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Items: 1 to 50 of 72

1.

Tolerance to sustained activation of the cAMP/Creb pathway activity in osteoblastic cells is enabled by loss of p53.

Walia MK, Taylor S, Ho PWM, Martin TJ, Walkley CR.

Cell Death Dis. 2018 Aug 28;9(9):844. doi: 10.1038/s41419-018-0944-8.

2.

Srsf2P95H initiates myeloid bias and myelodysplastic/myeloproliferative syndrome from hemopoietic stem cells.

Smeets MF, Tan SY, Xu JJ, Anande G, Unnikrishnan A, Chalk AM, Taylor SR, Pimanda JE, Wall M, Purton LE, Walkley CR.

Blood. 2018 Aug 9;132(6):608-621. doi: 10.1182/blood-2018-04-845602. Epub 2018 Jun 14.

PMID:
29903888
3.

Small animal models for the study of bone sarcoma pathogenesis:characteristics, therapeutic interests and limitations.

Jacques C, Renema N, Lezot F, Ory B, Walkley CR, Grigoriadis AE, Heymann D.

J Bone Oncol. 2018 Feb 21;12:7-13. doi: 10.1016/j.jbo.2018.02.004. eCollection 2018 Sep. Review.

4.

Adar3 Is Involved in Learning and Memory in Mice.

Mladenova D, Barry G, Konen LM, Pineda SS, Guennewig B, Avesson L, Zinn R, Schonrock N, Bitar M, Jonkhout N, Crumlish L, Kaczorowski DC, Gong A, Pinese M, Franco GR, Walkley CR, Vissel B, Mattick JS.

Front Neurosci. 2018 Apr 13;12:243. doi: 10.3389/fnins.2018.00243. eCollection 2018.

5.

Design, Synthesis, and Biological Activity of 1,2,3-Triazolobenzodiazepine BET Bromodomain Inhibitors.

Sharp PP, Garnier JM, Hatfaludi T, Xu Z, Segal D, Jarman KE, Jousset H, Garnham A, Feutrill JT, Cuzzupe A, Hall P, Taylor S, Walkley CR, Tyler D, Dawson MA, Czabotar P, Wilks AF, Glaser S, Huang DCS, Burns CJ.

ACS Med Chem Lett. 2017 Nov 14;8(12):1298-1303. doi: 10.1021/acsmedchemlett.7b00389. eCollection 2017 Dec 14.

PMID:
29259751
6.

Murine models of osteosarcoma: A piece of the translational puzzle.

Walia MK, Castillo-Tandazo W, Mutsaers AJ, Martin TJ, Walkley CR.

J Cell Biochem. 2018 Jun;119(6):4241-4250. doi: 10.1002/jcb.26601. Epub 2018 Feb 27.

PMID:
29236321
7.

Rewriting the transcriptome: adenosine-to-inosine RNA editing by ADARs.

Walkley CR, Li JB.

Genome Biol. 2017 Oct 30;18(1):205. doi: 10.1186/s13059-017-1347-3. Review.

8.

Dynamic landscape and regulation of RNA editing in mammals.

Tan MH, Li Q, Shanmugam R, Piskol R, Kohler J, Young AN, Liu KI, Zhang R, Ramaswami G, Ariyoshi K, Gupte A, Keegan LP, George CX, Ramu A, Huang N, Pollina EA, Leeman DS, Rustighi A, Goh YPS; GTEx Consortium; Laboratory, Data Analysis &Coordinating Center (LDACC)—Analysis Working Group; Statistical Methods groups—Analysis Working Group; Enhancing GTEx (eGTEx) groups; NIH Common Fund; NIH/NCI; NIH/NHGRI; NIH/NIMH; NIH/NIDA; Biospecimen Collection Source Site—NDRI; Biospecimen Collection Source Site—RPCI; Biospecimen Core Resource—VARI; Brain Bank Repository—University of Miami Brain Endowment Bank; Leidos Biomedical—Project Management; ELSI Study; Genome Browser Data Integration &Visualization—EBI; Genome Browser Data Integration &Visualization—UCSC Genomics Institute, University of California Santa Cruz, Chawla A, Del Sal G, Peltz G, Brunet A, Conrad DF, Samuel CE, O'Connell MA, Walkley CR, Nishikura K, Li JB.

Nature. 2017 Oct 11;550(7675):249-254. doi: 10.1038/nature24041.

9.

Protein recoding by ADAR1-mediated RNA editing is not essential for normal development and homeostasis.

