas.1600749113. Epub 2016 Jul 28.



Marin-Argany M, Lin Y, Misra P, Williams A, Wall JS, Howell KG, Elsbernd LR, McClure M, Ramirez-Alvarado M.

J Biol Chem. 2016 Sep 16;291(38):19813-25. doi: 10.1074/jbc.M116.736736. Epub 2016 Jul 26.


Comparative evaluation of p5+14 with SAP and peptide p5 by dual-energy SPECT imaging of mice with AA amyloidosis.

Martin EB, Williams A, Richey T, Stuckey A, Heidel RE, Kennel SJ, Wall JS.

Sci Rep. 2016 Mar 3;6:22695. doi: 10.1038/srep22695.


The pattern recognition reagents RAGE VC1 and peptide p5 share common binding sites and exhibit specific reactivity with AA amyloid in mice.

Kennel SJ, Williams A, Stuckey A, Richey T, Wooliver C, Chazin W, Stern DA, Martin EB, Wall JS.

Amyloid. 2016;23(1):8-16. doi: 10.3109/13506129.2015.1112782. Epub 2015 Dec 24.


A Routine PET/CT Protocol with Streamlined Calculations for Assessing Cardiac Amyloidosis Using (18)F-Florbetapir.

Osborne DR, Acuff SN, Stuckey A, Wall JS.

Front Cardiovasc Med. 2015 May 8;2:23. doi: 10.3389/fcvm.2015.00023. eCollection 2015.


α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils.

Dearborn AD, Wall JS, Cheng N, Heymann JB, Kajava AV, Varkey J, Langen R, Steven AC.

J Biol Chem. 2016 Jan 29;291(5):2310-8. doi: 10.1074/jbc.M115.698787. Epub 2015 Dec 7.


Tc-99m Radiolabeled Peptide p5 + 14 is an Effective Probe for SPECT Imaging of Systemic Amyloidosis.

Kennel SJ, Stuckey A, McWilliams-Koeppen HP, Richey T, Wall JS.

Mol Imaging Biol. 2016 Aug;18(4):483-9. doi: 10.1007/s11307-015-0914-9.


Light Chain Amyloid Fibrils Cause Metabolic Dysfunction in Human Cardiomyocytes.

McWilliams-Koeppen HP, Foster JS, Hackenbrack N, Ramirez-Alvarado M, Donohoe D, Williams A, Macy S, Wooliver C, Wortham D, Morrell-Falvey J, Foster CM, Kennel SJ, Wall JS.

PLoS One. 2015 Sep 22;10(9):e0137716. doi: 10.1371/journal.pone.0137716. eCollection 2015.


Novel heparan sulfate-binding peptides for blocking herpesvirus entry.

Dogra P, Martin EB, Williams A, Richardson RL, Foster JS, Hackenback N, Kennel SJ, Sparer TE, Wall JS.

PLoS One. 2015 May 18;10(5):e0126239. doi: 10.1371/journal.pone.0126239. eCollection 2015.


Preclinical Validation of the Heparin-Reactive Peptide p5+14 as a Molecular Imaging Agent for Visceral Amyloidosis.

Wall JS, Martin EB, Richey T, Stuckey AC, Macy S, Wooliver C, Williams A, Foster JS, McWilliams-Koeppen P, Uberbacher E, Cheng X, Kennel SJ.

Molecules. 2015 Apr 27;20(5):7657-82. doi: 10.3390/molecules20057657.


Dynamic PET and SPECT imaging with radioiodinated, amyloid-reactive peptide p5 in mice: a positive role for peptide dehalogenation.

Martin EB, Kennel SJ, Richey T, Wooliver C, Osborne D, Williams A, Stuckey A, Wall JS.

Peptides. 2014 Oct;60:63-70. doi: 10.1016/j.peptides.2014.07.024. Epub 2014 Aug 4.


A virus capsid-like nanocompartment that stores iron and protects bacteria from oxidative stress.

McHugh CA, Fontana J, Nemecek D, Cheng N, Aksyuk AA, Heymann JB, Winkler DC, Lam AS, Wall JS, Steven AC, Hoiczyk E.

