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Items: 19

1.

Rapid Tuberculosis Diagnosis Using Reporter Enzyme Fluorescence.

Sule P, Tilvawala R, Mustapha T, Hassounah H, Noormohamed A, Kundu S, Graviss EA, Walkup GK, Kong Y, Cirillo JD.

J Clin Microbiol. 2019 Nov 22;57(12). pii: e01462-19. doi: 10.1128/JCM.01462-19. Print 2019 Dec.

2.

New directions using reporter enzyme fluorescence (REF) as a tuberculosis diagnostic platform.

Sule P, Tilvawala R, Behinaein P, Walkup GK, Cirillo JD.

Tuberculosis (Edinb). 2016 Dec;101S:S78-S82. doi: 10.1016/j.tube.2016.09.009. Epub 2016 Sep 28.

3.

Inhibition of Neisseria gonorrhoeae Type II Topoisomerases by the Novel Spiropyrimidinetrione AZD0914.

Kern G, Palmer T, Ehmann DE, Shapiro AB, Andrews B, Basarab GS, Doig P, Fan J, Gao N, Mills SD, Mueller J, Sriram S, Thresher J, Walkup GK.

J Biol Chem. 2015 Aug 21;290(34):20984-94. doi: 10.1074/jbc.M115.663534. Epub 2015 Jul 6.

4.

ESKAPEing the labyrinth of antibacterial discovery.

Tommasi R, Brown DG, Walkup GK, Manchester JI, Miller AA.

Nat Rev Drug Discov. 2015 Aug;14(8):529-42. doi: 10.1038/nrd4572. Epub 2015 Jul 3. Review. Erratum in: Nat Rev Drug Discov. 2015 Sep;14(9):662.

PMID:
26139286
5.

Translating slow-binding inhibition kinetics into cellular and in vivo effects.

Walkup GK, You Z, Ross PL, Allen EK, Daryaee F, Hale MR, O'Donnell J, Ehmann DE, Schuck VJ, Buurman ET, Choy AL, Hajec L, Murphy-Benenato K, Marone V, Patey SA, Grosser LA, Johnstone M, Walker SG, Tonge PJ, Fisher SL.

Nat Chem Biol. 2015 Jun;11(6):416-23. doi: 10.1038/nchembio.1796. Epub 2015 Apr 20.

6.

Selection and molecular characterization of ceftazidime/avibactam-resistant mutants in Pseudomonas aeruginosa strains containing derepressed AmpC.

Lahiri SD, Walkup GK, Whiteaker JD, Palmer T, McCormack K, Tanudra MA, Nash TJ, Thresher J, Johnstone MR, Hajec L, Livchak S, McLaughlin RE, Alm RA.

J Antimicrob Chemother. 2015;70(6):1650-8. doi: 10.1093/jac/dkv004. Epub 2015 Feb 1.

PMID:
25645206
7.

Secreted Gaussia princeps luciferase as a reporter of Escherichia coli replication in a mouse tissue cage model of infection.

Liu M, Blinn C, McLeod SM, Wiseman JW, Newman JV, Fisher SL, Walkup GK.

PLoS One. 2014 Mar 4;9(3):e90382. doi: 10.1371/journal.pone.0090382. eCollection 2014.

8.

Discovery of inhibitors of 4'-phosphopantetheine adenylyltransferase (PPAT) to validate PPAT as a target for antibacterial therapy.

de Jonge BL, Walkup GK, Lahiri SD, Huynh H, Neckermann G, Utley L, Nash TJ, Brock J, San Martin M, Kutschke A, Johnstone M, Laganas V, Hajec L, Gu RF, Ni H, Chen B, Hutchings K, Holt E, McKinney D, Gao N, Livchak S, Thresher J.

Antimicrob Agents Chemother. 2013 Dec;57(12):6005-15. doi: 10.1128/AAC.01661-13. Epub 2013 Sep 16.

9.

Kinetics of avibactam inhibition against Class A, C, and D β-lactamases.