Heraud-Farlow JE, Chalk AM, Linder SE, Li Q, Taylor S, White JM, Pang L, Liddicoat BJ, Gupte A, Li JB, Walkley CR.

Genome Biol. 2017 Sep 5;18(1):166. doi: 10.1186/s13059-017-1301-4.

10.

Ssb1 and Ssb2 cooperate to regulate mouse hematopoietic stem and progenitor cells by resolving replicative stress.

Shi W, Vu T, Boucher D, Biernacka A, Nde J, Pandita RK, Straube J, Boyle GM, Al-Ejeh F, Nag P, Jeffery J, Harris JL, Bain AL, Grzelak M, Skrzypczak M, Mitra A, Dojer N, Crosetto N, Cloonan N, Becherel OJ, Finnie J, Skaar JR, Walkley CR, Pandita TK, Rowicka M, Ginalski K, Lane SW, Khanna KK.

Blood. 2017 May 4;129(18):2479-2492. doi: 10.1182/blood-2016-06-725093. Epub 2017 Mar 7.

11.

The Asymmetric Cell Division Regulators Par3, Scribble and Pins/Gpsm2 Are Not Essential for Erythroid Development or Enucleation.

Wölwer CB, Gödde N, Pase LB, Elsum IA, Lim KY, Sacirbegovic F, Walkley CR, Ellis S, Ohno S, Matsuzaki F, Russell SM, Humbert PO.

PLoS One. 2017 Jan 17;12(1):e0170295. doi: 10.1371/journal.pone.0170295. eCollection 2017.

12.

mTORC1 Plays an Important Role in Skeletal Development by Controlling Preosteoblast Differentiation.

Fitter S, Matthews MP, Martin SK, Xie J, Ooi SS, Walkley CR, Codrington JD, Ruegg MA, Hall MN, Proud CG, Gronthos S, Zannettino AC.

Mol Cell Biol. 2017 Mar 17;37(7). pii: e00668-16. doi: 10.1128/MCB.00668-16. Print 2017 Apr 1.

13.

Loss of ephrinB1 in osteogenic progenitor cells impedes endochondral ossification and compromises bone strength integrity during skeletal development.

Nguyen TM, Arthur A, Paton S, Hemming S, Panagopoulos R, Codrington J, Walkley CR, Zannettino AC, Gronthos S.

Bone. 2016 Dec;93:12-21. doi: 10.1016/j.bone.2016.09.009. Epub 2016 Sep 10.

PMID:
27622886
14.

Adenosine-to-inosine RNA editing by ADAR1 is essential for normal murine erythropoiesis.

Liddicoat BJ, Hartner JC, Piskol R, Ramaswami G, Chalk AM, Kingsley PD, Sankaran VG, Wall M, Purton LE, Seeburg PH, Palis J, Orkin SH, Lu J, Li JB, Walkley CR.

Exp Hematol. 2016 Oct;44(10):947-63. doi: 10.1016/j.exphem.2016.06.250. Epub 2016 Jul 1.

15.

Defining the Minimal Factors Required for Erythropoiesis through Direct Lineage Conversion.

Capellera-Garcia S, Pulecio J, Dhulipala K, Siva K, Rayon-Estrada V, Singbrant S, Sommarin MN, Walkley CR, Soneji S, Karlsson G, Raya Á, Sankaran VG, Flygare J.

Cell Rep. 2016 Jun 14;15(11):2550-62. doi: 10.1016/j.celrep.2016.05.027. Epub 2016 Jun 2.

16.

IAP antagonists sensitize murine osteosarcoma cells to killing by TNFα.

Shekhar TM, Miles MA, Gupte A, Taylor S, Tascone B, Walkley CR, Hawkins CJ.

Oncotarget. 2016 Jun 7;7(23):33866-86. doi: 10.18632/oncotarget.8980.

17.

Activation of PTHrP-cAMP-CREB1 signaling following p53 loss is essential for osteosarcoma initiation and maintenance.

Walia MK, Ho PM, Taylor S, Ng AJ, Gupte A, Chalk AM, Zannettino AC, Martin TJ, Walkley CR.

Elife. 2016 Apr 12;5. pii: e13446. doi: 10.7554/eLife.13446.

18.

The role of RNA editing by ADAR1 in prevention of innate immune sensing of self-RNA.

Heraud-Farlow JE, Walkley CR.

J Mol Med (Berl). 2016 Oct;94(10):1095-1102. Epub 2016 Apr 5. Review.