EMBO J. 2014 Sep 1;33(17):1896-911. doi: 10.15252/embj.201488566. Epub 2014 Jul 14.


Conformational switching in PolyGln amyloid fibrils resulting from a single amino acid insertion.

Huang RK, Baxa U, Aldrian G, Ahmed AB, Wall JS, Mizuno N, Antzutkin O, Steven AC, Kajava AV.

Biophys J. 2014 May 20;106(10):2134-42. doi: 10.1016/j.bpj.2014.03.047.


Membrane crystals of plant light-harvesting complex II disassemble reversibly in light.

Hind G, Wall JS, Várkonyi Z, Istokovics A, Lambrev PH, Garab G.

Plant Cell Physiol. 2014 Jul;55(7):1296-303. doi: 10.1093/pcp/pcu064. Epub 2014 May 3.


Structurally defined nanoscale sheets from self-assembly of collagen-mimetic peptides.

Jiang T, Xu C, Liu Y, Liu Z, Wall JS, Zuo X, Lian T, Salaita K, Ni C, Pochan D, Conticello VP.

J Am Chem Soc. 2014 Mar 19;136(11):4300-8. doi: 10.1021/ja412867z. Epub 2014 Mar 10.


Phagocyte depletion inhibits AA amyloid accumulation in AEF-induced huIL-6 transgenic mice.

Kennel SJ, Macy S, Wooliver C, Huang Y, Richey T, Heidel E, Wall JS.

Amyloid. 2014 Mar;21(1):45-53. doi: 10.3109/13506129.2013.876400. Epub 2014 Jan 22.


The N-terminal strand modulates immunoglobulin light chain fibrillogenesis.

del Pozo-Yauner L, Wall JS, González Andrade M, Sánchez-López R, Rodríguez-Ambriz SL, Pérez Carreón JI, Ochoa-Leyva A, Fernández-Velasco DA.

Biochem Biophys Res Commun. 2014 Jan 10;443(2):495-9. doi: 10.1016/j.bbrc.2013.11.123. Epub 2013 Dec 7.


LnPO4 nanoparticles doped with Ac-225 and sequestered daughters for targeted alpha therapy.

McLaughlin MF, Robertson D, Pevsner PH, Wall JS, Mirzadeh S, Kennel SJ.

Cancer Biother Radiopharm. 2014 Feb;29(1):34-41. doi: 10.1089/cbr.2013.1546. Epub 2013 Oct 8.


Rational design of helical nanotubes from self-assembly of coiled-coil lock washers.

Xu C, Liu R, Mehta AK, Guerrero-Ferreira RC, Wright ER, Dunin-Horkawicz S, Morris K, Serpell LC, Zuo X, Wall JS, Conticello VP.

J Am Chem Soc. 2013 Oct 16;135(41):15565-78. doi: 10.1021/ja4074529. Epub 2013 Oct 3.


A binding-site barrier affects imaging efficiency of high affinity amyloid-reactive peptide radiotracers in vivo.

Wall JS, Williams A, Richey T, Stuckey A, Huang Y, Wooliver C, Macy S, Heidel E, Gupta N, Lee A, Rader B, Martin EB, Kennel SJ.

PLoS One. 2013 Jun 4;8(6):e66181. doi: 10.1371/journal.pone.0066181. Print 2013.


Peptide p5 binds both heparinase-sensitive glycosaminoglycans and fibrils in patient-derived AL amyloid extracts.

Martin EB, Williams A, Heidel E, Macy S, Kennel SJ, Wall JS.

Biochem Biophys Res Commun. 2013 Jun 21;436(1):85-9. doi: 10.1016/j.bbrc.2013.05.063. Epub 2013 May 23.


Whole-body biodistribution of 3'-deoxy-3'-[(18) f]fluorothymidine ((18) FLT) in healthy adult cats.

Rowe JA, Morandi F, Wall JS, Akula M, Kennel SJ, Osborne D, Martin EB, Galyon GD, Long MJ, Stuckey AC, LeBlanc AK.

Vet Radiol Ultrasound. 2013 May-Jun;54(3):299-306. doi: 10.1111/vru.12024. Epub 2013 Mar 7.


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