Ehmann DE, Jahic H, Ross PL, Gu RF, Hu J, Durand-Réville TF, Lahiri S, Thresher J, Livchak S, Gao N, Palmer T, Walkup GK, Fisher SL.

J Biol Chem. 2013 Sep 27;288(39):27960-71. doi: 10.1074/jbc.M113.485979. Epub 2013 Aug 2.

10.

Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor.

Ehmann DE, Jahić H, Ross PL, Gu RF, Hu J, Kern G, Walkup GK, Fisher SL.

Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8. doi: 10.1073/pnas.1205073109. Epub 2012 Jul 2.

11.

Structure guided understanding of NAD+ recognition in bacterial DNA ligases.

Lahiri SD, Gu RF, Gao N, Karantzeni I, Walkup GK, Mills SD.

ACS Chem Biol. 2012 Mar 16;7(3):571-80. doi: 10.1021/cb200392g. Epub 2012 Jan 26.

PMID:
22230472
12.

Pyrrolamide DNA gyrase inhibitors: fragment-based nuclear magnetic resonance screening to identify antibacterial agents.

Eakin AE, Green O, Hales N, Walkup GK, Bist S, Singh A, Mullen G, Bryant J, Embrey K, Gao N, Breeze A, Timms D, Andrews B, Uria-Nickelsen M, Demeritt J, Loch JT 3rd, Hull K, Blodgett A, Illingworth RN, Prince B, Boriack-Sjodin PA, Hauck S, MacPherson LJ, Ni H, Sherer B.

Antimicrob Agents Chemother. 2012 Mar;56(3):1240-6. doi: 10.1128/AAC.05485-11. Epub 2011 Dec 19.

13.

A high-throughput absorbance-based assay for methionine produced by methionine aminopeptidase using S-adenosyl-L-methionine synthetase.

Shapiro AB, Gao N, Thresher J, Walkup GK, Whiteaker J.

J Biomol Screen. 2011 Jun;16(5):494-505. doi: 10.1177/1087057111398934. Epub 2011 Mar 14.

PMID:
21402755
14.

A high-throughput fluorescence resonance energy transfer-based assay for DNA ligase.

Shapiro AB, Eakin AE, Walkup GK, Rivin O.

J Biomol Screen. 2011 Jun;16(5):486-93. doi: 10.1177/1087057111398295. Epub 2011 Mar 11.

PMID:
21398623
15.

Novel bacterial NAD+-dependent DNA ligase inhibitors with broad-spectrum activity and antibacterial efficacy in vivo.

Mills SD, Eakin AE, Buurman ET, Newman JV, Gao N, Huynh H, Johnson KD, Lahiri S, Shapiro AB, Walkup GK, Yang W, Stokes SS.

Antimicrob Agents Chemother. 2011 Mar;55(3):1088-96. doi: 10.1128/AAC.01181-10. Epub 2010 Dec 28.

16.

Correction for interference by test samples in high-throughput assays.

Shapiro AB, Walkup GK, Keating TA.

J Biomol Screen. 2009 Sep;14(8):1008-16. doi: 10.1177/1087057109341768. Epub 2009 Jul 30.

PMID:
19643982
17.

New biarsenical ligands and tetracysteine motifs for protein labeling in vitro and in vivo: synthesis and biological applications.

Adams SR, Campbell RE, Gross LA, Martin BR, Walkup GK, Yao Y, Llopis J, Tsien RY.

J Am Chem Soc. 2002 May 29;124(21):6063-76.

PMID:
12022841
18.

Fluorescent sensors for Zn(2+) based on a fluorescein platform: synthesis, properties and intracellular distribution.

Burdette SC, Walkup GK, Spingler B, Tsien RY, Lippard SJ.

J Am Chem Soc. 2001 Aug 15;123(32):7831-41.

PMID:
11493056
19.

Peptidyl chemosensors incorporating a FRET mechanism for detection of Ni(II).

Pearce DA, Walkup GK, Imperiali B.

Bioorg Med Chem Lett. 1998 Aug 4;8(15):1963-8.

PMID:
9873467

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