PMID:
27044320
19.

PDGF-AB and 5-Azacytidine induce conversion of somatic cells into tissue-regenerative multipotent stem cells.

Chandrakanthan V, Yeola A, Kwan JC, Oliver RA, Qiao Q, Kang YC, Zarzour P, Beck D, Boelen L, Unnikrishnan A, Villanueva JE, Nunez AC, Knezevic K, Palu C, Nasrallah R, Carnell M, Macmillan A, Whan R, Yu Y, Hardy P, Grey ST, Gladbach A, Delerue F, Ittner L, Mobbs R, Walkley CR, Purton LE, Ward RL, Wong JW, Hesson LB, Walsh W, Pimanda JE.

Proc Natl Acad Sci U S A. 2016 Apr 19;113(16):E2306-15. doi: 10.1073/pnas.1518244113. Epub 2016 Apr 4.

20.

Increased miR-155-5p and reduced miR-148a-3p contribute to the suppression of osteosarcoma cell death.

Bhattacharya S, Chalk AM, Ng AJ, Martin TJ, Zannettino AC, Purton LE, Lu J, Baker EK, Walkley CR.

Oncogene. 2016 Oct 6;35(40):5282-5294. doi: 10.1038/onc.2016.68. Epub 2016 Apr 4.

PMID:
27041566
21.

The Transcription Factor ASCIZ and Its Target DYNLL1 Are Essential for the Development and Expansion of MYC-Driven B Cell Lymphoma.

Wong DM, Li L, Jurado S, King A, Bamford R, Wall M, Walia MK, Kelly GL, Walkley CR, Tarlinton DM, Strasser A, Heierhorst J.

Cell Rep. 2016 Feb 16;14(6):1488-1499. doi: 10.1016/j.celrep.2016.01.012. Epub 2016 Jan 28.

22.

ADAR1, inosine and the immune sensing system: distinguishing self from non-self.

Liddicoat BJ, Chalk AM, Walkley CR.

Wiley Interdiscip Rev RNA. 2016 Mar-Apr;7(2):157-72. doi: 10.1002/wrna.1322. Epub 2015 Dec 21. Review.

PMID:
26692549
23.

Ciliary neurotrophic factor has intrinsic and extrinsic roles in regulating B cell differentiation and bone structure.

Askmyr M, White KE, Jovic T, King HA, Quach JM, Maluenda AC, Baker EK, Smeets MF, Walkley CR, Purton LE.

Sci Rep. 2015 Oct 21;5:15529. doi: 10.1038/srep15529.

24.

Gene expression profiling to define the cell intrinsic role of the SKI proto-oncogene in hematopoiesis and myeloid neoplasms.

Chalk AM, Liddicoat BJ, Walkley CR, Singbrant S.

Genom Data. 2014 Jul 4;2:189-91. doi: 10.1016/j.gdata.2014.06.022. eCollection 2014 Dec.

25.

RNA editing by ADAR1 prevents MDA5 sensing of endogenous dsRNA as nonself.

Liddicoat BJ, Piskol R, Chalk AM, Ramaswami G, Higuchi M, Hartner JC, Li JB, Seeburg PH, Walkley CR.

Science. 2015 Sep 4;349(6252):1115-20. doi: 10.1126/science.aac7049. Epub 2015 Jul 23.

26.

BET inhibitors induce apoptosis through a MYC independent mechanism and synergise with CDK inhibitors to kill osteosarcoma cells.

Baker EK, Taylor S, Gupte A, Sharp PP, Walia M, Walsh NC, Zannettino AC, Chalk AM, Burns CJ, Walkley CR.

Sci Rep. 2015 May 6;5:10120. doi: 10.1038/srep10120.

27.

Systematic Screening Identifies Dual PI3K and mTOR Inhibition as a Conserved Therapeutic Vulnerability in Osteosarcoma.

Gupte A, Baker EK, Wan SS, Stewart E, Loh A, Shelat AA, Gould CM, Chalk AM, Taylor S, Lackovic K, Karlström Å, Mutsaers AJ, Desai J, Madhamshettiwar PB, Zannettino AC, Burns C, Huang DC, Dyer MA, Simpson KJ, Walkley CR.

Clin Cancer Res. 2015 Jul 15;21(14):3216-29. doi: 10.1158/1078-0432.CCR-14-3026. Epub 2015 Apr 10.

28.

The DNA helicase recql4 is required for normal osteoblast expansion and osteosarcoma formation.

Ng AJ, Walia MK, Smeets MF, Mutsaers AJ, Sims NA, Purton LE, Walsh NC, Martin TJ, Walkley CR.

PLoS Genet. 2015 Apr 10;11(4):e1005160. doi: 10.1371/journal.pgen.1005160. eCollection 2015 Apr.

29.

RARγ is a negative regulator of osteoclastogenesis.

Green AC, Poulton IJ, Vrahnas C, Häusler KD, Walkley CR, Wu JY, Martin TJ, Gillespie MT, Chandraratna RA, Quinn JM, Sims NA, Purton LE.

J Steroid Biochem Mol Biol. 2015 Jun;150:46-53. doi: 10.1016/j.jsbmb.2015.03.005. Epub 2015 Mar 20.

PMID:
25800721
30.

HIF-1α is required for hematopoietic stem cell mobilization and 4-prolyl hydroxylase inhibitors enhance mobilization by stabilizing HIF-1α.

Forristal CE, Nowlan B, Jacobsen RN, Barbier V, Walkinshaw G, Walkley CR, Winkler IG, Levesque JP.

Leukemia. 2015 Jun;29(6):1366-78. doi: 10.1038/leu.2015.8. Epub 2015 Jan 12.

31.

Wnt inhibitory factor 1 (WIF1) is a marker of osteoblastic differentiation stage and is not silenced by DNA methylation in osteosarcoma.

Baker EK, Taylor S, Gupte A, Chalk AM, Bhattacharya S, Green AC, Martin TJ, Strbenac D, Robinson MD, Purton LE, Walkley CR.

Bone. 2015 Apr;73:223-32. doi: 10.1016/j.bone.2014.12.063. Epub 2015 Jan 5.

PMID:
25571841
32.

Brief report: the differential roles of mTORC1 and mTORC2 in mesenchymal stem cell differentiation.

Martin SK, Fitter S, Dutta AK, Matthews MP, Walkley CR, Hall MN, Ruegg MA, Gronthos S, Zannettino AC.

Stem Cells. 2015 Apr;33(4):1359-65. doi: 10.1002/stem.1931.

33.

PTHrP, its receptor, and protein kinase A activation in osteosarcoma.

Walkley CR, Walia MK, Ho PW, Martin TJ.

Mol Cell Oncol. 2014 Dec 31;1(4):e965624. doi: 10.4161/23723548.2014.965624. eCollection 2014 Oct-Dec.

34.

Knockdown of PTHR1 in osteosarcoma cells decreases invasion and growth and increases tumor differentiation in vivo.

Ho PW, Goradia A, Russell MR, Chalk AM, Milley KM, Baker EK, Danks JA, Slavin JL, Walia M, Crimeen-Irwin B, Dickins RA, Martin TJ, Walkley CR.

Oncogene. 2015 May 28;34(22):2922-33. doi: 10.1038/onc.2014.217. Epub 2014 Jul 21.

PMID:
25043296
35.

The Rothmund-Thomson syndrome helicase RECQL4 is essential for hematopoiesis.

Smeets MF, DeLuca E, Wall M, Quach JM, Chalk AM, Deans AJ, Heierhorst J, Purton LE, Izon DJ, Walkley CR.

J Clin Invest. 2014 Aug;124(8):3551-65. doi: 10.1172/JCI75334. Epub 2014 Jun 24.

36.

Src family kinases and their role in hematological malignancies.

Ku M, Wall M, MacKinnon RN, Walkley CR, Purton LE, Tam C, Izon D, Campbell L, Cheng HC, Nandurkar H.

Leuk Lymphoma. 2015 Mar;56(3):577-86. doi: 10.3109/10428194.2014.907897. Epub 2015 Jan 21. Review.

PMID:
24898666
37.

Cells of origin in osteosarcoma: mesenchymal stem cells or osteoblast committed cells?

Mutsaers AJ, Walkley CR.

Bone. 2014 May;62:56-63. doi: 10.1016/j.bone.2014.02.003. Epub 2014 Feb 14. Review.

PMID:
24530473
38.

The SKI proto-oncogene enhances the in vivo repopulation of hematopoietic stem cells and causes myeloproliferative disease.

Singbrant S, Wall M, Moody J, Karlsson G, Chalk AM, Liddicoat B, Russell MR, Walkley CR, Karlsson S.

Haematologica. 2014 Apr;99(4):647-55. doi: 10.3324/haematol.2013.093971. Epub 2014 Jan 10.

39.

Erythroid-extrinsic regulation of normal erythropoiesis by retinoic acid receptors.

Dewamitta SR, Joseph C, Purton LE, Walkley CR.

Br J Haematol. 2014 Jan;164(2):280-5. doi: 10.1111/bjh.12578. Epub 2013 Sep 24.

PMID:
24383846
40.

Immune response to RB1-regulated senescence limits radiation-induced osteosarcoma formation.

Kansara M, Leong HS, Lin DM, Popkiss S, Pang P, Garsed DW, Walkley CR, Cullinane C, Ellul J, Haynes NM, Hicks R, Kuijjer ML, Cleton-Jansen AM, Hinds PW, Smyth MJ, Thomas DM.

J Clin Invest. 2013 Dec;123(12):5351-60. doi: 10.1172/JCI70559. Epub 2013 Nov 15.

41.

Deciphering hematopoietic stem cells in their niches: a critical appraisal of genetic models, lineage tracing, and imaging strategies.

Joseph C, Quach JM, Walkley CR, Lane SW, Lo Celso C, Purton LE.

Cell Stem Cell. 2013 Nov 7;13(5):520-33. doi: 10.1016/j.stem.2013.10.010. Review.

42.

Modeling distinct osteosarcoma subtypes in vivo using Cre:lox and lineage-restricted transgenic shRNA.

Mutsaers AJ, Ng AJ, Baker EK, Russell MR, Chalk AM, Wall M, Liddicoat BJ, Ho PW, Slavin JL, Goradia A, Martin TJ, Purton LE, Dickins RA, Walkley CR.

Bone. 2013 Jul;55(1):166-78. doi: 10.1016/j.bone.2013.02.016. Epub 2013 Feb 26.

PMID:
23486187
43.

Darbepoietin-alfa has comparable erythropoietic stimulatory effects to recombinant erythropoietin whilst preserving the bone marrow microenvironment.

Dewamitta SR, Russell MR, Nandurkar H, Walkley CR.

Haematologica. 2013 May;98(5):686-90. doi: 10.3324/haematol.2012.078709. Epub 2012 Dec 14.

44.

Genetically engineered mouse models and human osteosarcoma.

Ng AJ, Mutsaers AJ, Baker EK, Walkley CR.

Clin Sarcoma Res. 2012 Oct 4;2(1):19. doi: 10.1186/2045-3329-2-19.

45.

The Zinc-finger protein ASCIZ regulates B cell development via DYNLL1 and Bim.

Jurado S, Gleeson K, O'Donnell K, Izon DJ, Walkley CR, Strasser A, Tarlinton DM, Heierhorst J.

J Exp Med. 2012 Aug 27;209(9):1629-39. doi: 10.1084/jem.20120785. Epub 2012 Aug 13.

46.

Hematopoietic AMPK β1 reduces mouse adipose tissue macrophage inflammation and insulin resistance in obesity.

Galic S, Fullerton MD, Schertzer JD, Sikkema S, Marcinko K, Walkley CR, Izon D, Honeyman J, Chen ZP, van Denderen BJ, Kemp BE, Steinberg GR.

J Clin Invest. 2011 Dec;121(12):4903-15. doi: 10.1172/JCI58577. Epub 2011 Nov 14.

47.

Role of ADARs in mouse development.

Walkley CR, Liddicoat B, Hartner JC.

Curr Top Microbiol Immunol. 2012;353:197-220. doi: 10.1007/82_2011_150.

PMID:
21725896
48.

Taking HSCs down a Notch in leukemia.

Walkley CR, Izon DJ, Purton LE.

Cell Stem Cell. 2011 Jun 3;8(6):602-3. doi: 10.1016/j.stem.2011.04.010.

49.

Defining the hematopoietic stem cell niche: the chicken and the egg conundrum.

Singbrant S, Askmyr M, Purton LE, Walkley CR.

J Cell Biochem. 2011 Jun;112(6):1486-90. doi: 10.1002/jcb.23085. Review.

PMID:
21503954
50.

Erythropoietin couples erythropoiesis, B-lymphopoiesis, and bone homeostasis within the bone marrow microenvironment.

Singbrant S, Russell MR, Jovic T, Liddicoat B, Izon DJ, Purton LE, Sims NA, Martin TJ, Sankaran VG, Walkley CR.

Blood. 2011 May 26;117(21):5631-42. doi: 10.1182/blood-2010-11-320564. Epub 2011 Mar 18.

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